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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1014

FusionGeneSummary for AFF3_EIF5B

check button Fusion gene summary
Fusion gene informationFusion gene name: AFF3_EIF5B
Fusion gene ID: 1014
HgeneTgene
Gene symbol

AFF3

EIF5B

Gene ID

3899

9669

Gene nameAF4/FMR2 family member 3eukaryotic translation initiation factor 5B
SynonymsLAF4|MLLT2-likeIF2
Cytomap

2q11.2

2q11.2

Type of geneprotein-codingprotein-coding
DescriptionAF4/FMR2 family member 3MLLT2-related proteinlymphoid nuclear protein 4lymphoid nuclear protein related to AF4protein LAF-4eukaryotic translation initiation factor 5BeIF-5Btranslation initiation factor IF-2translation initiation factor IF2
Modification date2018052320180523
UniProtAcc

P51826

O60841

Ensembl transtripts involved in fusion geneENST00000409236, ENST00000356421, 
ENST00000317233, ENST00000409579, 
ENST00000483600, 
ENST00000289371, 
Fusion gene scores* DoF score12 X 9 X 5=5404 X 7 X 1=28
# samples 127
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/28*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AFF3 [Title/Abstract] AND EIF5B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEIF5B

GO:0006446

regulation of translational initiation

10432305


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA619466AFF3chr2

100720864

-EIF5Bchr2

99976698

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000409236ENST00000289371AFF3chr2

100720864

-EIF5Bchr2

99976698

+
Frame-shitENST00000356421ENST00000289371AFF3chr2

100720864

-EIF5Bchr2

99976698

+
Frame-shitENST00000317233ENST00000289371AFF3chr2

100720864

-EIF5Bchr2

99976698

+
Frame-shitENST00000409579ENST00000289371AFF3chr2

100720864

-EIF5Bchr2

99976698

+
intron-3CDSENST00000483600ENST00000289371AFF3chr2

100720864

-EIF5Bchr2

99976698

+

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FusionProtFeatures for AFF3_EIF5B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AFF3

P51826

EIF5B

O60841

Plays a role in translation initiation. TranslationalGTPase that catalyzes the joining of the 40S and 60S subunits toform the 80S initiation complex with the initiator methionine-tRNAin the P-site base paired to the start codon. GTP binding andhydrolysis induces conformational changes in the enzyme thatrenders it active for productive interactions with the ribosome.The release of the enzyme after formation of the initiationcomplex is a prerequisite to form elongation-competent ribosomes.{ECO:0000250|UniProtKB:P39730}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AFF3_EIF5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AFF3_EIF5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AFF3MLLT3, CDK9, PIP4K2AEIF5BPRKAA1, ZBTB3, POU5F1, HDGF, SIRT7, CAND1, EIF3C, BRCA1, ECT2, PAXIP1, FN1, CSNK2A1, MMS19, ETS1, YBX3, LGR4, TP53, TFCP2, OBSL1, RHOJ, DEGS1, TTC29, ZBTB38, PLK2, ABCF2, DKC1, FTSJ3, NCL, PIAS4, RPLP0, RPS6, RRP12, UBR4, GLTSCR2, GNL1, NHP2, PTMA, TSSC4, SFN, NTRK1, XPO1, XRCC3, FOXD4, FOXK2, C1orf131, EGFR, CDC42SE1, MTUS2, GTF2E2, CALM1, PA2G4, TRAP1, SND1, ANXA5, SNRPB2, GPI, IDH2, PDIA3, UBE2N, MRPL12, CRNN, ZNF207, CPNE3, CS, PYGL, UBE2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AFF3_EIF5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AFF3_EIF5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAFF3C0003873Rheumatoid Arthritis2CTD_human
HgeneAFF3C0236969Substance-Related Disorders1CTD_human