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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10413

FusionGeneSummary for DOCK7_INADL

check button Fusion gene summary
Fusion gene informationFusion gene name: DOCK7_INADL
Fusion gene ID: 10413
HgeneTgene
Gene symbol

DOCK7

INADL

Gene ID

85440

10207

Gene namededicator of cytokinesis 7PATJ, crumbs cell polarity complex component
SynonymsEIEE23|ZIR2Cipp|INADL|InaD-like|hINADL
Cytomap

1p31.3

1p31.3

Type of geneprotein-codingprotein-coding
Descriptiondedicator of cytokinesis protein 7inaD-like proteinPALS1-associated tight junction proteinPDZ domain proteinchannel-interacting PDZ domain proteininactivation no after-potential D-like proteininactivation-no-afterpotential D-likeprotein associated to tight junctions
Modification date2018052320180522
UniProtAcc

Q96N67

Ensembl transtripts involved in fusion geneENST00000251157, ENST00000340370, 
ENST00000489185, ENST00000404627, 
ENST00000316485, ENST00000371158, 
ENST00000543708, ENST00000545929, 
ENST00000472512, 
Fusion gene scores* DoF score7 X 4 X 5=1405 X 5 X 3=75
# samples 65
** MAII scorelog2(6/140*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DOCK7 [Title/Abstract] AND INADL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDOCK7

GO:0090630

activation of GTPase activity

16982419


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A24Z-01ADOCK7chr1

62958375

-INADLchr1

62626580

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000251157ENST00000316485DOCK7chr1

62958375

-INADLchr1

62626580

+
5CDS-intronENST00000251157ENST00000371158DOCK7chr1

62958375

-INADLchr1

62626580

+
5CDS-intronENST00000251157ENST00000543708DOCK7chr1

62958375

-INADLchr1

62626580

+
5CDS-intronENST00000251157ENST00000545929DOCK7chr1

62958375

-INADLchr1

62626580

+
5CDS-intronENST00000251157ENST00000472512DOCK7chr1

62958375

-INADLchr1

62626580

+
5CDS-intronENST00000340370ENST00000316485DOCK7chr1

62958375

-INADLchr1

62626580

+
5CDS-intronENST00000340370ENST00000371158DOCK7chr1

62958375

-INADLchr1

62626580

+
5CDS-intronENST00000340370ENST00000543708DOCK7chr1

62958375

-INADLchr1

62626580

+
5CDS-intronENST00000340370ENST00000545929DOCK7chr1

62958375

-INADLchr1

62626580

+
5CDS-intronENST00000340370ENST00000472512DOCK7chr1

62958375

-INADLchr1

62626580

+
intron-intronENST00000489185ENST00000316485DOCK7chr1

62958375

-INADLchr1

62626580

+
intron-intronENST00000489185ENST00000371158DOCK7chr1

62958375

-INADLchr1

62626580

+
intron-intronENST00000489185ENST00000543708DOCK7chr1

62958375

-INADLchr1

62626580

+
intron-intronENST00000489185ENST00000545929DOCK7chr1

62958375

-INADLchr1

62626580

+
intron-intronENST00000489185ENST00000472512DOCK7chr1

62958375

-INADLchr1

62626580

+
intron-intronENST00000404627ENST00000316485DOCK7chr1

62958375

-INADLchr1

62626580

+
intron-intronENST00000404627ENST00000371158DOCK7chr1

62958375

-INADLchr1

62626580

+
intron-intronENST00000404627ENST00000543708DOCK7chr1

62958375

-INADLchr1

62626580

+
intron-intronENST00000404627ENST00000545929DOCK7chr1

62958375

-INADLchr1

62626580

+
intron-intronENST00000404627ENST00000472512DOCK7chr1

62958375

-INADLchr1

62626580

+

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FusionProtFeatures for DOCK7_INADL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DOCK7

Q96N67

INADL

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DOCK7_INADL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DOCK7_INADL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DOCK7TSC1, USP19, USP7, GTF2A1, MLH1, YWHAG, MARK4, YWHAH, YWHAZ, PPP2CB, GRB7, BCL2L1, SNCA, RPP14, TK1, CDKN1A, SMN1, ANXA7, SOX2, SIRT7, VCP, PAN2, CRLF3, DOCK6, LRCH1, LRCH2, LRCH3, DOCK8, LRCH4, MOB1A, MOB1B, WHSC1L1, WWOX, LGR4, STAU1, AURKB, CEP250, TP53, TUBGCP3, MOV10, NXF1, CCDC8, PIH1D1, ARPC3, PPP1R18, SKAP1, LPCAT1, PTGER3, RASSF10, FBXW11, NTRK1, IFI16, PLK4, MED23, XPO1, CAPZA2, CDK2, MYH9, MYO1C, MYO19, MYO6, DUSP13, DUSP26, MTMR7, AVIL, TMOD3, ZNF785, TGM5, PRPSAP2, IRF3, LGALS7, KLHDC9, CBY1, DCAF7, UBE2AINADLTJP3, CLDN1, MPP5, ARHGAP17, AMOT, PARD3, BAI1, AMOTL2, LATS1, LATS2, SAV1, YAP1, TP53RK, RNF166, LIN7C, LIN7A, GBA, GJB2, HSF2, SNCA, SLC33A1, RNASEH2A, RAB32, ANAPC15, CEP170P1, CDH1, HOMER3, PCDHAC2, WWC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DOCK7_INADL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DOCK7_INADL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDOCK7C0023893Liver Cirrhosis, Experimental1CTD_human