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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10328

FusionGeneSummary for DNM2_SBNO2

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM2_SBNO2
Fusion gene ID: 10328
HgeneTgene
Gene symbol

DNM2

SBNO2

Gene ID

1785

22904

Gene namedynamin 2strawberry notch homolog 2
SynonymsCMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5KIAA0963|SNO|STNO
Cytomap

19p13.2

19p13.3

Type of geneprotein-codingprotein-coding
Descriptiondynamin-2dynamin IIprotein strawberry notch homolog 2
Modification date2018052720180523
UniProtAcc

P50570

Q9Y2G9

Ensembl transtripts involved in fusion geneENST00000585892, ENST00000314646, 
ENST00000359692, ENST00000389253, 
ENST00000355667, ENST00000408974, 
ENST00000591819, 
ENST00000361757, 
ENST00000587024, ENST00000438103, 
Fusion gene scores* DoF score27 X 13 X 12=42127 X 3 X 5=105
# samples 317
** MAII scorelog2(31/4212*10)=-3.76416531575148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNM2 [Title/Abstract] AND SBNO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313

TgeneSBNO2

GO:0071354

cellular response to interleukin-6

25903009


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-2092-01ADNM2chr19

10870487

+SBNO2chr19

1149441

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000585892ENST00000361757DNM2chr19

10870487

+SBNO2chr19

1149441

-
Frame-shiftENST00000585892ENST00000587024DNM2chr19

10870487

+SBNO2chr19

1149441

-
5CDS-intronENST00000585892ENST00000438103DNM2chr19

10870487

+SBNO2chr19

1149441

-
Frame-shiftENST00000314646ENST00000361757DNM2chr19

10870487

+SBNO2chr19

1149441

-
Frame-shiftENST00000314646ENST00000587024DNM2chr19

10870487

+SBNO2chr19

1149441

-
5CDS-intronENST00000314646ENST00000438103DNM2chr19

10870487

+SBNO2chr19

1149441

-
Frame-shiftENST00000359692ENST00000361757DNM2chr19

10870487

+SBNO2chr19

1149441

-
Frame-shiftENST00000359692ENST00000587024DNM2chr19

10870487

+SBNO2chr19

1149441

-
5CDS-intronENST00000359692ENST00000438103DNM2chr19

10870487

+SBNO2chr19

1149441

-
Frame-shiftENST00000389253ENST00000361757DNM2chr19

10870487

+SBNO2chr19

1149441

-
Frame-shiftENST00000389253ENST00000587024DNM2chr19

10870487

+SBNO2chr19

1149441

-
5CDS-intronENST00000389253ENST00000438103DNM2chr19

10870487

+SBNO2chr19

1149441

-
Frame-shiftENST00000355667ENST00000361757DNM2chr19

10870487

+SBNO2chr19

1149441

-
Frame-shiftENST00000355667ENST00000587024DNM2chr19

10870487

+SBNO2chr19

1149441

-
5CDS-intronENST00000355667ENST00000438103DNM2chr19

10870487

+SBNO2chr19

1149441

-
Frame-shiftENST00000408974ENST00000361757DNM2chr19

10870487

+SBNO2chr19

1149441

-
Frame-shiftENST00000408974ENST00000587024DNM2chr19

10870487

+SBNO2chr19

1149441

-
5CDS-intronENST00000408974ENST00000438103DNM2chr19

10870487

+SBNO2chr19

1149441

-
intron-3CDSENST00000591819ENST00000361757DNM2chr19

10870487

+SBNO2chr19

1149441

-
intron-3CDSENST00000591819ENST00000587024DNM2chr19

10870487

+SBNO2chr19

1149441

-
intron-intronENST00000591819ENST00000438103DNM2chr19

10870487

+SBNO2chr19

1149441

-

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FusionProtFeatures for DNM2_SBNO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM2

P50570

SBNO2

Q9Y2G9

Microtubule-associated force-producing protein involvedin producing microtubule bundles and able to bind and hydrolyzeGTP. Plays a role in the regulation of neuron morphology, axongrowth and formation of neuronal growth cones (By similarity).Plays an important role in vesicular trafficking processes, inparticular endocytosis. Involved in cytokinesis (PubMed:12498685).Regulates maturation of apoptotic cell corpse-containingphagosomes by recruiting PIK3C3 to the phagosome membrane (Bysimilarity). {ECO:0000250|UniProtKB:P39052,ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685}. Acts as a transcriptional coregulator, that can haveboth coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of thetranscription factor MITF to the DC-STAMP promoter in osteoclast.Plays a role in bone homeostasis; required as a positive regulatorin TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation ofosteoblast differentiation (By similarity). Involved in thetranscriptional corepression of NF-kappaB in macrophages(PubMed:18025162). Plays a role as a regulator in theproinflammatory cascade (PubMed:18025162).{ECO:0000250|UniProtKB:Q7TNB8, ECO:0000269|PubMed:18025162}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNM2_SBNO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNM2_SBNO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNM2SHANK1, SHANK2, SNX9, PDE6G, DDX39B, FER, EPS15, RUVBL2, MEPCE, RPAP2, GTF2E2, PACSIN1, PACSIN2, PACSIN3, TRIP10, PSTPIP1, FCHSD1, WIPI2, HMGB1, DNM1, RPS2, ATXN3, ZBTB16, MAN1B1, CCT7, RWDD2B, CCDC90B, DYNC1I1, TYK2, TIAM2, ITSN1, GDF9, SPRY2, ITSN2, SIRT7, SH3KBP1, CD2AP, AMPH, SH3GL2, SRC, GRB2, SHC1, APP, PICALM, RBMS1, SLC30A5, CTTN, FN1, VCAM1, PEX14, MANEA, KCNN3, ITGA4, AHI1, MPP6, FBXO6, FNBP1L, FNBP1, WBP4, EGFR, STAU1, DNM3, SCN2B, LYPD6, HTR6, BIN1, GBE1, GGA1, PTPN13, RPE, RTCB, NTRK1, OFD1, FGFR1OP, CNTRL, FBF1, NPHP1, DCTN1, RPGR, TCTN1, XRCC6, HNRNPD, PLK1, PML, BUB3, RHOU, SNW1, CDC5L, PTPN11, PIK3R1, PDGFRA, SNX18, GYPB, TMEM9B, TBC1D15, ZBBX, RBM3, DNALI1, TRIM25, TESSBNO2TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNM2_SBNO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNM2_SBNO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNM2C1834558Myopathy, Centronuclear, Autosomal Dominant9CTD_human;ORPHANET;UNIPROT
HgeneDNM2C1847902CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B (disorder)4CTD_human;ORPHANET;UNIPROT
HgeneDNM2C0752282Congenital Structural Myopathy1CTD_human
HgeneDNM2C3809272LETHAL CONGENITAL CONTRACTURE SYNDROME 51ORPHANET;UNIPROT
TgeneSBNO2C0036341Schizophrenia1PSYGENET