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Fusion gene ID: 10214 |
FusionGeneSummary for DNAJB1_TRPM4 |
Fusion gene summary |
Fusion gene information | Fusion gene name: DNAJB1_TRPM4 | Fusion gene ID: 10214 | Hgene | Tgene | Gene symbol | DNAJB1 | TRPM4 | Gene ID | 3337 | 54795 |
Gene name | DnaJ heat shock protein family (Hsp40) member B1 | transient receptor potential cation channel subfamily M member 4 | |
Synonyms | HSPF1|Hdj1|Hsp40|RSPH16B|Sis1 | LTrpC4|PFHB1B|TRPM4B|hTRPM4 | |
Cytomap | 19p13.12 | 19q13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | dnaJ homolog subfamily B member 1DnaJ (Hsp40) homolog, subfamily B, member 1dnaJ protein homolog 1heat shock 40 kDa protein 1human DnaJ protein 1radial spoke 16 homolog B | transient receptor potential cation channel subfamily M member 4calcium-activated non-selective cation channel 1long transient receptor potential channel 4melastatin-4 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P25685 | Q8TD43 | |
Ensembl transtripts involved in fusion gene | ENST00000254322, ENST00000396969, | ENST00000252826, ENST00000427978, ENST00000355712, ENST00000601347, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 1 X 1 X 1=1 |
# samples | 10 | 1 | |
** MAII score | log2(10/36*10)=1.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: DNAJB1 [Title/Abstract] AND TRPM4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DNAJB1 | GO:0032781 | positive regulation of ATPase activity | 23921388 |
Hgene | DNAJB1 | GO:0051085 | chaperone cofactor-dependent protein refolding | 18620420 |
Hgene | DNAJB1 | GO:0090084 | negative regulation of inclusion body assembly | 21231916 |
Hgene | DNAJB1 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress | 9499401 |
Tgene | TRPM4 | GO:0002724 | regulation of T cell cytokine production | 20656926 |
Tgene | TRPM4 | GO:0008284 | positive regulation of cell proliferation | 20625999 |
Tgene | TRPM4 | GO:0016925 | protein sumoylation | 19726882 |
Tgene | TRPM4 | GO:0019722 | calcium-mediated signaling | 27207958 |
Tgene | TRPM4 | GO:0051289 | protein homotetramerization | 29211723|29217581 |
Tgene | TRPM4 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 20625999 |
Tgene | TRPM4 | GO:0098662 | inorganic cation transmembrane transport | 29211723 |
Tgene | TRPM4 | GO:0098719 | sodium ion import across plasma membrane | 27207958 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-L5-A891-01A | DNAJB1 | chr19 | 14638499 | - | TRPM4 | chr19 | 49703557 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000254322 | ENST00000252826 | DNAJB1 | chr19 | 14638499 | - | TRPM4 | chr19 | 49703557 | + |
intron-3CDS | ENST00000254322 | ENST00000427978 | DNAJB1 | chr19 | 14638499 | - | TRPM4 | chr19 | 49703557 | + |
intron-3CDS | ENST00000254322 | ENST00000355712 | DNAJB1 | chr19 | 14638499 | - | TRPM4 | chr19 | 49703557 | + |
intron-intron | ENST00000254322 | ENST00000601347 | DNAJB1 | chr19 | 14638499 | - | TRPM4 | chr19 | 49703557 | + |
intron-3CDS | ENST00000396969 | ENST00000252826 | DNAJB1 | chr19 | 14638499 | - | TRPM4 | chr19 | 49703557 | + |
intron-3CDS | ENST00000396969 | ENST00000427978 | DNAJB1 | chr19 | 14638499 | - | TRPM4 | chr19 | 49703557 | + |
intron-3CDS | ENST00000396969 | ENST00000355712 | DNAJB1 | chr19 | 14638499 | - | TRPM4 | chr19 | 49703557 | + |
intron-intron | ENST00000396969 | ENST00000601347 | DNAJB1 | chr19 | 14638499 | - | TRPM4 | chr19 | 49703557 | + |
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FusionProtFeatures for DNAJB1_TRPM4 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
DNAJB1 | TRPM4 |
Interacts with HSP70 and can stimulate its ATPaseactivity. Stimulates the association between HSC70 and HIP.Negatively regulates heat shock-induced HSF1 transcriptionalactivity during the attenuation and recovery phase period of theheat shock response (PubMed:9499401). Stimulates ATP hydrolysisand the folding of unfolded proteins mediated by HSPA1A/B (invitro) (PubMed:24318877). {ECO:0000269|PubMed:24318877,ECO:0000269|PubMed:9499401}. | Calcium-activated non selective (CAN) cation channelthat mediates membrane depolarization (PubMed:12015988,PubMed:29211723). While it is activated by increase inintracellular Ca(2+), it is impermeable to it (PubMed:12015988).Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) >Li(+)), leading to depolarize the membrane. It thereby plays acentral role in cadiomyocytes, neurons from entorhinal cortex,dorsal root and vomeronasal neurons, endocrine pancreas cells,kidney epithelial cells, cochlea hair cells etc. Participates inT-cell activation by modulating Ca(2+) oscillations after Tlymphocyte activation, which is required for NFAT-dependent IL2production. Involved in myogenic constriction of cerebralarteries. Controls insulin secretion in pancreatic beta-cells. Mayalso be involved in pacemaking or could cause irregular electricalactivity under conditions of Ca(2+) overload. Affects T-helper 1(Th1) and T-helper 2 (Th2) cell motility and cytokine productionthrough differential regulation of calcium signaling and NFATC1localization. Enhances cell proliferation through up-regulation ofthe beta-catenin signaling pathway. {ECO:0000269|PubMed:11535825,ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:12799367,ECO:0000269|PubMed:14758478, ECO:0000269|PubMed:15121803,ECO:0000269|PubMed:15331675, ECO:0000269|PubMed:15472118,ECO:0000269|PubMed:15550671, ECO:0000269|PubMed:15590641,ECO:0000269|PubMed:15845551, ECO:0000269|PubMed:16186107,ECO:0000269|PubMed:16407466, ECO:0000269|PubMed:16424899,ECO:0000269|PubMed:16806463, ECO:0000269|PubMed:20625999,ECO:0000269|PubMed:20656926, ECO:0000269|PubMed:29211723}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for DNAJB1_TRPM4 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for DNAJB1_TRPM4 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
DNAJB1 | FANCA, HSPA4, HSF1, HSPA8, CFTR, STUB1, PARK2, GPR37, OTUD4, ATG2A, PRKAA2, WIPI2, TELO2, CENPE, POT1, FANCC, UBC, AKT1, NRAS, PLEKHO1, HIF1A, ISG15, SPP1, TERF1, CUL3, PHLDA1, HTT, SNCA, APP, CDC37, CYP2C8, ECSIT, MAST1, PSEN2, A2M, BRCA1, FN1, SLC12A3, ANKRD28, ADSL, RNASEH2B, DPYSL2, PDE12, UBQLN2, WDR4, XPO7, MDM2, TP53, BAG1, BAG2, BAG4, MLF2, NUDC, HUWE1, ZFP36, HSPA1A, HSPA6, FAF2, DNAJB4, LLGL2, RPS6KB2, AMBRA1, DAG1, EDF1, GRPEL1, HSPA4L, HSPA9, HSPH1, KIAA0368, TSG101, VPS37B, ETF1, HYOU1, PPID, STIP1, NTRK1, MED4, MED20, EWSR1, HSPA5, DNAJC7, TUBG1, MAGED2, CDH1, PTPN18, DUSP16, TTLL12, DNAJB5, DCAF6, TBL1Y, KCNC4, GLB1, TARDBP, DNAJA2, FOXA1, ESR1 | TRPM4 | FUS, LGALS8, IFT57, FNDC4, CCDC107, TRPM8, CD79B, UPK1A |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for DNAJB1_TRPM4 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DNAJB1_TRPM4 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DNAJB1 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Tgene | TRPM4 | C1970298 | Progressive Familial Heart Block, Type Ib | 3 | CTD_human;UNIPROT |