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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10361

FusionGeneSummary for DNMT3B_MMP9

check button Fusion gene summary
Fusion gene informationFusion gene name: DNMT3B_MMP9
Fusion gene ID: 10361
HgeneTgene
Gene symbol

DNMT3B

MMP9

Gene ID

1789

4318

Gene nameDNA methyltransferase 3 betamatrix metallopeptidase 9
SynonymsICF|ICF1|M.HsaIIIBCLG4B|GELB|MANDP2|MMP-9
Cytomap

20q11.21

20q13.12

Type of geneprotein-codingprotein-coding
DescriptionDNA (cytosine-5)-methyltransferase 3BDNA (cytosine-5-)-methyltransferase 3 betaDNA MTase HsaIIIBDNA cytosine-5--methyltransferase 3 betaDNA methyltransferase HsaIIIBmatrix metalloproteinase-9macrophage gelatinasematrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)type V collagenase
Modification date2018052220180527
UniProtAcc

Q9UBC3

P14780

Ensembl transtripts involved in fusion geneENST00000328111, ENST00000348286, 
ENST00000353855, ENST00000443239, 
ENST00000344505, ENST00000375623, 
ENST00000456297, ENST00000201963, 
ENST00000372330, 
Fusion gene scores* DoF score5 X 5 X 5=1255 X 4 X 5=100
# samples 55
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNMT3B [Title/Abstract] AND MMP9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNMT3B

GO:0000122

negative regulation of transcription by RNA polymerase II

17303076

TgeneMMP9

GO:0006508

proteolysis

2551898|15863497|19022250|24164424

TgeneMMP9

GO:0034614

cellular response to reactive oxygen species

26514923

TgeneMMP9

GO:0043388

positive regulation of DNA binding

22984561

TgeneMMP9

GO:0071276

cellular response to cadmium ion

26514923

TgeneMMP9

GO:1900122

positive regulation of receptor binding

24164424

TgeneMMP9

GO:2001258

negative regulation of cation channel activity

24164424


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-Y8-A8S1-01ADNMT3Bchr20

31350505

+MMP9chr20

44638505

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000328111ENST00000372330DNMT3Bchr20

31350505

+MMP9chr20

44638505

+
5UTR-3CDSENST00000348286ENST00000372330DNMT3Bchr20

31350505

+MMP9chr20

44638505

+
5UTR-3CDSENST00000353855ENST00000372330DNMT3Bchr20

31350505

+MMP9chr20

44638505

+
5UTR-3CDSENST00000443239ENST00000372330DNMT3Bchr20

31350505

+MMP9chr20

44638505

+
5UTR-3CDSENST00000344505ENST00000372330DNMT3Bchr20

31350505

+MMP9chr20

44638505

+
5UTR-3CDSENST00000375623ENST00000372330DNMT3Bchr20

31350505

+MMP9chr20

44638505

+
5UTR-3CDSENST00000456297ENST00000372330DNMT3Bchr20

31350505

+MMP9chr20

44638505

+
intron-3CDSENST00000201963ENST00000372330DNMT3Bchr20

31350505

+MMP9chr20

44638505

+

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FusionProtFeatures for DNMT3B_MMP9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNMT3B

Q9UBC3

MMP9

P14780

May play an essential role in local proteolysis of theextracellular matrix and in leukocyte migration. Could play a rolein bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leubond. Cleaves type IV and type V collagen into large C-terminalthree quarter fragments and shorter N-terminal one quarterfragments. Degrades fibronectin but not laminin or Pz-peptide.{ECO:0000269|PubMed:1480034}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNMT3B_MMP9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNMT3B_MMP9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNMT3BSMC4, SMC2, KIF4A, SIN3A, HDAC1, SMARCA5, NCAPG, DNMT3A, CBX5, DNMT1, UBE2I, SUMO1, DNMT3L, SPI1, TDG, MBD4, UHRF1, SETDB1, EZH2, EED, BAZ2A, HDAC2, SUV39H1, CBX3, HELLS, HIST1H1A, CBX1, NEDD8, CUL1, CUL2, CUL3, CUL5, CUL4A, PIAS1, CMTM6, PCYT2, RPS10, PAM16, PLEKHJ1, DUSP23, MAP1LC3B, UBE2W, WARS, TSC22D1, UHRF2, TRIM28, ZFP57, CREB1, EPHB1, SIRT1, SUZ12, NRIP1, PAF1, CDC73, POLR2H, POLR2C, POLR2A, RTF1, LEO1, CTR9, CHD4, MTA1, MTA2, RBBP4, RBBP7, UGGT1, SGOL1, RELA, PCDHGB4, HIST1H3AMMP9CXCL5, CXCL6, TGFB1, THBS1, THBS2, CLU, COL12A1, TIMP1, COL2A1, COL14A1, COL5A1, COL6A2, COL4A1, FN1, COL4A2, COL6A1, COL18A1, SCARA3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNMT3B_MMP9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMMP9P14780DB01197CaptoprilMatrix metalloproteinase-9small moleculeapproved
TgeneMMP9P14780DB01017MinocyclineMatrix metalloproteinase-9small moleculeapproved|investigational
TgeneMMP9P14780DB01296GlucosamineMatrix metalloproteinase-9small moleculeapproved|investigational
TgeneMMP9P14780DB01593ZincMatrix metalloproteinase-9small moleculeapproved|investigational
TgeneMMP9P14780DB00143GlutathioneMatrix metalloproteinase-9small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for DNMT3B_MMP9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNMT3BC0398788Immunodeficiency syndrome, variable10CTD_human;UNIPROT
HgeneDNMT3BC1458155Mammary Neoplasms2CTD_human
HgeneDNMT3BC0021051Immunologic Deficiency Syndromes1CTD_human;HPO
HgeneDNMT3BC0033578Prostatic Neoplasms1CTD_human
HgeneDNMT3BC0036341Schizophrenia1PSYGENET
HgeneDNMT3BC0038356Stomach Neoplasms1CTD_human
HgeneDNMT3BC0376634Craniofacial Abnormalities1CTD_human
HgeneDNMT3BC0525045Mood Disorders1PSYGENET
HgeneDNMT3BC1510586Autism Spectrum Disorders1CTD_human
HgeneDNMT3BC1656427early onset schizophrenia1PSYGENET
HgeneDNMT3BC1834671FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY 1B1UNIPROT
TgeneMMP9C0027626Neoplasm Invasiveness7CTD_human
TgeneMMP9C0027627Neoplasm Metastasis5CTD_human
TgeneMMP9C2937358Cerebral Hemorrhage5CTD_human
TgeneMMP9C0001973Alcoholic Intoxication, Chronic3PSYGENET
TgeneMMP9C0007621Neoplastic Cell Transformation3CTD_human
TgeneMMP9C0004096Asthma2CTD_human
TgeneMMP9C0005586Bipolar Disorder2PSYGENET
TgeneMMP9C0006663Calcinosis2CTD_human
TgeneMMP9C0011853Diabetes Mellitus, Experimental2CTD_human
TgeneMMP9C0021368Inflammation2CTD_human
TgeneMMP9C0023895Liver diseases2CTD_human
TgeneMMP9C0027051Myocardial Infarction2CTD_human
TgeneMMP9C0031099Periodontitis2CTD_human
TgeneMMP9C0036341Schizophrenia2PSYGENET
TgeneMMP9C0003486Aortic Aneurysm1CTD_human
TgeneMMP9C0003493Aortic Diseases1CTD_human
TgeneMMP9C0003496Aortic Rupture1CTD_human
TgeneMMP9C0004114Astrocytoma1CTD_human
TgeneMMP9C0005967Bone neoplasms1CTD_human
TgeneMMP9C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneMMP9C0007137Squamous cell carcinoma1CTD_human
TgeneMMP9C0007786Brain Ischemia1CTD_human
TgeneMMP9C0009324Ulcerative Colitis1CTD_human
TgeneMMP9C0009375Colonic Neoplasms1CTD_human
TgeneMMP9C0011882Diabetic Neuropathies1CTD_human
TgeneMMP9C0017636Glioblastoma1CTD_human
TgeneMMP9C0020507Hyperplasia1CTD_human
TgeneMMP9C0020538Hypertensive disease1CTD_human
TgeneMMP9C0023176Lead Poisoning1CTD_human
TgeneMMP9C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneMMP9C0024117Chronic Obstructive Airway Disease1CTD_human
TgeneMMP9C0024143Lupus Nephritis1CTD_human
TgeneMMP9C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneMMP9C0024796Marfan Syndrome1CTD_human
TgeneMMP9C0026552Morphine Dependence1CTD_human
TgeneMMP9C0026766Multiple Organ Failure1CTD_human
TgeneMMP9C0028754Obesity1CTD_human
TgeneMMP9C0029172Oral Submucous Fibrosis1CTD_human
TgeneMMP9C0030297Pancreatic Neoplasm1CTD_human
TgeneMMP9C0033578Prostatic Neoplasms1CTD_human
TgeneMMP9C0034067Pulmonary Emphysema1CTD_human
TgeneMMP9C0034069Pulmonary Fibrosis1CTD_human
TgeneMMP9C0035126Reperfusion Injury1CTD_human
TgeneMMP9C0035309Retinal Diseases1CTD_human
TgeneMMP9C0037286Skin Neoplasms1CTD_human
TgeneMMP9C0038358Gastric ulcer1CTD_human
TgeneMMP9C0038587Substance Withdrawal Syndrome1CTD_human
TgeneMMP9C0086132Depressive Symptoms1PSYGENET
TgeneMMP9C0151526Premature Birth1CTD_human
TgeneMMP9C0162871Aortic Aneurysm, Abdominal1CTD_human
TgeneMMP9C0162872Aortic Aneurysm, Thoracic1CTD_human
TgeneMMP9C0243026Sepsis1CTD_human
TgeneMMP9C0338831Manic1PSYGENET
TgeneMMP9C0340288Stable angina1CTD_human
TgeneMMP9C0432291Mandibuloacral dysostosis1CTD_human
TgeneMMP9C0740392Infarction, Middle Cerebral Artery1CTD_human
TgeneMMP9C0948089Acute Coronary Syndrome1CTD_human
TgeneMMP9C1458155Mammary Neoplasms1CTD_human
TgeneMMP9C1527311Brain Edema1CTD_human
TgeneMMP9C2239176Liver carcinoma1CTD_human
TgeneMMP9C2936380Neointima1CTD_human