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Fusion gene ID: 10220 |
FusionGeneSummary for DNAJB6_FTX |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNAJB6_FTX | Fusion gene ID: 10220 | Hgene | Tgene | Gene symbol | DNAJB6 | FTX | Gene ID | 10049 | 100302692 |
| Gene name | DnaJ heat shock protein family (Hsp40) member B6 | FTX transcript, XIST regulator | |
| Synonyms | DJ4|DnaJ|HHDJ1|HSJ-2|HSJ2|LGMD1D|LGMD1E|MRJ|MSJ-1 | LINC00182|MIR374AHG|NCRNA00182 | |
| Cytomap | 7q36.3 | Xq13.2 | |
| Type of gene | protein-coding | ncRNA | |
| Description | dnaJ homolog subfamily B member 6DnaJ (Hsp40) homolog, subfamily B, member 6DnaJ-like 2 proteinheat shock protein J2 | FTX transcript, XIST regulator (non-protein coding)five prime to XISTmir-374a-545 cluster host gene (non-protein coding) | |
| Modification date | 20180529 | 20180517 | |
| UniProtAcc | O75190 | ||
| Ensembl transtripts involved in fusion gene | ENST00000429029, ENST00000262177, ENST00000452797, ENST00000443280, ENST00000494267, | ENST00000429124, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 5 X 5 X 2=50 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/50*10)=0 | |
| Context | PubMed: DNAJB6 [Title/Abstract] AND FTX [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DNAJB6 | GO:0006457 | protein folding | 11896048 |
| Hgene | DNAJB6 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 11896048 |
| Hgene | DNAJB6 | GO:0045109 | intermediate filament organization | 10954706 |
| Hgene | DNAJB6 | GO:0090084 | negative regulation of inclusion body assembly | 21231916 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW375983 | DNAJB6 | chr7 | 157155924 | + | FTX | chrX | 73470417 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000429029 | ENST00000429124 | DNAJB6 | chr7 | 157155924 | + | FTX | chrX | 73470417 | - |
| 5CDS-intron | ENST00000262177 | ENST00000429124 | DNAJB6 | chr7 | 157155924 | + | FTX | chrX | 73470417 | - |
| intron-intron | ENST00000452797 | ENST00000429124 | DNAJB6 | chr7 | 157155924 | + | FTX | chrX | 73470417 | - |
| 5CDS-intron | ENST00000443280 | ENST00000429124 | DNAJB6 | chr7 | 157155924 | + | FTX | chrX | 73470417 | - |
| intron-intron | ENST00000494267 | ENST00000429124 | DNAJB6 | chr7 | 157155924 | + | FTX | chrX | 73470417 | - |
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FusionProtFeatures for DNAJB6_FTX |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DNAJB6 | FTX |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAJB6_FTX |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAJB6_FTX |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAJB6_FTX |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAJB6_FTX |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DNAJB6 | C3148763 | MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1E | 2 | ORPHANET;UNIPROT |
| Hgene | DNAJB6 | C0686353 | Muscular Dystrophies, Limb-Girdle | 1 | CTD_human |
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