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Fusion gene ID: 10530 |
FusionGeneSummary for DPYSL2_BNIP3L |
Fusion gene summary |
Fusion gene information | Fusion gene name: DPYSL2_BNIP3L | Fusion gene ID: 10530 | Hgene | Tgene | Gene symbol | DPYSL2 | BNIP3L | Gene ID | 1808 | 665 |
Gene name | dihydropyrimidinase like 2 | BCL2 interacting protein 3 like | |
Synonyms | CRMP-2|CRMP2|DHPRP2|DRP-2|DRP2|N2A3|ULIP-2|ULIP2 | BNIP3a|NIX | |
Cytomap | 8p21.2 | 8p21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | dihydropyrimidinase-related protein 2collapsin response mediator protein hCRMP-2unc-33-like phosphoprotein 2 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-likeBCL2/adenovirus E1B 19 kDa protein-interacting protein 3ABCL2/adenovirus E1B 19-kd protein-interacting protein 3aBCL2/adenovirus E1B 19kDa interacting protein 3 likeNIP-3-like protein XNIP3 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q16555 | O60238 | |
Ensembl transtripts involved in fusion gene | ENST00000521913, ENST00000311151, ENST00000523027, ENST00000521983, | ENST00000380629, ENST00000523515, ENST00000520409, ENST00000518611, ENST00000521254, | |
Fusion gene scores | * DoF score | 9 X 7 X 3=189 | 5 X 3 X 5=75 |
# samples | 9 | 5 | |
** MAII score | log2(9/189*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DPYSL2 [Title/Abstract] AND BNIP3L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BNIP3L | GO:0043065 | positive regulation of apoptotic process | 9973195 |
Tgene | BNIP3L | GO:0043066 | negative regulation of apoptotic process | 10381623 |
Tgene | BNIP3L | GO:0051607 | defense response to virus | 9973195 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-96-A4JK-01A | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000521913 | ENST00000380629 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000521913 | ENST00000523515 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000521913 | ENST00000520409 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000521913 | ENST00000518611 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000521913 | ENST00000521254 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000311151 | ENST00000380629 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000311151 | ENST00000523515 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000311151 | ENST00000520409 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000311151 | ENST00000518611 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000311151 | ENST00000521254 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000523027 | ENST00000380629 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000523027 | ENST00000523515 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000523027 | ENST00000520409 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000523027 | ENST00000518611 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
5CDS-intron | ENST00000523027 | ENST00000521254 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
intron-intron | ENST00000521983 | ENST00000380629 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
intron-intron | ENST00000521983 | ENST00000523515 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
intron-intron | ENST00000521983 | ENST00000520409 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
intron-intron | ENST00000521983 | ENST00000518611 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
intron-intron | ENST00000521983 | ENST00000521254 | DPYSL2 | chr8 | 26441499 | + | BNIP3L | chr8 | 26362823 | + |
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FusionProtFeatures for DPYSL2_BNIP3L |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
DPYSL2 | BNIP3L |
Plays a role in neuronal development and polarity, aswell as in axon growth and guidance, neuronal growth cone collapseand cell migration. Necessary for signaling by class 3 semaphorinsand subsequent remodeling of the cytoskeleton. May play a role inendocytosis. {ECO:0000269|PubMed:11477421,ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. | Induces apoptosis. Interacts with viral and cellularanti-apoptosis proteins. Can overcome the suppressors BCL-2 andBCL-XL, although high levels of BCL-XL expression will inhibitapoptosis. Inhibits apoptosis induced by BNIP3. Involved inmitochondrial quality control via its interaction withSPATA18/MIEAP: in response to mitochondrial damage, participatesin mitochondrial protein catabolic process (also named MALM)leading to the degradation of damaged proteins insidemitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 andBNIP3L/NIX at the mitochondrial outer membrane regulates theopening of a pore in the mitochondrial double membrane in order tomediate the translocation of lysosomal proteins from the cytoplasmto the mitochondrial matrix. May function as a tumor suppressor.{ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DPYSL2_BNIP3L |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DPYSL2_BNIP3L |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DPYSL2 | AP2A1, NUMB, CRMP1, RHOA, DISC1, TNIK, DPYSL4, ELAVL1, SIRT7, CDK2, IQCB1, LEF1, DNAJB1, EIF3J, XPO7, HSPH1, PDE3A, PUS7, RANBP6, DPYSL2, DPYSL3, GORASP2, DPYSL5, ARMC1, HAX1, NUFIP1, RRP7A, CDCA8, DGUOK, DNAAF2, WDR83, KLHDC3, UNK, ARFIP1, CAP1, CDA, DPH2, LYPLA1, TSG101, UNC13D, NTMT1, VPS28, NTRK1, PPP1CA, PPP1CC, MCM2, DPYS, FAM19A3, LGALS7, TGIF2LY, G3BP1 | BNIP3L | DOK5, EWSR1, BNIP3L, BNIP3, TMEM11, STEAP3, BCL2, ROBO2, GNB5, KLHL23, GBP2, ATP13A2, RHEB, CLN8, MAP1LC3B, MAP1LC3A, GABARAP, GABARAPL1, GABARAPL2, CEP192, ECM1, CASK, CAMK1D, DUSP3, SMCO4, CLEC7A, FATE1, LDLRAD1, WIPI2, BCL2L1, PPTC7, LMNA |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DPYSL2_BNIP3L |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | DPYSL2 | Q16555 | DB11638 | Artenimol | Dihydropyrimidinase-related protein 2 | small molecule | approved|investigational |
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RelatedDiseases for DPYSL2_BNIP3L |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DPYSL2 | C0005586 | Bipolar Disorder | 4 | PSYGENET |
Hgene | DPYSL2 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | DPYSL2 | C0002395 | Alzheimer's Disease | 1 | CTD_human |
Hgene | DPYSL2 | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | DPYSL2 | C0011581 | Depressive disorder | 1 | PSYGENET |
Hgene | DPYSL2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | DPYSL2 | C0033937 | Psychoses, Drug | 1 | PSYGENET |
Hgene | DPYSL2 | C0036349 | Paranoid Schizophrenia | 1 | CTD_human |