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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10201

FusionGeneSummary for DNAJA2_SRP68

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAJA2_SRP68
Fusion gene ID: 10201
HgeneTgene
Gene symbol

DNAJA2

SRP68

Gene ID

10294

6730

Gene nameDnaJ heat shock protein family (Hsp40) member A2signal recognition particle 68
SynonymsCPR3|DJ3|DJA2|DNAJ|DNJ3|HIRIP4|PRO3015|RDJ2-
Cytomap

16q11.2

17q25.1

Type of geneprotein-codingprotein-coding
DescriptiondnaJ homolog subfamily A member 2DnaJ (Hsp40) homolog, subfamily A, member 2HIRA interacting protein 4cell cycle progression 3 proteincell cycle progression restoration gene 3 proteinrenal carcinoma antigen NY-REN-14signal recognition particle subunit SRP68signal recognition particle 68 kDa proteinsignal recognition particle 68kDsignal recognition particle 68kDa
Modification date2018052320180523
UniProtAcc

O60884

Q9UHB9

Ensembl transtripts involved in fusion geneENST00000317089, ENST00000307877, 
ENST00000539137, ENST00000355113, 
ENST00000602720, ENST00000542536, 
Fusion gene scores* DoF score5 X 5 X 2=5010 X 10 X 9=900
# samples 615
** MAII scorelog2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(15/900*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNAJA2 [Title/Abstract] AND SRP68 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDNAJA2

GO:0042026

protein refolding

21231916

TgeneSRP68

GO:0042493

response to drug

18089836


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CD365788DNAJA2chr16

46989563

+SRP68chr17

74044029

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000317089ENST00000307877DNAJA2chr16

46989563

+SRP68chr17

74044029

+
intron-3CDSENST00000317089ENST00000539137DNAJA2chr16

46989563

+SRP68chr17

74044029

+
intron-3CDSENST00000317089ENST00000355113DNAJA2chr16

46989563

+SRP68chr17

74044029

+
intron-3CDSENST00000317089ENST00000602720DNAJA2chr16

46989563

+SRP68chr17

74044029

+
intron-5UTRENST00000317089ENST00000542536DNAJA2chr16

46989563

+SRP68chr17

74044029

+

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FusionProtFeatures for DNAJA2_SRP68


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAJA2

O60884

SRP68

Q9UHB9

Co-chaperone of Hsc70. Stimulates ATP hydrolysis and thefolding of unfolded proteins mediated by HSPA1A/B (in vitro)(PubMed:24318877). {ECO:0000269|PubMed:24318877}. Signal-recognition-particle assembly has a crucial rolein targeting secretory proteins to the rough endoplasmic reticulummembrane. SRP68 binds the 7S RNA, SRP72 binds to this complexsubsequently. This ribonucleoprotein complex might interactdirectly with the docking protein in the ER membrane and possiblyparticipate in the elongation arrest function.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAJA2_SRP68


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAJA2_SRP68


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNAJA2SAP25, HIRA, RB1, TERF2, UBC, MYC, AGO4, VHL, SMARCAD1, SOX2, ELAVL1, ERG, CUL3, COPS5, SPRTN, SMAD2, SMAD3, SHC1, EPAS1, IFIT2, HSP90AA1, NOS2, METTL21B, METTL23, CFTR, PAN2, NPM1, HDAC11, EGFR, FBXO6, HECW2, DNAJA4, HSPA8, IRS4, NUDC, TP53, PCSK9, HSPA1A, HSPA6, RNF2, ARAF, ILK, IRAK1, LIMK2, LLGL2, NF2, STRN3, RPS6KB2, NTRK1, ABCF2, CAD, CCT4, DCTN1, HSP90AB1, HSPA4, HSPA4L, HSPA5, HSPH1, PSMC4, PSMD11, STIP1, HSPA9, PSMA6, SMC3, TCP1, TUBB4B, XPO1, MKS1, POC1A, NEFM, HUWE1, TUBA1C, PIGS, NLRP3, MCM2, ESRRB, POU5F1, FAM210A, ZNF131, WWP2, MTMR11, PTPN18, DNAJB1, CYLD, DLD, PDHA1, TRIM25, ESR1, BRCA1, URI1SRP68USP7, MEPCE, RNF185, HDGF, SIRT7, CUL3, CAND1, SRP72, KIF5B, SRP9, SRP54, SMN1, METTL18, SOX2, KIF21A, ELP4, KDM3B, NCS1, STAU1, RNF2, NIFK, RPL31, ALDH1B1, ATAD3B, DDX27, FTSJ3, SRP14, NTRK1, IFI16, MED4, XPO1, NOP56, GBA2, MCM2, SNW1, CDC5L, ZNF746, SRP19, FZR1, GIMAP8, RBM34, EPB41L2, AXDND1, RPL26L1, CDC27, KIAA0020, RPL18A, GTPBP4, NOP2, CEBPZ, MYBBP1A, RBM28, RPL3, EBNA1BP2, DDX31, SF3A3, PA2G4, TRAP1, SND1, UBE2N, DLST, PDHA1, UBE2S, BRCA1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAJA2_SRP68


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAJA2_SRP68


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSRP68C0037274Dermatologic disorders1CTD_human
TgeneSRP68C0311375Arsenic Poisoning1CTD_human
TgeneSRP68C0376634Craniofacial Abnormalities1CTD_human