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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1043

FusionGeneSummary for AFTPH_THRB

check button Fusion gene summary
Fusion gene informationFusion gene name: AFTPH_THRB
Fusion gene ID: 1043
HgeneTgene
Gene symbol

AFTPH

THRB

Gene ID

54812

7068

Gene nameaftiphilinthyroid hormone receptor beta
SynonymsNbla10388C-ERBA-2|C-ERBA-BETA|ERBA2|GRTH|NR1A2|PRTH|THR1|THRB1|THRB2
Cytomap

2p14

3p24.2

Type of geneprotein-codingprotein-coding
Descriptionaftiphilinaftiphilin proteinthyroid hormone receptor betanuclear receptor subfamily 1 group A member 2oncogene ERBA2thyroid hormone nuclear receptor beta variant 1thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
Modification date2018052320180523
UniProtAcc

Q6ULP2

P10828

Ensembl transtripts involved in fusion geneENST00000238855, ENST00000422803, 
ENST00000238856, ENST00000409933, 
ENST00000409183, ENST00000487769, 
ENST00000396671, ENST00000356447, 
ENST00000416420, ENST00000280696, 
Fusion gene scores* DoF score6 X 5 X 5=1504 X 4 X 4=64
# samples 74
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AFTPH [Title/Abstract] AND THRB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-CJ-5681-01AAFTPHchr2

64812679

+THRBchr3

24193981

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000238855ENST00000396671AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000238855ENST00000356447AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000238855ENST00000416420AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000238855ENST00000280696AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000422803ENST00000396671AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000422803ENST00000356447AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000422803ENST00000416420AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000422803ENST00000280696AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000238856ENST00000396671AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000238856ENST00000356447AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000238856ENST00000416420AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000238856ENST00000280696AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000409933ENST00000396671AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000409933ENST00000356447AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000409933ENST00000416420AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000409933ENST00000280696AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000409183ENST00000396671AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000409183ENST00000356447AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000409183ENST00000416420AFTPHchr2

64812679

+THRBchr3

24193981

-
Frame-shitENST00000409183ENST00000280696AFTPHchr2

64812679

+THRBchr3

24193981

-
In-frameENST00000487769ENST00000396671AFTPHchr2

64812679

+THRBchr3

24193981

-
In-frameENST00000487769ENST00000356447AFTPHchr2

64812679

+THRBchr3

24193981

-
In-frameENST00000487769ENST00000416420AFTPHchr2

64812679

+THRBchr3

24193981

-
In-frameENST00000487769ENST00000280696AFTPHchr2

64812679

+THRBchr3

24193981

-

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FusionProtFeatures for AFTPH_THRB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AFTPH

Q6ULP2

THRB

P10828

May play a role in membrane trafficking. Nuclear hormone receptor that can act as a repressor oractivator of transcription. High affinity receptor for thyroidhormones, including triiodothyronine and thyroxine.{ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100,ECO:0000269|PubMed:16781732, ECO:0000269|PubMed:17418816,ECO:0000269|PubMed:18237438, ECO:0000269|PubMed:18798561,ECO:0000269|PubMed:19926848}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AFTPH_THRB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AFTPH_ENST00000487769_chr2_64812679_+_THRB_ENST00000396671_chr3_24193981_-_628aa
FPHFSEPGDDFGEFGDINAVSCQEETILTKSDLKQTSDNLSEECQLARKSSGTGTEPVAKLKNGQEGEIGHFDSVPNIQDDCNGFQDSDD
FADFSSAGPSQVVDWNAFEDEQKDSCSWAAFGDQQATESHHRKEAWQSHRTDENIDTPGTPKTHSVPSATSKGAVASGHLQESATSVQGM
LEPTKEPLKPLSAAEKIASIGQTATMSPDMNTCTSDQFQVWIRSCMS_QLLSWKSPPQASK_LMHLQDSCLQ_RRQAHLPGYIPSYLDKD
ELCVVCGDKATGTHYRCITCEGCKGFFRRTIQKNLHPSTSCKTEGKCVIDKVTRNQCQECRFKKCITVGMATDLVLDDSKRLAKRKLIEE
NREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVV
DFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRTDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQ

>In-frame_AFTPH_ENST00000487769_chr2_64812679_+_THRB_ENST00000356447_chr3_24193981_-_628aa
FPHFSEPGDDFGEFGDINAVSCQEETILTKSDLKQTSDNLSEECQLARKSSGTGTEPVAKLKNGQEGEIGHFDSVPNIQDDCNGFQDSDD
FADFSSAGPSQVVDWNAFEDEQKDSCSWAAFGDQQATESHHRKEAWQSHRTDENIDTPGTPKTHSVPSATSKGAVASGHLQESATSVQGM
LEPTKEPLKPLSAAEKIASIGQTATMSPDMNTCTSDQFQVWIRSCMS_QLLSWKSPPQASK_LMHLQDSCLQ_RRQAHLPGYIPSYLDKD
ELCVVCGDKATGTHYRCITCEGCKGFFRRTIQKNLHPSTSCKTEGKCVIDKVTRNQCQECRFKKCITVGMATDLVLDDSKRLAKRKLIEE
NREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVV
DFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRTDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQ

>In-frame_AFTPH_ENST00000487769_chr2_64812679_+_THRB_ENST00000416420_chr3_24193981_-_628aa
FPHFSEPGDDFGEFGDINAVSCQEETILTKSDLKQTSDNLSEECQLARKSSGTGTEPVAKLKNGQEGEIGHFDSVPNIQDDCNGFQDSDD
FADFSSAGPSQVVDWNAFEDEQKDSCSWAAFGDQQATESHHRKEAWQSHRTDENIDTPGTPKTHSVPSATSKGAVASGHLQESATSVQGM
LEPTKEPLKPLSAAEKIASIGQTATMSPDMNTCTSDQFQVWIRSCMS_QLLSWKSPPQASK_LMHLQDSCLQ_RRQAHLPGYIPSYLDKD
ELCVVCGDKATGTHYRCITCEGCKGFFRRTIQKNLHPSTSCKTEGKCVIDKVTRNQCQECRFKKCITVGMATDLVLDDSKRLAKRKLIEE
NREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVV
DFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRTDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQ

>In-frame_AFTPH_ENST00000487769_chr2_64812679_+_THRB_ENST00000280696_chr3_24193981_-_628aa
FPHFSEPGDDFGEFGDINAVSCQEETILTKSDLKQTSDNLSEECQLARKSSGTGTEPVAKLKNGQEGEIGHFDSVPNIQDDCNGFQDSDD
FADFSSAGPSQVVDWNAFEDEQKDSCSWAAFGDQQATESHHRKEAWQSHRTDENIDTPGTPKTHSVPSATSKGAVASGHLQESATSVQGM
LEPTKEPLKPLSAAEKIASIGQTATMSPDMNTCTSDQFQVWIRSCMS_QLLSWKSPPQASK_LMHLQDSCLQ_RRQAHLPGYIPSYLDKD
ELCVVCGDKATGTHYRCITCEGCKGFFRRTIQKNLHPSTSCKTEGKCVIDKVTRNQCQECRFKKCITVGMATDLVLDDSKRLAKRKLIEE
NREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVV
DFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRTDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AFTPH_ENST00000487769_chr2_64812679_+_THRB_ENST00000396671_chr3_24193981_-_1884nt
TTTCCACATTTTAGTGAACCAGGTGATGACTTTGGAGAATTTGGGGATATAAATGCTGTTTCTTGCCAAGAGGAGACAATATTAACAAAG
TCAGACCTAAAACAGACTTCTGATAATTTATCAGAAGAATGTCAATTGGCAAGAAAATCTAGTGGAACAGGCACTGAACCTGTTGCAAAA
CTTAAAAATGGGCAAGAAGGTGAGATTGGACATTTTGATTCTGTGCCAAATATTCAGGATGACTGCAATGGTTTTCAAGACTCTGATGAT
TTTGCAGACTTCAGTTCAGCTGGTCCTAGCCAAGTTGTAGATTGGAATGCTTTTGAGGATGAACAAAAAGATAGTTGTTCTTGGGCTGCT
TTTGGAGACCAGCAGGCTACTGAATCTCATCATCGAAAGGAAGCCTGGCAGTCACATAGGACAGATGAAAATATTGATACTCCAGGAACC
CCCAAAACGCACAGTGTACCTTCAGCAACTTCCAAAGGAGCAGTTGCTAGTGGCCATTTACAGGAATCAGCCACTTCAGTTCAGGGTATG
TTAGAGCCCACCAAGGAACCACTGAAACCACTTTCTGCTGCAGAAAAAATAGCTTCCATCGGTCAGACAGCCACCATGTCACCAGATATG
AACACATGTACATCTGATCAGTTCCAGGTGTGGATCCGGAGTTGTATGAGTTAACAACTTCTAAGCTGGAAATCTCCACCTCAAGCCTCA
AAGTGACTGATGCATTTGCAAGACTCATGTCTACAGTAGAGAAGACAAGCACATCTACCAGGGTACATCCCCAGTTACTTAGACAAGGAC
GAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACC
ATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGT
CGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAG
AACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACT
GTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGCCAGAAGACATTGGACAAGCACCA
ATAGTCAATGCCCCAGAAGGTGGAAAGGTTGACTTGGAAGCCTTCAGCCATTTTACAAAAATCATCACACCAGCAATTACCAGAGTGGTG
GATTTTGCCAAAAAGTTGCCTATGTTTTGTGAGCTGCCATGTGAAGACCAGATCATCCTCCTCAAAGGCTGCTGCATGGAGATCATGTCC
CTTCGCGCTGCTGTGCGCTATGACCCAGAAAGTGAGACTTTAACCTTGAATGGGGAAATGGCAGTGACACGGGGCCAGCTGAAAAATGGG
GGTCTTGGGGTGGTGTCAGACGCCATCTTTGACCTGGGCATGTCTCTGTCTTCTTTCAACCTGGATGACACTGAAGTAGCCCTCCTTCAG
GCCGTCCTGCTGATGTCTTCAGATCGCCCGGGGCTTGCCTGTGTTGAGAGAATAGAAAAGTACCAAGATAGTTTCCTGCTGGCCTTTGAA
CACTATATCAATTACCGAAAACACCACGTGACACACTTTTGGCCAAAACTCCTGATGAAGGTGACAGATCTGCGGATGATAGGAGCCTGC

>In-frame_AFTPH_ENST00000487769_chr2_64812679_+_THRB_ENST00000356447_chr3_24193981_-_1884nt
TTTCCACATTTTAGTGAACCAGGTGATGACTTTGGAGAATTTGGGGATATAAATGCTGTTTCTTGCCAAGAGGAGACAATATTAACAAAG
TCAGACCTAAAACAGACTTCTGATAATTTATCAGAAGAATGTCAATTGGCAAGAAAATCTAGTGGAACAGGCACTGAACCTGTTGCAAAA
CTTAAAAATGGGCAAGAAGGTGAGATTGGACATTTTGATTCTGTGCCAAATATTCAGGATGACTGCAATGGTTTTCAAGACTCTGATGAT
TTTGCAGACTTCAGTTCAGCTGGTCCTAGCCAAGTTGTAGATTGGAATGCTTTTGAGGATGAACAAAAAGATAGTTGTTCTTGGGCTGCT
TTTGGAGACCAGCAGGCTACTGAATCTCATCATCGAAAGGAAGCCTGGCAGTCACATAGGACAGATGAAAATATTGATACTCCAGGAACC
CCCAAAACGCACAGTGTACCTTCAGCAACTTCCAAAGGAGCAGTTGCTAGTGGCCATTTACAGGAATCAGCCACTTCAGTTCAGGGTATG
TTAGAGCCCACCAAGGAACCACTGAAACCACTTTCTGCTGCAGAAAAAATAGCTTCCATCGGTCAGACAGCCACCATGTCACCAGATATG
AACACATGTACATCTGATCAGTTCCAGGTGTGGATCCGGAGTTGTATGAGTTAACAACTTCTAAGCTGGAAATCTCCACCTCAAGCCTCA
AAGTGACTGATGCATTTGCAAGACTCATGTCTACAGTAGAGAAGACAAGCACATCTACCAGGGTACATCCCCAGTTACTTAGACAAGGAC
GAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACC
ATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGT
CGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAG
AACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACT
GTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGCCAGAAGACATTGGACAAGCACCA
ATAGTCAATGCCCCAGAAGGTGGAAAGGTTGACTTGGAAGCCTTCAGCCATTTTACAAAAATCATCACACCAGCAATTACCAGAGTGGTG
GATTTTGCCAAAAAGTTGCCTATGTTTTGTGAGCTGCCATGTGAAGACCAGATCATCCTCCTCAAAGGCTGCTGCATGGAGATCATGTCC
CTTCGCGCTGCTGTGCGCTATGACCCAGAAAGTGAGACTTTAACCTTGAATGGGGAAATGGCAGTGACACGGGGCCAGCTGAAAAATGGG
GGTCTTGGGGTGGTGTCAGACGCCATCTTTGACCTGGGCATGTCTCTGTCTTCTTTCAACCTGGATGACACTGAAGTAGCCCTCCTTCAG
GCCGTCCTGCTGATGTCTTCAGATCGCCCGGGGCTTGCCTGTGTTGAGAGAATAGAAAAGTACCAAGATAGTTTCCTGCTGGCCTTTGAA
CACTATATCAATTACCGAAAACACCACGTGACACACTTTTGGCCAAAACTCCTGATGAAGGTGACAGATCTGCGGATGATAGGAGCCTGC

