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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10156

FusionGeneSummary for DMTF1_GRM3

check button Fusion gene summary
Fusion gene informationFusion gene name: DMTF1_GRM3
Fusion gene ID: 10156
HgeneTgene
Gene symbol

DMTF1

GRM3

Gene ID

9988

2913

Gene namecyclin D binding myb like transcription factor 1glutamate metabotropic receptor 3
SynonymsDMP1|DMTF|MRUL|hDMP1GLUR3|GPRC1C|MGLUR3|mGlu3
Cytomap

7q21.12

7q21.11-q21.12

Type of geneprotein-codingprotein-coding
Descriptioncyclin-D-binding Myb-like transcription factor 1cyclin D-binding Myb-like proteincyclin-D-interacting Myb-like protein 1hDMTF1metabotropic glutamate receptor 3glutamate receptor, metabotropic 3
Modification date2018052320180524
UniProtAcc

Q9Y222

Q14832

Ensembl transtripts involved in fusion geneENST00000394702, ENST00000331242, 
ENST00000413276, ENST00000411766, 
ENST00000432937, ENST00000394703, 
ENST00000580710, ENST00000414194, 
ENST00000361669, ENST00000546348, 
ENST00000536043, ENST00000439827, 
ENST00000394720, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 1=4
# samples 32
** MAII scorelog2(3/8*10)=1.90689059560852log2(2/4*10)=2.32192809488736
Context

PubMed: DMTF1 [Title/Abstract] AND GRM3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-22-4594-01ADMTF1chr7

86794366

+GRM3chr7

86415577

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000394702ENST00000361669DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000394702ENST00000546348DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000394702ENST00000536043DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000394702ENST00000439827DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000394702ENST00000394720DMTF1chr7

86794366

+GRM3chr7

86415577

+
Frame-shitENST00000331242ENST00000361669DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000331242ENST00000546348DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000331242ENST00000536043DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000331242ENST00000439827DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000331242ENST00000394720DMTF1chr7

86794366

+GRM3chr7

86415577

+
Frame-shitENST00000413276ENST00000361669DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000413276ENST00000546348DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000413276ENST00000536043DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000413276ENST00000439827DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000413276ENST00000394720DMTF1chr7

86794366

+GRM3chr7

86415577

+
Frame-shitENST00000411766ENST00000361669DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000411766ENST00000546348DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000411766ENST00000536043DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000411766ENST00000439827DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000411766ENST00000394720DMTF1chr7

86794366

+GRM3chr7

86415577

+
intron-3CDSENST00000432937ENST00000361669DMTF1chr7

86794366

+GRM3chr7

86415577

+
intron-intronENST00000432937ENST00000546348DMTF1chr7

86794366

+GRM3chr7

86415577

+
intron-intronENST00000432937ENST00000536043DMTF1chr7

86794366

+GRM3chr7

86415577

+
intron-intronENST00000432937ENST00000439827DMTF1chr7

86794366

+GRM3chr7

86415577

+
intron-intronENST00000432937ENST00000394720DMTF1chr7

86794366

+GRM3chr7

86415577

+
Frame-shitENST00000394703ENST00000361669DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000394703ENST00000546348DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000394703ENST00000536043DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000394703ENST00000439827DMTF1chr7

86794366

+GRM3chr7

86415577

+
5CDS-intronENST00000394703ENST00000394720DMTF1chr7

86794366

+GRM3chr7

86415577

+
intron-3CDSENST00000580710ENST00000361669DMTF1chr7

86794366

+GRM3chr7

86415577

+
intron-intronENST00000580710ENST00000546348DMTF1chr7

86794366

+GRM3chr7

86415577

+
intron-intronENST00000580710ENST00000536043DMTF1chr7

86794366

+GRM3chr7

86415577

+
intron-intronENST00000580710ENST00000439827DMTF1chr7

86794366

+GRM3chr7

86415577

+
intron-intronENST00000580710ENST00000394720DMTF1chr7

86794366

+GRM3chr7

86415577

+
5UTR-3CDSENST00000414194ENST00000361669DMTF1chr7

86794366

+GRM3chr7

86415577

+
5UTR-intronENST00000414194ENST00000546348DMTF1chr7

86794366

+GRM3chr7

86415577

+
5UTR-intronENST00000414194ENST00000536043DMTF1chr7

86794366

+GRM3chr7

86415577

+
5UTR-intronENST00000414194ENST00000439827DMTF1chr7

86794366

+GRM3chr7

86415577

+
5UTR-intronENST00000414194ENST00000394720DMTF1chr7

86794366

+GRM3chr7

86415577

+

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FusionProtFeatures for DMTF1_GRM3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DMTF1

Q9Y222

GRM3

Q14832

G-protein coupled receptor for glutamate. Ligand bindingcauses a conformation change that triggers signaling via guaninenucleotide-binding proteins (G proteins) and modulates theactivity of down-stream effectors. Signaling inhibits adenylatecyclase activity. {ECO:0000269|PubMed:8840013}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DMTF1_GRM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DMTF1_GRM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DMTF1TP53, SRA1, DNMT3L, TRIM25GRM3PPM1A, GRIP1, PICK1, SDCBP, FBXW7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DMTF1_GRM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DMTF1_GRM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGRM3C0005586Bipolar Disorder5PSYGENET
TgeneGRM3C0025202melanoma2CTD_human
TgeneGRM3C0525045Mood Disorders2PSYGENET
TgeneGRM3C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneGRM3C0014556Epilepsy, Temporal Lobe1CTD_human
TgeneGRM3C0036341Schizophrenia1CTD_human
TgeneGRM3C0858355addicted to cocaine1PSYGENET