	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
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Fusion gene ID: 10083

FusionGeneSummary for DLG1_P2RX5

Fusion gene summary

Fusion gene information	Fusion gene name: DLG1_P2RX5
	Fusion gene ID: 10083
		Hgene	Tgene
	Gene symbol	DLG1	P2RX5
	Gene ID	1739	5026
	Gene name	discs large MAGUK scaffold protein 1	purinergic receptor P2X 5
	Synonyms	DLGH1\|SAP-97\|SAP97\|dJ1061C18.1.1\|hdlg	LRH-1\|P2X5\|P2X5R
	Cytomap	3q29	17p13.2
	Type of gene	protein-coding	protein-coding
	Description	disks large homolog 1discs large homolog 1, scribble cell polarity complex componentdiscs, large homolog 1 transcript variant 6-v1discs, large homolog 1 transcript variant 6-v2presynaptic protein SAP97synapse-associated protein 97	P2X purinoceptor 5ATP receptor subunitionotropic ATP receptor P2X5lymphoid-restricted histocompatibility antigen-1purinergic receptor P2X, ligand gated ion channel, 5
	Modification date	20180523	20180523
	UniProtAcc	Q12959	Q93086
	Ensembl transtripts involved in fusion gene	ENST00000357674, ENST00000314062, ENST00000346964, ENST00000419354, ENST00000452595, ENST00000422288, ENST00000448528, ENST00000443183, ENST00000450955, ENST00000392382, ENST00000485409,	ENST00000552276, ENST00000435558, ENST00000551178, ENST00000547178, ENST00000225328, ENST00000345901, ENST00000552050, ENST00000550772,
Fusion gene scores	* DoF score	20 X 10 X 13=2600	3 X 3 X 3=27
	# samples	23	3
	** MAII score	log2(23/2600*10)=-3.49880585697144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: DLG1 [Title/Abstract] AND P2RX5 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DLG1	GO:0001935	endothelial cell proliferation	14699157
Hgene	DLG1	GO:0007015	actin filament organization	14699157
Hgene	DLG1	GO:0030866	cortical actin cytoskeleton organization	14699157
Hgene	DLG1	GO:0042391	regulation of membrane potential	12970345
Hgene	DLG1	GO:0043268	positive regulation of potassium ion transport	12970345
Hgene	DLG1	GO:0070830	bicellular tight junction assembly	17332497
Hgene	DLG1	GO:0098609	cell-cell adhesion	14699157
Hgene	DLG1	GO:1903078	positive regulation of protein localization to plasma membrane	12970345

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BQ878018	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000357674	ENST00000552276	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000357674	ENST00000435558	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000357674	ENST00000551178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000357674	ENST00000547178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000357674	ENST00000225328	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000357674	ENST00000345901	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000357674	ENST00000552050	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000357674	ENST00000550772	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000314062	ENST00000552276	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000314062	ENST00000435558	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000314062	ENST00000551178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000314062	ENST00000547178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000314062	ENST00000225328	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000314062	ENST00000345901	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000314062	ENST00000552050	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000314062	ENST00000550772	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000346964	ENST00000552276	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000346964	ENST00000435558	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000346964	ENST00000551178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000346964	ENST00000547178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000346964	ENST00000225328	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000346964	ENST00000345901	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000346964	ENST00000552050	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000346964	ENST00000550772	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000419354	ENST00000552276	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000419354	ENST00000435558	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000419354	ENST00000551178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000419354	ENST00000547178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000419354	ENST00000225328	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000419354	ENST00000345901	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000419354	ENST00000552050	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000419354	ENST00000550772	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000452595	ENST00000552276	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000452595	ENST00000435558	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000452595	ENST00000551178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000452595	ENST00000547178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000452595	ENST00000225328	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000452595	ENST00000345901	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000452595	ENST00000552050	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000452595	ENST00000550772	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000422288	ENST00000552276	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000422288	ENST00000435558	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000422288	ENST00000551178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000422288	ENST00000547178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000422288	ENST00000225328	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000422288	ENST00000345901	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000422288	ENST00000552050	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000422288	ENST00000550772	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000448528	ENST00000552276	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000448528	ENST00000435558	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000448528	ENST00000551178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000448528	ENST00000547178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000448528	ENST00000225328	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000448528	ENST00000345901	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000448528	ENST00000552050	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000448528	ENST00000550772	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000443183	ENST00000552276	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000443183	ENST00000435558	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000443183	ENST00000551178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000443183	ENST00000547178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000443183	ENST00000225328	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000443183	ENST00000345901	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000443183	ENST00000552050	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000443183	ENST00000550772	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000450955	ENST00000552276	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000450955	ENST00000435558	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000450955	ENST00000551178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000450955	ENST00000547178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000450955	ENST00000225328	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000450955	ENST00000345901	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000450955	ENST00000552050	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000450955	ENST00000550772	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000392382	ENST00000552276	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000392382	ENST00000435558	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000392382	ENST00000551178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000392382	ENST00000547178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000392382	ENST00000225328	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000392382	ENST00000345901	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000392382	ENST00000552050	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000392382	ENST00000550772	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000485409	ENST00000552276	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000485409	ENST00000435558	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000485409	ENST00000551178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000485409	ENST00000547178	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000485409	ENST00000225328	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000485409	ENST00000345901	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000485409	ENST00000552050	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+
intron-intron	ENST00000485409	ENST00000550772	DLG1	chr3	196867020	-	P2RX5	chr17	3572117	+

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FusionProtFeatures for DLG1_P2RX5

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DLG1 Q12959	P2RX5 Q93086

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for DLG1_P2RX5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DLG1_P2RX5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for DLG1_P2RX5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for DLG1_P2RX5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	DLG1	C0036341	Schizophrenia	3	CTD_human
Hgene	DLG1	C0008925	Cleft Palate	1	CTD_human

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Fusion gene ID: 10083

FusionGeneSummary for DLG1_P2RX5

FusionProtFeatures for DLG1_P2RX5

FusionGeneSequence for DLG1_P2RX5

FusionGenePPI for DLG1_P2RX5

RelatedDrugs for DLG1_P2RX5

RelatedDiseases for DLG1_P2RX5