>In-frame_AFTPH_ENST00000487769_chr2_64812679_+_THRB_ENST00000416420_chr3_24193981_-_1884nt
TTTCCACATTTTAGTGAACCAGGTGATGACTTTGGAGAATTTGGGGATATAAATGCTGTTTCTTGCCAAGAGGAGACAATATTAACAAAG
TCAGACCTAAAACAGACTTCTGATAATTTATCAGAAGAATGTCAATTGGCAAGAAAATCTAGTGGAACAGGCACTGAACCTGTTGCAAAA
CTTAAAAATGGGCAAGAAGGTGAGATTGGACATTTTGATTCTGTGCCAAATATTCAGGATGACTGCAATGGTTTTCAAGACTCTGATGAT
TTTGCAGACTTCAGTTCAGCTGGTCCTAGCCAAGTTGTAGATTGGAATGCTTTTGAGGATGAACAAAAAGATAGTTGTTCTTGGGCTGCT
TTTGGAGACCAGCAGGCTACTGAATCTCATCATCGAAAGGAAGCCTGGCAGTCACATAGGACAGATGAAAATATTGATACTCCAGGAACC
CCCAAAACGCACAGTGTACCTTCAGCAACTTCCAAAGGAGCAGTTGCTAGTGGCCATTTACAGGAATCAGCCACTTCAGTTCAGGGTATG
TTAGAGCCCACCAAGGAACCACTGAAACCACTTTCTGCTGCAGAAAAAATAGCTTCCATCGGTCAGACAGCCACCATGTCACCAGATATG
AACACATGTACATCTGATCAGTTCCAGGTGTGGATCCGGAGTTGTATGAGTTAACAACTTCTAAGCTGGAAATCTCCACCTCAAGCCTCA
AAGTGACTGATGCATTTGCAAGACTCATGTCTACAGTAGAGAAGACAAGCACATCTACCAGGGTACATCCCCAGTTACTTAGACAAGGAC
GAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACC
ATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGT
CGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAG
AACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACT
GTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGCCAGAAGACATTGGACAAGCACCA
ATAGTCAATGCCCCAGAAGGTGGAAAGGTTGACTTGGAAGCCTTCAGCCATTTTACAAAAATCATCACACCAGCAATTACCAGAGTGGTG
GATTTTGCCAAAAAGTTGCCTATGTTTTGTGAGCTGCCATGTGAAGACCAGATCATCCTCCTCAAAGGCTGCTGCATGGAGATCATGTCC
CTTCGCGCTGCTGTGCGCTATGACCCAGAAAGTGAGACTTTAACCTTGAATGGGGAAATGGCAGTGACACGGGGCCAGCTGAAAAATGGG
GGTCTTGGGGTGGTGTCAGACGCCATCTTTGACCTGGGCATGTCTCTGTCTTCTTTCAACCTGGATGACACTGAAGTAGCCCTCCTTCAG
GCCGTCCTGCTGATGTCTTCAGATCGCCCGGGGCTTGCCTGTGTTGAGAGAATAGAAAAGTACCAAGATAGTTTCCTGCTGGCCTTTGAA
CACTATATCAATTACCGAAAACACCACGTGACACACTTTTGGCCAAAACTCCTGATGAAGGTGACAGATCTGCGGATGATAGGAGCCTGC

>In-frame_AFTPH_ENST00000487769_chr2_64812679_+_THRB_ENST00000280696_chr3_24193981_-_1884nt
TTTCCACATTTTAGTGAACCAGGTGATGACTTTGGAGAATTTGGGGATATAAATGCTGTTTCTTGCCAAGAGGAGACAATATTAACAAAG
TCAGACCTAAAACAGACTTCTGATAATTTATCAGAAGAATGTCAATTGGCAAGAAAATCTAGTGGAACAGGCACTGAACCTGTTGCAAAA
CTTAAAAATGGGCAAGAAGGTGAGATTGGACATTTTGATTCTGTGCCAAATATTCAGGATGACTGCAATGGTTTTCAAGACTCTGATGAT
TTTGCAGACTTCAGTTCAGCTGGTCCTAGCCAAGTTGTAGATTGGAATGCTTTTGAGGATGAACAAAAAGATAGTTGTTCTTGGGCTGCT
TTTGGAGACCAGCAGGCTACTGAATCTCATCATCGAAAGGAAGCCTGGCAGTCACATAGGACAGATGAAAATATTGATACTCCAGGAACC
CCCAAAACGCACAGTGTACCTTCAGCAACTTCCAAAGGAGCAGTTGCTAGTGGCCATTTACAGGAATCAGCCACTTCAGTTCAGGGTATG
TTAGAGCCCACCAAGGAACCACTGAAACCACTTTCTGCTGCAGAAAAAATAGCTTCCATCGGTCAGACAGCCACCATGTCACCAGATATG
AACACATGTACATCTGATCAGTTCCAGGTGTGGATCCGGAGTTGTATGAGTTAACAACTTCTAAGCTGGAAATCTCCACCTCAAGCCTCA
AAGTGACTGATGCATTTGCAAGACTCATGTCTACAGTAGAGAAGACAAGCACATCTACCAGGGTACATCCCCAGTTACTTAGACAAGGAC
GAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACC
ATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGT
CGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAG
AACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACT
GTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGCCAGAAGACATTGGACAAGCACCA
ATAGTCAATGCCCCAGAAGGTGGAAAGGTTGACTTGGAAGCCTTCAGCCATTTTACAAAAATCATCACACCAGCAATTACCAGAGTGGTG
GATTTTGCCAAAAAGTTGCCTATGTTTTGTGAGCTGCCATGTGAAGACCAGATCATCCTCCTCAAAGGCTGCTGCATGGAGATCATGTCC
CTTCGCGCTGCTGTGCGCTATGACCCAGAAAGTGAGACTTTAACCTTGAATGGGGAAATGGCAGTGACACGGGGCCAGCTGAAAAATGGG
GGTCTTGGGGTGGTGTCAGACGCCATCTTTGACCTGGGCATGTCTCTGTCTTCTTTCAACCTGGATGACACTGAAGTAGCCCTCCTTCAG
GCCGTCCTGCTGATGTCTTCAGATCGCCCGGGGCTTGCCTGTGTTGAGAGAATAGAAAAGTACCAAGATAGTTTCCTGCTGGCCTTTGAA
CACTATATCAATTACCGAAAACACCACGTGACACACTTTTGGCCAAAACTCCTGATGAAGGTGACAGATCTGCGGATGATAGGAGCCTGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_AFTPH_ENST00000487769_chr2_64812679_+_THRB_ENST00000396671_chr3_24193981_-_7608nt
TTTCCACATTTTAGTGAACCAGGTGATGACTTTGGAGAATTTGGGGATATAAATGCTGTTTCTTGCCAAGAGGAGACAATATTAACAAAG
TCAGACCTAAAACAGACTTCTGATAATTTATCAGAAGAATGTCAATTGGCAAGAAAATCTAGTGGAACAGGCACTGAACCTGTTGCAAAA
CTTAAAAATGGGCAAGAAGGTGAGATTGGACATTTTGATTCTGTGCCAAATATTCAGGATGACTGCAATGGTTTTCAAGACTCTGATGAT
TTTGCAGACTTCAGTTCAGCTGGTCCTAGCCAAGTTGTAGATTGGAATGCTTTTGAGGATGAACAAAAAGATAGTTGTTCTTGGGCTGCT
TTTGGAGACCAGCAGGCTACTGAATCTCATCATCGAAAGGAAGCCTGGCAGTCACATAGGACAGATGAAAATATTGATACTCCAGGAACC
CCCAAAACGCACAGTGTACCTTCAGCAACTTCCAAAGGAGCAGTTGCTAGTGGCCATTTACAGGAATCAGCCACTTCAGTTCAGGGTATG
TTAGAGCCCACCAAGGAACCACTGAAACCACTTTCTGCTGCAGAAAAAATAGCTTCCATCGGTCAGACAGCCACCATGTCACCAGATATG
AACACATGTACATCTGATCAGTTCCAGGTGTGGATCCGGAGTTGTATGAGTTAACAACTTCTAAGCTGGAAATCTCCACCTCAAGCCTCA
AAGTGACTGATGCATTTGCAAGACTCATGTCTACAGTAGAGAAGACAAGCACATCTACCAGGGTACATCCCCAGTTACTTAGACAAGGAC
GAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACC
ATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGT
CGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAG
AACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACT
GTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGCCAGAAGACATTGGACAAGCACCA
ATAGTCAATGCCCCAGAAGGTGGAAAGGTTGACTTGGAAGCCTTCAGCCATTTTACAAAAATCATCACACCAGCAATTACCAGAGTGGTG
GATTTTGCCAAAAAGTTGCCTATGTTTTGTGAGCTGCCATGTGAAGACCAGATCATCCTCCTCAAAGGCTGCTGCATGGAGATCATGTCC
CTTCGCGCTGCTGTGCGCTATGACCCAGAAAGTGAGACTTTAACCTTGAATGGGGAAATGGCAGTGACACGGGGCCAGCTGAAAAATGGG
GGTCTTGGGGTGGTGTCAGACGCCATCTTTGACCTGGGCATGTCTCTGTCTTCTTTCAACCTGGATGACACTGAAGTAGCCCTCCTTCAG
GCCGTCCTGCTGATGTCTTCAGATCGCCCGGGGCTTGCCTGTGTTGAGAGAATAGAAAAGTACCAAGATAGTTTCCTGCTGGCCTTTGAA
CACTATATCAATTACCGAAAACACCACGTGACACACTTTTGGCCAAAACTCCTGATGAAGGTGACAGATCTGCGGATGATAGGAGCCTGC
CATGCCAGCCGCTTCCTGCACATGAAGGTGGAATGCCCCACAGAACTCTTCCCCCCTTTGTTCTTGGAAGTGTTCGAGGATTAGACTGAC
TGGATTCATTCTCATAATTCCTACAGCACTACTGGGTGTCATTTCATTCCATTGCCTAGCTCTTTTTTGTTTGTTTCTTTGTGTTGGGAG
GGATTATTTGGGAGGGAAAAGGGAAGTAGTCCTTGGCATAGACATGGATGAAATTGCCCCTTGAATGCGGGTACTTGAAACTATTGCATT
TCGTTCTCCGGTCCTGTGATGTGAATGCTCTGAAGGTTTTATGGTTGTGGAGGTGGGGTGGGGGACAATCATTAACTCACCAGCACCAAG
CATCACCAGCTCCCACCCGTCCCTGGTCCAAGACTTGAGTCAGCAAAATGGCGCCACAGGACACTAAAGAAGCCTTAAAACCAAGATAAT
ACGACCACCTCCACCCAATCCTGATGTTCGCAGGGCTGAAGTTAACAGAGCACAGACCACCTTTAGTTAGATGTGGCTTTCAGCCTTTTA
GGGAAAGACTCGAACAAATTTTCATCTATTCAAGAGCATGCTGTTTGCAGCACTCTTTATGGTCTCCTAGGAGCATAACTTGGAATGTAC
AGGAATATTTGTGTCCTAAAAAAATCAGCTGCCCTTCCAATATCATTTTTATAACGTTATGGTTTAATTCAAGTTATACAAAGGTGTGAC
TCAAGGATGTGCAGGTATTGACTGATGGAGGCCAACAAGGAAAATATTTTTTTTCAGTGAGCCCAGAGAAATTAGAAATCTTCACCAATG
TCAGTGACTGCATGGTTTCCAAAAATTCACATAGTATTACCTCACAGTAGGAAGGCTTCTTTCCCATTTAGGCTCAGAGAACACTTTTAC
AGAAATCAAACCTATTTACAGGGTGGCACCCCTTTTCTGTGGCATCTGATCTGTCATCTCCCAAGCTCCTGAAGTTCTTTATCCAGGTTG
TATCTTTGCTGAGCTGACAACAGATTTCTCTATGGATCAAATATTCTAATCAAGGAAAGATACGGTGAAACTTCAGTCTTCTTCTGGAGA
AATGCTGAGGCGAGATTAGTGCAGCTACATTCTGAGTTGAAGGAAATGCAGTGTTCTGAGGGCCCCTTTGTGTCCTGATGGCTGGAGGAC
GCTTCCTCCTGGTTAGATCCTCAAGCTCCTTGCCTCATTGACAAATGTCTCCTAGTCCCCTTTTTCCCTCTGACTCTGAGGAACTAAATA
GCTTGACTATCTCTAAACAGAGACTGGCCCTGCCACTGACCCTCCTGTCCCTCTCATAGCATACCCTGACAGATACTCAATAGAAAACAC
CTGCAGACCATGTGCACACTTAACTTTCCTGCCCAACCTGCCTCCCCAACGGCCCATGCTAGAATAGCTTGTGCCCAGAAAACAAACAGT
GACACTTCATCTCTTCAGCGTCAGAAAATGGGCATAGAATGTACCCATGCAATTGAATGTATCTCATTCTCCACTGGCATAGTAGATATA
AACTATTCCTTTGCCTACCTTTTACTGCCTTATCCTGGAAATATTGGGGAAAATAAGCCATATCAGTGAGATTTACCTAAAAACAAAGGA
AGGAAAGTCACTATGGAAACCAAGTAGATGCTTTTTGTAAGTTTGGTGGAGCATAACTGGCCCAGAAGTCTGGGTGCCTGAGTTCTAGTT
CGTGCTCTGTCAACTGGTAGATTTGTAATTCTAGGTCTTGGTTTTCTTACCTGGTGAATAAGTCATGATCTCTAAAACCCTTCCTGCCCT
TAATATTGTCTGAATTTCAAGGGGAAAAAAAAAATCTGGTTCCTTTAATTATTTTTTTTTAACACTTAAATTCCTAACTTTATTAGACAA
GAAGTATGGCCCACTTAACAGTTAAGGAACGTAAATTTGTTATTGGCTCGAAATAATAATTTGACACAATACTAGTCAACCATTTAGAGG
CCTTGGAAAAAGAAGAGGAACAGCACTGAAAATTCCAAGTATGATTGGAAATTATCTGGGAGCGGGGAATTAAATATTCAATGCATGAAA
GCAATTGTACTGGCTTCTGGGAAAAAGGAAACAAGAACATTGCTATGGAACTTGTTACCCAGAGAAAGGAAGTGAAAAGATTTACAATTA
TAAGCACGAAATTCATTGGCAGATTACCTGCTTTATCTACAGACAGATTGTTTTGGGGTTTGGTTTTGTCTAGGCAGCCTCTGGCCAGGC
TCCTTAATTGCTTGCTCTGCTAATATTTCAGCTTCCTCTCTTGACTCCTTGAGGAACCAACCGCTCTTTGGAAGACAAACACTTAGCCAC
CTCTGTGCTCCAGGGTAACCCTGAGAAGCTCTGCTGTCTGGGGCAAGCTTTCTTTCCAAAGGGAATGAGAGGAAGGCAAGCAGGCAGGGT
CCTGCAGCGTCAGGCCTTCTGGGGAAAGTTTCCTCATTTTGTTTGACAGGGTCCTCAGTACATCAGACACCCAGATTTGAATATAAGTTC
AGAGCCTGATCTCAAGCTAAATCAGAATGCTTTGGGGACTAACCATGATCGAGAATTGGCCAAATAGTATGGCATATAAACAGCCATCCA
GCCAGCCGCAAGTAAAGGAACGTTTGATCCTTGGCACCTTAAATGATTGATTGCCTTCAATAGGCAAACTGCTGGTCTGGAAATCTCGTT
GAAGGCTGAATACTTCATGCGGAGTAGGACAAGCCTTAGCCCACCTTCAGGTTGAAAGGAAAGGCCATAGGACTCAAAAGATAATGACTC
TGAAACTAAACTCCTTCCTTCTGAAGCTGACAGAGGTACTTAGTGCATCTCAAGACTCCATCTCATAAAACTCATTTGTGAGGGATTTGC
TCTAGATTTTTCTAAACATTTTTTCATCTATTGTCCAGACTTGCAAATCCAGTGTGGACCTGATGGAGATACCCTTCACACCTGCGCTCC
CACCCCCTCGGCAGGGAGACGTCTCAGTAGAGGAGAACACACCCATTATGCTGGGATTTGTATTTATAAATCACTTCCCTTTTAGGGATG
AGCGGTGTGGGGCGTGTGTGCGTGTGAGTGTATGCGCGTGCGTGTGTGACCCTCAAGTGTACTTTGCTCAATTTAGACGTGCAGTATTTC
CAGAAACAATGAAAAAAGTAAGATGTTTTCTTCTTTATGATTCTGCTCAAAACACCACGTGCCGCCTCAGAGCTTTTTCTAGAGCCTCGG
TCCTCAATGACGCGCTTGACCTGTTGATGCCTCAGCCCAGCGAAGCCCCTCACCTGTGCCCCGGGCGACAGCTCTTCAGTGTGCAGTGCA
GGCCTGGGGTGGACTGCCAGGCCTTCGCTCTGTGCCAGCAACGCCGTTCTTGTTGCTCCTCCATGAACAGGGGTACAAGCCCTGGCCCCT
CCTCGACACTAAGCCCCCCACAGACTCAGCCTCCAAGGAACCGCTGAGCACCCTTGAAGCATGTCATTGTCAGTGATACCTTTTTATTCT
ATGGAACTCTAACCTATTCGTGTCATATTGACCTTTTGCTGCATGAGTCATAAATTATGAAATCAGTCTTACAGTTTTTGAAATGTAGCC
AGCATTTGTAAGGCTAAACCTTTTTCATGAACTGAATTTAAGTGAATAACCAAGCCACAGTTCCTCCTCAAATGGAGAGTGATGATCGAC
ATTTGAATCTCTTTGCCCTTTCCAACGGCTATGGCATCAGGTTCTAAAATAAGCTCGTAATTTTTCCTGTTATTTTAATAATATGGAAAT
ATTAGCATAGTGTTTCTTTTGATAGTGATAGACTATAATCCATATTTAAATTTTATAGAGAAGAAATTTTATTGTACTGTGATGTAGATA
TTTATTATCCAGGTAAGGATTTGCCCGGTGTGTATTTTTTACAATTGAGACATTTTACTTTAATCTTTAAAAAAAATGCATTAAAAACAC
ACTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACCAGACTGGGGGAAAAAAGGTTTGGCCTTATCACAGAATTTTTACTGTGCTGTATA
AATGTTTGCAAATGCGAAAAGTGTGCATTTATAGTGTGTTTCCACATTAATTAATGCCGCCTTCAAGAGCAATATTGTGCAGGTAAAACG
CTGTTTGTGGCTTTCTGTTGCACAGTTAAAGCTGACCCACCCTATGCACAAGACAATCAAATATAAATCTGTCCTCCTCAGGATGCAGAT
AATACTCATGTAAATTATGGAGCACAATGTAAGACAAAAGGAGACACTTTACATATGTATTGTTGATACAGAAATTATCAGGGCATGAAT
GAGCTGATGTGACATTATGCCACTTCTTTCTTTTGGTTCTCCCTTATTAACTTGGCATTTTTAATTTGACCATAGAGCCAAATTAGTTCT
CCATGCTTTCTTCGTAGAAAATCCTTTTTTTTCCCATAATGTTTTCATGCCCTGAGAATCAGAAAAATACTACAGAATAGAAAAAGATTT
ACAGTCATTGGAAGATTTGTGTTTTGCAAACAGTGTTAAGTGATATTGCTAGATGGTGATATTTTTTTCAGCCTAAAACTCTGTTGAAAT
CTGTGATCAAAATGTTTTAAACTATCCAAAAAAAATTTGTATATTTGGGAAAAATGGATTTTTACATAGCTTTTGTATGCAGATATAAAA
CTGTAATTATGAATATAGTGGGCGTAGATAAACTCATAAGCTTAAATTCTAAAAAAGAAAAAGCTTATAACAGATATATTTTCCTGTCTC
TTTCTTTAAATATTATTATTTTCTACATAGGCAAAGAGTTGCCTGCTCTTCTCACTTCAGCTGCTGCCAAAAGACGGAACCACGGATGTA
AGGACATTTATTTCATAAATAAACATCTACTAGAATAAGCAAATTTACTTGAGAAGAAACTATGGAGGGAGAGAAGAAACTAAGTAAAAT
GCTGATGGGGGGTTACCTCTTTGGAAGGGGCCACAAAGATGAAGGGAGGAGAGAGGTGAAGTTTTGCAGCTCAAGGACAACATTCATCTT
CTCATCTCAAATTATTCAGGAATATTACTAATGGAATTATGTTAACATCAGCTGCCAACATATATCTCAATCTCTGTTGCCCTGAACACA
TGTTAATTGAGATTCTTTCTATGACAAGTAACAAAAAGCTAACTCAAACTGGCTTAAGCAGAAAGCTAATTATTGACTTTAATATCTGGG
ATCTAGGGTATTGCATACCAAAGCTTCAGGCATGGCTGGATCTGGGTGCACTTACTCAGTATTCTCAGGAAGCTCCTTTTTTTGTCATTC
ATGTAGACTTAACATTCACATGGCCTTTCACCTTACGGTGGCCTCCAATAGCTCCAGGATGAGCTTTACAGCTCCAAATATAGTGAAAGG
AGAATTTCTTTTCTCCAACAATTCTAATGAAAATTCTGGCCTAATTCTCACTGGCCCAAGTTCAGTCATGTGCCCATTCCTGAGCCAATC
ACTGTGGTGAGGAAAACAGATGCATAACCAACCTTATCCTCAGGAATCCTGGAACTGGGTGAGGGGAAAGAGGGACAGTCAGCTTCATCT
AAACTATGGACTGAGAGTTGAGGCAAGATGATTCCTGAAAGAAAATTCTAAGTCTTGCTGCTATAAGTGGAAGAGAATGGTGGGCAAGCA
AAAGCAACCAGTGCCCACACCAAAGGTAAATCTAAAACAACATCCCATTTCAGTACAGCAAGCGGTTCTCCTTCACACAGAGGAAGCTCA

