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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 10166

FusionGeneSummary for DMXL2_PTPRR

check button Fusion gene summary
Fusion gene informationFusion gene name: DMXL2_PTPRR
Fusion gene ID: 10166
HgeneTgene
Gene symbol

DMXL2

PTPRR

Gene ID

23312

5801

Gene nameDmx like 2protein tyrosine phosphatase, receptor type R
SynonymsDFNA71|PEPNS|RC3EC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQ
Cytomap

15q21.2

12q15

Type of geneprotein-codingprotein-coding
DescriptiondmX-like protein 2rabconnectin-3receptor-type tyrosine-protein phosphatase RCh-1 PTPaseNC-PTPCOM1R-PTP-Rch-1PTPaseprotein tyrosine phosphatase Cr1PTPaseprotein-tyrosine phosphatase NC-PTPCOM1protein-tyrosine phosphatase PCPTP1
Modification date2018052320180519
UniProtAcc

Q8TDJ6

Q15256

Ensembl transtripts involved in fusion geneENST00000251076, ENST00000543779, 
ENST00000449909, ENST00000560421, 
ENST00000283228, ENST00000440835, 
ENST00000537619, ENST00000378778, 
ENST00000342084, ENST00000549308, 
Fusion gene scores* DoF score3 X 3 X 3=2733 X 13 X 10=4290
# samples 331
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(31/4290*10)=-3.79063752711267
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DMXL2 [Title/Abstract] AND PTPRR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-EE-A2MS-06ADMXL2chr15

51914656

-PTPRRchr12

71158558

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000251076ENST00000283228DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000251076ENST00000440835DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000251076ENST00000537619DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000251076ENST00000378778DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000251076ENST00000342084DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000251076ENST00000549308DMXL2chr15

51914656

-PTPRRchr12

71158558

-
In-frameENST00000543779ENST00000283228DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000543779ENST00000440835DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000543779ENST00000537619DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000543779ENST00000378778DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000543779ENST00000342084DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000543779ENST00000549308DMXL2chr15

51914656

-PTPRRchr12

71158558

-
In-frameENST00000449909ENST00000283228DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000449909ENST00000440835DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000449909ENST00000537619DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000449909ENST00000378778DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000449909ENST00000342084DMXL2chr15

51914656

-PTPRRchr12

71158558

-
5CDS-intronENST00000449909ENST00000549308DMXL2chr15

51914656

-PTPRRchr12

71158558

-
intron-3CDSENST00000560421ENST00000283228DMXL2chr15

51914656

-PTPRRchr12

71158558

-
intron-intronENST00000560421ENST00000440835DMXL2chr15

51914656

-PTPRRchr12

71158558

-
intron-intronENST00000560421ENST00000537619DMXL2chr15

51914656

-PTPRRchr12

71158558

-
intron-intronENST00000560421ENST00000378778DMXL2chr15

51914656

-PTPRRchr12

71158558

-
intron-intronENST00000560421ENST00000342084DMXL2chr15

51914656

-PTPRRchr12

71158558

-
intron-intronENST00000560421ENST00000549308DMXL2chr15

51914656

-PTPRRchr12

71158558

-

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FusionProtFeatures for DMXL2_PTPRR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DMXL2

Q8TDJ6

PTPRR

Q15256

May serve as a scaffold protein for MADD and RAB3GA onsynaptic vesicles (PubMed:11809763). Plays a role in the brain asa key controller of neuronal and endocrine homeostatic processes(By similarity). {ECO:0000250|UniProtKB:Q8BPN8,ECO:0000269|PubMed:11809763}. Sequesters mitogen-activated protein kinases (MAPKs)such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactiveform. The MAPKs bind to a dephosphorylated kinase interactingmotif, phosphorylation of which by the protein kinase A complexreleases the MAPKs for activation and translocation into thenucleus (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTPRRchr15:51914656chr12:71158558ENST00000283228-114393_647119658DomainTyrosine-protein phosphatase
TgenePTPRRchr15:51914656chr12:71158558ENST00000342084-013393_6477546DomainTyrosine-protein phosphatase
TgenePTPRRchr15:51914656chr12:71158558ENST00000378778-011393_6470452DomainTyrosine-protein phosphatase
TgenePTPRRchr15:51914656chr12:71158558ENST00000440835-010393_647-156413DomainTyrosine-protein phosphatase
TgenePTPRRchr15:51914656chr12:71158558ENST00000549308-011393_647-80413DomainTyrosine-protein phosphatase
TgenePTPRRchr15:51914656chr12:71158558ENST00000283228-114588_594119658RegionSubstrate binding
TgenePTPRRchr15:51914656chr12:71158558ENST00000342084-013588_5947546RegionSubstrate binding
TgenePTPRRchr15:51914656chr12:71158558ENST00000378778-011588_5940452RegionSubstrate binding
TgenePTPRRchr15:51914656chr12:71158558ENST00000440835-010588_594-156413RegionSubstrate binding
TgenePTPRRchr15:51914656chr12:71158558ENST00000549308-011588_594-80413RegionSubstrate binding
TgenePTPRRchr15:51914656chr12:71158558ENST00000283228-114249_657119658Topological domainCytoplasmic
TgenePTPRRchr15:51914656chr12:71158558ENST00000342084-01322_2277546Topological domainExtracellular
TgenePTPRRchr15:51914656chr12:71158558ENST00000342084-013249_6577546Topological domainCytoplasmic
TgenePTPRRchr15:51914656chr12:71158558ENST00000378778-01122_2270452Topological domainExtracellular
TgenePTPRRchr15:51914656chr12:71158558ENST00000378778-011249_6570452Topological domainCytoplasmic
TgenePTPRRchr15:51914656chr12:71158558ENST00000440835-01022_227-156413Topological domainExtracellular
TgenePTPRRchr15:51914656chr12:71158558ENST00000440835-010249_657-156413Topological domainCytoplasmic
TgenePTPRRchr15:51914656chr12:71158558ENST00000549308-01122_227-80413Topological domainExtracellular
TgenePTPRRchr15:51914656chr12:71158558ENST00000549308-011249_657-80413Topological domainCytoplasmic
TgenePTPRRchr15:51914656chr12:71158558ENST00000283228-114228_248119658TransmembraneHelical
TgenePTPRRchr15:51914656chr12:71158558ENST00000342084-013228_2487546TransmembraneHelical
TgenePTPRRchr15:51914656chr12:71158558ENST00000378778-011228_2480452TransmembraneHelical
TgenePTPRRchr15:51914656chr12:71158558ENST00000440835-010228_248-156413TransmembraneHelical
TgenePTPRRchr15:51914656chr12:71158558ENST00000549308-011228_248-80413TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-1432122_2153293037Coiled coilOntology_term=ECO:0000255
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-1412122_2153292401Coiled coilOntology_term=ECO:0000255
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-1432122_2153293038Coiled coilOntology_term=ECO:0000255
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-1431000_1037293037RepeatNote=WD 8
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-143108_145293037RepeatNote=WD 1
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-1431163_1204293037RepeatNote=WD 9
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-1431244_1281293037RepeatNote=WD 10
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-143167_207293037RepeatNote=WD 2
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-143230_278293037RepeatNote=WD 3
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-1432761_2800293037RepeatNote=WD 11
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-1432804_2843293037RepeatNote=WD 12
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-1432850_2892293037RepeatNote=WD 13
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-1432898_2937293037RepeatNote=WD 14
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-1432940_2979293037RepeatNote=WD 15
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-1432992_3030293037RepeatNote=WD 16
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-143492_532293037RepeatNote=WD 4
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-143595_634293037RepeatNote=WD 5
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-143751_803293037RepeatNote=WD 6
HgeneDMXL2chr15:51914656chr12:71158558ENST00000251076-143878_920293037RepeatNote=WD 7
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-1411000_1037292401RepeatNote=WD 8
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-141108_145292401RepeatNote=WD 1
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-1411163_1204292401RepeatNote=WD 9
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-1411244_1281292401RepeatNote=WD 10
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-141167_207292401RepeatNote=WD 2
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-141230_278292401RepeatNote=WD 3
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-1412761_2800292401RepeatNote=WD 11
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-1412804_2843292401RepeatNote=WD 12
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-1412850_2892292401RepeatNote=WD 13
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-1412898_2937292401RepeatNote=WD 14
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-1412940_2979292401RepeatNote=WD 15
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-1412992_3030292401RepeatNote=WD 16
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-141492_532292401RepeatNote=WD 4
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-141595_634292401RepeatNote=WD 5
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-141751_803292401RepeatNote=WD 6
HgeneDMXL2chr15:51914656chr12:71158558ENST00000449909-141878_920292401RepeatNote=WD 7
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-1431000_1037293038RepeatNote=WD 8
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-143108_145293038RepeatNote=WD 1
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-1431163_1204293038RepeatNote=WD 9
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-1431244_1281293038RepeatNote=WD 10
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-143167_207293038RepeatNote=WD 2
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-143230_278293038RepeatNote=WD 3
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-1432761_2800293038RepeatNote=WD 11
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-1432804_2843293038RepeatNote=WD 12
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-1432850_2892293038RepeatNote=WD 13
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-1432898_2937293038RepeatNote=WD 14
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-1432940_2979293038RepeatNote=WD 15
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-1432992_3030293038RepeatNote=WD 16
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-143492_532293038RepeatNote=WD 4
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-143595_634293038RepeatNote=WD 5
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-143751_803293038RepeatNote=WD 6
HgeneDMXL2chr15:51914656chr12:71158558ENST00000543779-143878_920293038RepeatNote=WD 7
TgenePTPRRchr15:51914656chr12:71158558ENST00000283228-11422_227119658Topological domainExtracellular


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FusionGeneSequence for DMXL2_PTPRR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DMXL2_ENST00000251076_chr15_51914656_-_PTPRR_ENST00000283228_chr12_71158558_-_568aa
MHLHQVLTGAVNPGDNCYSVGSVGDVPFTTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDAL
PSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIH
LSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIP
TPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINAN
YIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSH
TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGM

>In-frame_DMXL2_ENST00000543779_chr15_51914656_-_PTPRR_ENST00000283228_chr12_71158558_-_568aa
MHLHQVLTGAVNPGDNCYSVGSVGDVPFTTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDAL
PSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIH
LSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIP
TPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINAN
YIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSH
TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGM

>In-frame_DMXL2_ENST00000449909_chr15_51914656_-_PTPRR_ENST00000283228_chr12_71158558_-_568aa
MHLHQVLTGAVNPGDNCYSVGSVGDVPFTTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDAL
PSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIH
LSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIP
TPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINAN
YIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSH
TQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGM


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DMXL2_ENST00000251076_chr15_51914656_-_PTPRR_ENST00000283228_chr12_71158558_-_1704nt
ATGCATCTGCATCAGGTCCTCACCGGAGCTGTCAACCCTGGAGACAACTGCTACTCCGTGGGCAGCGTCGGGGATGTCCCCTTCACGACA
CTGCAAATGGATGTAAACAAGCTGAACATAACCTTGCTTCGGATCTTCCGCCAAGGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAA
GTGCACATCAATCGCCTCATTGGAAAGAAGAACAGTATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACAGGAATTTCTGATGCTCTG
CCCTCTGAGGAAGTTCTTCGTTCACTTAATATCAATGTTTTGCATCAAAGTTTATCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAA
AATGTTTTACAAGGGCAGCATGAAGCGGACAAAATCTGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATT
ATAGTAACGTGTTTGATGATTCTTTACAGATTAAAAGAAAGATTTCAGCTTTCCTTAAGACAAGACAAAGAGAAAAACCAGGAGATCCAC
CTATCGCCCATCACATTACAGCCAGCACTGTCCGAGGCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAAT
GTTGTCGTGGACCCTCAAGGCCGAGGTGCTCCTGAGATCAAAGCTACCACCGCTACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCC
ATAGGACTTCAAGAGAGAAGAGGGTCCAACGTATCTCTTACATTGGACATGAGTAGCTTGGGGAACATTGAACCCTTTGTGTCTATACCA
ACACCACGGGAGAAGGTAGCAATGGAGTATCTGCAGTCAGCCAGCCGAATTCTCACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCA
CATTTACTCCAAAGTGAATTCATGGAAATACCAATGAACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGC
TATAAGACCATTTTACCAAATCCCCTCAGCAGAGTGTGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAAT
TATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTTCATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTT
TGGCAGGAAGACAGCCCTGTGATTGTTATGATCACAAAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGG
ATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGTAAATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCAC
ACCCAACATGTGAAGCATTACTGGTACACCTCATGGCCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGAT
GTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGGGCCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCT
ACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGAGTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATG

>In-frame_DMXL2_ENST00000543779_chr15_51914656_-_PTPRR_ENST00000283228_chr12_71158558_-_1704nt
ATGCATCTGCATCAGGTCCTCACCGGAGCTGTCAACCCTGGAGACAACTGCTACTCCGTGGGCAGCGTCGGGGATGTCCCCTTCACGACA
CTGCAAATGGATGTAAACAAGCTGAACATAACCTTGCTTCGGATCTTCCGCCAAGGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAA
GTGCACATCAATCGCCTCATTGGAAAGAAGAACAGTATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACAGGAATTTCTGATGCTCTG
CCCTCTGAGGAAGTTCTTCGTTCACTTAATATCAATGTTTTGCATCAAAGTTTATCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAA
AATGTTTTACAAGGGCAGCATGAAGCGGACAAAATCTGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATT
ATAGTAACGTGTTTGATGATTCTTTACAGATTAAAAGAAAGATTTCAGCTTTCCTTAAGACAAGACAAAGAGAAAAACCAGGAGATCCAC
CTATCGCCCATCACATTACAGCCAGCACTGTCCGAGGCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAAT
GTTGTCGTGGACCCTCAAGGCCGAGGTGCTCCTGAGATCAAAGCTACCACCGCTACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCC
ATAGGACTTCAAGAGAGAAGAGGGTCCAACGTATCTCTTACATTGGACATGAGTAGCTTGGGGAACATTGAACCCTTTGTGTCTATACCA
ACACCACGGGAGAAGGTAGCAATGGAGTATCTGCAGTCAGCCAGCCGAATTCTCACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCA
CATTTACTCCAAAGTGAATTCATGGAAATACCAATGAACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGC
TATAAGACCATTTTACCAAATCCCCTCAGCAGAGTGTGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAAT
TATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTTCATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTT
TGGCAGGAAGACAGCCCTGTGATTGTTATGATCACAAAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGG
ATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGTAAATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCAC
ACCCAACATGTGAAGCATTACTGGTACACCTCATGGCCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGAT
GTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGGGCCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCT
ACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGAGTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATG

>In-frame_DMXL2_ENST00000449909_chr15_51914656_-_PTPRR_ENST00000283228_chr12_71158558_-_1704nt
ATGCATCTGCATCAGGTCCTCACCGGAGCTGTCAACCCTGGAGACAACTGCTACTCCGTGGGCAGCGTCGGGGATGTCCCCTTCACGACA
CTGCAAATGGATGTAAACAAGCTGAACATAACCTTGCTTCGGATCTTCCGCCAAGGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAA
GTGCACATCAATCGCCTCATTGGAAAGAAGAACAGTATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACAGGAATTTCTGATGCTCTG
CCCTCTGAGGAAGTTCTTCGTTCACTTAATATCAATGTTTTGCATCAAAGTTTATCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAA
AATGTTTTACAAGGGCAGCATGAAGCGGACAAAATCTGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATT
ATAGTAACGTGTTTGATGATTCTTTACAGATTAAAAGAAAGATTTCAGCTTTCCTTAAGACAAGACAAAGAGAAAAACCAGGAGATCCAC
CTATCGCCCATCACATTACAGCCAGCACTGTCCGAGGCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAAT
GTTGTCGTGGACCCTCAAGGCCGAGGTGCTCCTGAGATCAAAGCTACCACCGCTACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCC
ATAGGACTTCAAGAGAGAAGAGGGTCCAACGTATCTCTTACATTGGACATGAGTAGCTTGGGGAACATTGAACCCTTTGTGTCTATACCA
ACACCACGGGAGAAGGTAGCAATGGAGTATCTGCAGTCAGCCAGCCGAATTCTCACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCA
CATTTACTCCAAAGTGAATTCATGGAAATACCAATGAACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGC
TATAAGACCATTTTACCAAATCCCCTCAGCAGAGTGTGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAAT
TATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTTCATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTT
TGGCAGGAAGACAGCCCTGTGATTGTTATGATCACAAAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGG
ATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGTAAATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCAC
ACCCAACATGTGAAGCATTACTGGTACACCTCATGGCCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGAT
GTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGGGCCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCT
ACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGAGTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATG


* Fusion transcript sequences (Full-length transcript).
>In-frame_DMXL2_ENST00000251076_chr15_51914656_-_PTPRR_ENST00000283228_chr12_71158558_-_3094nt
ACAAGCACCCTTGCCCTCCCGCATTTGTGCGCCGGTGCAGCAGGCAGTGGGAACATCCGGGCATTTCCGCAGCTGAGCGGCGACCCGGGC
GGCGGCGGCGGTCGAGGAGCTCCCATGGCAGGGACGAGGCGGAGGGAAGGCGAAAGGGGGGCGAGGAGTTAAGCCAGAGCCTCCGCGGGG
CGGGTTTCCGAGGGAGGCACAGAGGGAAACGGCTCTCGCAGCCCGAGGAGGGTCAGGCGCGGAGCTTGTCGCACCTCCCGCGCATTCTGT
CCAGCCCGGGCTCCGGAGATGCATCTGCATCAGGTCCTCACCGGAGCTGTCAACCCTGGAGACAACTGCTACTCCGTGGGCAGCGTCGGG
GATGTCCCCTTCACGACACTGCAAATGGATGTAAACAAGCTGAACATAACCTTGCTTCGGATCTTCCGCCAAGGAGTGGCTGCAGCTTTA
GGACTCTTACCCCAGCAAGTGCACATCAATCGCCTCATTGGAAAGAAGAACAGTATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACA
GGAATTTCTGATGCTCTGCCCTCTGAGGAAGTTCTTCGTTCACTTAATATCAATGTTTTGCATCAAAGTTTATCCCAGTTTGGAATTACA
GAAGTCTCTCCTGAGAAAAATGTTTTACAAGGGCAGCATGAAGCGGACAAAATCTGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTT
CTCAGCATCTTTGTTATTATAGTAACGTGTTTGATGATTCTTTACAGATTAAAAGAAAGATTTCAGCTTTCCTTAAGACAAGACAAAGAG
AAAAACCAGGAGATCCACCTATCGCCCATCACATTACAGCCAGCACTGTCCGAGGCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAG
GCCCCAAAGGTACTGAATGTTGTCGTGGACCCTCAAGGCCGAGGTGCTCCTGAGATCAAAGCTACCACCGCTACCTCTGTTTGCCCTTCT
CCTTTCAAAATGAAGCCCATAGGACTTCAAGAGAGAAGAGGGTCCAACGTATCTCTTACATTGGACATGAGTAGCTTGGGGAACATTGAA
CCCTTTGTGTCTATACCAACACCACGGGAGAAGGTAGCAATGGAGTATCTGCAGTCAGCCAGCCGAATTCTCACAAGGTCTCAGCTGAGG
GACGTCGTGGCAAGTTCACATTTACTCCAAAGTGAATTCATGGAAATACCAATGAACTTTGTGGATCCCAAAGAAATTGATATTCCGCGT
CATGGAACTAAAAATCGCTATAAGACCATTTTACCAAATCCCCTCAGCAGAGTGTGTTTAAGACCAAAAAATGTAACCGATTCATTGAGC
ACCTACATTAATGCTAATTATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTTCATTGCCACGCAGGGCCCCATGATCAACACCGTGGAT
GATTTCTGGCAGATGGTTTGGCAGGAAGACAGCCCTGTGATTGTTATGATCACAAAACTCAAAGAAAAAAATGAGAAATGTGTGCTATAC
TGGCCGGAAAAGAGAGGGATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGTAAATGAATGTGATAACTACACCATTCGAAACCTTGTC
TTAAAGCAAGGAAGCCACACCCAACATGTGAAGCATTACTGGTACACCTCATGGCCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTC
CTACAGCTCATGCTGGATGTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGGGCCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGA
ACAGGGTGTTTTATTGCTACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGAGTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGT
ATGGATAGAGGTGGAATGGTGCAAACCAGTGAGCAGTATGAATTTGTGCACCATGCTCTGTGCCTGTATGAGAGCAGACTTTCAGCAGAG
ACTGTCCAGTGAGTCATTGAAGACTTGTCAGACCATCAATCTCTTGGGGTGATTAATCAAATTACCCACCCAAGGCTTCTAGAAGGAGCT
TCCTGCAATGGAAGGAAGGAGAAGCTCTGAAGCCCATGTATGGCATGGATTGTGGAAGACTGGGCAACATATTTAAGATTTCCAGCTCCT
TGTGTATATGAATGCATTTGTAAGCATCCCCCAAATTATTCTGAAGGTTTTTTGATGATGGAGGTATGATAGGTTTATCACACAGCCTAA
GGCAGATTTTGTTTTGTCTGTACTGACTCTATCTGCCACACAGAATGTATGTATGTAATATTCAGTAATAAATGTCATCAGGTGATGACT
GGATGAGCTGCTGAAGACATTCGTATTATGTGTTAGATGCTTTAATGTTTGCAAAATCTGTCTTGTGAATGGACTGTCAGCTGTTAAACT
GTTCCTGTTTTGAAGTGCTATTACCTTTCTCAGTTACCAGAATCTTGCTGCTAAAGTTGCAAGTGATTGATAATGGATTTTTAACAGAGA
AGTCTTTGTTTTTGAAAAACAAAAATCAAAAACAGTAACTATTTTATATGGAAATGTGTCTTGATAATATTACCTATTAAATGTGTATTT
ATAGTCCCTCCTATCAAACAATTACAGAGCACAATGATTGTCATTGGGTATATATGTATTTACTCTCTATTATTGGGCATAAAGGTGGCT
TCTGCTCCAGAACTCTATCCACTGTATTTCCACATCGTGAGTCATTTTACTTTAAAAGGGAAAAACAAATTTGTAGCAACTCTGAAGTAT
CAAGAGTTTTAACTACTTGTCTCTCTTTTGCTAAGAAGGGATTTTTGAATATGCTATCTACCTGGAATCTCTCTCTCAACAAAAGGTATA
TGCCTTCAGGAATGATATAATCTGTCCCATTTTCGAGGCTCCTTATAAGGACATTTCCATGTATGTCCTTACATTTCTGAAAGCTTTCAA
TCTTCAAGAGACAAAAAAAATTAAAATAACTACCCTCAGCAAACACTAGCTGTTCTGCTCATATATGAATTTTTAATGCAGCAATGTTGA

>In-frame_DMXL2_ENST00000543779_chr15_51914656_-_PTPRR_ENST00000283228_chr12_71158558_-_2896nt
ACAGAGGGAAACGGCTCTCGCAGCCCGAGGAGGGTCAGGCGCGGAGCTTGTCGCACCTCCCGCGCATTCTGTCCAGCCCGGGCTCCGGAG
ATGCATCTGCATCAGGTCCTCACCGGAGCTGTCAACCCTGGAGACAACTGCTACTCCGTGGGCAGCGTCGGGGATGTCCCCTTCACGACA
CTGCAAATGGATGTAAACAAGCTGAACATAACCTTGCTTCGGATCTTCCGCCAAGGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAA
GTGCACATCAATCGCCTCATTGGAAAGAAGAACAGTATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACAGGAATTTCTGATGCTCTG
CCCTCTGAGGAAGTTCTTCGTTCACTTAATATCAATGTTTTGCATCAAAGTTTATCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAA
AATGTTTTACAAGGGCAGCATGAAGCGGACAAAATCTGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATT
ATAGTAACGTGTTTGATGATTCTTTACAGATTAAAAGAAAGATTTCAGCTTTCCTTAAGACAAGACAAAGAGAAAAACCAGGAGATCCAC
CTATCGCCCATCACATTACAGCCAGCACTGTCCGAGGCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAAT
GTTGTCGTGGACCCTCAAGGCCGAGGTGCTCCTGAGATCAAAGCTACCACCGCTACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCC
ATAGGACTTCAAGAGAGAAGAGGGTCCAACGTATCTCTTACATTGGACATGAGTAGCTTGGGGAACATTGAACCCTTTGTGTCTATACCA
ACACCACGGGAGAAGGTAGCAATGGAGTATCTGCAGTCAGCCAGCCGAATTCTCACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCA
CATTTACTCCAAAGTGAATTCATGGAAATACCAATGAACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGC
TATAAGACCATTTTACCAAATCCCCTCAGCAGAGTGTGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAAT
TATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTTCATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTT
TGGCAGGAAGACAGCCCTGTGATTGTTATGATCACAAAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGG
ATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGTAAATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCAC
ACCCAACATGTGAAGCATTACTGGTACACCTCATGGCCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGAT
GTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGGGCCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCT
ACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGAGTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATG
GTGCAAACCAGTGAGCAGTATGAATTTGTGCACCATGCTCTGTGCCTGTATGAGAGCAGACTTTCAGCAGAGACTGTCCAGTGAGTCATT
GAAGACTTGTCAGACCATCAATCTCTTGGGGTGATTAATCAAATTACCCACCCAAGGCTTCTAGAAGGAGCTTCCTGCAATGGAAGGAAG
GAGAAGCTCTGAAGCCCATGTATGGCATGGATTGTGGAAGACTGGGCAACATATTTAAGATTTCCAGCTCCTTGTGTATATGAATGCATT
TGTAAGCATCCCCCAAATTATTCTGAAGGTTTTTTGATGATGGAGGTATGATAGGTTTATCACACAGCCTAAGGCAGATTTTGTTTTGTC
TGTACTGACTCTATCTGCCACACAGAATGTATGTATGTAATATTCAGTAATAAATGTCATCAGGTGATGACTGGATGAGCTGCTGAAGAC
ATTCGTATTATGTGTTAGATGCTTTAATGTTTGCAAAATCTGTCTTGTGAATGGACTGTCAGCTGTTAAACTGTTCCTGTTTTGAAGTGC
TATTACCTTTCTCAGTTACCAGAATCTTGCTGCTAAAGTTGCAAGTGATTGATAATGGATTTTTAACAGAGAAGTCTTTGTTTTTGAAAA
ACAAAAATCAAAAACAGTAACTATTTTATATGGAAATGTGTCTTGATAATATTACCTATTAAATGTGTATTTATAGTCCCTCCTATCAAA
CAATTACAGAGCACAATGATTGTCATTGGGTATATATGTATTTACTCTCTATTATTGGGCATAAAGGTGGCTTCTGCTCCAGAACTCTAT
CCACTGTATTTCCACATCGTGAGTCATTTTACTTTAAAAGGGAAAAACAAATTTGTAGCAACTCTGAAGTATCAAGAGTTTTAACTACTT
GTCTCTCTTTTGCTAAGAAGGGATTTTTGAATATGCTATCTACCTGGAATCTCTCTCTCAACAAAAGGTATATGCCTTCAGGAATGATAT
AATCTGTCCCATTTTCGAGGCTCCTTATAAGGACATTTCCATGTATGTCCTTACATTTCTGAAAGCTTTCAATCTTCAAGAGACAAAAAA
AATTAAAATAACTACCCTCAGCAAACACTAGCTGTTCTGCTCATATATGAATTTTTAATGCAGCAATGTTGACTTTGTTTCATACTGCCA

>In-frame_DMXL2_ENST00000449909_chr15_51914656_-_PTPRR_ENST00000283228_chr12_71158558_-_2896nt
ACAGAGGGAAACGGCTCTCGCAGCCCGAGGAGGGTCAGGCGCGGAGCTTGTCGCACCTCCCGCGCATTCTGTCCAGCCCGGGCTCCGGAG
ATGCATCTGCATCAGGTCCTCACCGGAGCTGTCAACCCTGGAGACAACTGCTACTCCGTGGGCAGCGTCGGGGATGTCCCCTTCACGACA
CTGCAAATGGATGTAAACAAGCTGAACATAACCTTGCTTCGGATCTTCCGCCAAGGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAA
GTGCACATCAATCGCCTCATTGGAAAGAAGAACAGTATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACAGGAATTTCTGATGCTCTG
CCCTCTGAGGAAGTTCTTCGTTCACTTAATATCAATGTTTTGCATCAAAGTTTATCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAA
AATGTTTTACAAGGGCAGCATGAAGCGGACAAAATCTGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATT
ATAGTAACGTGTTTGATGATTCTTTACAGATTAAAAGAAAGATTTCAGCTTTCCTTAAGACAAGACAAAGAGAAAAACCAGGAGATCCAC
CTATCGCCCATCACATTACAGCCAGCACTGTCCGAGGCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAAT
GTTGTCGTGGACCCTCAAGGCCGAGGTGCTCCTGAGATCAAAGCTACCACCGCTACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCC
ATAGGACTTCAAGAGAGAAGAGGGTCCAACGTATCTCTTACATTGGACATGAGTAGCTTGGGGAACATTGAACCCTTTGTGTCTATACCA
ACACCACGGGAGAAGGTAGCAATGGAGTATCTGCAGTCAGCCAGCCGAATTCTCACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCA
CATTTACTCCAAAGTGAATTCATGGAAATACCAATGAACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGC
TATAAGACCATTTTACCAAATCCCCTCAGCAGAGTGTGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAAT
TATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTTCATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTT
TGGCAGGAAGACAGCCCTGTGATTGTTATGATCACAAAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGG
ATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGTAAATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCAC
ACCCAACATGTGAAGCATTACTGGTACACCTCATGGCCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGAT
GTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGGGCCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCT
ACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGAGTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATG
GTGCAAACCAGTGAGCAGTATGAATTTGTGCACCATGCTCTGTGCCTGTATGAGAGCAGACTTTCAGCAGAGACTGTCCAGTGAGTCATT
GAAGACTTGTCAGACCATCAATCTCTTGGGGTGATTAATCAAATTACCCACCCAAGGCTTCTAGAAGGAGCTTCCTGCAATGGAAGGAAG
GAGAAGCTCTGAAGCCCATGTATGGCATGGATTGTGGAAGACTGGGCAACATATTTAAGATTTCCAGCTCCTTGTGTATATGAATGCATT
TGTAAGCATCCCCCAAATTATTCTGAAGGTTTTTTGATGATGGAGGTATGATAGGTTTATCACACAGCCTAAGGCAGATTTTGTTTTGTC
TGTACTGACTCTATCTGCCACACAGAATGTATGTATGTAATATTCAGTAATAAATGTCATCAGGTGATGACTGGATGAGCTGCTGAAGAC
ATTCGTATTATGTGTTAGATGCTTTAATGTTTGCAAAATCTGTCTTGTGAATGGACTGTCAGCTGTTAAACTGTTCCTGTTTTGAAGTGC
TATTACCTTTCTCAGTTACCAGAATCTTGCTGCTAAAGTTGCAAGTGATTGATAATGGATTTTTAACAGAGAAGTCTTTGTTTTTGAAAA
ACAAAAATCAAAAACAGTAACTATTTTATATGGAAATGTGTCTTGATAATATTACCTATTAAATGTGTATTTATAGTCCCTCCTATCAAA
CAATTACAGAGCACAATGATTGTCATTGGGTATATATGTATTTACTCTCTATTATTGGGCATAAAGGTGGCTTCTGCTCCAGAACTCTAT
CCACTGTATTTCCACATCGTGAGTCATTTTACTTTAAAAGGGAAAAACAAATTTGTAGCAACTCTGAAGTATCAAGAGTTTTAACTACTT
GTCTCTCTTTTGCTAAGAAGGGATTTTTGAATATGCTATCTACCTGGAATCTCTCTCTCAACAAAAGGTATATGCCTTCAGGAATGATAT
AATCTGTCCCATTTTCGAGGCTCCTTATAAGGACATTTCCATGTATGTCCTTACATTTCTGAAAGCTTTCAATCTTCAAGAGACAAAAAA
AATTAAAATAACTACCCTCAGCAAACACTAGCTGTTCTGCTCATATATGAATTTTTAATGCAGCAATGTTGACTTTGTTTCATACTGCCA


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FusionGenePPI for DMXL2_PTPRR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DMXL2WDR7, RAB3GAP1, C1QTNF2, ROGDI, ANTXR1, GLUL, RP2, FAF2, TSPYL6, NPY2R, YBEY, WDYHV1, DEF8, MTNR1BPTPRRMAPK1, MAPK3, MAPK7, MAPK14, NTRK1, CEP290, EGFR, ERBB2, IGF1R, RET, MST1R, ERBB4, FGFR2, FGFR4, KDR, TEK, INSR, ALDH18A1, DHPS, PNMA2, TRIM11, KIAA0196, TBC1D5, DNAJC13, SNX6, PTPRR, MAPK1IP1L, MAPKAPK3, MAD2L1BP, CBS, MAPK11, CCT8L1P, HSPA4L, LMTK2, AATK, ERBB3, RYK, ROR1, ROR2, PTK7, EPHA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DMXL2_PTPRR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DMXL2_PTPRR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTPRRC0041696Unipolar Depression1PSYGENET
TgenePTPRRC1269683Major Depressive Disorder1PSYGENET