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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10360

FusionGeneSummary for DNMT3B_MDM4

check button Fusion gene summary
Fusion gene informationFusion gene name: DNMT3B_MDM4
Fusion gene ID: 10360
HgeneTgene
Gene symbol

DNMT3B

MDM4

Gene ID

1789

4194

Gene nameDNA methyltransferase 3 betaMDM4, p53 regulator
SynonymsICF|ICF1|M.HsaIIIBHDMX|MDMX|MRP1
Cytomap

20q11.21

1q32.1

Type of geneprotein-codingprotein-coding
DescriptionDNA (cytosine-5)-methyltransferase 3BDNA (cytosine-5-)-methyltransferase 3 betaDNA MTase HsaIIIBDNA cytosine-5--methyltransferase 3 betaDNA methyltransferase HsaIIIBprotein Mdm4MDM4 protein variant GMDM4 protein variant YMDM4-related protein 1Mdm4 p53 binding protein homologdouble minute 4, human homolog of; p53-binding proteinmdm2-like p53-binding proteinprotein Mdmx
Modification date2018052220180519
UniProtAcc

Q9UBC3

O15151

Ensembl transtripts involved in fusion geneENST00000328111, ENST00000348286, 
ENST00000353855, ENST00000443239, 
ENST00000344505, ENST00000375623, 
ENST00000456297, ENST00000201963, 
ENST00000367182, ENST00000463049, 
ENST00000507825, ENST00000454264, 
ENST00000367183, ENST00000367180, 
ENST00000391947, 
Fusion gene scores* DoF score5 X 5 X 5=1256 X 7 X 3=126
# samples 57
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNMT3B [Title/Abstract] AND MDM4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNMT3B

GO:0000122

negative regulation of transcription by RNA polymerase II

17303076

TgeneMDM4

GO:0000122

negative regulation of transcription by RNA polymerase II

9226370

TgeneMDM4

GO:0065003

protein-containing complex assembly

10608892


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLAMLTCGA-AB-2904-03ADNMT3Bchr20

31390276

+MDM4chr1

204494612

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000328111ENST00000367182DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-3UTRENST00000328111ENST00000463049DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000328111ENST00000507825DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000328111ENST00000454264DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000328111ENST00000367183DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000328111ENST00000367180DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-intronENST00000328111ENST00000391947DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000348286ENST00000367182DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-3UTRENST00000348286ENST00000463049DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000348286ENST00000507825DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000348286ENST00000454264DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000348286ENST00000367183DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000348286ENST00000367180DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-intronENST00000348286ENST00000391947DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000353855ENST00000367182DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-3UTRENST00000353855ENST00000463049DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000353855ENST00000507825DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000353855ENST00000454264DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000353855ENST00000367183DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000353855ENST00000367180DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-intronENST00000353855ENST00000391947DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000443239ENST00000367182DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-3UTRENST00000443239ENST00000463049DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000443239ENST00000507825DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000443239ENST00000454264DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000443239ENST00000367183DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000443239ENST00000367180DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-intronENST00000443239ENST00000391947DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000344505ENST00000367182DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-3UTRENST00000344505ENST00000463049DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000344505ENST00000507825DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000344505ENST00000454264DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000344505ENST00000367183DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000344505ENST00000367180DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-intronENST00000344505ENST00000391947DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
intron-5UTRENST00000375623ENST00000367182DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
intron-3UTRENST00000375623ENST00000463049DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
intron-5UTRENST00000375623ENST00000507825DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
intron-5UTRENST00000375623ENST00000454264DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
intron-5UTRENST00000375623ENST00000367183DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
intron-5UTRENST00000375623ENST00000367180DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
intron-intronENST00000375623ENST00000391947DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000456297ENST00000367182DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-3UTRENST00000456297ENST00000463049DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000456297ENST00000507825DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000456297ENST00000454264DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000456297ENST00000367183DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000456297ENST00000367180DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-intronENST00000456297ENST00000391947DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000201963ENST00000367182DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-3UTRENST00000201963ENST00000463049DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000201963ENST00000507825DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000201963ENST00000454264DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000201963ENST00000367183DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-5UTRENST00000201963ENST00000367180DNMT3Bchr20

31390276

+MDM4chr1

204494612

+
5CDS-intronENST00000201963ENST00000391947DNMT3Bchr20

31390276

+MDM4chr1

204494612

+

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FusionProtFeatures for DNMT3B_MDM4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNMT3B

Q9UBC3

MDM4

O15151

Inhibits p53/TP53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activationdomain. Inhibits degradation of MDM2. Can reverse MDM2-targeteddegradation of TP53 while maintaining suppression of TP53transactivation and apoptotic functions.{ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNMT3B_MDM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNMT3B_MDM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNMT3BSMC4, SMC2, KIF4A, SIN3A, HDAC1, SMARCA5, NCAPG, DNMT3A, CBX5, DNMT1, UBE2I, SUMO1, DNMT3L, SPI1, TDG, MBD4, UHRF1, SETDB1, EZH2, EED, BAZ2A, HDAC2, SUV39H1, CBX3, HELLS, HIST1H1A, CBX1, NEDD8, CUL1, CUL2, CUL3, CUL5, CUL4A, PIAS1, CMTM6, PCYT2, RPS10, PAM16, PLEKHJ1, DUSP23, MAP1LC3B, UBE2W, WARS, TSC22D1, UHRF2, TRIM28, ZFP57, CREB1, EPHB1, SIRT1, SUZ12, NRIP1, PAF1, CDC73, POLR2H, POLR2C, POLR2A, RTF1, LEO1, CTR9, CHD4, MTA1, MTA2, RBBP4, RBBP7, UGGT1, SGOL1, RELA, PCDHGB4, HIST1H3AMDM4SMAD3, SMAD4, EP300, MDM2, E2F1, TP53, UBE2D1, CDKN2A, YWHAG, CHEK1, SFN, YWHAB, YWHAE, YWHAH, CHEK2, CSNK1A1, TP73, USP7, MDM4, CDKN1A, PSMC5, PSMD2, TP63, USP2, RFWD2, RCHY1, RN5S1@, UBE2D2, ABL1, YWHAQ, YWHAZ, UBE2D3, RB1, APP, PPP1CA, PPP1CB, PPP1CC, HSP90AA1, BCL2, RPL37, RPS15, RPS20, MKRN3, LRSAM1, TRIM55, TRIM46, MNAT1, PRKAA1, UBC, CD160, CAPN7, RNF115, RAD54B, SMARCA2, C1orf111, PPARD, NBN, MRE11A, RAD50, USP22, MAGEA1, MAGEB1, FAM193A, PELI1, CCNDBP1, ASRGL1, EIF2AK4, HBB, CDK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNMT3B_MDM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNMT3B_MDM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNMT3BC0398788Immunodeficiency syndrome, variable10CTD_human;UNIPROT
HgeneDNMT3BC1458155Mammary Neoplasms2CTD_human
HgeneDNMT3BC0021051Immunologic Deficiency Syndromes1CTD_human;HPO
HgeneDNMT3BC0033578Prostatic Neoplasms1CTD_human
HgeneDNMT3BC0036341Schizophrenia1PSYGENET
HgeneDNMT3BC0038356Stomach Neoplasms1CTD_human
HgeneDNMT3BC0376634Craniofacial Abnormalities1CTD_human
HgeneDNMT3BC0525045Mood Disorders1PSYGENET
HgeneDNMT3BC1510586Autism Spectrum Disorders1CTD_human
HgeneDNMT3BC1656427early onset schizophrenia1PSYGENET
HgeneDNMT3BC1834671FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY 1B1UNIPROT
TgeneMDM4C0017636Glioblastoma1CTD_human
TgeneMDM4C0032273Pneumoconiosis1CTD_human
TgeneMDM4C0041696Unipolar Depression1PSYGENET
TgeneMDM4C1269683Major Depressive Disorder1PSYGENET
TgeneMDM4C1458155Mammary Neoplasms1CTD_human