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Fusion gene ID: 10452 |
FusionGeneSummary for DOT1L_OAZ1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DOT1L_OAZ1 | Fusion gene ID: 10452 | Hgene | Tgene | Gene symbol | DOT1L | OAZ1 | Gene ID | 84444 | 4946 |
| Gene name | DOT1 like histone lysine methyltransferase | ornithine decarboxylase antizyme 1 | |
| Synonyms | DOT1|KMT4 | AZ1|AZI|OAZ | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone-lysine N-methyltransferase, H3 lysine-79 specificDOT1 like histone H3K79 methyltransferaseDOT1-like histone methyltransferaseDOT1-like proteinDOT1-like, histone H3 methyltransferaseH3-K79-HMTasehistone H3-K79 methyltransferasehistone methyl | ornithine decarboxylase antizyme 1ODC-Azantizyme 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8TEK3 | P54368 | |
| Ensembl transtripts involved in fusion gene | ENST00000398665, ENST00000608122, | ENST00000582888, ENST00000602676, ENST00000322297, ENST00000583542, ENST00000588673, | |
| Fusion gene scores | * DoF score | 12 X 8 X 9=864 | 7 X 5 X 5=175 |
| # samples | 21 | 7 | |
| ** MAII score | log2(21/864*10)=-2.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DOT1L [Title/Abstract] AND OAZ1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DOT1L | GO:0008284 | positive regulation of cell proliferation | 15851025 |
| Hgene | DOT1L | GO:0034729 | histone H3-K79 methylation | 15851025 |
| Hgene | DOT1L | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15851025 |
| Hgene | DOT1L | GO:0046425 | regulation of JAK-STAT cascade | 22002246 |
| Tgene | OAZ1 | GO:0045732 | positive regulation of protein catabolic process | 17900240 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-0801-01A | DOT1L | chr19 | 2164264 | + | OAZ1 | chr19 | 2271781 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000398665 | ENST00000582888 | DOT1L | chr19 | 2164264 | + | OAZ1 | chr19 | 2271781 | + |
| In-frame | ENST00000398665 | ENST00000602676 | DOT1L | chr19 | 2164264 | + | OAZ1 | chr19 | 2271781 | + |
| In-frame | ENST00000398665 | ENST00000322297 | DOT1L | chr19 | 2164264 | + | OAZ1 | chr19 | 2271781 | + |
| In-frame | ENST00000398665 | ENST00000583542 | DOT1L | chr19 | 2164264 | + | OAZ1 | chr19 | 2271781 | + |
| In-frame | ENST00000398665 | ENST00000588673 | DOT1L | chr19 | 2164264 | + | OAZ1 | chr19 | 2271781 | + |
| intron-3CDS | ENST00000608122 | ENST00000582888 | DOT1L | chr19 | 2164264 | + | OAZ1 | chr19 | 2271781 | + |
| intron-3CDS | ENST00000608122 | ENST00000602676 | DOT1L | chr19 | 2164264 | + | OAZ1 | chr19 | 2271781 | + |
| intron-3CDS | ENST00000608122 | ENST00000322297 | DOT1L | chr19 | 2164264 | + | OAZ1 | chr19 | 2271781 | + |
| intron-3CDS | ENST00000608122 | ENST00000583542 | DOT1L | chr19 | 2164264 | + | OAZ1 | chr19 | 2271781 | + |
| intron-3CDS | ENST00000608122 | ENST00000588673 | DOT1L | chr19 | 2164264 | + | OAZ1 | chr19 | 2271781 | + |
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FusionProtFeatures for DOT1L_OAZ1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DOT1L | OAZ1 |
| Histone methyltransferase. Methylates 'Lys-79' ofhistone H3. Nucleosomes are preferred as substrate compared tofree histones. Binds to DNA. | Ornithine decarboxylase (ODC) antizyme protein thatnegatively regulates ODC activity and intracellular polyaminebiosynthesis and uptake in response to increased intracellularpolyamine levels. Binds to ODC monomers, inhibiting the assemblyof the functional ODC homodimer, and targets the monomers forubiquitin-independent proteolytic destruction by the 26Sproteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277).Triggers ODC degradation by inducing the exposure of a crypticproteasome-interacting surface of ODC (PubMed:26305948).Stabilizes AZIN2 by interfering with its ubiquitination(PubMed:17900240). Also inhibits cellular uptake of polyamines byinactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4complex mediates the degradation of the CREBBP/EP300 repressorSNIP1. Involved in the translocation of AZIN2 from ER-Golgiintermediate compartment (ERGIC) to the cytosol (PubMed:12097147).{ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:17900240,ECO:0000269|PubMed:26305948, ECO:0000269|PubMed:26443277}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >DOT1L | chr19:2164264 | chr19:2271781 | ENST00000398665 | + | 1 | 28 | 16_330 | 27 | 1538 | Domain | DOT1 |
