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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10214

FusionGeneSummary for DNAJB1_TRPM4

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJB1_TRPM4
Fusion gene ID: 10214
HgeneTgene
Gene symbol

DNAJB1

TRPM4

Gene ID

3337

54795

Gene nameDnaJ heat shock protein family (Hsp40) member B1transient receptor potential cation channel subfamily M member 4
SynonymsHSPF1|Hdj1|Hsp40|RSPH16B|Sis1LTrpC4|PFHB1B|TRPM4B|hTRPM4
Cytomap

19p13.12

19q13.33

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily B member 1DnaJ (Hsp40) homolog, subfamily B, member 1dnaJ protein homolog 1heat shock 40 kDa protein 1human DnaJ protein 1radial spoke 16 homolog Btransient receptor potential cation channel subfamily M member 4calcium-activated non-selective cation channel 1long transient receptor potential channel 4melastatin-4
Modification date2018052320180519
UniProtAcc

P25685

Q8TD43

Ensembl transtripts involved in fusion geneENST00000254322, ENST00000396969, 
ENST00000252826, ENST00000427978, 
ENST00000355712, ENST00000601347, 
Fusion gene scores* DoF score4 X 3 X 3=361 X 1 X 1=1
# samples 101
** MAII scorelog2(10/36*10)=1.47393118833241
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: DNAJB1 [Title/Abstract] AND TRPM4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAJB1

GO:0032781

positive regulation of ATPase activity

23921388

HgeneDNAJB1

GO:0051085

chaperone cofactor-dependent protein refolding

18620420

HgeneDNAJB1

GO:0090084

negative regulation of inclusion body assembly

21231916

HgeneDNAJB1

GO:0097201

negative regulation of transcription from RNA polymerase II promoter in response to stress

9499401

TgeneTRPM4

GO:0002724

regulation of T cell cytokine production

20656926

TgeneTRPM4

GO:0008284

positive regulation of cell proliferation

20625999

TgeneTRPM4

GO:0016925

protein sumoylation

19726882

TgeneTRPM4

GO:0019722

calcium-mediated signaling

27207958

TgeneTRPM4

GO:0051289

protein homotetramerization

29211723|29217581

TgeneTRPM4

GO:0090263

positive regulation of canonical Wnt signaling pathway

20625999

TgeneTRPM4

GO:0098662

inorganic cation transmembrane transport

29211723

TgeneTRPM4

GO:0098719

sodium ion import across plasma membrane

27207958


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A891-01ADNAJB1chr19

14638499

-TRPM4chr19

49703557

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000254322ENST00000252826DNAJB1chr19

14638499

-TRPM4chr19

49703557

+
intron-3CDSENST00000254322ENST00000427978DNAJB1chr19

14638499

-TRPM4chr19

49703557

+
intron-3CDSENST00000254322ENST00000355712DNAJB1chr19

14638499

-TRPM4chr19

49703557

+
intron-intronENST00000254322ENST00000601347DNAJB1chr19

14638499

-TRPM4chr19

49703557

+
intron-3CDSENST00000396969ENST00000252826DNAJB1chr19

14638499

-TRPM4chr19

49703557

+
intron-3CDSENST00000396969ENST00000427978DNAJB1chr19

14638499

-TRPM4chr19

49703557

+
intron-3CDSENST00000396969ENST00000355712DNAJB1chr19

14638499

-TRPM4chr19

49703557

+
intron-intronENST00000396969ENST00000601347DNAJB1chr19

14638499

-TRPM4chr19

49703557

+

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FusionProtFeatures for DNAJB1_TRPM4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJB1

P25685

TRPM4

Q8TD43

Interacts with HSP70 and can stimulate its ATPaseactivity. Stimulates the association between HSC70 and HIP.Negatively regulates heat shock-induced HSF1 transcriptionalactivity during the attenuation and recovery phase period of theheat shock response (PubMed:9499401). Stimulates ATP hydrolysisand the folding of unfolded proteins mediated by HSPA1A/B (invitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877,ECO:0000269|PubMed:9499401}. Calcium-activated non selective (CAN) cation channelthat mediates membrane depolarization (PubMed:12015988,PubMed:29211723). While it is activated by increase inintracellular Ca(2+), it is impermeable to it (PubMed:12015988).Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) >Li(+)), leading to depolarize the membrane. It thereby plays acentral role in cadiomyocytes, neurons from entorhinal cortex,dorsal root and vomeronasal neurons, endocrine pancreas cells,kidney epithelial cells, cochlea hair cells etc. Participates inT-cell activation by modulating Ca(2+) oscillations after Tlymphocyte activation, which is required for NFAT-dependent IL2production. Involved in myogenic constriction of cerebralarteries. Controls insulin secretion in pancreatic beta-cells. Mayalso be involved in pacemaking or could cause irregular electricalactivity under conditions of Ca(2+) overload. Affects T-helper 1(Th1) and T-helper 2 (Th2) cell motility and cytokine productionthrough differential regulation of calcium signaling and NFATC1localization. Enhances cell proliferation through up-regulation ofthe beta-catenin signaling pathway. {ECO:0000269|PubMed:11535825,ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367,ECO:0000269|PubMed:14758478, ECO:0000269|PubMed:15121803,ECO:0000269|PubMed:15331675, ECO:0000269|PubMed:15472118,ECO:0000269|PubMed:15550671, ECO:0000269|PubMed:15590641,ECO:0000269|PubMed:15845551, ECO:0000269|PubMed:16186107,ECO:0000269|PubMed:16407466, ECO:0000269|PubMed:16424899,ECO:0000269|PubMed:16806463, ECO:0000269|PubMed:20625999,ECO:0000269|PubMed:20656926, ECO:0000269|PubMed:29211723}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAJB1_TRPM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAJB1_TRPM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNAJB1FANCA, HSPA4, HSF1, HSPA8, CFTR, STUB1, PARK2, GPR37, OTUD4, ATG2A, PRKAA2, WIPI2, TELO2, CENPE, POT1, FANCC, UBC, AKT1, NRAS, PLEKHO1, HIF1A, ISG15, SPP1, TERF1, CUL3, PHLDA1, HTT, SNCA, APP, CDC37, CYP2C8, ECSIT, MAST1, PSEN2, A2M, BRCA1, FN1, SLC12A3, ANKRD28, ADSL, RNASEH2B, DPYSL2, PDE12, UBQLN2, WDR4, XPO7, MDM2, TP53, BAG1, BAG2, BAG4, MLF2, NUDC, HUWE1, ZFP36, HSPA1A, HSPA6, FAF2, DNAJB4, LLGL2, RPS6KB2, AMBRA1, DAG1, EDF1, GRPEL1, HSPA4L, HSPA9, HSPH1, KIAA0368, TSG101, VPS37B, ETF1, HYOU1, PPID, STIP1, NTRK1, MED4, MED20, EWSR1, HSPA5, DNAJC7, TUBG1, MAGED2, CDH1, PTPN18, DUSP16, TTLL12, DNAJB5, DCAF6, TBL1Y, KCNC4, GLB1, TARDBP, DNAJA2, FOXA1, ESR1TRPM4FUS, LGALS8, IFT57, FNDC4, CCDC107, TRPM8, CD79B, UPK1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAJB1_TRPM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAJB1_TRPM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNAJB1C0005586Bipolar Disorder2PSYGENET
TgeneTRPM4C1970298Progressive Familial Heart Block, Type Ib3CTD_human;UNIPROT