>In-frame_AFTPH_ENST00000487769_chr2_64812679_+_THRB_ENST00000356447_chr3_24193981_-_6554nt
TTTCCACATTTTAGTGAACCAGGTGATGACTTTGGAGAATTTGGGGATATAAATGCTGTTTCTTGCCAAGAGGAGACAATATTAACAAAG
TCAGACCTAAAACAGACTTCTGATAATTTATCAGAAGAATGTCAATTGGCAAGAAAATCTAGTGGAACAGGCACTGAACCTGTTGCAAAA
CTTAAAAATGGGCAAGAAGGTGAGATTGGACATTTTGATTCTGTGCCAAATATTCAGGATGACTGCAATGGTTTTCAAGACTCTGATGAT
TTTGCAGACTTCAGTTCAGCTGGTCCTAGCCAAGTTGTAGATTGGAATGCTTTTGAGGATGAACAAAAAGATAGTTGTTCTTGGGCTGCT
TTTGGAGACCAGCAGGCTACTGAATCTCATCATCGAAAGGAAGCCTGGCAGTCACATAGGACAGATGAAAATATTGATACTCCAGGAACC
CCCAAAACGCACAGTGTACCTTCAGCAACTTCCAAAGGAGCAGTTGCTAGTGGCCATTTACAGGAATCAGCCACTTCAGTTCAGGGTATG
TTAGAGCCCACCAAGGAACCACTGAAACCACTTTCTGCTGCAGAAAAAATAGCTTCCATCGGTCAGACAGCCACCATGTCACCAGATATG
AACACATGTACATCTGATCAGTTCCAGGTGTGGATCCGGAGTTGTATGAGTTAACAACTTCTAAGCTGGAAATCTCCACCTCAAGCCTCA
AAGTGACTGATGCATTTGCAAGACTCATGTCTACAGTAGAGAAGACAAGCACATCTACCAGGGTACATCCCCAGTTACTTAGACAAGGAC
GAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACC
ATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGT
CGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAG
AACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACT
GTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGCCAGAAGACATTGGACAAGCACCA
ATAGTCAATGCCCCAGAAGGTGGAAAGGTTGACTTGGAAGCCTTCAGCCATTTTACAAAAATCATCACACCAGCAATTACCAGAGTGGTG
GATTTTGCCAAAAAGTTGCCTATGTTTTGTGAGCTGCCATGTGAAGACCAGATCATCCTCCTCAAAGGCTGCTGCATGGAGATCATGTCC
CTTCGCGCTGCTGTGCGCTATGACCCAGAAAGTGAGACTTTAACCTTGAATGGGGAAATGGCAGTGACACGGGGCCAGCTGAAAAATGGG
GGTCTTGGGGTGGTGTCAGACGCCATCTTTGACCTGGGCATGTCTCTGTCTTCTTTCAACCTGGATGACACTGAAGTAGCCCTCCTTCAG
GCCGTCCTGCTGATGTCTTCAGATCGCCCGGGGCTTGCCTGTGTTGAGAGAATAGAAAAGTACCAAGATAGTTTCCTGCTGGCCTTTGAA
CACTATATCAATTACCGAAAACACCACGTGACACACTTTTGGCCAAAACTCCTGATGAAGGTGACAGATCTGCGGATGATAGGAGCCTGC
CATGCCAGCCGCTTCCTGCACATGAAGGTGGAATGCCCCACAGAACTCTTCCCCCCTTTGTTCTTGGAAGTGTTCGAGGATTAGACTGAC
TGGATTCATTCTCATAATTCCTACAGCACTACTGGGTGTCATTTCATTCCATTGCCTAGCTCTTTTTTGTTTGTTTCTTTGTGTTGGGAG
GGATTATTTGGGAGGGAAAAGGGAAGTAGTCCTTGGCATAGACATGGATGAAATTGCCCCTTGAATGCGGGTACTTGAAACTATTGCATT
TCGTTCTCCGGTCCTGTGATGTGAATGCTCTGAAGGTTTTATGGTTGTGGAGGTGGGGTGGGGGACAATCATTAACTCACCAGCACCAAG
CATCACCAGCTCCCACCCGTCCCTGGTCCAAGACTTGAGTCAGCAAAATGGCGCCACAGGACACTAAAGAAGCCTTAAAACCAAGATAAT
ACGACCACCTCCACCCAATCCTGATGTTCGCAGGGCTGAAGTTAACAGAGCACAGACCACCTTTAGTTAGATGTGGCTTTCAGCCTTTTA
GGGAAAGACTCGAACAAATTTTCATCTATTCAAGAGCATGCTGTTTGCAGCACTCTTTATGGTCTCCTAGGAGCATAACTTGGAATGTAC
AGGAATATTTGTGTCCTAAAAAAATCAGCTGCCCTTCCAATATCATTTTTATAACGTTATGGTTTAATTCAAGTTATACAAAGGTGTGAC
TCAAGGATGTGCAGGTATTGACTGATGGAGGCCAACAAGGAAAATATTTTTTTTCAGTGAGCCCAGAGAAATTAGAAATCTTCACCAATG
TCAGTGACTGCATGGTTTCCAAAAATTCACATAGTATTACCTCACAGTAGGAAGGCTTCTTTCCCATTTAGGCTCAGAGAACACTTTTAC
AGAAATCAAACCTATTTACAGGGTGGCACCCCTTTTCTGTGGCATCTGATCTGTCATCTCCCAAGCTCCTGAAGTTCTTTATCCAGGTTG
TATCTTTGCTGAGCTGACAACAGATTTCTCTATGGATCAAATATTCTAATCAAGGAAAGATACGGTGAAACTTCAGTCTTCTTCTGGAGA
AATGCTGAGGCGAGATTAGTGCAGCTACATTCTGAGTTGAAGGAAATGCAGTGTTCTGAGGGCCCCTTTGTGTCCTGATGGCTGGAGGAC
GCTTCCTCCTGGTTAGATCCTCAAGCTCCTTGCCTCATTGACAAATGTCTCCTAGTCCCCTTTTTCCCTCTGACTCTGAGGAACTAAATA
GCTTGACTATCTCTAAACAGAGACTGGCCCTGCCACTGACCCTCCTGTCCCTCTCATAGCATACCCTGACAGATACTCAATAGAAAACAC
CTGCAGACCATGTGCACACTTAACTTTCCTGCCCAACCTGCCTCCCCAACGGCCCATGCTAGAATAGCTTGTGCCCAGAAAACAAACAGT
GACACTTCATCTCTTCAGCGTCAGAAAATGGGCATAGAATGTACCCATGCAATTGAATGTATCTCATTCTCCACTGGCATAGTAGATATA
AACTATTCCTTTGCCTACCTTTTACTGCCTTATCCTGGAAATATTGGGGAAAATAAGCCATATCAGTGAGATTTACCTAAAAACAAAGGA
AGGAAAGTCACTATGGAAACCAAGTAGATGCTTTTTGTAAGTTTGGTGGAGCATAACTGGCCCAGAAGTCTGGGTGCCTGAGTTCTAGTT
CGTGCTCTGTCAACTGGTAGATTTGTAATTCTAGGTCTTGGTTTTCTTACCTGGTGAATAAGTCATGATCTCTAAAACCCTTCCTGCCCT
TAATATTGTCTGAATTTCAAGGGGAAAAAAAAAATCTGGTTCCTTTAATTATTTTTTTTTAACACTTAAATTCCTAACTTTATTAGACAA
GAAGTATGGCCCACTTAACAGTTAAGGAACGTAAATTTGTTATTGGCTCGAAATAATAATTTGACACAATACTAGTCAACCATTTAGAGG
CCTTGGAAAAAGAAGAGGAACAGCACTGAAAATTCCAAGTATGATTGGAAATTATCTGGGAGCGGGGAATTAAATATTCAATGCATGAAA
GCAATTGTACTGGCTTCTGGGAAAAAGGAAACAAGAACATTGCTATGGAACTTGTTACCCAGAGAAAGGAAGTGAAAAGATTTACAATTA
TAAGCACGAAATTCATTGGCAGATTACCTGCTTTATCTACAGACAGATTGTTTTGGGGTTTGGTTTTGTCTAGGCAGCCTCTGGCCAGGC
TCCTTAATTGCTTGCTCTGCTAATATTTCAGCTTCCTCTCTTGACTCCTTGAGGAACCAACCGCTCTTTGGAAGACAAACACTTAGCCAC
CTCTGTGCTCCAGGGTAACCCTGAGAAGCTCTGCTGTCTGGGGCAAGCTTTCTTTCCAAAGGGAATGAGAGGAAGGCAAGCAGGCAGGGT
CCTGCAGCGTCAGGCCTTCTGGGGAAAGTTTCCTCATTTTGTTTGACAGGGTCCTCAGTACATCAGACACCCAGATTTGAATATAAGTTC
AGAGCCTGATCTCAAGCTAAATCAGAATGCTTTGGGGACTAACCATGATCGAGAATTGGCCAAATAGTATGGCATATAAACAGCCATCCA
GCCAGCCGCAAGTAAAGGAACGTTTGATCCTTGGCACCTTAAATGATTGATTGCCTTCAATAGGCAAACTGCTGGTCTGGAAATCTCGTT
GAAGGCTGAATACTTCATGCGGAGTAGGACAAGCCTTAGCCCACCTTCAGGTTGAAAGGAAAGGCCATAGGACTCAAAAGATAATGACTC
TGAAACTAAACTCCTTCCTTCTGAAGCTGACAGAGGTACTTAGTGCATCTCAAGACTCCATCTCATAAAACTCATTTGTGAGGGATTTGC
TCTAGATTTTTCTAAACATTTTTTCATCTATTGTCCAGACTTGCAAATCCAGTGTGGACCTGATGGAGATACCCTTCACACCTGCGCTCC
CACCCCCTCGGCAGGGAGACGTCTCAGTAGAGGAGAACACACCCATTATGCTGGGATTTGTATTTATAAATCACTTCCCTTTTAGGGATG
AGCGGTGTGGGGCGTGTGTGCGTGTGAGTGTATGCGCGTGCGTGTGTGACCCTCAAGTGTACTTTGCTCAATTTAGACGTGCAGTATTTC
CAGAAACAATGAAAAAAGTAAGATGTTTTCTTCTTTATGATTCTGCTCAAAACACCACGTGCCGCCTCAGAGCTTTTTCTAGAGCCTCGG
TCCTCAATGACGCGCTTGACCTGTTGATGCCTCAGCCCAGCGAAGCCCCTCACCTGTGCCCCGGGCGACAGCTCTTCAGTGTGCAGTGCA
GGCCTGGGGTGGACTGCCAGGCCTTCGCTCTGTGCCAGCAACGCCGTTCTTGTTGCTCCTCCATGAACAGGGGTACAAGCCCTGGCCCCT
CCTCGACACTAAGCCCCCCACAGACTCAGCCTCCAAGGAACCGCTGAGCACCCTTGAAGCATGTCATTGTCAGTGATACCTTTTTATTCT
ATGGAACTCTAACCTATTCGTGTCATATTGACCTTTTGCTGCATGAGTCATAAATTATGAAATCAGTCTTACAGTTTTTGAAATGTAGCC
AGCATTTGTAAGGCTAAACCTTTTTCATGAACTGAATTTAAGTGAATAACCAAGCCACAGTTCCTCCTCAAATGGAGAGTGATGATCGAC
ATTTGAATCTCTTTGCCCTTTCCAACGGCTATGGCATCAGGTTCTAAAATAAGCTCGTAATTTTTCCTGTTATTTTAATAATATGGAAAT
ATTAGCATAGTGTTTCTTTTGATAGTGATAGACTATAATCCATATTTAAATTTTATAGAGAAGAAATTTTATTGTACTGTGATGTAGATA
TTTATTATCCAGGTAAGGATTTGCCCGGTGTGTATTTTTTACAATTGAGACATTTTACTTTAATCTTTAAAAAAAATGCATTAAAAACAC
ACTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACCAGACTGGGGGAAAAAAGGTTTGGCCTTATCACAGAATTTTTACTGTGCTGTATA
AATGTTTGCAAATGCGAAAAGTGTGCATTTATAGTGTGTTTCCACATTAATTAATGCCGCCTTCAAGAGCAATATTGTGCAGGTAAAACG
CTGTTTGTGGCTTTCTGTTGCACAGTTAAAGCTGACCCACCCTATGCACAAGACAATCAAATATAAATCTGTCCTCCTCAGGATGCAGAT
AATACTCATGTAAATTATGGAGCACAATGTAAGACAAAAGGAGACACTTTACATATGTATTGTTGATACAGAAATTATCAGGGCATGAAT
GAGCTGATGTGACATTATGCCACTTCTTTCTTTTGGTTCTCCCTTATTAACTTGGCATTTTTAATTTGACCATAGAGCCAAATTAGTTCT
CCATGCTTTCTTCGTAGAAAATCCTTTTTTTTCCCATAATGTTTTCATGCCCTGAGAATCAGAAAAATACTACAGAATAGAAAAAGATTT
ACAGTCATTGGAAGATTTGTGTTTTGCAAACAGTGTTAAGTGATATTGCTAGATGGTGATATTTTTTTCAGCCTAAAACTCTGTTGAAAT
CTGTGATCAAAATGTTTTAAACTATCCAAAAAAAATTTGTATATTTGGGAAAAATGGATTTTTACATAGCTTTTGTATGCAGATATAAAA

