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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10135

FusionGeneSummary for DLK1_RPS11

check button Fusion gene summary
Fusion gene informationFusion gene name: DLK1_RPS11
Fusion gene ID: 10135
HgeneTgene
Gene symbol

DLK1

RPS11

Gene ID

8788

6205

Gene namedelta like non-canonical Notch ligand 1ribosomal protein S11
SynonymsDLK|DLK-1|Delta1|FA1|PREF1|Pref-1|ZOG|pG2S11
Cytomap

14q32.2

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionprotein delta homolog 1delta-like 1 homologfetal antigen 1preadipocyte factor 1secredeltin40S ribosomal protein S11small ribosomal subunit protein uS17
Modification date2018052320180523
UniProtAcc

P80370

P62280

Ensembl transtripts involved in fusion geneENST00000341267, ENST00000331224, 
ENST00000556051, 
ENST00000270625, 
ENST00000596873, ENST00000594493, 
ENST00000599561, 
Fusion gene scores* DoF score7 X 5 X 4=1403 X 3 X 1=9
# samples 83
** MAII scorelog2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DLK1 [Title/Abstract] AND RPS11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDLK1

GO:0045746

negative regulation of Notch signaling pathway

25093684


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA368503DLK1chr14

101201247

-RPS11chr19

50000561

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000341267ENST00000270625DLK1chr14

101201247

-RPS11chr19

50000561

+
3UTR-3CDSENST00000341267ENST00000596873DLK1chr14

101201247

-RPS11chr19

50000561

+
3UTR-5UTRENST00000341267ENST00000594493DLK1chr14

101201247

-RPS11chr19

50000561

+
3UTR-intronENST00000341267ENST00000599561DLK1chr14

101201247

-RPS11chr19

50000561

+
3UTR-3CDSENST00000331224ENST00000270625DLK1chr14

101201247

-RPS11chr19

50000561

+
3UTR-3CDSENST00000331224ENST00000596873DLK1chr14

101201247

-RPS11chr19

50000561

+
3UTR-5UTRENST00000331224ENST00000594493DLK1chr14

101201247

-RPS11chr19

50000561

+
3UTR-intronENST00000331224ENST00000599561DLK1chr14

101201247

-RPS11chr19

50000561

+
intron-3CDSENST00000556051ENST00000270625DLK1chr14

101201247

-RPS11chr19

50000561

+
intron-3CDSENST00000556051ENST00000596873DLK1chr14

101201247

-RPS11chr19

50000561

+
intron-5UTRENST00000556051ENST00000594493DLK1chr14

101201247

-RPS11chr19

50000561

+
intron-intronENST00000556051ENST00000599561DLK1chr14

101201247

-RPS11chr19

50000561

+

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FusionProtFeatures for DLK1_RPS11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLK1

P80370

RPS11

P62280

May have a role in neuroendocrine differentiation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DLK1_RPS11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DLK1_RPS11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DLK1_RPS11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DLK1_RPS11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDLK1C0015934Fetal Growth Retardation1CTD_human
HgeneDLK1C3463824MYELODYSPLASTIC SYNDROME1CTD_human