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Fusion gene ID: 10256 |
FusionGeneSummary for DNAJC2_ZNF385D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNAJC2_ZNF385D | Fusion gene ID: 10256 | Hgene | Tgene | Gene symbol | DNAJC2 | ZNF385D | Gene ID | 27000 | 79750 |
| Gene name | DnaJ heat shock protein family (Hsp40) member C2 | zinc finger protein 385D | |
| Synonyms | MPHOSPH11|MPP11|ZRF1|ZUO1 | ZNF659 | |
| Cytomap | 7q22.1 | 3p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dnaJ homolog subfamily C member 2DnaJ (Hsp40) homolog, subfamily C, member 2M-phase phosphoprotein 11zuotin-related factor 1 | zinc finger protein 385Dzinc finger protein 659 | |
| Modification date | 20180519 | 20180403 | |
| UniProtAcc | Q99543 | Q9H6B1 | |
| Ensembl transtripts involved in fusion gene | ENST00000249270, ENST00000379263, ENST00000412522, | ENST00000494118, ENST00000281523, | |
| Fusion gene scores | * DoF score | 6 X 4 X 4=96 | 9 X 5 X 6=270 |
| # samples | 7 | 9 | |
| ** MAII score | log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DNAJC2 [Title/Abstract] AND ZNF385D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DNAJC2 | GO:0045893 | positive regulation of transcription, DNA-templated | 21179169 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-D7-6527-01A | DNAJC2 | chr7 | 102978183 | - | ZNF385D | chr3 | 21706520 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000249270 | ENST00000494118 | DNAJC2 | chr7 | 102978183 | - | ZNF385D | chr3 | 21706520 | - |
| 5CDS-intron | ENST00000249270 | ENST00000281523 | DNAJC2 | chr7 | 102978183 | - | ZNF385D | chr3 | 21706520 | - |
| 5CDS-intron | ENST00000379263 | ENST00000494118 | DNAJC2 | chr7 | 102978183 | - | ZNF385D | chr3 | 21706520 | - |
| 5CDS-intron | ENST00000379263 | ENST00000281523 | DNAJC2 | chr7 | 102978183 | - | ZNF385D | chr3 | 21706520 | - |
| intron-intron | ENST00000412522 | ENST00000494118 | DNAJC2 | chr7 | 102978183 | - | ZNF385D | chr3 | 21706520 | - |
| intron-intron | ENST00000412522 | ENST00000281523 | DNAJC2 | chr7 | 102978183 | - | ZNF385D | chr3 | 21706520 | - |
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FusionProtFeatures for DNAJC2_ZNF385D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNAJC2 | ZNF385D |
| Acts both as a chaperone in the cytosol and as achromatin regulator in the nucleus. When cytosolic, acts as amolecular chaperone: component of the ribosome-associated complex(RAC), a complex involved in folding or maintaining nascentpolypeptides in a folding-competent state. In the RAC complex,stimulates the ATPase activity of the ribosome-associated pool ofHsp70-type chaperones HSPA14 that bind to the nascent polypeptidechain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited athistone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotesthe displacement of the polycomb PRC1 complex from chromatin,thereby facilitating transcription activation. Specifically bindsDNA sequence 5'-GTCAAGC-3'. {ECO:0000269|PubMed:15802566,ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAJC2_ZNF385D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAJC2_ZNF385D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| DNAJC2 | HIST2H2AA3, RNF2, DDX5, BANF1, FKBP2, HSPA5, HSPA8, SFTPD, WDR61, DNMT1, HSPA14, HSPA4L, HYOU1, MYO6, NTRK1, SGTB, HYPK, GTF2E2, USP47, MTF1 | ZNF385D |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAJC2_ZNF385D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAJC2_ZNF385D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ZNF385D | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| Tgene | ZNF385D | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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