>In-frame_AFTPH_ENST00000487769_chr2_64812679_+_THRB_ENST00000416420_chr3_24193981_-_2560nt
TTTCCACATTTTAGTGAACCAGGTGATGACTTTGGAGAATTTGGGGATATAAATGCTGTTTCTTGCCAAGAGGAGACAATATTAACAAAG
TCAGACCTAAAACAGACTTCTGATAATTTATCAGAAGAATGTCAATTGGCAAGAAAATCTAGTGGAACAGGCACTGAACCTGTTGCAAAA
CTTAAAAATGGGCAAGAAGGTGAGATTGGACATTTTGATTCTGTGCCAAATATTCAGGATGACTGCAATGGTTTTCAAGACTCTGATGAT
TTTGCAGACTTCAGTTCAGCTGGTCCTAGCCAAGTTGTAGATTGGAATGCTTTTGAGGATGAACAAAAAGATAGTTGTTCTTGGGCTGCT
TTTGGAGACCAGCAGGCTACTGAATCTCATCATCGAAAGGAAGCCTGGCAGTCACATAGGACAGATGAAAATATTGATACTCCAGGAACC
CCCAAAACGCACAGTGTACCTTCAGCAACTTCCAAAGGAGCAGTTGCTAGTGGCCATTTACAGGAATCAGCCACTTCAGTTCAGGGTATG
TTAGAGCCCACCAAGGAACCACTGAAACCACTTTCTGCTGCAGAAAAAATAGCTTCCATCGGTCAGACAGCCACCATGTCACCAGATATG
AACACATGTACATCTGATCAGTTCCAGGTGTGGATCCGGAGTTGTATGAGTTAACAACTTCTAAGCTGGAAATCTCCACCTCAAGCCTCA
AAGTGACTGATGCATTTGCAAGACTCATGTCTACAGTAGAGAAGACAAGCACATCTACCAGGGTACATCCCCAGTTACTTAGACAAGGAC
GAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACC
ATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGT
CGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAG
AACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACT
GTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGCCAGAAGACATTGGACAAGCACCA
ATAGTCAATGCCCCAGAAGGTGGAAAGGTTGACTTGGAAGCCTTCAGCCATTTTACAAAAATCATCACACCAGCAATTACCAGAGTGGTG
GATTTTGCCAAAAAGTTGCCTATGTTTTGTGAGCTGCCATGTGAAGACCAGATCATCCTCCTCAAAGGCTGCTGCATGGAGATCATGTCC
CTTCGCGCTGCTGTGCGCTATGACCCAGAAAGTGAGACTTTAACCTTGAATGGGGAAATGGCAGTGACACGGGGCCAGCTGAAAAATGGG
GGTCTTGGGGTGGTGTCAGACGCCATCTTTGACCTGGGCATGTCTCTGTCTTCTTTCAACCTGGATGACACTGAAGTAGCCCTCCTTCAG
GCCGTCCTGCTGATGTCTTCAGATCGCCCGGGGCTTGCCTGTGTTGAGAGAATAGAAAAGTACCAAGATAGTTTCCTGCTGGCCTTTGAA
CACTATATCAATTACCGAAAACACCACGTGACACACTTTTGGCCAAAACTCCTGATGAAGGTGACAGATCTGCGGATGATAGGAGCCTGC
CATGCCAGCCGCTTCCTGCACATGAAGGTGGAATGCCCCACAGAACTCTTCCCCCCTTTGTTCTTGGAAGTGTTCGAGGATTAGACTGAC
TGGATTCATTCTCATAATTCCTACAGCACTACTGGGTGTCATTTCATTCCATTGCCTAGCTCTTTTTTGTTTGTTTCTTTGTGTTGGGAG
GGATTATTTGGGAGGGAAAAGGGAAGTAGTCCTTGGCATAGACATGGATGAAATTGCCCCTTGAATGCGGGTACTTGAAACTATTGCATT
TCGTTCTCCGGTCCTGTGATGTGAATGCTCTGAAGGTTTTATGGTTGTGGAGGTGGGGTGGGGGACAATCATTAACTCACCAGCACCAAG
CATCACCAGCTCCCACCCGTCCCTGGTCCAAGACTTGAGTCAGCAAAATGGCGCCACAGGACACTAAAGAAGCCTTAAAACCAAGATAAT
ACGACCACCTCCACCCAATCCTGATGTTCGCAGGGCTGAAGTTAACAGAGCACAGACCACCTTTAGTTAGATGTGGCTTTCAGCCTTTTA
GGGAAAGACTCGAACAAATTTTCATCTATTCAAGAGCATGCTGTTTGCAGCACTCTTTATGGTCTCCTAGGAGCATAACTTGGAATGTAC
AGGAATATTTGTGTCCTAAAAAAATCAGCTGCCCTTCCAATATCATTTTTATAACGTTATGGTTTAATTCAAGTTATACAAAGGTGTGAC

>In-frame_AFTPH_ENST00000487769_chr2_64812679_+_THRB_ENST00000280696_chr3_24193981_-_1930nt
TTTCCACATTTTAGTGAACCAGGTGATGACTTTGGAGAATTTGGGGATATAAATGCTGTTTCTTGCCAAGAGGAGACAATATTAACAAAG
TCAGACCTAAAACAGACTTCTGATAATTTATCAGAAGAATGTCAATTGGCAAGAAAATCTAGTGGAACAGGCACTGAACCTGTTGCAAAA
CTTAAAAATGGGCAAGAAGGTGAGATTGGACATTTTGATTCTGTGCCAAATATTCAGGATGACTGCAATGGTTTTCAAGACTCTGATGAT
TTTGCAGACTTCAGTTCAGCTGGTCCTAGCCAAGTTGTAGATTGGAATGCTTTTGAGGATGAACAAAAAGATAGTTGTTCTTGGGCTGCT
TTTGGAGACCAGCAGGCTACTGAATCTCATCATCGAAAGGAAGCCTGGCAGTCACATAGGACAGATGAAAATATTGATACTCCAGGAACC
CCCAAAACGCACAGTGTACCTTCAGCAACTTCCAAAGGAGCAGTTGCTAGTGGCCATTTACAGGAATCAGCCACTTCAGTTCAGGGTATG
TTAGAGCCCACCAAGGAACCACTGAAACCACTTTCTGCTGCAGAAAAAATAGCTTCCATCGGTCAGACAGCCACCATGTCACCAGATATG
AACACATGTACATCTGATCAGTTCCAGGTGTGGATCCGGAGTTGTATGAGTTAACAACTTCTAAGCTGGAAATCTCCACCTCAAGCCTCA
AAGTGACTGATGCATTTGCAAGACTCATGTCTACAGTAGAGAAGACAAGCACATCTACCAGGGTACATCCCCAGTTACTTAGACAAGGAC
GAGCTCTGTGTAGTGTGTGGTGACAAAGCCACCGGGTATCACTACCGCTGTATCACGTGTGAAGGCTGCAAGGGTTTCTTTAGAAGAACC
ATTCAGAAAAATCTCCATCCATCCTATTCCTGTAAATATGAAGGAAAATGTGTCATAGACAAAGTCACGCGAAATCAGTGCCAGGAATGT
CGCTTTAAGAAATGCATCTATGTTGGCATGGCAACAGATTTGGTGCTGGATGACAGCAAGAGGCTGGCCAAGAGGAAGCTGATAGAGGAG
AACCGGGAGAAAAGACGGCGGGAAGAGCTGCAGAAGTCCATCGGGCACAAGCCAGAGCCCACAGACGAGGAATGGGAGCTCATCAAAACT
GTCACCGAAGCCCATGTGGCGACCAACGCCCAAGGCAGCCACTGGAAGCAAAAACGGAAATTCCTGCCAGAAGACATTGGACAAGCACCA
ATAGTCAATGCCCCAGAAGGTGGAAAGGTTGACTTGGAAGCCTTCAGCCATTTTACAAAAATCATCACACCAGCAATTACCAGAGTGGTG
GATTTTGCCAAAAAGTTGCCTATGTTTTGTGAGCTGCCATGTGAAGACCAGATCATCCTCCTCAAAGGCTGCTGCATGGAGATCATGTCC
CTTCGCGCTGCTGTGCGCTATGACCCAGAAAGTGAGACTTTAACCTTGAATGGGGAAATGGCAGTGACACGGGGCCAGCTGAAAAATGGG
GGTCTTGGGGTGGTGTCAGACGCCATCTTTGACCTGGGCATGTCTCTGTCTTCTTTCAACCTGGATGACACTGAAGTAGCCCTCCTTCAG
GCCGTCCTGCTGATGTCTTCAGATCGCCCGGGGCTTGCCTGTGTTGAGAGAATAGAAAAGTACCAAGATAGTTTCCTGCTGGCCTTTGAA
CACTATATCAATTACCGAAAACACCACGTGACACACTTTTGGCCAAAACTCCTGATGAAGGTGACAGATCTGCGGATGATAGGAGCCTGC
CATGCCAGCCGCTTCCTGCACATGAAGGTGGAATGCCCCACAGAACTCTTCCCCCCTTTGTTCTTGGAAGTGTTCGAGGATTAGACTGAC


