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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10248

FusionGeneSummary for DNAJC21_TMEM106B

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJC21_TMEM106B
Fusion gene ID: 10248
HgeneTgene
Gene symbol

DNAJC21

TMEM106B

Gene ID

134218

54664

Gene nameDnaJ heat shock protein family (Hsp40) member C21transmembrane protein 106B
SynonymsBMFS3|DNAJA5|GS3|JJJ1HLD16
Cytomap

5p13.2

7p21.3

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily C member 21DnaJ (Hsp40) homolog, subfamily C, member 21DnaJ homology subfamily A member 5JJJ1 DnaJ domain protein homologdnaJ homolog subfamily A member 5transmembrane protein 106B
Modification date2018051920180523
UniProtAcc

Q5F1R6

Q9NUM4

Ensembl transtripts involved in fusion geneENST00000342382, ENST00000303525, 
ENST00000382021, ENST00000512136, 
ENST00000396668, ENST00000396667, 
ENST00000453686, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 2 X 2=8
# samples 42
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: DNAJC21 [Title/Abstract] AND TMEM106B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ310434DNAJC21chr5

34944975

-TMEM106Bchr7

12258146

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000342382ENST00000396668DNAJC21chr5

34944975

-TMEM106Bchr7

12258146

-
intron-intronENST00000342382ENST00000396667DNAJC21chr5

34944975

-TMEM106Bchr7

12258146

-
intron-intronENST00000342382ENST00000453686DNAJC21chr5

34944975

-TMEM106Bchr7

12258146

-
intron-intronENST00000303525ENST00000396668DNAJC21chr5

34944975

-TMEM106Bchr7

12258146

-
intron-intronENST00000303525ENST00000396667DNAJC21chr5

34944975

-TMEM106Bchr7

12258146

-
intron-intronENST00000303525ENST00000453686DNAJC21chr5

34944975

-TMEM106Bchr7

12258146

-
intron-intronENST00000382021ENST00000396668DNAJC21chr5

34944975

-TMEM106Bchr7

12258146

-
intron-intronENST00000382021ENST00000396667DNAJC21chr5

34944975

-TMEM106Bchr7

12258146

-
intron-intronENST00000382021ENST00000453686DNAJC21chr5

34944975

-TMEM106Bchr7

12258146

-
intron-intronENST00000512136ENST00000396668DNAJC21chr5

34944975

-TMEM106Bchr7

12258146

-
intron-intronENST00000512136ENST00000396667DNAJC21chr5

34944975

-TMEM106Bchr7

12258146

-
intron-intronENST00000512136ENST00000453686DNAJC21chr5

34944975

-TMEM106Bchr7

12258146

-

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FusionProtFeatures for DNAJC21_TMEM106B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJC21

Q5F1R6

TMEM106B

Q9NUM4

May act as a co-chaperone for HSP70. May play a role inribosomal RNA (rRNA) biogenesis, possibly in the maturation of the60S subunit. Binds the precursor 45S rRNA.{ECO:0000269|PubMed:27346687}. Involved in dendrite morphogenesis and maintenance byregulating lysosomal trafficking via its interaction with MAP6.May act by inhibiting retrograde transport of lysosomes alongdendrites. Required for dendrite branching.{ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:24357581}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAJC21_TMEM106B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAJC21_TMEM106B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAJC21_TMEM106B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAJC21_TMEM106B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTMEM106BC0751072Frontotemporal Lobar Degeneration1CTD_human