FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 10481

FusionGeneSummary for DPP10_RUNX1

check button Fusion gene summary
Fusion gene informationFusion gene name: DPP10_RUNX1
Fusion gene ID: 10481
HgeneTgene
Gene symbol

DPP10

RUNX1

Gene ID

57628

861

Gene namedipeptidyl peptidase like 10runt related transcription factor 1
SynonymsDPL2|DPPY|DPRP-3|DPRP3AML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alpha
Cytomap

2q14.1

21q22.12

Type of geneprotein-codingprotein-coding
Descriptioninactive dipeptidyl peptidase 10DPP Xdipeptidyl peptidase 10dipeptidyl peptidase IV-related protein 3dipeptidyl peptidase Xdipeptidyl peptidase-like protein 2dipeptidyl-peptidase 10 (inactive)dipeptidyl-peptidase 10 (non-functional)runt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2
Modification date2018051920180527
UniProtAcc

Q8N608

Q01196

Ensembl transtripts involved in fusion geneENST00000410059, ENST00000409163, 
ENST00000393147, ENST00000310323, 
ENST00000488208, 
ENST00000344691, 
ENST00000325074, ENST00000437180, 
ENST00000300305, ENST00000399240, 
ENST00000486278, ENST00000494829, 
ENST00000358356, 
Fusion gene scores* DoF score3 X 3 X 1=917 X 29 X 7=3451
# samples 533
** MAII scorelog2(5/9*10)=2.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(33/3451*10)=-3.3864765441897
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DPP10 [Title/Abstract] AND RUNX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDPP10

GO:1903078

positive regulation of protein localization to plasma membrane

15671030

TgeneRUNX1

GO:0030097

hemopoiesis

21873977

TgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

TgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DR004240DPP10chr2

115344416

-RUNX1chr21

36421327

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000410059ENST00000344691DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000410059ENST00000325074DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000410059ENST00000437180DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-5UTRENST00000410059ENST00000300305DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000410059ENST00000399240DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000410059ENST00000486278DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000410059ENST00000494829DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000410059ENST00000358356DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000409163ENST00000344691DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000409163ENST00000325074DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000409163ENST00000437180DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-5UTRENST00000409163ENST00000300305DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000409163ENST00000399240DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000409163ENST00000486278DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000409163ENST00000494829DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000409163ENST00000358356DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000393147ENST00000344691DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000393147ENST00000325074DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000393147ENST00000437180DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-5UTRENST00000393147ENST00000300305DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000393147ENST00000399240DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000393147ENST00000486278DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000393147ENST00000494829DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000393147ENST00000358356DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000310323ENST00000344691DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000310323ENST00000325074DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000310323ENST00000437180DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-5UTRENST00000310323ENST00000300305DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000310323ENST00000399240DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000310323ENST00000486278DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000310323ENST00000494829DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000310323ENST00000358356DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000488208ENST00000344691DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000488208ENST00000325074DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000488208ENST00000437180DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-5UTRENST00000488208ENST00000300305DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000488208ENST00000399240DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000488208ENST00000486278DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000488208ENST00000494829DPP10chr2

115344416

-RUNX1chr21

36421327

-
intron-intronENST00000488208ENST00000358356DPP10chr2

115344416

-RUNX1chr21

36421327

-

Top

FusionProtFeatures for DPP10_RUNX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DPP10

Q8N608

RUNX1

Q01196


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for DPP10_RUNX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for DPP10_RUNX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for DPP10_RUNX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for DPP10_RUNX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDPP10C0023903Liver neoplasms1CTD_human
HgeneDPP10C0032927Precancerous Conditions1CTD_human
HgeneDPP10C1510586Autism Spectrum Disorders1CTD_human
TgeneRUNX1C0023467Leukemia, Myelocytic, Acute2CTD_human;HPO
TgeneRUNX1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
TgeneRUNX1C0003873Rheumatoid Arthritis1CTD_human
TgeneRUNX1C0017636Glioblastoma1CTD_human
TgeneRUNX1C0033578Prostatic Neoplasms1CTD_human
TgeneRUNX1C0349639Juvenile Myelomonocytic Leukemia1CTD_human
TgeneRUNX1C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy1CTD_human;ORPHANET;UNIPROT
TgeneRUNX1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human