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FusionGenePPI for AFTPH_THRB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AFTPHUBE3A, LIG4, STAT5B, VAPB, NTRK1, XPO1, AP1S2, VAPA, AP1M2THRBPSMC5, BRD8, NCOA2, NRBF2, NCOA6, RXRA, CCND1, TBL1X, TRIP4, PRMT1, TSG101, TP53, PPARGC1B, PPARGC1A, COPS2, THRB, NCOR2, NCOA1, NR2F6, NCOR1, SRC, LRIF1, PRKDC, SMC1A, PARP1, LIG3, XRCC5, XRCC6, HSPA4, TBL1XR1, HDAC3, GPS2, CAMK2B, NRIP1, HMGN3, NCOA3, RXRG, RXRB, MED21, ROBO4, ANP32A, ATF2, C1D, MMS19, ADAT3, RANBP9, NSD1, UBE2I, ACTA2, ACTBL2, ACTB, PDLIM7, DNM3, NRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AFTPH_THRB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTHRBP10828DB00451LevothyroxineThyroid hormone receptor betasmall moleculeapproved
TgeneTHRBP10828DB00509DextrothyroxineThyroid hormone receptor betasmall moleculeapproved|investigational
TgeneTHRBP10828DB01118AmiodaroneThyroid hormone receptor betasmall moleculeapproved|investigational
TgeneTHRBP10828DB00279LiothyronineThyroid hormone receptor betasmall moleculeapproved|vet_approved

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RelatedDiseases for AFTPH_THRB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTHRBC2937288THYROID HORMONE RESISTANCE, GENERALIZED, AUTOSOMAL DOMINANT19CTD_human;UNIPROT
TgeneTHRBC1840364THYROID HORMONE RESISTANCE, SELECTIVE PITUITARY3CTD_human;ORPHANET;UNIPROT
TgeneTHRBC2940786Thyroid Hormone Resistance Syndrome2CTD_human;HPO;ORPHANET
TgeneTHRBC0019284Diaphragmatic Hernia1CTD_human
TgeneTHRBC0206682Follicular thyroid carcinoma1CTD_human
TgeneTHRBC0376634Craniofacial Abnormalities1CTD_human