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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10217

FusionGeneSummary for DNAJB4_NEXN

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJB4_NEXN
Fusion gene ID: 10217
HgeneTgene
Gene symbol

DNAJB4

NEXN

Gene ID

11080

91624

Gene nameDnaJ heat shock protein family (Hsp40) member B4nexilin F-actin binding protein
SynonymsDNAJW|DjB4|HLJ1CMH20|NELIN
Cytomap

1p31.1

1p31.1

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily B member 4DnaJ (Hsp40) homolog, subfamily B, member 4DnaJ-like heat shock protein 40HSP40 homologheat shock 40 kDa protein 1 homologheat shock protein 40 homologhuman liver DnaJ-like proteinnexilin
Modification date2018052320180519
UniProtAcc

Q9UDY4

Q0ZGT2

Ensembl transtripts involved in fusion geneENST00000487931, ENST00000370763, 
ENST00000457030, ENST00000330010, 
ENST00000294624, ENST00000334785, 
ENST00000480732, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 3 X 2=12
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DNAJB4 [Title/Abstract] AND NEXN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNEXN

GO:0030334

regulation of cell migration

15823560


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-CJ-4869-01ADNAJB4chr1

78445303

+NEXNchr1

78407708

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000487931ENST00000457030DNAJB4chr1

78445303

+NEXNchr1

78407708

+
intron-3CDSENST00000487931ENST00000330010DNAJB4chr1

78445303

+NEXNchr1

78407708

+
intron-intronENST00000487931ENST00000294624DNAJB4chr1

78445303

+NEXNchr1

78407708

+
intron-intronENST00000487931ENST00000334785DNAJB4chr1

78445303

+NEXNchr1

78407708

+
intron-3UTRENST00000487931ENST00000480732DNAJB4chr1

78445303

+NEXNchr1

78407708

+
intron-3CDSENST00000370763ENST00000457030DNAJB4chr1

78445303

+NEXNchr1

78407708

+
intron-3CDSENST00000370763ENST00000330010DNAJB4chr1

78445303

+NEXNchr1

78407708

+
intron-intronENST00000370763ENST00000294624DNAJB4chr1

78445303

+NEXNchr1

78407708

+
intron-intronENST00000370763ENST00000334785DNAJB4chr1

78445303

+NEXNchr1

78407708

+
intron-3UTRENST00000370763ENST00000480732DNAJB4chr1

78445303

+NEXNchr1

78407708

+

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FusionProtFeatures for DNAJB4_NEXN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJB4

Q9UDY4

NEXN

Q0ZGT2

Probable chaperone. Stimulates ATP hydrolysis and thefolding of unfolded proteins mediated by HSPA1A/B (in vitro)(PubMed:24318877). {ECO:0000269|PubMed:24318877}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAJB4_NEXN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAJB4_NEXN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNAJB4PABPN1, RAD21, ISG15, AHSA1, BAG3, HSPA6, SMAD3, MDM2, TBL1X, POLR1D, CRMP1, RANBP3, ASB4, BAG1, MLF2, TBPL2, SHMT2, MOV10, HSPA1A, PELI3, DNAJB5, DNAJB1, GLB1, SYNM, C3orf38, TTLL12, P2RX6, TTLL1, TBC1D22A, WRAP73, FBXW11, GRPEL1, HSPA4, HSPA8, HSPA9, HSPH1, KIAA0368, PSPC1, ETF1, HYOU1, STIP1, HSPA5, DNAJC7, YWHAZ, TGS1, NPM1, SDIM1, KCNC4, ABHD15, MANSC1, TBL1Y, APOBEC3D, ANGPTL4, NUDC, TRIM25, ESR1NEXNCALM1, CUL1, PAN2, LGR4, HSPB1, CAPZA2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, MYO5C, MYO19, MYO18A, TRIM15, GSN, MYO1B, ACTB, PPP1R9A, ACTA2, ACTBL2, ANK3, ACTR10, CPVL, MYO1D, FBXO34, FBXO46, G3BP1, FAM107A, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAJB4_NEXN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAJB4_NEXN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNEXNC2751084Cardiomyopathy, Dilated, 1CC1CTD_human;UNIPROT
TgeneNEXNC3151267CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 201UNIPROT