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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10023

FusionGeneSummary for DIRAS2_GNA14

check button Fusion gene summary
Fusion gene informationFusion gene name: DIRAS2_GNA14
Fusion gene ID: 10023
HgeneTgene
Gene symbol

DIRAS2

GNA14

Gene ID

54769

9630

Gene nameDIRAS family GTPase 2G protein subunit alpha 14
SynonymsDi-Ras2-
Cytomap

9q22.2

9q21.2

Type of geneprotein-codingprotein-coding
DescriptionGTP-binding protein Di-Ras2DIRAS family, GTP-binding RAS-like 2distinct subgroup of the Ras family member 2guanine nucleotide-binding protein subunit alpha-14g alpha-14guanine nucleotide binding protein (G protein), alpha 14guanine nucleotide-binding protein 14
Modification date2018051920180523
UniProtAcc

Q96HU8

O95837

Ensembl transtripts involved in fusion geneENST00000375765, ENST00000341700, 
ENST00000464095, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 3 X 4=60
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DIRAS2 [Title/Abstract] AND GNA14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDIRAS2

GO:0043406

positive regulation of MAP kinase activity

12194967


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-A2I1-01ADIRAS2chr9

93405034

-GNA14chr9

80049438

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000375765ENST00000341700DIRAS2chr9

93405034

-GNA14chr9

80049438

-
5UTR-intronENST00000375765ENST00000464095DIRAS2chr9

93405034

-GNA14chr9

80049438

-

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FusionProtFeatures for DIRAS2_GNA14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIRAS2

Q96HU8

GNA14

O95837

Displays low GTPase activity and exists predominantly inthe GTP-bound form. {ECO:0000269|PubMed:12194967}. Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DIRAS2_GNA14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DIRAS2_GNA14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DIRAS2UNC13B, RAP1GDS1, ZNF581, SIRPD, FTOGNA14JMJD6, DNAL4, SNW1, DUSP22


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DIRAS2_GNA14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DIRAS2_GNA14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGNA14C0023893Liver Cirrhosis, Experimental1CTD_human