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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10358

FusionGeneSummary for DNMT3B_COMMD7

check button Fusion gene summary
Fusion gene informationFusion gene name: DNMT3B_COMMD7
Fusion gene ID: 10358
HgeneTgene
Gene symbol

DNMT3B

COMMD7

Gene ID

1789

149951

Gene nameDNA methyltransferase 3 betaCOMM domain containing 7
SynonymsICF|ICF1|M.HsaIIIBC20orf92|dJ1085F17.3
Cytomap

20q11.21

20q11.21

Type of geneprotein-codingprotein-coding
DescriptionDNA (cytosine-5)-methyltransferase 3BDNA (cytosine-5-)-methyltransferase 3 betaDNA MTase HsaIIIBDNA cytosine-5--methyltransferase 3 betaDNA methyltransferase HsaIIIBCOMM domain-containing protein 7
Modification date2018052220180519
UniProtAcc

Q9UBC3

Q86VX2

Ensembl transtripts involved in fusion geneENST00000328111, ENST00000348286, 
ENST00000353855, ENST00000443239, 
ENST00000344505, ENST00000375623, 
ENST00000456297, ENST00000201963, 
ENST00000278980, ENST00000446419, 
Fusion gene scores* DoF score5 X 5 X 5=1255 X 2 X 4=40
# samples 56
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DNMT3B [Title/Abstract] AND COMMD7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNMT3B

GO:0000122

negative regulation of transcription by RNA polymerase II

17303076

TgeneCOMMD7

GO:0032088

negative regulation of NF-kappaB transcription factor activity

15799966

TgeneCOMMD7

GO:0033209

tumor necrosis factor-mediated signaling pathway

15799966

TgeneCOMMD7

GO:0045892

negative regulation of transcription, DNA-templated

15799966


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-NA-A5I1-01ADNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000328111ENST00000278980DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000328111ENST00000446419DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000348286ENST00000278980DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000348286ENST00000446419DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000353855ENST00000278980DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000353855ENST00000446419DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000443239ENST00000278980DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000443239ENST00000446419DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000344505ENST00000278980DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000344505ENST00000446419DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000375623ENST00000278980DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000375623ENST00000446419DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000456297ENST00000278980DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000456297ENST00000446419DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000201963ENST00000278980DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-
In-frameENST00000201963ENST00000446419DNMT3Bchr20

31369220

+COMMD7chr20

31315949

-

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FusionProtFeatures for DNMT3B_COMMD7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNMT3B

Q9UBC3

COMMD7

Q86VX2

May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). Associates with the NF-kappa-Bcomplex and suppresses its transcriptional activity(PubMed:15799966). {ECO:0000269|PubMed:15799966,ECO:0000305|PubMed:21778237}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOMMD7chr20:31369220chr20:31315949ENST00000278980-09133_20028201DomainCOMM
TgeneCOMMD7chr20:31369220chr20:31315949ENST00000446419-09133_20028200DomainCOMM

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000201963+322225_28380846DomainPWWP
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000201963+322423_55580846DomainADD
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000201963+322575_85380846DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000328111+323225_28368854DomainPWWP
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000328111+323423_55568854DomainADD
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000328111+323575_85368854DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000344505+321225_28368793DomainPWWP
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000344505+321423_55568793DomainADD
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000344505+321575_85368793DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000348286+320225_28368771DomainPWWP
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000348286+320423_55568771DomainADD
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000348286+320575_85368771DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000353855+322225_28368834DomainPWWP
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000353855+322423_55568834DomainADD
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000353855+322575_85368834DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000443239+319225_28368729DomainPWWP
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000443239+319423_55568729DomainADD
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000443239+319575_85368729DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000456297+318225_28368695DomainPWWP
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000456297+318423_55568695DomainADD
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000456297+318575_85368695DomainSAM-dependent MTase C5-type
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000201963+322582_58680846RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000201963+322627_62980846RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000201963+322832_83480846RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000328111+323582_58668854RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000328111+323627_62968854RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000328111+323832_83468854RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000344505+321582_58668793RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000344505+321627_62968793RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000344505+321832_83468793RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000348286+320582_58668771RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000348286+320627_62968771RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000348286+320832_83468771RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000353855+322582_58668834RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000353855+322627_62968834RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000353855+322832_83468834RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000443239+319582_58668729RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000443239+319627_62968729RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000443239+319832_83468729RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000456297+318582_58668695RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000456297+318627_62968695RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000456297+318832_83468695RegionS-adenosyl-L-methionine binding
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000201963+322434_46480846Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000201963+322475_53180846Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000328111+323434_46468854Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000328111+323475_53168854Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000344505+321434_46468793Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000344505+321475_53168793Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000348286+320434_46468771Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000348286+320475_53168771Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000353855+322434_46468834Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000353855+322475_53168834Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000443239+319434_46468729Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000443239+319475_53168729Zinc fingerPHD-type%3B atypical
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000456297+318434_46468695Zinc fingerGATA-type%3B atypical
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000456297+318475_53168695Zinc fingerPHD-type%3B atypical


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FusionGeneSequence for DNMT3B_COMMD7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNMT3B_COMMD7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNMT3BSMC4, SMC2, KIF4A, SIN3A, HDAC1, SMARCA5, NCAPG, DNMT3A, CBX5, DNMT1, UBE2I, SUMO1, DNMT3L, SPI1, TDG, MBD4, UHRF1, SETDB1, EZH2, EED, BAZ2A, HDAC2, SUV39H1, CBX3, HELLS, HIST1H1A, CBX1, NEDD8, CUL1, CUL2, CUL3, CUL5, CUL4A, PIAS1, CMTM6, PCYT2, RPS10, PAM16, PLEKHJ1, DUSP23, MAP1LC3B, UBE2W, WARS, TSC22D1, UHRF2, TRIM28, ZFP57, CREB1, EPHB1, SIRT1, SUZ12, NRIP1, PAF1, CDC73, POLR2H, POLR2C, POLR2A, RTF1, LEO1, CTR9, CHD4, MTA1, MTA2, RBBP4, RBBP7, UGGT1, SGOL1, RELA, PCDHGB4, HIST1H3ACOMMD7COMMD1, RELA, COMMD8, COMMD10, COMMD9, COMMD3, COMMD4, CCDC22, CCDC93, IKBKG, COMMD6, CHUK, IKBKB, COMMD2, FAM45A, VPS29


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000201963+3221_29880846DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000328111+3231_29868854DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000344505+3211_29868793DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000348286+3201_29868771DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000353855+3221_29868834DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000443239+3191_29868729DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000456297+3181_29868695DNMT1 and DNMT3A
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000201963+322435_52780846the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000328111+323435_52768854the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000344505+321435_52768793the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000348286+320435_52768771the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000353855+322435_52768834the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000443239+319435_52768729the PRC2/EED-EZH2 complex
HgeneDNMT3Bchr20:31369220chr20:31315949ENST00000456297+318435_52768695the PRC2/EED-EZH2 complex


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNMT3B_COMMD7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNMT3B_COMMD7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNMT3BC0398788Immunodeficiency syndrome, variable10CTD_human;UNIPROT
HgeneDNMT3BC1458155Mammary Neoplasms2CTD_human
HgeneDNMT3BC0021051Immunologic Deficiency Syndromes1CTD_human;HPO
HgeneDNMT3BC0033578Prostatic Neoplasms1CTD_human
HgeneDNMT3BC0036341Schizophrenia1PSYGENET
HgeneDNMT3BC0038356Stomach Neoplasms1CTD_human
HgeneDNMT3BC0376634Craniofacial Abnormalities1CTD_human
HgeneDNMT3BC0525045Mood Disorders1PSYGENET
HgeneDNMT3BC1510586Autism Spectrum Disorders1CTD_human
HgeneDNMT3BC1656427early onset schizophrenia1PSYGENET
HgeneDNMT3BC1834671FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY 1B1UNIPROT