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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10065

FusionGeneSummary for DLEU2_BMP4

check button Fusion gene summary
Fusion gene informationFusion gene name: DLEU2_BMP4
Fusion gene ID: 10065
HgeneTgene
Gene symbol

DLEU2

BMP4

Gene ID

10301

652

Gene namedeleted in lymphocytic leukemia 1bone morphogenetic protein 4
SynonymsBCMS|BCMS1|DLB1|DLEU2|LEU1|LEU2|LINC00021|NCRNA00021|XTP6BMP2B|BMP2B1|MCOPS6|OFC11|ZYME
Cytomap

13q14.2-q14.3

14q22.2

Type of genencRNAprotein-coding
DescriptionB-cell neoplasia-associated gene with multiple splicingdeleted in lymphocytic leukemia 1 (non-protein coding)leukemia-associated protein 2long intergenic non-protein coding RNA 21bone morphogenetic protein 4bone morphogenetic protein 2B
Modification date2018051920180523
UniProtAcc

P12644

Ensembl transtripts involved in fusion geneENST00000607334, ENST00000245451, 
ENST00000559087, ENST00000417573, 
ENST00000558984, ENST00000558489, 
Fusion gene scores* DoF score7 X 6 X 5=2102 X 1 X 2=4
# samples 72
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: DLEU2 [Title/Abstract] AND BMP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBMP4

