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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1022

FusionGeneSummary for AFF3_TMPRSS2

check button Fusion gene summary
Fusion gene informationFusion gene name: AFF3_TMPRSS2
Fusion gene ID: 1022
HgeneTgene
Gene symbol

AFF3

TMPRSS2

Gene ID

3899

7113

Gene nameAF4/FMR2 family member 3transmembrane serine protease 2
SynonymsLAF4|MLLT2-likePP9284|PRSS10
Cytomap

2q11.2

21q22.3

Type of geneprotein-codingprotein-coding
DescriptionAF4/FMR2 family member 3MLLT2-related proteinlymphoid nuclear protein 4lymphoid nuclear protein related to AF4protein LAF-4transmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2
Modification date2018052320180523
UniProtAcc

P51826

O15393

Ensembl transtripts involved in fusion geneENST00000409236, ENST00000356421, 
ENST00000317233, ENST00000409579, 
ENST00000483600, 
ENST00000332149, 
ENST00000398585, ENST00000458356, 
ENST00000497881, 
Fusion gene scores* DoF score12 X 9 X 5=54016 X 12 X 3=576
# samples 1220
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(20/576*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AFF3 [Title/Abstract] AND TMPRSS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

TgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-G9-6384-01AAFF3chr2

100623094

-TMPRSS2chr21

42870116

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000409236ENST00000332149AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000409236ENST00000398585AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000409236ENST00000458356AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000409236ENST00000497881AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000356421ENST00000332149AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000356421ENST00000398585AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000356421ENST00000458356AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000356421ENST00000497881AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000317233ENST00000332149AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000317233ENST00000398585AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000317233ENST00000458356AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000317233ENST00000497881AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000409579ENST00000332149AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000409579ENST00000398585AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000409579ENST00000458356AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
5CDS-5UTRENST00000409579ENST00000497881AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
intron-5UTRENST00000483600ENST00000332149AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
intron-5UTRENST00000483600ENST00000398585AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
intron-5UTRENST00000483600ENST00000458356AFF3chr2

100623094

-TMPRSS2chr21

42870116

-
intron-5UTRENST00000483600ENST00000497881AFF3chr2

100623094

-TMPRSS2chr21

42870116

-

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FusionProtFeatures for AFF3_TMPRSS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AFF3

P51826

TMPRSS2

O15393

Serine protease that proteolytically cleaves andactivates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized andmaintained in precursor intermediate folding states andproteolysis permits the refolding and energy release required tocreate stable virus-cell linkages and membrane coalescence.Facilitates human SARS coronavirus (SARS-CoV) infection via twoindependent mechanisms, proteolytic cleavage of ACE2, which mightpromote viral uptake, and cleavage of coronavirus spikeglycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activatesthe spike glycoproteins of human coronavirus 229E (HCoV-229E) andhuman coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0of Sendai virus (SeV), human metapneumovirus (HMPV), humanparainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential forspread and pathogenesis of influenza A virus (strains H1N1, H3N2and H7N9); involved in proteolytic cleavage and activation ofhemagglutinin (HA) protein which is essential for viralinfectivity. {ECO:0000269|PubMed:21068237,ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651,ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332,ECO:0000269|PubMed:24227843}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AFF3_TMPRSS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AFF3_TMPRSS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AFF3MLLT3, CDK9, PIP4K2ATMPRSS2CLK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AFF3_TMPRSS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AFF3_TMPRSS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAFF3C0003873Rheumatoid Arthritis2CTD_human
HgeneAFF3C0236969Substance-Related Disorders1CTD_human
TgeneTMPRSS2C0033578Prostatic Neoplasms2CTD_human