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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10094

FusionGeneSummary for DLG2_XRCC6BP1

check button Fusion gene summary
Fusion gene informationFusion gene name: DLG2_XRCC6BP1
Fusion gene ID: 10094
HgeneTgene
Gene symbol

DLG2

XRCC6BP1

Gene ID

4355

91419

Gene namemembrane palmitoylated protein 2ATP23 metallopeptidase and ATP synthase assembly factor homolog
SynonymsDLG2KUB3|XRCC6BP1
Cytomap

17q21.31

12q14.1

Type of geneprotein-codingprotein-coding
DescriptionMAGUK p55 subfamily member 2discs large, homolog 2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)mitochondrial inner membrane protease ATP23 homologKu70-binding protein 3XRCC6-binding protein 1
Modification date2018051920180519
UniProtAcc

Q15700

Ensembl transtripts involved in fusion geneENST00000398309, ENST00000376104, 
ENST00000418306, ENST00000280241, 
ENST00000543673, ENST00000376106, 
ENST00000330014, ENST00000537455, 
ENST00000524982, ENST00000532653, 
ENST00000531015, ENST00000398301, 
ENST00000426717, ENST00000404783, 
ENST00000398304, ENST00000530800, 
ENST00000472545, 		ENST00000300145, 
ENST00000546709, 
Fusion gene scores* DoF score5 X 6 X 3=908 X 4 X 4=128
# samples 68
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/128*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DLG2 [Title/Abstract] AND XRCC6BP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-AB2H-01ADLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000398309ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5CDS-intronENST00000398309ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
In-frameENST00000376104ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5CDS-intronENST00000376104ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
Frame-shiftENST00000418306ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5CDS-intronENST00000418306ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
Frame-shiftENST00000280241ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5CDS-intronENST00000280241ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
Frame-shiftENST00000543673ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5CDS-intronENST00000543673ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5UTR-3CDSENST00000376106ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5UTR-intronENST00000376106ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
Frame-shiftENST00000330014ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5CDS-intronENST00000330014ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5UTR-3CDSENST00000537455ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5UTR-intronENST00000537455ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
Frame-shiftENST00000524982ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5CDS-intronENST00000524982ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
Frame-shiftENST00000532653ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5CDS-intronENST00000532653ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
Frame-shiftENST00000531015ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5CDS-intronENST00000531015ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
Frame-shiftENST00000398301ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
5CDS-intronENST00000398301ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
intron-3CDSENST00000426717ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
intron-intronENST00000426717ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
intron-3CDSENST00000404783ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
intron-intronENST00000404783ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
intron-3CDSENST00000398304ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
intron-intronENST00000398304ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
intron-3CDSENST00000530800ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
intron-intronENST00000530800ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
intron-3CDSENST00000472545ENST00000300145DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+
intron-intronENST00000472545ENST00000546709DLG2chr11

83874504

-XRCC6BP1chr12

58339411

+

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FusionProtFeatures for DLG2_XRCC6BP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLG2

Q15700

XRCC6BP1

Required for perception of chronic pain through NMDAreceptor signaling. Regulates surface expression of NMDA receptorsin dorsal horn neurons of the spinal cord. Interacts with thecytoplasmic tail of NMDA receptor subunits as well as inwardrectifying potassium channels. Involved in regulation of synapticstability at cholinergic synapses. Part of the postsynapticprotein scaffold of excitatory synapses (By similarity).{ECO:0000250}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DLG2_XRCC6BP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_DLG2_ENST00000376104_chr11_83874504_-_XRCC6BP1_ENST00000300145_chr12_58339411_+_392aa
MGIFKSSLFQALLDIQEFYEVTLLNSQKSCEQKIEEANQVLQKWEKTSLLAPCHDRLQKSSELTDCSGSKENASCIEQNKENQSFENETD
ETTTQNQGRCPAQNCSVEAPAWMPVHHCTKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPII
VNTDTLDTIPYVNGTEIEYEFEEITLERIHMSNFCLMLXNTQVVLLTKIDTFLAKTVMEMSVEVLMLQHLRXFCARIISIIRPIXTEWSH
TSLFMHLIIVVPMSTGSPTSDIWRAQRFELLTLVETAHLSMKYSGYILDXNNTTRLVCETEPLFLSWLLGISAKKXLKRLLMKFLNLVSM


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_DLG2_ENST00000376104_chr11_83874504_-_XRCC6BP1_ENST00000300145_chr12_58339411_+_1178nt
ATGGGTATCTTTAAGAGCAGCTTATTCCAAGCTTTGCTAGATATCCAAGAATTTTATGAGGTGACATTGCTAAATTCTCAAAAAAGTTGT
GAGCAGAAGATAGAAGAAGCCAATCAAGTTTTACAGAAATGGGAGAAGACATCCCTTCTTGCTCCGTGCCATGACAGACTTCAAAAATCT
TCAGAGCTTACAGATTGCAGTGGATCAAAGGAAAATGCTTCATGTATTGAGCAAAATAAAGAAAATCAGAGTTTTGAAAATGAAACTGAT
GAGACGACAACTCAAAACCAAGGCAGATGCCCAGCCCAGAATTGTTCAGTGGAAGCCCCTGCTTGGATGCCTGTCCACCACTGTACTAAG
TATCGATATCAAGATGAGGACGCTCCACATGATCATTCCTTACCTCGACTAACCCACGAAGTAAGAGGCCCAGAACTCGTGCATGTATCA
GAAAAGAACCTCTCTCAAATAGAAAATGTCCATGGATATGTCTTGCAGTCTCATATTTCTCCTCTGAAGGCCAGTCCTGCTCCTATAATT
GTCAACACAGATACTTTGGACACAATTCCTTATGTCAATGGGACAGAAATTGAATATGAATTTGAAGAAATTACACTGGAGAGGATCCAT
ATGTCAAACTTCTGCTTGATGCTATGAAACACTCAGGTTGTGCTGTTAACAAAGATAGACACTTTTCTTGCGAAGACTGTAATGGAAATG
TCAGTGGAGGTTTTGATGCTTCAACATCTCAGATAGTTTTGTGCCAGAATAATATCCATAATCAGGCCCATATGAACAGAGTGGTCACAC
ACGAGCTTATTCATGCATTTGATCATTGTCGTGCCCATGTCGACTGGTTCACCAACATCAGACATTTGGCGTGCTCAGAGGTTCGAGCTG
CTAACCTTAGTGGAGACTGCTCACTTGTCAATGAAATATTCAGGTTACATTTTGGATTAAAACAACACCACCAGACTTGTGTGCGAGACA
GAGCCACTCTTTCTATCCTGGCTGTTAGGAATATCAGCAAAGAAGTAGCTAAAAAGGCTGTTGATGAAGTTTTTGAATCTTGTTTCAATG
ACCATGAACCTTTTGGAAGGATCCCACATAACAAGACTTATGCAAGATATGCTCACAGAGACTTTGAAAACCGTGATCGGTATTATTCAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_DLG2_ENST00000376104_chr11_83874504_-_XRCC6BP1_ENST00000300145_chr12_58339411_+_1869nt
ACAGAAGAAAAAAATGAAAGGGACAGCAAGCTGGATTCTGAGTTACTGAGGGGAAGACTCAGCCTGGATTTCAAAACTGAACACTGAAGT
GGTTTGCAACAGTTACCTGGCTCTTGGCCTCAATCCAGCTGGATCAAACTGAGACCTGAAAAGAGATATTGACTCCTGTGGCAGTGGAAA
GACCCAAGAATGCCAGTCAAGAAGACAGGTGGGCCATAAGATACTGACCGAGCTTTATCATTACTGGAAGAATACTGCAAAAAATTAAGG
AAACCAGAGGAGCAGCTGTTGAAAAATGCGGTTAAAAAGGTGATGGGTATCTTTAAGAGCAGCTTATTCCAAGCTTTGCTAGATATCCAA
GAATTTTATGAGGTGACATTGCTAAATTCTCAAAAAAGTTGTGAGCAGAAGATAGAAGAAGCCAATCAAGTTTTACAGAAATGGGAGAAG
ACATCCCTTCTTGCTCCGTGCCATGACAGACTTCAAAAATCTTCAGAGCTTACAGATTGCAGTGGATCAAAGGAAAATGCTTCATGTATT
GAGCAAAATAAAGAAAATCAGAGTTTTGAAAATGAAACTGATGAGACGACAACTCAAAACCAAGGCAGATGCCCAGCCCAGAATTGTTCA
