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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10112

FusionGeneSummary for DLGAP1_GNL2

check button Fusion gene summary
Fusion gene informationFusion gene name: DLGAP1_GNL2
Fusion gene ID: 10112
HgeneTgene
Gene symbol

DLGAP1

GNL2

Gene ID

9229

29889

Gene nameDLG associated protein 1G protein nucleolar 2
SynonymsDAP-1|DAP-1-ALPHA|DAP-1-BETA|DAP1|DLGAP1A|DLGAP1B|GKAP|SAPAP1HUMAUANTIG|NGP1|Ngp-1|Nog2|Nug2
Cytomap

18p11.31

1p34.3

Type of geneprotein-codingprotein-coding
Descriptiondisks large-associated protein 1PSD-95/SAP90 binding protein 1SAP90/PSD-95-associated protein 1discs large homolog associated protein 1guanylate kinase-associated proteinnucleolar GTP-binding protein 2autoantigen NGP-1guanine nucleotide binding protein-like 2 (nucleolar)novel nucleolar guanosine 5'-triphosphate binding protein autoantigennucleolar G-protein gene 1nucleolar GTPasenucleostemin-2
Modification date2018051920180523
UniProtAcc

O14490

Q13823

Ensembl transtripts involved in fusion geneENST00000315677, ENST00000581527, 
ENST00000400147, ENST00000400149, 
ENST00000400155, ENST00000400150, 
ENST00000584874, ENST00000534970, 
ENST00000539435, ENST00000581699, 
ENST00000400145, ENST00000515196, 
ENST00000478161, 
ENST00000373062, 
ENST00000462812, 
Fusion gene scores* DoF score10 X 7 X 6=4202 X 2 X 1=4
# samples 92
** MAII scorelog2(9/420*10)=-2.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: DLGAP1 [Title/Abstract] AND GNL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF930028DLGAP1chr18

4218105

+GNL2chr1

38034674

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000315677ENST00000373062DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-5UTRENST00000315677ENST00000462812DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-3CDSENST00000581527ENST00000373062DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-5UTRENST00000581527ENST00000462812DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-3CDSENST00000400147ENST00000373062DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-5UTRENST00000400147ENST00000462812DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-3CDSENST00000400149ENST00000373062DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-5UTRENST00000400149ENST00000462812DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-3CDSENST00000400155ENST00000373062DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-5UTRENST00000400155ENST00000462812DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-3CDSENST00000400150ENST00000373062DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-5UTRENST00000400150ENST00000462812DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-3CDSENST00000584874ENST00000373062DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-5UTRENST00000584874ENST00000462812DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-3CDSENST00000534970ENST00000373062DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-5UTRENST00000534970ENST00000462812DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-3CDSENST00000539435ENST00000373062DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-5UTRENST00000539435ENST00000462812DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-3CDSENST00000581699ENST00000373062DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-5UTRENST00000581699ENST00000462812DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-3CDSENST00000400145ENST00000373062DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-5UTRENST00000400145ENST00000462812DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-3CDSENST00000515196ENST00000373062DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-5UTRENST00000515196ENST00000462812DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-3CDSENST00000478161ENST00000373062DLGAP1chr18

4218105

+GNL2chr1

38034674

-
intron-5UTRENST00000478161ENST00000462812DLGAP1chr18

4218105

+GNL2chr1

38034674

-

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FusionProtFeatures for DLGAP1_GNL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLGAP1

O14490

GNL2

Q13823

GTPase that associates with pre-60S ribosomal subunitsin the nucleolus and is required for their nuclear export andmaturation (By similarity). May promote cell proliferationpossibly by increasing p53/TP53 protein levels, and consequentlythose of its downstream product CDKN1A/p21, and decreasing RPL23Aprotein levels (PubMed:26203195). {ECO:0000250,ECO:0000269|PubMed:26203195}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DLGAP1_GNL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DLGAP1_GNL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DLGAP1_GNL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DLGAP1_GNL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDLGAP1C0036341Schizophrenia3PSYGENET