| Hgene | >DOT1L | chr19:2164264 | chr19:2271781 | ENST00000398665 | + | 1 | 28 | 136_139 | 27 | 1538 | Region | Note=S-adenosyl-L-methionine binding |
| Hgene | >DOT1L | chr19:2164264 | chr19:2271781 | ENST00000398665 | + | 1 | 28 | 159_168 | 27 | 1538 | Region | Note=S-adenosyl-L-methionine binding |
| Hgene | >DOT1L | chr19:2164264 | chr19:2271781 | ENST00000398665 | + | 1 | 28 | 222_223 | 27 | 1538 | Region | Note=S-adenosyl-L-methionine binding |
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FusionGeneSequence for DOT1L_OAZ1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000582888_chr19_2271781_+_159aa MGEKLELRLKSPVGAEPAVYPWPLPVYDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLL >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000602676_chr19_2271781_+_159aa MGEKLELRLKSPVGAEPAVYPWPLPVYDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLL >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000322297_chr19_2271781_+_159aa MGEKLELRLKSPVGAEPAVYPWPLPVYDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLL >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000583542_chr19_2271781_+_167aa MGEKLELRLKSPVGAEPAVYPWPLPVYDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSRDADT >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000588673_chr19_2271781_+_159aa MGEKLELRLKSPVGAEPAVYPWPLPVYDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000582888_chr19_2271781_+_477nt ATGGGGGAGAAGCTGGAGCTGAGACTGAAGTCGCCCGTGGGGGCTGAGCCCGCCGTCTACCCGTGGCCGCTGCCGGTCTACGATGATCGG CTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCAAACGCATTAACTGG CGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTG GAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGCCGCCTTGCTCCGAACCTTC AGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGA >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000602676_chr19_2271781_+_477nt ATGGGGGAGAAGCTGGAGCTGAGACTGAAGTCGCCCGTGGGGGCTGAGCCCGCCGTCTACCCGTGGCCGCTGCCGGTCTACGATGATCGG CTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCAAACGCATTAACTGG CGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTG GAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGCCGCCTTGCTCCGAACCTTC AGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGA >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000322297_chr19_2271781_+_477nt ATGGGGGAGAAGCTGGAGCTGAGACTGAAGTCGCCCGTGGGGGCTGAGCCCGCCGTCTACCCGTGGCCGCTGCCGGTCTACGATGATCGG CTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCAAACGCATTAACTGG CGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTG GAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGCCGCCTTGCTCCGAACCTTC AGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGA >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000583542_chr19_2271781_+_501nt ATGGGGGAGAAGCTGGAGCTGAGACTGAAGTCGCCCGTGGGGGCTGAGCCCGCCGTCTACCCGTGGCCGCTGCCGGTCTACGATGATCGG CTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCAAACGCATTAACTGG CGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCCGAGACGCTGACACT CGCTGCAGCTTTGCAGTTCTCCTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCGAGGAC AGAGCCGCCTTGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGC >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000588673_chr19_2271781_+_477nt ATGGGGGAGAAGCTGGAGCTGAGACTGAAGTCGCCCGTGGGGGCTGAGCCCGCCGTCTACCCGTGGCCGCTGCCGGTCTACGATGATCGG CTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGACGCCAAACGCATTAACTGG CGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTG GAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGCCGCCTTGCTCCGAACCTTC AGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000582888_chr19_2271781_+_738nt CCCGCCTAGCATGGTGCGGCGGCCGCGCGCGCGGACATGGGGGAGAAGCTGGAGCTGAGACTGAAGTCGCCCGTGGGGGCTGAGCCCGCC GTCTACCCGTGGCCGCTGCCGGTCTACGATGATCGGCTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTC CAGTCCAGGCTCACAGACGCCAAACGCATTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTG CCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAG AACCGCGAGGACAGAGCCGCCTTGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGA CCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCCGGCC CCTGGGGCCACCCCTTGTCAGCCGGGTGGGTAGGAACCGTAGACTCGCTCATCTCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAAT AAACGCTCACTCCGAATTAGCGGTGTATTTCTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCTTTAATTCTAAATAAAAAT >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000602676_chr19_2271781_+_893nt CCCGCCTAGCATGGTGCGGCGGCCGCGCGCGCGGACATGGGGGAGAAGCTGGAGCTGAGACTGAAGTCGCCCGTGGGGGCTGAGCCCGCC GTCTACCCGTGGCCGCTGCCGGTCTACGATGATCGGCTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTC CAGTCCAGGCTCACAGACGCCAAACGCATTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTG CCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAG AACCGCGAGGACAGAGCCGCCTTGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGA CCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCCGGCC CCTGGGGCCACCCCTTGTCAGCCGGGTGGGTAGGAACCGTAGACTCGCTCATCTCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAAT AAACGCTCACTCCGAATTAGCGGTGTATTTCTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCTTTAATTCTAAATAAAAAT TTATATTTTACTTTTTTATTGCTGGTTTAAGATGATTCAGATTATCCTTGTACTTTGAGGAGAAGTTTCTTATTTGGAGTCTTTTGGAAA >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000322297_chr19_2271781_+_893nt CCCGCCTAGCATGGTGCGGCGGCCGCGCGCGCGGACATGGGGGAGAAGCTGGAGCTGAGACTGAAGTCGCCCGTGGGGGCTGAGCCCGCC GTCTACCCGTGGCCGCTGCCGGTCTACGATGATCGGCTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTC CAGTCCAGGCTCACAGACGCCAAACGCATTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTG CCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAG AACCGCGAGGACAGAGCCGCCTTGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGA CCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCCGGCC CCTGGGGCCACCCCTTGTCAGCCGGGTGGGTAGGAACCGTAGACTCGCTCATCTCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAAT AAACGCTCACTCCGAATTAGCGGTGTATTTCTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCTTTAATTCTAAATAAAAAT TTATATTTTACTTTTTTATTGCTGGTTTAAGATGATTCAGATTATCCTTGTACTTTGAGGAGAAGTTTCTTATTTGGAGTCTTTTGGAAA >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000583542_chr19_2271781_+_917nt CCCGCCTAGCATGGTGCGGCGGCCGCGCGCGCGGACATGGGGGAGAAGCTGGAGCTGAGACTGAAGTCGCCCGTGGGGGCTGAGCCCGCC GTCTACCCGTGGCCGCTGCCGGTCTACGATGATCGGCTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTC CAGTCCAGGCTCACAGACGCCAAACGCATTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTG CCCGAGGGGAGCAAGGACAGCCGAGACGCTGACACTCGCTGCAGCTTTGCAGTTCTCCTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGAC CATGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGCCGCCTTGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCG GGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGC CGCCTCGGGGCTGGGCATCCGGCCCCTGGGGCCACCCCTTGTCAGCCGGGTGGGTAGGAACCGTAGACTCGCTCATCTCGCCTGGGTTTG TCCGCATGTTGTAATCGTGCAAATAAACGCTCACTCCGAATTAGCGGTGTATTTCTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTA TTTGCTTTAATTCTAAATAAAAATTTATATTTTACTTTTTTATTGCTGGTTTAAGATGATTCAGATTATCCTTGTACTTTGAGGAGAAGT TTCTTATTTGGAGTCTTTTGGAAACAGTCTTAGTCTTTTAACTTGGAAAGATGAGGTATTAATCCCCTCCATTGCTCTCCAAAAGCCAAT >In-frame_DOT1L_ENST00000398665_chr19_2164264_+_OAZ1_ENST00000588673_chr19_2271781_+_579nt CCCGCCTAGCATGGTGCGGCGGCCGCGCGCGCGGACATGGGGGAGAAGCTGGAGCTGAGACTGAAGTCGCCCGTGGGGGCTGAGCCCGCC GTCTACCCGTGGCCGCTGCCGGTCTACGATGATCGGCTGAATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTC CAGTCCAGGCTCACAGACGCCAAACGCATTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGGGCGGCGCGCTG CCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTGGAGTTCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAG AACCGCGAGGACAGAGCCGCCTTGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGA CCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCCGGCC |
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FusionGenePPI for DOT1L_OAZ1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DOT1L | MLLT10, MLLT3, MLLT6, SIRT1, NPM1, HNRNPM, MLLT1, HIST1H1C, DDX21, HIST1H2BB, GRWD1, HNRNPU, HIST1H2AA, ALYREF, YBX3, SYNCRIP, GNL3, H1FX, HIST1H1A, KMT2A, AFF1, HIST2H3C, STAT1, HIST3H3, LIN28A, NANOG, BAG6, TP53, MAPK7, EBNA1BP2, IBTK, NIN, PARP16, ORC1, YEATS4, CKAP5, VWA9, RBM45, KIF24, BRINP1 | OAZ1 | EGFR, SMAD1, PSMB4, ATXN1, PIAS4, TP73, AZIN1, ODC1, GBE1, UPF1, RAB7A, TAF1B, SRA1, CEPT1, CAMSAP2, GPATCH4, PLXNA3, RNF20, LENG8, PGM2L1, NLGN3, AZIN2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DOT1L_OAZ1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DOT1L_OAZ1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DOT1L | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
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