GO:0000122

negative regulation of transcription by RNA polymerase II

9187146

TgeneBMP4

GO:0000186

activation of MAPKK activity

17600318|17992660

TgeneBMP4

GO:0001649

osteoblast differentiation

17720811

TgeneBMP4

GO:0001657

ureteric bud development

12141440

TgeneBMP4

GO:0001658

branching involved in ureteric bud morphogenesis

12631064

TgeneBMP4

GO:0001934

positive regulation of protein phosphorylation

14749725

TgeneBMP4

GO:0001938

positive regulation of endothelial cell proliferation

17992660

TgeneBMP4

GO:0002043

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

18787191

TgeneBMP4

GO:0002244

hematopoietic progenitor cell differentiation

15451575

TgeneBMP4

GO:0003323

type B pancreatic cell development

11865031

TgeneBMP4

GO:0003337

mesenchymal to epithelial transition involved in metanephros morphogenesis

10706139

TgeneBMP4

GO:0007182

common-partner SMAD protein phosphorylation

20573232

TgeneBMP4

GO:0008284

positive regulation of cell proliferation

15516325

TgeneBMP4

GO:0008285

negative regulation of cell proliferation

9187146

TgeneBMP4

GO:0009791

post-embryonic development

8674409

TgeneBMP4

GO:0010453

regulation of cell fate commitment

18823971

TgeneBMP4

GO:0010595

positive regulation of endothelial cell migration

17992660

TgeneBMP4

GO:0010628

positive regulation of gene expression

24906886|28124060

TgeneBMP4

GO:0010629

negative regulation of gene expression

28124060

TgeneBMP4

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

9389648|16816361|17244894|20559569

TgeneBMP4

GO:0010942

positive regulation of cell death

8674409

TgeneBMP4

GO:0021537

telencephalon development

9187146

TgeneBMP4

GO:0030224

monocyte differentiation

21149635

TgeneBMP4

GO:0030225

macrophage differentiation

21149635

TgeneBMP4

GO:0030501

positive regulation of bone mineralization

14749725|18436533

TgeneBMP4

GO:0030509

BMP signaling pathway

9389648|18436533

TgeneBMP4

GO:0032092

positive regulation of protein binding

23610558

TgeneBMP4

GO:0032967

positive regulation of collagen biosynthetic process

17720811

TgeneBMP4

GO:0034504

protein localization to nucleus

17244894

TgeneBMP4

GO:0042306

regulation of protein import into nucleus

22529382

TgeneBMP4

GO:0042326

negative regulation of phosphorylation

17244894

TgeneBMP4

GO:0043065

positive regulation of apoptotic process

9187146|10706139

TgeneBMP4

GO:0043066

negative regulation of apoptotic process

17992660

TgeneBMP4

GO:0043407

negative regulation of MAP kinase activity

17244894

TgeneBMP4

GO:0045606

positive regulation of epidermal cell differentiation

18823971

TgeneBMP4

GO:0045662

negative regulation of myoblast differentiation

14749725

TgeneBMP4

GO:0045669

positive regulation of osteoblast differentiation

14749725|18436533

TgeneBMP4

GO:0045778

positive regulation of ossification

14749725

TgeneBMP4

GO:0045786

negative regulation of cell cycle

11502704

TgeneBMP4

GO:0045839

negative regulation of mitotic nuclear division

17244894

TgeneBMP4

GO:0045843

negative regulation of striated muscle tissue development

14749725

TgeneBMP4

GO:0045892

negative regulation of transcription, DNA-templated

10706139|12631064|17244894

TgeneBMP4

GO:0045893

positive regulation of transcription, DNA-templated

10021330|17600318|17992660

TgeneBMP4

GO:0045944

positive regulation of transcription by RNA polymerase II

9187146|15516325

TgeneBMP4

GO:0048286

lung alveolus development

8674409

TgeneBMP4

GO:0048392

intermediate mesodermal cell differentiation

10021330

TgeneBMP4

GO:0048661

positive regulation of smooth muscle cell proliferation

10706139|17600318

TgeneBMP4

GO:0048754

branching morphogenesis of an epithelial tube

10706139

TgeneBMP4

GO:0050679

positive regulation of epithelial cell proliferation

11865031

TgeneBMP4

GO:0060391

positive regulation of SMAD protein signal transduction

9389648

TgeneBMP4

GO:0060393

regulation of pathway-restricted SMAD protein phosphorylation

18787191

TgeneBMP4

GO:0060395

SMAD protein signal transduction

17244894

TgeneBMP4

GO:0060425

lung morphogenesis

8674409

TgeneBMP4

GO:0060433

bronchus development

8674409

TgeneBMP4

GO:0060438

trachea development

8674409

TgeneBMP4

GO:0060441

epithelial tube branching involved in lung morphogenesis

8674409

TgeneBMP4

GO:0060502

epithelial cell proliferation involved in lung morphogenesis

8674409

TgeneBMP4

GO:0060503

bud dilation involved in lung branching

8674409

TgeneBMP4

GO:0060548

negative regulation of cell death

12631064

TgeneBMP4

GO:0061036

positive regulation of cartilage development

3201241

TgeneBMP4

GO:0061155

pulmonary artery endothelial tube morphogenesis

17992660

TgeneBMP4

GO:0071893

BMP signaling pathway involved in nephric duct formation

10021330

TgeneBMP4

GO:0072097

negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway

10706139|17118062

TgeneBMP4

GO:0072101

specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway

10706139|17118062

TgeneBMP4

GO:0072125

negative regulation of glomerular mesangial cell proliferation

17244894

TgeneBMP4

GO:0072200

negative regulation of mesenchymal cell proliferation involved in ureter development

12399320

TgeneBMP4

GO:0090184

positive regulation of kidney development

10021330

TgeneBMP4

GO:0090191

negative regulation of branching involved in ureteric bud morphogenesis

12141440|17118062

TgeneBMP4

GO:0090194

negative regulation of glomerulus development

12141440

TgeneBMP4

GO:1902894

negative regulation of pri-miRNA transcription by RNA polymerase II

28124060

TgeneBMP4

GO:1903800

positive regulation of production of miRNAs involved in gene silencing by miRNA

18548003

TgeneBMP4

GO:2000005

negative regulation of metanephric S-shaped body morphogenesis

12141440

TgeneBMP4

GO:2000007

negative regulation of metanephric comma-shaped body morphogenesis

12141440


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-78-7161-01ADLEU2chr13

50642233

-BMP4chr14

54420118

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000607334ENST00000245451DLEU2chr13

50642233

-BMP4chr14

54420118

-
intron-5UTRENST00000607334ENST00000559087DLEU2chr13

50642233

-BMP4chr14

54420118

-
intron-5UTRENST00000607334ENST00000417573DLEU2chr13

50642233

-BMP4chr14

54420118

-
intron-5UTRENST00000607334ENST00000558984DLEU2chr13

50642233

-BMP4chr14

54420118

-
intron-intronENST00000607334ENST00000558489DLEU2chr13

50642233

-BMP4chr14

54420118

-

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FusionProtFeatures for DLEU2_BMP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLEU2

BMP4

P12644

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Induces cartilage and bone formation. Also act inmesoderm induction, tooth development, limb formation and fracturerepair. Acts in concert with PTHLH/PTHRP to stimulate ductaloutgrowth during embryonic mammary development and to inhibit hairfollicle induction (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DLEU2_BMP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DLEU2_BMP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DLEU2CUL1, ACE2BMP4SOSTDC1, BMPR2, BMPR1A, BMPR1B, TWSG1, ZFYVE9, DCAF16, SLC22A23, UBE2O, PDP1, SUFU, PROS1, CALR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DLEU2_BMP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneBMP4P12644DB01373CalciumBone morphogenetic protein 4small moleculeapproved|nutraceutical

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RelatedDiseases for DLEU2_BMP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDLEU2C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneBMP4C2677434OROFACIAL CLEFT 113CTD_human;UNIPROT
TgeneBMP4C0003872Arthritis, Psoriatic1CTD_human
TgeneBMP4C0003873Rheumatoid Arthritis1CTD_human
TgeneBMP4C0009404Colorectal Neoplasms1CTD_human
TgeneBMP4C0019284Diaphragmatic Hernia1CTD_human
TgeneBMP4C0029408Degenerative polyarthritis1CTD_human
TgeneBMP4C0033375Prolactinoma1CTD_human
TgeneBMP4C0042842Vitamin A Deficiency1CTD_human
TgeneBMP4C1306214ACTH-Secreting Pituitary Adenoma1CTD_human
TgeneBMP4C1458155Mammary Neoplasms1CTD_human
TgeneBMP4C1864689MICROPHTHALMIA, SYNDROMIC 6 (disorder)1CTD_human;ORPHANET;UNIPROT