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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10530

FusionGeneSummary for DPYSL2_BNIP3L

check button Fusion gene summary
Fusion gene informationFusion gene name: DPYSL2_BNIP3L
Fusion gene ID: 10530
HgeneTgene
Gene symbol

DPYSL2

BNIP3L

Gene ID

1808

665

Gene namedihydropyrimidinase like 2BCL2 interacting protein 3 like
SynonymsCRMP-2|CRMP2|DHPRP2|DRP-2|DRP2|N2A3|ULIP-2|ULIP2BNIP3a|NIX
Cytomap

8p21.2

8p21.2

Type of geneprotein-codingprotein-coding
Descriptiondihydropyrimidinase-related protein 2collapsin response mediator protein hCRMP-2unc-33-like phosphoprotein 2BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-likeBCL2/adenovirus E1B 19 kDa protein-interacting protein 3ABCL2/adenovirus E1B 19-kd protein-interacting protein 3aBCL2/adenovirus E1B 19kDa interacting protein 3 likeNIP-3-like protein XNIP3
Modification date2018051920180523
UniProtAcc

Q16555

O60238

Ensembl transtripts involved in fusion geneENST00000521913, ENST00000311151, 
ENST00000523027, ENST00000521983, 
ENST00000380629, ENST00000523515, 
ENST00000520409, ENST00000518611, 
ENST00000521254, 
Fusion gene scores* DoF score9 X 7 X 3=1895 X 3 X 5=75
# samples 95
** MAII scorelog2(9/189*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DPYSL2 [Title/Abstract] AND BNIP3L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBNIP3L

GO:0043065

positive regulation of apoptotic process

9973195

TgeneBNIP3L

GO:0043066

negative regulation of apoptotic process

10381623

TgeneBNIP3L

GO:0051607

defense response to virus

9973195


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-96-A4JK-01ADPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000521913ENST00000380629DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000521913ENST00000523515DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000521913ENST00000520409DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000521913ENST00000518611DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000521913ENST00000521254DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000311151ENST00000380629DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000311151ENST00000523515DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000311151ENST00000520409DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000311151ENST00000518611DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000311151ENST00000521254DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000523027ENST00000380629DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000523027ENST00000523515DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000523027ENST00000520409DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000523027ENST00000518611DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
5CDS-intronENST00000523027ENST00000521254DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
intron-intronENST00000521983ENST00000380629DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
intron-intronENST00000521983ENST00000523515DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
intron-intronENST00000521983ENST00000520409DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
intron-intronENST00000521983ENST00000518611DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+
intron-intronENST00000521983ENST00000521254DPYSL2chr8

26441499

+BNIP3Lchr8

26362823

+

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FusionProtFeatures for DPYSL2_BNIP3L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DPYSL2

Q16555

BNIP3L

O60238

Plays a role in neuronal development and polarity, aswell as in axon growth and guidance, neuronal growth cone collapseand cell migration. Necessary for signaling by class 3 semaphorinsand subsequent remodeling of the cytoskeleton. May play a role inendocytosis. {ECO:0000269|PubMed:11477421,ECO:0000269|PubMed:15466863, ECO:0000269|PubMed:20801876}. Induces apoptosis. Interacts with viral and cellularanti-apoptosis proteins. Can overcome the suppressors BCL-2 andBCL-XL, although high levels of BCL-XL expression will inhibitapoptosis. Inhibits apoptosis induced by BNIP3. Involved inmitochondrial quality control via its interaction withSPATA18/MIEAP: in response to mitochondrial damage, participatesin mitochondrial protein catabolic process (also named MALM)leading to the degradation of damaged proteins insidemitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 andBNIP3L/NIX at the mitochondrial outer membrane regulates theopening of a pore in the mitochondrial double membrane in order tomediate the translocation of lysosomal proteins from the cytoplasmto the mitochondrial matrix. May function as a tumor suppressor.{ECO:0000269|PubMed:10381623, ECO:0000269|PubMed:21264228}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DPYSL2_BNIP3L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DPYSL2_BNIP3L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DPYSL2AP2A1, NUMB, CRMP1, RHOA, DISC1, TNIK, DPYSL4, ELAVL1, SIRT7, CDK2, IQCB1, LEF1, DNAJB1, EIF3J, XPO7, HSPH1, PDE3A, PUS7, RANBP6, DPYSL2, DPYSL3, GORASP2, DPYSL5, ARMC1, HAX1, NUFIP1, RRP7A, CDCA8, DGUOK, DNAAF2, WDR83, KLHDC3, UNK, ARFIP1, CAP1, CDA, DPH2, LYPLA1, TSG101, UNC13D, NTMT1, VPS28, NTRK1, PPP1CA, PPP1CC, MCM2, DPYS, FAM19A3, LGALS7, TGIF2LY, G3BP1BNIP3LDOK5, EWSR1, BNIP3L, BNIP3, TMEM11, STEAP3, BCL2, ROBO2, GNB5, KLHL23, GBP2, ATP13A2, RHEB, CLN8, MAP1LC3B, MAP1LC3A, GABARAP, GABARAPL1, GABARAPL2, CEP192, ECM1, CASK, CAMK1D, DUSP3, SMCO4, CLEC7A, FATE1, LDLRAD1, WIPI2, BCL2L1, PPTC7, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DPYSL2_BNIP3L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDPYSL2Q16555DB11638ArtenimolDihydropyrimidinase-related protein 2small moleculeapproved|investigational

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RelatedDiseases for DPYSL2_BNIP3L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDPYSL2C0005586Bipolar Disorder4PSYGENET
HgeneDPYSL2C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneDPYSL2C0002395Alzheimer's Disease1CTD_human
HgeneDPYSL2C0011570Mental Depression1PSYGENET
HgeneDPYSL2C0011581Depressive disorder1PSYGENET
HgeneDPYSL2C0029408Degenerative polyarthritis1CTD_human
HgeneDPYSL2C0033937Psychoses, Drug1PSYGENET
HgeneDPYSL2C0036349Paranoid Schizophrenia1CTD_human