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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10194

FusionGeneSummary for DNAH8_TMEM217

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAH8_TMEM217
Fusion gene ID: 10194
HgeneTgene
Gene symbol

DNAH8

TMEM217

Gene ID

1769

221468

Gene namedynein axonemal heavy chain 8transmembrane protein 217
SynonymsATPase|hdhc9C6orf128|dJ355M6.2
Cytomap

6p21.2

6p21.2

Type of geneprotein-codingprotein-coding
Descriptiondynein heavy chain 8, axonemalaxonemal beta dynein heavy chain 8ciliary dynein heavy chain 8dynein, axonemal, heavy polypeptide 8transmembrane protein 217
Modification date2018052320180331
UniProtAcc

Q96JB1

Q8N7C4

Ensembl transtripts involved in fusion geneENST00000449981, ENST00000359357, 
ENST00000441566, 
ENST00000356757, 
ENST00000336655, ENST00000497775, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 2 X 5=50
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/50*10)=0
Context

PubMed: DNAH8 [Title/Abstract] AND TMEM217 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-06-0129-01ADNAH8chr6

38919296

+TMEM217chr6

37180772

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000449981ENST00000356757DNAH8chr6

38919296

+TMEM217chr6

37180772

-
5CDS-3UTRENST00000449981ENST00000336655DNAH8chr6

38919296

+TMEM217chr6

37180772

-
5CDS-5UTRENST00000449981ENST00000497775DNAH8chr6

38919296

+TMEM217chr6

37180772

-
Frame-shiftENST00000359357ENST00000356757DNAH8chr6

38919296

+TMEM217chr6

37180772

-
5CDS-3UTRENST00000359357ENST00000336655DNAH8chr6

38919296

+TMEM217chr6

37180772

-
5CDS-5UTRENST00000359357ENST00000497775DNAH8chr6

38919296

+TMEM217chr6

37180772

-
Frame-shiftENST00000441566ENST00000356757DNAH8chr6

38919296

+TMEM217chr6

37180772

-
5CDS-3UTRENST00000441566ENST00000336655DNAH8chr6

38919296

+TMEM217chr6

37180772

-
5CDS-5UTRENST00000441566ENST00000497775DNAH8chr6

38919296

+TMEM217chr6

37180772

-

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FusionProtFeatures for DNAH8_TMEM217


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAH8

Q96JB1

TMEM217

Q8N7C4

Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP. Involved in sperm motility; implicated in spermflagellar assembly (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAH8_TMEM217


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAH8_TMEM217


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DNAH8GAN, EGFRTMEM217


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAH8_TMEM217


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAH8_TMEM217


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNAH8C0005586Bipolar Disorder4PSYGENET
HgeneDNAH8C0338831Manic2PSYGENET
HgeneDNAH8C0236736Cocaine-Related Disorders1CTD_human
HgeneDNAH8C0236969Substance-Related Disorders1CTD_human
HgeneDNAH8C1456784Paranoia1CTD_human