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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10177

FusionGeneSummary for DNAH12_WHSC1

check button Fusion gene summary
Fusion gene informationFusion gene name: DNAH12_WHSC1
Fusion gene ID: 10177
HgeneTgene
Gene symbol

DNAH12

WHSC1

Gene ID

201625

7468

Gene namedynein axonemal heavy chain 12nuclear receptor binding SET domain protein 2
SynonymsDHC3|DLP12|DLP3|DNAH12L|DNAH7L|DNAHC12|DNAHC3|DNHD2|HDHC3|HL-19|HL19KMT3F|KMT3G|MMSET|REIIBP|TRX5|WHS|WHSC1
Cytomap

3p14.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptiondynein heavy chain 12, axonemalaxonemal beta dynein heavy chain 12axonemal dynein heavy chain isotype3ciliary dynein heavy chain 12dynein heavy chain domain-containing protein 2dynein, axonemal, heavy polypeptide 12dynein, heavy chain-5histone-lysine N-methyltransferase NSD2IL5 promoter REII region-binding proteinWolf-Hirschhorn syndrome candidate 1multiple myeloma SET domain containing protein type IIInuclear SET domain-containing protein 2probable histone-lysine N-methyltransfera
Modification date2018032920180519
UniProtAcc

Q6ZR08

Ensembl transtripts involved in fusion geneENST00000351747, ENST00000462713, 
ENST00000344804, ENST00000389536, 
ENST00000311202, 
ENST00000508803, 
ENST00000382892, ENST00000382891, 
ENST00000382895, ENST00000482415, 
ENST00000382888, ENST00000514045, 
ENST00000436793, ENST00000420906, 
ENST00000503128, ENST00000398261, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 5 X 1=25
# samples 36
** MAII scorelog2(3/4*10)=2.90689059560852log2(6/25*10)=1.26303440583379
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DNAH12 [Title/Abstract] AND WHSC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DN999429DNAH12chr3

57409936

-WHSC1chr4

1902351

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000351747ENST00000508803DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000351747ENST00000382892DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000351747ENST00000382891DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000351747ENST00000382895DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-intronENST00000351747ENST00000482415DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-intronENST00000351747ENST00000382888DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000351747ENST00000514045DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000351747ENST00000436793DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000351747ENST00000420906DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000351747ENST00000503128DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000351747ENST00000398261DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000462713ENST00000508803DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000462713ENST00000382892DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000462713ENST00000382891DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000462713ENST00000382895DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-intronENST00000462713ENST00000482415DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-intronENST00000462713ENST00000382888DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000462713ENST00000514045DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000462713ENST00000436793DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000462713ENST00000420906DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000462713ENST00000503128DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000462713ENST00000398261DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000344804ENST00000508803DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000344804ENST00000382892DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000344804ENST00000382891DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000344804ENST00000382895DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-intronENST00000344804ENST00000482415DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-intronENST00000344804ENST00000382888DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000344804ENST00000514045DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000344804ENST00000436793DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000344804ENST00000420906DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000344804ENST00000503128DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000344804ENST00000398261DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000389536ENST00000508803DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000389536ENST00000382892DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000389536ENST00000382891DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000389536ENST00000382895DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-intronENST00000389536ENST00000482415DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-intronENST00000389536ENST00000382888DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000389536ENST00000514045DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000389536ENST00000436793DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000389536ENST00000420906DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000389536ENST00000503128DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000389536ENST00000398261DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000311202ENST00000508803DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000311202ENST00000382892DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000311202ENST00000382891DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000311202ENST00000382895DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-intronENST00000311202ENST00000482415DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-intronENST00000311202ENST00000382888DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000311202ENST00000514045DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000311202ENST00000436793DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000311202ENST00000420906DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000311202ENST00000503128DNAH12chr3

57409936

-WHSC1chr4

1902351

+
intron-5UTRENST00000311202ENST00000398261DNAH12chr3

57409936

-WHSC1chr4

1902351

+

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FusionProtFeatures for DNAH12_WHSC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNAH12

Q6ZR08

WHSC1

Force generating protein of respiratory cilia. Producesforce towards the minus ends of microtubules. Dynein has ATPaseactivity; the force-producing power stroke is thought to occur onrelease of ADP. Involved in sperm motility; implicated in spermflagellar assembly (By similarity). {ECO:0000250}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DNAH12_WHSC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DNAH12_WHSC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DNAH12_WHSC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DNAH12_WHSC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource