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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1011

FusionGeneSummary for AFF2_AFF2

check button Fusion gene summary
Fusion gene informationFusion gene name: AFF2_AFF2
Fusion gene ID: 1011
HgeneTgene
Gene symbol

AFF2

AFF2

Gene ID

2334

2334

Gene nameAF4/FMR2 family member 2AF4/FMR2 family member 2
SynonymsFMR2|FMR2P|FRAXE|MRX2|OX19FMR2|FMR2P|FRAXE|MRX2|OX19
Cytomap

Xq28

Xq28

Type of geneprotein-codingprotein-coding
DescriptionAF4/FMR2 family member 2fragile X E mental retardation syndrome proteinfragile X mental retardation 2 proteinprotein FMR-2AF4/FMR2 family member 2fragile X E mental retardation syndrome proteinfragile X mental retardation 2 proteinprotein FMR-2
Modification date2018052320180523
UniProtAcc

P51816

P51816

Ensembl transtripts involved in fusion geneENST00000370460, ENST00000370457, 
ENST00000342251, ENST00000370458, 
ENST00000286437, 
ENST00000370460, 
ENST00000370457, ENST00000342251, 
ENST00000370458, ENST00000286437, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: AFF2 [Title/Abstract] AND AFF2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF999372AFF2chrX

147743429

-AFF2chrX

147744289

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000370460ENST00000370460AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370460ENST00000370457AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370460ENST00000342251AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370460ENST00000370458AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370460ENST00000286437AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370457ENST00000370460AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370457ENST00000370457AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370457ENST00000342251AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370457ENST00000370458AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370457ENST00000286437AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000342251ENST00000370460AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000342251ENST00000370457AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000342251ENST00000342251AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000342251ENST00000370458AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000342251ENST00000286437AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370458ENST00000370460AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370458ENST00000370457AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370458ENST00000342251AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370458ENST00000370458AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000370458ENST00000286437AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000286437ENST00000370460AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000286437ENST00000370457AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000286437ENST00000342251AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000286437ENST00000370458AFF2chrX

147743429

-AFF2chrX

147744289

-
intron-intronENST00000286437ENST00000286437AFF2chrX

147743429

-AFF2chrX

147744289

-

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FusionProtFeatures for AFF2_AFF2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AFF2

P51816

AFF2

P51816


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AFF2_AFF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AFF2_AFF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AFF2_AFF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AFF2_AFF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource