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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10433

FusionGeneSummary for DOLPP1_TBC1D13

check button Fusion gene summary
Fusion gene informationFusion gene name: DOLPP1_TBC1D13
Fusion gene ID: 10433
HgeneTgene
Gene symbol

DOLPP1

TBC1D13

Gene ID

57171

54662

Gene namedolichyldiphosphatase 1TBC1 domain family member 13
SynonymsLSFR2-
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptiondolichyldiphosphatase 1dolichyl pyrophosphate phosphatase 1linked to Surfeit genes in Fugu rubripes 2TBC1 domain family member 13
Modification date2018052320180523
UniProtAcc

Q86YN1

Q9NVG8

Ensembl transtripts involved in fusion geneENST00000372546, ENST00000406974, 
ENST00000540102, 
ENST00000372648, 
ENST00000539497, ENST00000466056, 
ENST00000223865, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 3 X 4=60
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DOLPP1 [Title/Abstract] AND TBC1D13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-EW-A2FR-01ADOLPP1chr9

131843486

+TBC1D13chr9

131559334

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000372546ENST00000372648DOLPP1chr9

131843486

+TBC1D13chr9

131559334

+
5CDS-5UTRENST00000372546ENST00000539497DOLPP1chr9

131843486

+TBC1D13chr9

131559334

+
5CDS-3UTRENST00000372546ENST00000466056DOLPP1chr9

131843486

+TBC1D13chr9

131559334

+
5CDS-3UTRENST00000372546ENST00000223865DOLPP1chr9

131843486

+TBC1D13chr9

131559334

+
Frame-shiftENST00000406974ENST00000372648DOLPP1chr9

131843486

+TBC1D13chr9

131559334

+
5CDS-5UTRENST00000406974ENST00000539497DOLPP1chr9

131843486

+TBC1D13chr9

131559334

+
5CDS-3UTRENST00000406974ENST00000466056DOLPP1chr9

131843486

+TBC1D13chr9

131559334

+
5CDS-3UTRENST00000406974ENST00000223865DOLPP1chr9

131843486

+TBC1D13chr9

131559334

+
5UTR-3CDSENST00000540102ENST00000372648DOLPP1chr9

131843486

+TBC1D13chr9

131559334

+
5UTR-5UTRENST00000540102ENST00000539497DOLPP1chr9

131843486

+TBC1D13chr9

131559334

+
5UTR-3UTRENST00000540102ENST00000466056DOLPP1chr9

131843486

+TBC1D13chr9

131559334

+
5UTR-3UTRENST00000540102ENST00000223865DOLPP1chr9

131843486

+TBC1D13chr9

131559334

+

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FusionProtFeatures for DOLPP1_TBC1D13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DOLPP1

Q86YN1

TBC1D13

Q9NVG8

Required for efficient N-glycosylation. Necessary formaintaining optimal levels of dolichol-linked oligosaccharides.Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichylmonophosphate at a much lower rate. Does not act on phosphatidate(By similarity). {ECO:0000250|UniProtKB:Q9JMF7}. Acts as a GTPase-activating protein for RAB35. Togetherwith RAB35 may be involved in regulation of insulin-inducedglucose transporter SLC2A4/GLUT4 translocation to the plasmamembrane in adipocytes. {ECO:0000250|UniProtKB:Q8R3D1}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DOLPP1_TBC1D13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DOLPP1_TBC1D13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DOLPP1ELAVL1, HEPHL1, SELENBP1, LYG2, ASS1, LRRC15, PKP3, VSIG8, TCTN2, TCTN3TBC1D13SEC23IP, WDR12


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DOLPP1_TBC1D13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DOLPP1_TBC1D13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource