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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for THRAP3

check button Gene summary
Gene informationGene symbol

THRAP3

Gene ID

9967

Gene namethyroid hormone receptor associated protein 3
SynonymsBCLAF2|TRAP150
Cytomap

1p34.3

Type of geneprotein-coding
Descriptionthyroid hormone receptor-associated protein 3BCLAF1 and THRAP3 family member 2TR-associated protein, 150-kDathyroid hormone receptor-associated protein complex 150 kDa componentthyroid hormone receptor-associated protein, 150 kDa subunit
Modification date20180522
UniProtAcc

Q9Y2W1

ContextPubMed: THRAP3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
THRAP3

GO:0000956

nuclear-transcribed mRNA catabolic process

20123736

THRAP3

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

THRAP3

GO:0030518

intracellular steroid hormone receptor signaling pathway

11867769

THRAP3

GO:0030521

androgen receptor signaling pathway

12218053

THRAP3

GO:0045893

positive regulation of transcription, DNA-templated

10198638

THRAP3

GO:0045944

positive regulation of transcription by RNA polymerase II

12037571


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Exon skipping events across known transcript of Ensembl for THRAP3 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for THRAP3

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for THRAP3

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_4289136690033:36690106:36690571:36690703:36724982:3672508536690571:36690703ENSG00000054118.9ENST00000469141.2
exon_skip_4292136690033:36690106:36691012:36691064:36724982:3672508536691012:36691064ENSG00000054118.9ENST00000478853.1
exon_skip_4301136690571:36690703:36724982:36725085:36748133:3674828536724982:36725085ENSG00000054118.9ENST00000469141.2
exon_skip_4303136691012:36691064:36724982:36725085:36748133:3674828536724982:36725085ENSG00000054118.9ENST00000478853.1
exon_skip_4307136748133:36748301:36751968:36752871:36754660:3675536536751968:36752871ENSG00000054118.9ENST00000469141.2,ENST00000354618.5
exon_skip_4311136758198:36758310:36759451:36759536:36762183:3676237136759451:36759536ENSG00000054118.9ENST00000469141.2,ENST00000354618.5
exon_skip_4318136759451:36759536:36762183:36762371:36766486:3676668536762183:36762371ENSG00000054118.9ENST00000469141.2,ENST00000354618.5
exon_skip_4321136766486:36766685:36767153:36767297:36769396:3676974936767153:36767297ENSG00000054118.9ENST00000469141.2,ENST00000354618.5

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for THRAP3

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_4289136690033:36690106:36690571:36690703:36724982:3672508536690571:36690703ENSG00000054118.9ENST00000469141.2
exon_skip_4292136690033:36690106:36691012:36691064:36724982:3672508536691012:36691064ENSG00000054118.9ENST00000478853.1
exon_skip_4301136690571:36690703:36724982:36725085:36748133:3674828536724982:36725085ENSG00000054118.9ENST00000469141.2
exon_skip_4303136691012:36691064:36724982:36725085:36748133:3674828536724982:36725085ENSG00000054118.9ENST00000478853.1
exon_skip_4307136748133:36748301:36751968:36752871:36754660:3675536536751968:36752871ENSG00000054118.9ENST00000354618.5,ENST00000469141.2
exon_skip_4311136758198:36758310:36759451:36759536:36762183:3676237136759451:36759536ENSG00000054118.9ENST00000354618.5,ENST00000469141.2
exon_skip_4318136759451:36759536:36762183:36762371:36766486:3676668536762183:36762371ENSG00000054118.9ENST00000354618.5,ENST00000469141.2
exon_skip_4321136766486:36766685:36767153:36767297:36769396:3676974936767153:36767297ENSG00000054118.9ENST00000354618.5,ENST00000469141.2

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for THRAP3

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000046914136690571366907035UTR-5UTR
ENST0000046914136724982367250855UTR-5UTR
ENST000003546183675945136759536Frame-shift
ENST000004691413675945136759536Frame-shift
ENST000003546183676218336762371Frame-shift
ENST000004691413676218336762371Frame-shift
ENST000003546183675196836752871In-frame
ENST000004691413675196836752871In-frame
ENST000003546183676715336767297In-frame
ENST000004691413676715336767297In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000046914136690571366907035UTR-5UTR
ENST0000046914136724982367250855UTR-5UTR
ENST000003546183675945136759536Frame-shift
ENST000004691413675945136759536Frame-shift
ENST000003546183676218336762371Frame-shift
ENST000004691413676218336762371Frame-shift
ENST000003546183675196836752871In-frame
ENST000004691413675196836752871In-frame
ENST000003546183676715336767297In-frame
ENST000004691413676715336767297In-frame

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Infer the effects of exon skipping event on protein functional features for THRAP3

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000035461844499553675196836752871362126446346
ENST0000046914133569553675196836752871478138046346
ENST000003546184449955367671533676729727272870834882
ENST000004691413356955367671533676729728432986834882

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000035461844499553675196836752871362126446346
ENST0000046914133569553675196836752871478138046346
ENST000003546184449955367671533676729727272870834882
ENST000004691413356955367671533676729728432986834882

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9Y2W1463462955ChainID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
Q9Y2W1463462955ChainID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
Q9Y2W1463467339Compositional biasNote=Ser-rich
Q9Y2W1463467339Compositional biasNote=Ser-rich
Q9Y2W14634612161Compositional biasNote=Arg-rich
Q9Y2W14634612161Compositional biasNote=Arg-rich
Q9Y2W146346202202Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
Q9Y2W146346202202Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
Q9Y2W146346202202Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346202202Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346215215Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346215215Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346221221Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346221221Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346252252Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346252252Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346333333Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346333333Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346346346Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346346346Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1463466666Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1463466666Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346101101Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346101101Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346108108Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346108108Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346220220Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W146346220220Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W146346221221Modified residueNote=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
Q9Y2W146346221221Modified residueNote=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
Q9Y2W146346232232Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y2W146346232232Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y2W146346237237Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q9Y2W146346237237Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q9Y2W146346240240Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163
Q9Y2W146346240240Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163
Q9Y2W146346243243Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:00002
Q9Y2W146346243243Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:00002
Q9Y2W146346248248Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,E
Q9Y2W146346248248Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,E
Q9Y2W146346252252Modified residueNote=N6-methyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346252252Modified residueNote=N6-methyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346253253Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMe
Q9Y2W146346253253Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMe
Q9Y2W146346257257Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
Q9Y2W146346257257Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
Q9Y2W146346315315Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID
Q9Y2W146346315315Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID
Q9Y2W146346320320Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569,E
Q9Y2W146346320320Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569,E
Q9Y2W146346323323Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W146346323323Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W146346324324Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W146346324324Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W146346326326Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W146346326326Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W146346328328Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W146346328328Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W146346339339Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
Q9Y2W146346339339Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
Q9Y2W146346346346Modified residueNote=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W146346346346Modified residueNote=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W146346201201Natural variantID=VAR_024552;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10198638,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs6425977,PMID:10198638,PMID:15489334
Q9Y2W146346201201Natural variantID=VAR_024552;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10198638,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs6425977,PMID:10198638,PMID:15489334
Q9Y2W1463462190RegionNote=Required for mRNA splicing activation
Q9Y2W1463462190RegionNote=Required for mRNA splicing activation
Q9Y2W18348822955ChainID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
Q9Y2W18348822955ChainID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
Q9Y2W1834882876876Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1834882876876Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1834882879879Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1834882879879Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1834882845845Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W1834882845845Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W1834882874874Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
Q9Y2W1834882874874Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
Q9Y2W1834882359955RegionNote=Required for mRNA decay activity
Q9Y2W1834882359955RegionNote=Required for mRNA decay activity


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
Q9Y2W1463462955ChainID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
Q9Y2W1463462955ChainID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
Q9Y2W1463467339Compositional biasNote=Ser-rich
Q9Y2W1463467339Compositional biasNote=Ser-rich
Q9Y2W14634612161Compositional biasNote=Arg-rich
Q9Y2W14634612161Compositional biasNote=Arg-rich
Q9Y2W146346202202Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
Q9Y2W146346202202Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:25114211;Dbxref=PMID:25114211
Q9Y2W146346202202Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346202202Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346215215Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346215215Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346221221Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346221221Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346252252Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346252252Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346333333Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346333333Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346346346Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W146346346346Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1463466666Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W1463466666Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346101101Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346101101Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346108108Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346108108Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346220220Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W146346220220Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W146346221221Modified residueNote=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
Q9Y2W146346221221Modified residueNote=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:19608861;Dbxref=PMID:19608861
Q9Y2W146346232232Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y2W146346232232Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:23186163
Q9Y2W146346237237Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q9Y2W146346237237Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163
Q9Y2W146346240240Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163
Q9Y2W146346240240Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:18669648,PMID:23186163
Q9Y2W146346243243Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:00002
Q9Y2W146346243243Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:16964243,ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:00002
Q9Y2W146346248248Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,E
Q9Y2W146346248248Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,E
Q9Y2W146346252252Modified residueNote=N6-methyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346252252Modified residueNote=N6-methyllysine%3B alternate;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24129315;Dbxref=PMID:24129315
Q9Y2W146346253253Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMe
Q9Y2W146346253253Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:18220336,ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:20068231,ECO:0000244|PubMe
Q9Y2W146346257257Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
Q9Y2W146346257257Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569;Dbxref=PMID:20068231,PMID:23186163,PMID:24275569
Q9Y2W146346315315Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID
Q9Y2W146346315315Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID
Q9Y2W146346320320Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569,E
Q9Y2W146346320320Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000269;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163,ECO:0000244|PubMed:24275569,E
Q9Y2W146346323323Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W146346323323Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W146346324324Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W146346324324Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W146346326326Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W146346326326Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163
Q9Y2W146346328328Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W146346328328Modified residueNote=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W146346339339Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
Q9Y2W146346339339Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:21406692;Dbxref=PMID:21406692
Q9Y2W146346346346Modified residueNote=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W146346346346Modified residueNote=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W146346201201Natural variantID=VAR_024552;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10198638,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs6425977,PMID:10198638,PMID:15489334
Q9Y2W146346201201Natural variantID=VAR_024552;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10198638,ECO:0000269|PubMed:15489334,ECO:0000269|Ref.3;Dbxref=dbSNP:rs6425977,PMID:10198638,PMID:15489334
Q9Y2W1463462190RegionNote=Required for mRNA splicing activation
Q9Y2W1463462190RegionNote=Required for mRNA splicing activation
Q9Y2W18348822955ChainID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
Q9Y2W18348822955ChainID=PRO_0000065583;Note=Thyroid hormone receptor-associated protein 3
Q9Y2W1834882876876Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1834882876876Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1834882879879Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1834882879879Cross-linkNote=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733
Q9Y2W1834882845845Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W1834882845845Modified residueNote=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q569Z6
Q9Y2W1834882874874Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
Q9Y2W1834882874874Modified residueNote=Phosphothreonine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:19690332,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:23186163
Q9Y2W1834882359955RegionNote=Required for mRNA decay activity
Q9Y2W1834882359955RegionNote=Required for mRNA decay activity


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SNVs in the skipped exons for THRAP3

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A3A0-01exon_skip_4307
36751969367528713675202636752026Frame_Shift_DelA-p.P65fs
LIHCTCGA-DD-A1EG-01exon_skip_4307
36751969367528713675214636752146Frame_Shift_DelA-p.G105fs
UCECTCGA-BS-A0U8-01exon_skip_4307
36751969367528713675226636752267Frame_Shift_DelCT-p.N145fs
UCECTCGA-BS-A0U8-01exon_skip_4307
36751969367528713675226636752267Frame_Shift_DelCT-p.S146fs
LIHCTCGA-DD-A1EG-01exon_skip_4307
36751969367528713675241136752411Frame_Shift_DelG-p.G194fs
LIHCTCGA-G3-A3CJ-01exon_skip_4307
36751969367528713675241136752411Frame_Shift_DelG-p.G194fs
STADTCGA-BR-4184-01exon_skip_4307
36751969367528713675263536752635Frame_Shift_DelC-p.S268fs
CHOLTCGA-W5-AA39-01exon_skip_4311
36759452367595363675944236759456Frame_Shift_DelTCAATTTTAGGAGAA-p.677_678del
LIHCTCGA-DD-A39Y-01exon_skip_4318
36762184367623713676224136762241Frame_Shift_DelA-p.K726fs
LUADTCGA-69-8254-01exon_skip_4318
36762184367623713676233736762338Frame_Shift_DelAC-p.T757fs
LIHCTCGA-DD-A39Y-01exon_skip_4321
36767154367672973676722836767228Frame_Shift_DelT-p.D859fs
KIRPTCGA-BQ-7059-01exon_skip_4321
36767154367672973676724536767245Frame_Shift_DelG-p.R865fs
LIHCTCGA-DD-A3A0-01exon_skip_4321
36767154367672973676727436767274Frame_Shift_DelC-p.P875fs
BLCATCGA-GC-A6I1-01exon_skip_4318
36762184367623713676233136762332Frame_Shift_Ins-Ap.E755fs
BLCATCGA-ZF-AA4W-01exon_skip_4318
36762184367623713676233136762332Frame_Shift_Ins-Ap.E755fs
STADTCGA-BR-8360-01exon_skip_4318
36762184367623713676233136762332Frame_Shift_Ins-Ap.E755fs
STADTCGA-CG-4440-01exon_skip_4318
36762184367623713676233136762332Frame_Shift_Ins-Ap.E755fs
STADTCGA-BR-8360-01exon_skip_4318
36762184367623713676233236762333Frame_Shift_Ins-Ap.E755fs
STADTCGA-CG-4440-01exon_skip_4318
36762184367623713676233236762333Frame_Shift_Ins-Ap.E755fs
SARCTCGA-QC-A7B5-01exon_skip_4307
36751969367528713675212336752123Nonsense_MutationCTp.Q98*
STADTCGA-BR-4184-01exon_skip_4307
36751969367528713675213236752132Nonsense_MutationCTp.R101*
STADTCGA-BR-4370-01exon_skip_4307
36751969367528713675213536752135Nonsense_MutationGTp.G102*
STADTCGA-BR-4370-01exon_skip_4307
36751969367528713675213536752135Nonsense_MutationGTp.G102X
CESCTCGA-JW-A5VL-01exon_skip_4307
36751969367528713675215736752157Nonsense_MutationCGp.S109*
UCECTCGA-B5-A11H-01exon_skip_4307
36751969367528713675257036752570Nonsense_MutationCTp.R247*
LUADTCGA-NJ-A4YF-01exon_skip_4307
36751969367528713675272636752726Nonsense_MutationCTp.Q299*
BLCATCGA-BT-A2LB-01exon_skip_4307
36751969367528713675282536752825Nonsense_MutationCTp.Q332*
UCECTCGA-BS-A0TJ-01exon_skip_4318
36762184367623713676229836762298Nonsense_MutationCTp.R744*

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LOVO_LARGE_INTESTINE36762184367623713676233136762332Frame_Shift_Ins-Ap.E755fs
P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE36762184367623713676233136762332Frame_Shift_Ins-Ap.E755fs
BICR18_UPPER_AERODIGESTIVE_TRACT36751969367528713675250736752508In_Frame_Ins-CCAp.227_228insT
OC316_OVARY36751969367528713675198036751980Missense_MutationGAp.R50H
OC314_OVARY36751969367528713675198036751980Missense_MutationGAp.R50H
NCIH1651_LUNG36751969367528713675202136752021Missense_MutationCTp.H64Y
CORL303_LUNG36751969367528713675207936752079Missense_MutationCTp.P83L
IGR1_SKIN36751969367528713675211536752115Missense_MutationCAp.P95Q
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE36751969367528713675215436752154Missense_MutationGAp.R108H
22RV1_PROSTATE36751969367528713675228836752288Missense_MutationCTp.R153W
NCIH2342_LUNG36751969367528713675229836752298Missense_MutationGTp.R156L
BICR10_UPPER_AERODIGESTIVE_TRACT36751969367528713675239336752393Missense_MutationCTp.R188W
WM793_SKIN36751969367528713675245036752450Missense_MutationTCp.S207P
MDAMB453_BREAST36751969367528713675245336752453Missense_MutationGAp.G208R
SNUC2B_LARGE_INTESTINE36751969367528713675261936752619Missense_MutationGAp.R263Q
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE36751969367528713675262836752628Missense_MutationGAp.R266H
CCRFCEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE36751969367528713675269436752694Missense_MutationCTp.P288L
SARC9371_BONE36751969367528713675276336752763Missense_MutationCTp.P311L
LU135_LUNG36751969367528713675277336752773Missense_MutationGCp.K314N
HEC108_ENDOMETRIUM36759452367595363675947236759472Missense_MutationGAp.S684N
OV90_OVARY36759452367595363675948436759484Missense_MutationAGp.K688R
SLR26_KIDNEY36759452367595363675951636759516Missense_MutationCGp.P699A
NCIH2172_LUNG36762184367623713676226936762269Missense_MutationGAp.R734Q
SNUC5_LARGE_INTESTINE36751969367528713675219536752195Nonsense_MutationCTp.R122*
HCC2998_LARGE_INTESTINE36767154367672973676716036767160Nonsense_MutationCTp.R837*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for THRAP3