GTGGAAGCCCCTGCTTGGATGCCTGTCCACCACTGTACTAAGTATCGATATCAAGATGAGGACGCTCCACATGATCATTCCTTACCTCGA
CTAACCCACGAAGTAAGAGGCCCAGAACTCGTGCATGTATCAGAAAAGAACCTCTCTCAAATAGAAAATGTCCATGGATATGTCTTGCAG
TCTCATATTTCTCCTCTGAAGGCCAGTCCTGCTCCTATAATTGTCAACACAGATACTTTGGACACAATTCCTTATGTCAATGGGACAGAA
ATTGAATATGAATTTGAAGAAATTACACTGGAGAGGATCCATATGTCAAACTTCTGCTTGATGCTATGAAACACTCAGGTTGTGCTGTTA
ACAAAGATAGACACTTTTCTTGCGAAGACTGTAATGGAAATGTCAGTGGAGGTTTTGATGCTTCAACATCTCAGATAGTTTTGTGCCAGA
ATAATATCCATAATCAGGCCCATATGAACAGAGTGGTCACACACGAGCTTATTCATGCATTTGATCATTGTCGTGCCCATGTCGACTGGT
TCACCAACATCAGACATTTGGCGTGCTCAGAGGTTCGAGCTGCTAACCTTAGTGGAGACTGCTCACTTGTCAATGAAATATTCAGGTTAC
ATTTTGGATTAAAACAACACCACCAGACTTGTGTGCGAGACAGAGCCACTCTTTCTATCCTGGCTGTTAGGAATATCAGCAAAGAAGTAG
CTAAAAAGGCTGTTGATGAAGTTTTTGAATCTTGTTTCAATGACCATGAACCTTTTGGAAGGATCCCACATAACAAGACTTATGCAAGAT
ATGCTCACAGAGACTTTGAAAACCGTGATCGGTATTATTCAAATATATGAGCACAATGACATTTTTATATTACAGAGCTTCCATCATCAT
GAAGAAAAAAAAATTTGGTTCTCAAGTGAACAAACATATAAAATGTAAACAATCCCTACAATCCAGATAAAACAGAGAAGACTGTGATTC
TAGCATATTATCAGAAAAAGTAACTATGGCAAAAAATGAAACTGCTTTAAACTCCAAGGCAGAAATTGTATCTTTATAGCTAACCATTTA
GTAAATAAATACATTACATTTTTGTATTTTAGTCATTTGTTTTTATTACATGTGATTATTTTAAAATTTGATTATGAAACCTGTGAAGTG


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FusionGenePPI for DLG2_XRCC6BP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DLG2LRP2, ERBB4, KCNJ12, KCNJ4, GRIN2B, KCNA4, DLGAP1, DYNLL1, DYNLL2, DLG4, NLGN2, NLGN1, NLGN3, GRIN2A, SEMA4C, NOS1, ATP2B2, ATP2B4, GUCY1A2, KHDRBS1, FASLG, MAP1AXRCC6BP1XRCC6, AP2B1, TRIP6, CSPP1, NUP35, HLA-E, ATG7, BACH1, EEF1D, PROZ, CHST12, CD79A, FAM136A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DLG2_XRCC6BP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DLG2_XRCC6BP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDLG2C0036341Schizophrenia4PSYGENET
HgeneDLG2C0005586Bipolar Disorder2PSYGENET
HgeneDLG2C0025202melanoma1CTD_human
HgeneDLG2C0041696Unipolar Depression1PSYGENET
HgeneDLG2C0809983Schizophrenia and related disorders1PSYGENET
HgeneDLG2C1269683Major Depressive Disorder1PSYGENET