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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10489

FusionGeneSummary for DPP4_CD109

check button Fusion gene summary
Fusion gene informationFusion gene name: DPP4_CD109
Fusion gene ID: 10489
HgeneTgene
Gene symbol

DPP4

CD109

Gene ID

1803

135228

Gene namedipeptidyl peptidase 4CD109 molecule
SynonymsADABP|ADCP2|CD26|DPPIV|TP103CPAMD7|p180|r150
Cytomap

2q24.2

6q13

Type of geneprotein-codingprotein-coding
Descriptiondipeptidyl peptidase 4ADCP-2DPP IVT-cell activation antigen CD26adenosine deaminase complexing protein 2dipeptidyl peptidase IVdipeptidylpeptidase 4dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)CD109 antigen150 kDa TGF-beta-1-binding proteinC3 and PZP-like alpha-2-macroglobulin domain-containing protein 7Gov platelet alloantigensactivated T-cell marker CD109platelet-specific Gov antigen
Modification date2018051920180522
UniProtAcc

P27487

Q6YHK3

Ensembl transtripts involved in fusion geneENST00000360534, ENST00000491591, 
ENST00000422508, ENST00000437994, 
ENST00000287097, ENST00000474094, 
Fusion gene scores* DoF score3 X 3 X 3=271 X 1 X 1=1
# samples 31
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: DPP4 [Title/Abstract] AND CD109 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDPP4

GO:0001666

response to hypoxia

16670267

HgeneDPP4

GO:0006508

proteolysis

27198182

HgeneDPP4

GO:0008284

positive regulation of cell proliferation

17549790

HgeneDPP4

GO:0010716

negative regulation of extracellular matrix disassembly

16651416

HgeneDPP4

GO:0031295

T cell costimulation

10900005|17287217

HgeneDPP4

GO:0033632

regulation of cell-cell adhesion mediated by integrin

11772392

HgeneDPP4

GO:0042110

T cell activation

7594462

HgeneDPP4

GO:0043542

endothelial cell migration

16651416

TgeneCD109

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

16754747

TgeneCD109

GO:0061045

negative regulation of wound healing

16754747


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG231728DPP4chr2

162916134

+CD109chr6

74457269

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000360534ENST00000422508DPP4chr2

162916134

+CD109chr6

74457269

-
intron-intronENST00000360534ENST00000437994DPP4chr2

162916134

+CD109chr6

74457269

-
intron-intronENST00000360534ENST00000287097DPP4chr2

162916134

+CD109chr6

74457269

-
intron-intronENST00000360534ENST00000474094DPP4chr2

162916134

+CD109chr6

74457269

-
intron-intronENST00000491591ENST00000422508DPP4chr2

162916134

+CD109chr6

74457269

-
intron-intronENST00000491591ENST00000437994DPP4chr2

162916134

+CD109chr6

74457269

-
intron-intronENST00000491591ENST00000287097DPP4chr2

162916134

+CD109chr6

74457269

-
intron-intronENST00000491591ENST00000474094DPP4chr2

162916134

+CD109chr6

74457269

-

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FusionProtFeatures for DPP4_CD109


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DPP4

P27487

CD109

Q6YHK3

Cell surface glycoprotein receptor involved in thecostimulatory signal essential for T-cell receptor (TCR)-mediatedT-cell activation. Acts as a positive regulator of T-cellcoactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Itsbinding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Itsinteraction with ADA also regulates lymphocyte-epithelial celladhesion. In association with FAP is involved in the pericellularproteolysis of the extracellular matrix (ECM), the migration andinvasion of endothelial cells into the ECM. May be involved in thepromotion of lymphatic endothelial cells adhesion, migration andtube formation. When overexpressed, enhanced cell proliferation, aprocess inhibited by GPC3. Acts also as a serine exopeptidase witha dipeptidyl peptidase activity that regulates variousphysiological processes by cleaving peptides in the circulation,including many chemokines, mitogenic growth factors, neuropeptidesand peptide hormones. Removes N-terminal dipeptides sequentiallyfrom polypeptides having unsubstituted N-termini provided that thepenultimate residue is proline. {ECO:0000269|PubMed:10570924,ECO:0000269|PubMed:10593948, ECO:0000269|PubMed:10900005,ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:11772392,ECO:0000269|PubMed:14691230, ECO:0000269|PubMed:16651416,ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:17549790,ECO:0000269|PubMed:18708048}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DPP4_CD109


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DPP4_CD109


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DPP4_CD109


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDPP4P27487DB01076AtorvastatinDipeptidyl peptidase 4small moleculeapproved
HgeneDPP4P27487DB06203AlogliptinDipeptidyl peptidase 4small moleculeapproved
HgeneDPP4P27487DB06335SaxagliptinDipeptidyl peptidase 4small moleculeapproved
HgeneDPP4P27487DB08882LinagliptinDipeptidyl peptidase 4small moleculeapproved
HgeneDPP4P27487DB01261SitagliptinDipeptidyl peptidase 4small moleculeapproved|investigational
HgeneDPP4P27487DB04876VildagliptinDipeptidyl peptidase 4small moleculeapproved|investigational

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RelatedDiseases for DPP4_CD109


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDPP4C0011570Mental Depression2PSYGENET
HgeneDPP4C0011581Depressive disorder2PSYGENET
HgeneDPP4C0033687Proteinuria1CTD_human
TgeneCD109C0009404Colorectal Neoplasms2CTD_human
TgeneCD109C1458155Mammary Neoplasms1CTD_human