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_4289136690033:36690106:36690571:36690703:36724982:3672508536690571:36690703ENST00000469141.2GBMrs17439489chr1:36690599A/G1.15e-03
exon_skip_4289136690033:36690106:36690571:36690703:36724982:3672508536690571:36690703ENST00000469141.2ESCArs17439489chr1:36690599A/G4.61e-09
exon_skip_4289136690033:36690106:36690571:36690703:36724982:3672508536690571:36690703ENST00000469141.2HNSCrs17439489chr1:36690599A/G3.90e-11
exon_skip_4289136690033:36690106:36690571:36690703:36724982:3672508536690571:36690703ENST00000469141.2LGGrs17439489chr1:36690599A/G1.07e-19
exon_skip_4289136690033:36690106:36690571:36690703:36724982:3672508536690571:36690703ENST00000469141.2KIRCrs17439489chr1:36690599A/G5.50e-10
exon_skip_4289136690033:36690106:36690571:36690703:36724982:3672508536690571:36690703ENST00000469141.2LUADrs17439489chr1:36690599A/G5.61e-12
exon_skip_4289136690033:36690106:36690571:36690703:36724982:3672508536690571:36690703ENST00000469141.2OVrs17439489chr1:36690599A/G9.93e-11
exon_skip_4289136690033:36690106:36690571:36690703:36724982:3672508536690571:36690703ENST00000469141.2PRADrs17439489chr1:36690599A/G5.98e-11
exon_skip_4289136690033:36690106:36690571:36690703:36724982:3672508536690571:36690703ENST00000469141.2STADrs17439489chr1:36690599A/G1.59e-18
exon_skip_4289136690033:36690106:36690571:36690703:36724982:3672508536690571:36690703ENST00000469141.2THCArs17439489chr1:36690599A/G2.23e-10
exon_skip_4307136748133:36748301:36751968:36752871:36754660:3675536536751968:36752871ENST00000469141.2,ENST00000354618.5ESCArs6425977chr1:36752433C/T3.90e-09
exon_skip_4307136748133:36748301:36751968:36752871:36754660:3675536536751968:36752871ENST00000469141.2,ENST00000354618.5HNSCrs6425977chr1:36752433C/T2.75e-10
exon_skip_4307136748133:36748301:36751968:36752871:36754660:3675536536751968:36752871ENST00000469141.2,ENST00000354618.5LGGrs6425977chr1:36752433C/T1.14e-15
exon_skip_4307136748133:36748301:36751968:36752871:36754660:3675536536751968:36752871ENST00000469141.2,ENST00000354618.5KIRCrs6425977chr1:36752433C/T1.55e-08
exon_skip_4307136748133:36748301:36751968:36752871:36754660:3675536536751968:36752871ENST00000469141.2,ENST00000354618.5LUADrs6425977chr1:36752433C/T5.16e-07
exon_skip_4307136748133:36748301:36751968:36752871:36754660:3675536536751968:36752871ENST00000469141.2,ENST00000354618.5LUSCrs6425977chr1:36752433C/T4.48e-18
exon_skip_4307136748133:36748301:36751968:36752871:36754660:3675536536751968:36752871ENST00000469141.2,ENST00000354618.5OVrs6425977chr1:36752433C/T5.90e-07
exon_skip_4307136748133:36748301:36751968:36752871:36754660:3675536536751968:36752871ENST00000469141.2,ENST00000354618.5PRADrs6425977chr1:36752433C/T3.27e-10
exon_skip_4307136748133:36748301:36751968:36752871:36754660:3675536536751968:36752871ENST00000469141.2,ENST00000354618.5STADrs6425977chr1:36752433C/T7.56e-14
exon_skip_4307136748133:36748301:36751968:36752871:36754660:3675536536751968:36752871ENST00000469141.2,ENST00000354618.5THCArs6425977chr1:36752433C/T2.33e-08

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for THRAP3


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for THRAP3


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RelatedDrugs for THRAP3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for THRAP3

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource