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Fusion gene ID: 10314 |
FusionGeneSummary for DNM2_GDF15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNM2_GDF15 | Fusion gene ID: 10314 | Hgene | Tgene | Gene symbol | DNM2 | GDF15 | Gene ID | 1785 | 9518 |
| Gene name | dynamin 2 | growth differentiation factor 15 | |
| Synonyms | CMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5 | GDF-15|MIC-1|MIC1|NAG-1|PDF|PLAB|PTGFB | |
| Cytomap | 19p13.2 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dynamin-2dynamin II | growth/differentiation factor 15NRG-1NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1NSAID-activated gene 1 proteinNSAID-regulated gene 1 proteinPTGF-betamacrophage inhibitory cytokine 1non-steroidal anti-inflammatory drug-activated | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P50570 | Q99988 | |
| Ensembl transtripts involved in fusion gene | ENST00000585892, ENST00000314646, ENST00000359692, ENST00000389253, ENST00000355667, ENST00000408974, ENST00000591819, | ENST00000604609, ENST00000252809, | |
| Fusion gene scores | * DoF score | 27 X 13 X 12=4212 | 3 X 3 X 3=27 |
| # samples | 31 | 3 | |
| ** MAII score | log2(31/4212*10)=-3.76416531575148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: DNM2 [Title/Abstract] AND GDF15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DNM2 | GO:1903526 | negative regulation of membrane tubulation | 18388313 |
| Tgene | GDF15 | GO:0000187 | activation of MAPK activity | 28953886 |
| Tgene | GDF15 | GO:0002023 | reduction of food intake in response to dietary excess | 28846097|28846098|28846099|28953886|29046435 |
| Tgene | GDF15 | GO:0035860 | glial cell-derived neurotrophic factor receptor signaling pathway | 28953886 |
| Tgene | GDF15 | GO:0051897 | positive regulation of protein kinase B signaling | 28846097 |
| Tgene | GDF15 | GO:0060395 | SMAD protein signal transduction | 25893289 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-FX-A2QS-01A | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000585892 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-intron | ENST00000585892 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-3UTR | ENST00000314646 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-intron | ENST00000314646 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-3UTR | ENST00000359692 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-intron | ENST00000359692 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-3UTR | ENST00000389253 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-intron | ENST00000389253 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-3UTR | ENST00000355667 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-intron | ENST00000355667 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-3UTR | ENST00000408974 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| 5CDS-intron | ENST00000408974 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| intron-3UTR | ENST00000591819 | ENST00000604609 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
| intron-intron | ENST00000591819 | ENST00000252809 | DNM2 | chr19 | 10829079 | + | GDF15 | chr19 | 18493160 | + |
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FusionProtFeatures for DNM2_GDF15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNM2 | GDF15 |
| Microtubule-associated force-producing protein involvedin producing microtubule bundles and able to bind and hydrolyzeGTP. Plays a role in the regulation of neuron morphology, axongrowth and formation of neuronal growth cones (By similarity).Plays an important role in vesicular trafficking processes, inparticular endocytosis. Involved in cytokinesis (PubMed:12498685).Regulates maturation of apoptotic cell corpse-containingphagosomes by recruiting PIK3C3 to the phagosome membrane (Bysimilarity). {ECO:0000250|UniProtKB:P39052,ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685}. | Regulates food intake, energy expenditure and bodyweight in response to metabolic and toxin-induced stresses(PubMed:28953886, PubMed:28846097, PubMed:28846098,PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to itsreceptor, GFRAL, and activates GFRAL-expressing neurons localizedin the area postrema and nucleus tractus solitarius of thebrainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098,PubMed:28846099). It then triggers the activation of neuronslocalized within the parabrachial nucleus and central amygdala,which contitutes part of the 'emergency circuit' that shapesfeeding responses to stressful conditions (PubMed:28953886). Onhepatocytes, inhibits growth hormone signaling (By similarity).{ECO:0000250|UniProtKB:Q9Z0J7, ECO:0000269|PubMed:23468844,ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846098,ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886,ECO:0000269|PubMed:29046435}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNM2_GDF15 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNM2_GDF15 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DNM2 | SHANK1, SHANK2, SNX9, PDE6G, DDX39B, FER, EPS15, RUVBL2, MEPCE, RPAP2, GTF2E2, PACSIN1, PACSIN2, PACSIN3, TRIP10, PSTPIP1, FCHSD1, WIPI2, HMGB1, DNM1, RPS2, ATXN3, ZBTB16, MAN1B1, CCT7, RWDD2B, CCDC90B, DYNC1I1, TYK2, TIAM2, ITSN1, GDF9, SPRY2, ITSN2, SIRT7, SH3KBP1, CD2AP, AMPH, SH3GL2, SRC, GRB2, SHC1, APP, PICALM, RBMS1, SLC30A5, CTTN, FN1, VCAM1, PEX14, MANEA, KCNN3, ITGA4, AHI1, MPP6, FBXO6, FNBP1L, FNBP1, WBP4, EGFR, STAU1, DNM3, SCN2B, LYPD6, HTR6, BIN1, GBE1, GGA1, PTPN13, RPE, RTCB, NTRK1, OFD1, FGFR1OP, CNTRL, FBF1, NPHP1, DCTN1, RPGR, TCTN1, XRCC6, HNRNPD, PLK1, PML, BUB3, RHOU, SNW1, CDC5L, PTPN11, PIK3R1, PDGFRA, SNX18, GYPB, TMEM9B, TBC1D15, ZBBX, RBM3, DNALI1, TRIM25, TES | GDF15 | GDF15, MAPK14, MDFI, STAT5A, NUPL1, SAE1, SETD4, MRPL50, NLGN3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNM2_GDF15 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNM2_GDF15 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DNM2 | C1834558 | Myopathy, Centronuclear, Autosomal Dominant | 9 | CTD_human;ORPHANET;UNIPROT |
| Hgene | DNM2 | C1847902 | CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE B (disorder) | 4 | CTD_human;ORPHANET;UNIPROT |
| Hgene | DNM2 | C0752282 | Congenital Structural Myopathy | 1 | CTD_human |
| Hgene | DNM2 | C3809272 | LETHAL CONGENITAL CONTRACTURE SYNDROME 5 | 1 | ORPHANET;UNIPROT |
| Tgene | GDF15 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Tgene | GDF15 | C0002896 | Sideroblastic anemia | 1 | CTD_human |
| Tgene | GDF15 | C0017185 | Gastrointestinal Neoplasms | 1 | CTD_human |
| Tgene | GDF15 | C0018801 | Heart failure | 1 | CTD_human |
| Tgene | GDF15 | C0025202 | melanoma | 1 | CTD_human |
| Tgene | GDF15 | C0026636 | Mouth Diseases | 1 | CTD_human |
| Tgene | GDF15 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | GDF15 | C0043094 | Weight Gain | 1 | CTD_human |
| Tgene | GDF15 | C0149721 | Left Ventricular Hypertrophy | 1 | CTD_human |
| Tgene | GDF15 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Tgene | GDF15 | C1956346 | Coronary Artery Disease | 1 | CTD_human |
| Tgene | GDF15 | C2239176 | Liver carcinoma | 1 | CTD_human |
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