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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10439

FusionGeneSummary for DOPEY1_SMIM8

check button Fusion gene summary
Fusion gene informationFusion gene name: DOPEY1_SMIM8
Fusion gene ID: 10439
HgeneTgene
Gene symbol

DOPEY1

SMIM8

Gene ID

23033

57150

Gene namedopey family member 1small integral membrane protein 8
SynonymsDOP1|KIAA1117|dJ202D23.2C6orf162|dJ102H19.2
Cytomap

6q14.1

6q15

Type of geneprotein-codingprotein-coding
Descriptionprotein dopey-1homolog of yeast DOP1small integral membrane protein 8UPF0708 protein C6orf162
Modification date2018052320180519
UniProtAcc

Q5JWR5

Q96KF7

Ensembl transtripts involved in fusion geneENST00000237163, ENST00000349129, 
ENST00000536812, ENST00000369739, 
ENST00000484282, 
ENST00000608353, 
ENST00000392863, ENST00000229570, 
ENST00000608525, ENST00000608868, 
Fusion gene scores* DoF score2 X 1 X 2=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: DOPEY1 [Title/Abstract] AND SMIM8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-30-1861-01ADOPEY1chr6

83777498

+SMIM8chr6

88046727

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000237163ENST00000608353DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000237163ENST00000392863DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000237163ENST00000229570DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000237163ENST00000608525DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000237163ENST00000608868DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000349129ENST00000608353DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000349129ENST00000392863DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000349129ENST00000229570DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000349129ENST00000608525DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000349129ENST00000608868DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000536812ENST00000608353DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000536812ENST00000392863DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000536812ENST00000229570DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000536812ENST00000608525DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
5UTR-5UTRENST00000536812ENST00000608868DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
intron-5UTRENST00000369739ENST00000608353DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
intron-5UTRENST00000369739ENST00000392863DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
intron-5UTRENST00000369739ENST00000229570DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
intron-5UTRENST00000369739ENST00000608525DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
intron-5UTRENST00000369739ENST00000608868DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
intron-5UTRENST00000484282ENST00000608353DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
intron-5UTRENST00000484282ENST00000392863DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
intron-5UTRENST00000484282ENST00000229570DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
intron-5UTRENST00000484282ENST00000608525DOPEY1chr6

83777498

+SMIM8chr6

88046727

+
intron-5UTRENST00000484282ENST00000608868DOPEY1chr6

83777498

+SMIM8chr6

88046727

+

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FusionProtFeatures for DOPEY1_SMIM8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DOPEY1

Q5JWR5

SMIM8

Q96KF7

May be involved in protein traffic between late Golgiand early endosomes. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DOPEY1_SMIM8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DOPEY1_SMIM8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DOPEY1EGFR, VAPBSMIM8RANBP6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DOPEY1_SMIM8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DOPEY1_SMIM8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource