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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10304

FusionGeneSummary for DNM1_FGFR2

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM1_FGFR2
Fusion gene ID: 10304
HgeneTgene
Gene symbol

DNM1

FGFR2

Gene ID

1759

2263

Gene namedynamin 1fibroblast growth factor receptor 2
SynonymsDNM|EIEE31BBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25
Cytomap

9q34.11

10q26.13

Type of geneprotein-codingprotein-coding
Descriptiondynamin-1fibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14
Modification date2018052320180527
UniProtAcc

Q05193

P21802

Ensembl transtripts involved in fusion geneENST00000475805, ENST00000341179, 
ENST00000372923, ENST00000393594, 
ENST00000486160, ENST00000493925, 
ENST00000369061, ENST00000357555, 
ENST00000358487, ENST00000356226, 
ENST00000369060, ENST00000369059, 
ENST00000346997, ENST00000457416, 
ENST00000351936, ENST00000360144, 
ENST00000369056, ENST00000490349, 
ENST00000359354, ENST00000478859, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 6 X 7=294
# samples 211
** MAII scorelog2(2/8*10)=1.32192809488736log2(11/294*10)=-1.4183126313117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNM1 [Title/Abstract] AND FGFR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGFR2

GO:0008284

positive regulation of cell proliferation

8663044

TgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

TgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

TgeneFGFR2

GO:0046777

protein autophosphorylation

15629145


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCHOLTCGA-W5-AA2Z-01ADNM1chr9

130954059

+FGFR2chr10

123239535

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000475805ENST00000369061DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000357555DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000358487DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000356226DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000369060DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000369059DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000346997DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000457416DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000351936DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000360144DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000369056DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000490349DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000359354DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000475805ENST00000478859DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-3CDSENST00000341179ENST00000369061DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000357555DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000358487DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000356226DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000369060DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000369059DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000346997DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000457416DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000351936DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000360144DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000369056DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000490349DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000359354DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000341179ENST00000478859DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-3CDSENST00000372923ENST00000369061DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000357555DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000358487DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000356226DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000369060DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000369059DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000346997DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000457416DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000351936DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000360144DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000369056DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000490349DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000359354DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000372923ENST00000478859DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-3CDSENST00000393594ENST00000369061DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000357555DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000358487DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000356226DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000369060DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000369059DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000346997DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000457416DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000351936DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000360144DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000369056DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000490349DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000359354DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000393594ENST00000478859DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-3CDSENST00000486160ENST00000369061DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000357555DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000358487DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000356226DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000369060DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000369059DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000346997DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000457416DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000351936DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000360144DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000369056DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000490349DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000359354DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000486160ENST00000478859DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-3CDSENST00000493925ENST00000369061DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000357555DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000358487DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000356226DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000369060DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000369059DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000346997DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000457416DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000351936DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000360144DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000369056DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000490349DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000359354DNM1chr9

130954059

+FGFR2chr10

123239535

-
intron-intronENST00000493925ENST00000478859DNM1chr9

130954059

+FGFR2chr10

123239535

-

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FusionProtFeatures for DNM1_FGFR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM1

Q05193

FGFR2

P21802

Microtubule-associated force-producing protein involvedin producing microtubule bundles and able to bind and hydrolyzeGTP. Most probably involved in vesicular trafficking processes.Involved in receptor-mediated endocytosis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNM1_FGFR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNM1_FGFR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNM1FNBP1, PACSIN1, DNMBP, ASB13, PIN4, MED31, KIAA1377, FER, NCK1, SH3GL2, AMPH, PACSIN3, PACSIN2, MAP3K10, SH3GL1, CLINT1, CABIN1, GRB2, DYRK1A, DNM1, UBASH3A, ADAM2, DNM2, ARRB1, SH3KBP1, CDK5, ITSN1, SRC, PTK2B, SUMO1, PIAS1, UBE2I, SH3BP4, NCK2, IQCB1, SNX9, FANCD2, IRF2BPL, NCL, NPM3, SNRPA1, TBC1D2, BIN1, HAX1, NUFIP1, DGUOK, DNAAF2, DNM3, SCN2B, LYPD6, RPE, NTRK1, TBC1D15, SLC39A9, TMEM9B, ZBBX, CDKAL1FGFR2FGF1, FGFR2, FGF7, FGF10, PIK3R1, ITGA5, STAT3, PGR, STAT5A, STAT5B, NEDD4, FRS2, CBL, LYN, FYN, HGS, APP, PPM1A, TSPAN3, C8orf74, BEX1, BEX2, ERRFI1, GLCE, HOXC6, MTA3, PDLIM2, RASL10B, RHOBTB2, S100A14, TFF1, FGF5, FGF23, FGF8, PLCG1, FGF2, FGF3, FGF6, FGF9, FGF17, PVRL1, BRAF, MAP3K1, PTPN6, PTPN11, PTPN12, PTPRR, FGFR3, FGFR1, SNX24, GAPVD1, SNX22, UBE4A, IP6K1, RPS6KA3, IFFO2, TMEM30B, DNAJC30, XPR1, GOLGA3, KIDINS220, BCL11A, CEP295, CD44, RPS6KA2, LRRIQ1, RPS6KA1, LITAF, MRAP2, SDC2, FCGRT, SIGLECL1, RAET1E, FAM171B, CHERP, U2SURP, SLC9A6, TIMP1, CCDC120, CD83, PKP4, UBXN4, CTDSP1, CTDSPL, DUSP14, MTMR3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNM1_FGFR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFGFR2P21802DB00039PaliferminFibroblast growth factor receptor 2biotechapproved
TgeneFGFR2P21802DB08896RegorafenibFibroblast growth factor receptor 2small moleculeapproved
TgeneFGFR2P21802DB09079NintedanibFibroblast growth factor receptor 2small moleculeapproved
TgeneFGFR2P21802DB01109HeparinFibroblast growth factor receptor 2small moleculeapproved|investigational
TgeneFGFR2P21802DB08901PonatinibFibroblast growth factor receptor 2small moleculeapproved|investigational
TgeneFGFR2P21802DB09078LenvatinibFibroblast growth factor receptor 2small moleculeapproved|investigational
TgeneFGFR2P21802DB01041ThalidomideFibroblast growth factor receptor 2small moleculeapproved|investigational|withdrawn

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RelatedDiseases for DNM1_FGFR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNM1C4225357EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 312UNIPROT
HgeneDNM1C0036341Schizophrenia1PSYGENET
TgeneFGFR2C2931196Craniofacial dysostosis type 121ORPHANET;UNIPROT
TgeneFGFR2C0220658Pfeiffer Syndrome10UNIPROT
TgeneFGFR2C0001193Apert syndrome8ORPHANET;UNIPROT
TgeneFGFR2C1510455Acrocephalosyndactylia4CTD_human
TgeneFGFR2C0010278Craniosynostosis3CTD_human;HPO
TgeneFGFR2C0036341Schizophrenia3PSYGENET
TgeneFGFR2C0376634Craniofacial Abnormalities3CTD_human
TgeneFGFR2C1458155Mammary Neoplasms3CTD_human
TgeneFGFR2C0011570Mental Depression2PSYGENET
TgeneFGFR2C0011581Depressive disorder2PSYGENET
TgeneFGFR2C0038356Stomach Neoplasms2CTD_human
TgeneFGFR2C1865070SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION2CTD_human;ORPHANET;UNIPROT
TgeneFGFR2C0003090Ankylosis1CTD_human
TgeneFGFR2C0005586Bipolar Disorder1PSYGENET
TgeneFGFR2C0008924Cleft Lip1CTD_human
TgeneFGFR2C0008925Cleft Palate1CTD_human;HPO
TgeneFGFR2C0010273Craniofacial Dysostosis1CTD_human;HPO
TgeneFGFR2C0014170Endometrial Neoplasms1CTD_human
TgeneFGFR2C0018553Hamartoma Syndrome, Multiple1CTD_human
TgeneFGFR2C0023890Liver Cirrhosis1CTD_human
TgeneFGFR2C0024121Lung Neoplasms1CTD_human
TgeneFGFR2C0026613Motor Skills Disorders1CTD_human
TgeneFGFR2C0033975Psychotic Disorders1PSYGENET
TgeneFGFR2C0037268Skin Abnormalities1CTD_human
TgeneFGFR2C0037274Dermatologic disorders1CTD_human
TgeneFGFR2C0040427Tooth Abnormalities1CTD_human
TgeneFGFR2C0080178Spina Bifida1CTD_human
TgeneFGFR2C0206698Cholangiocarcinoma1CTD_human
TgeneFGFR2C0206762Limb Deformities, Congenital1CTD_human
TgeneFGFR2C0265269Lacrimoauriculodentodigital syndrome1CTD_human;ORPHANET;UNIPROT
TgeneFGFR2C0349204Nonorganic psychosis1PSYGENET
TgeneFGFR2C1450010Plagiocephaly, Nonsynostotic1CTD_human;HPO
TgeneFGFR2C1852406Cutis Gyrata Syndrome of Beare And Stevenson1CTD_human;ORPHANET;UNIPROT
TgeneFGFR2C2350233Antley-Bixler Syndrome Phenotype1CTD_human
TgeneFGFR2C3281247BENT BONE DYSPLASIA SYNDROME1ORPHANET;UNIPROT
TgeneFGFR2C3714756Intellectual Disability1CTD_human;HPO