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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 10006

FusionGeneSummary for DIP2B_TBC1D15

check button Fusion gene summary
Fusion gene informationFusion gene name: DIP2B_TBC1D15
Fusion gene ID: 10006
HgeneTgene
Gene symbol

DIP2B

TBC1D15

Gene ID

57609

64786

Gene namedisco interacting protein 2 homolog BTBC1 domain family member 15
Synonyms-RAB7-GAP
Cytomap

12q13.12

12q21.1

Type of geneprotein-codingprotein-coding
Descriptiondisco-interacting protein 2 homolog BDIP2 disco-interacting protein 2 homolog BTBC1 domain family member 15GAP for RAB7GTPase-activating protein RAB7Tre-2-budding uninhibited by benzimidazole-cell division cycle 16 domain, domain family member 15Tre2/Bub2/Cdc16 domain family member 15
Modification date2018051920180523
UniProtAcc

Q9P265

Q8TC07

Ensembl transtripts involved in fusion geneENST00000301180, ENST00000550746, 
ENST00000319106, ENST00000485960, 
ENST00000393309, ENST00000548679, 
Fusion gene scores* DoF score11 X 8 X 9=7927 X 6 X 3=126
# samples 137
** MAII scorelog2(13/792*10)=-2.60698880705116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DIP2B [Title/Abstract] AND TBC1D15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-BF-A1PU-01ADIP2Bchr12

50899023

+TBC1D15chr12

72315148

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000301180ENST00000550746DIP2Bchr12

50899023

+TBC1D15chr12

72315148

+
Frame-shiftENST00000301180ENST00000319106DIP2Bchr12

50899023

+TBC1D15chr12

72315148

+
Frame-shiftENST00000301180ENST00000485960DIP2Bchr12

50899023

+TBC1D15chr12

72315148

+
Frame-shiftENST00000301180ENST00000393309DIP2Bchr12

50899023

+TBC1D15chr12

72315148

+
5CDS-intronENST00000301180ENST00000548679DIP2Bchr12

50899023

+TBC1D15chr12

72315148

+

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FusionProtFeatures for DIP2B_TBC1D15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DIP2B

Q9P265

TBC1D15

Q8TC07

Acts as a GTPase activating protein for RAB7A. Does notact on RAB4, RAB5 or RAB6 (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for DIP2B_TBC1D15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for DIP2B_TBC1D15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
DIP2BSQSTM1, RAD21, ELAVL1, AUP1, EFNB2, NTRK1, HAVCR2, CNKSR3, ARFGAP1, SELE, TRIM25TBC1D15MEPCE, GABARAP, TERF2, UBC, CUL2, NEDD8, RAB5A, RAB5B, RAB5C, FIS1, PARK2, ARFIP1, ATP6V1C1, DNM1L, IDE, PSMG3, SHMT2, SNX2, STAT3, VPS26A, OPTN, CALCOCO1, CEP63, CCDC8, UBAC2, SPINT2, STX12, CCDC121, CCNH, ST3GAL4, PNKD, DLK1, FLOT2, FAM189A2, PTGER3, ALDH3A2, NTRK1, XPO1, UBXN8, GRAMD4, KIF22, TBC1D17, CAMLG, ATF6B, MRS2, DNM1, UTP15, SLC30A9, HTR2C, VTI1B, TMEM206, DNM2, TNFRSF1A, UXS1, PTPN1, PTPRN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for DIP2B_TBC1D15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for DIP2B_TBC1D15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource