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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TRIM14 |
 Gene summary |
| Gene information | Gene symbol | TRIM14 | Gene ID | 9830 |
| Gene name | tripartite motif containing 14 | |
| Synonyms | - | |
| Cytomap | 9q22.33 | |
| Type of gene | protein-coding | |
| Description | tripartite motif-containing protein 14tripartite motif protein TRIM14 | |
| Modification date | 20180527 | |
| UniProtAcc | Q14142 | |
| Context | PubMed: TRIM14 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRIM14 | GO:0032897 | negative regulation of viral transcription | 18248090 |
| TRIM14 | GO:0045087 | innate immune response | 18248090 |
| TRIM14 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 23077300 |
| TRIM14 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 23077300 |
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Exon skipping events across known transcript of Ensembl for TRIM14 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TRIM14 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TRIM14 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_505311 | 9 | 100850181:100850287:100854190:100854283:100857148:100857311 | 100854190:100854283 | ENSG00000106785.10 | ENST00000342043.3,ENST00000475147.1,ENST00000341469.2,ENST00000375098.3 |
| exon_skip_505316 | 9 | 100854241:100854283:100857148:100857311:100862212:100862258 | 100857148:100857311 | ENSG00000106785.10 | ENST00000342043.3,ENST00000475147.1,ENST00000341469.2,ENST00000375098.3 |
| exon_skip_505318 | 9 | 100857148:100857311:100862212:100862446:100872170:100872266 | 100862212:100862446 | ENSG00000106785.10 | ENST00000478401.1,ENST00000342043.3,ENST00000341469.2,ENST00000375098.3 |
| exon_skip_505320 | 9 | 100862212:100862446:100872170:100872266:100881263:100881418 | 100872170:100872266 | ENSG00000106785.10 | ENST00000342043.3,ENST00000341469.2 |
| exon_skip_505322 | 9 | 100872170:100872266:100872350:100872516:100881263:100881418 | 100872350:100872516 | ENSG00000106785.10 | ENST00000478401.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TRIM14 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_505311 | 9 | 100850181:100850287:100854190:100854283:100857148:100857311 | 100854190:100854283 | ENSG00000106785.10 | ENST00000375098.3,ENST00000341469.2,ENST00000342043.3,ENST00000475147.1 |
| exon_skip_505316 | 9 | 100854241:100854283:100857148:100857311:100862212:100862258 | 100857148:100857311 | ENSG00000106785.10 | ENST00000375098.3,ENST00000341469.2,ENST00000342043.3,ENST00000475147.1 |
| exon_skip_505318 | 9 | 100857148:100857311:100862212:100862446:100872170:100872266 | 100862212:100862446 | ENSG00000106785.10 | ENST00000375098.3,ENST00000341469.2,ENST00000342043.3,ENST00000478401.1 |
| exon_skip_505320 | 9 | 100862212:100862446:100872170:100872266:100881263:100881418 | 100872170:100872266 | ENSG00000106785.10 | ENST00000341469.2,ENST00000342043.3 |
| exon_skip_505322 | 9 | 100872170:100872266:100872350:100872516:100881263:100881418 | 100872350:100872516 | ENSG00000106785.10 | ENST00000478401.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TRIM14 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000341469 | 100857148 | 100857311 | Frame-shift |
| ENST00000342043 | 100857148 | 100857311 | Frame-shift |
| ENST00000375098 | 100857148 | 100857311 | Frame-shift |
| ENST00000341469 | 100854190 | 100854283 | In-frame |
| ENST00000342043 | 100854190 | 100854283 | In-frame |
| ENST00000375098 | 100854190 | 100854283 | In-frame |
| ENST00000341469 | 100862212 | 100862446 | In-frame |
| ENST00000342043 | 100862212 | 100862446 | In-frame |
| ENST00000375098 | 100862212 | 100862446 | In-frame |
| ENST00000341469 | 100872170 | 100872266 | In-frame |
| ENST00000342043 | 100872170 | 100872266 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000341469 | 100857148 | 100857311 | Frame-shift |
| ENST00000342043 | 100857148 | 100857311 | Frame-shift |
| ENST00000375098 | 100857148 | 100857311 | Frame-shift |
| ENST00000341469 | 100854190 | 100854283 | In-frame |
| ENST00000342043 | 100854190 | 100854283 | In-frame |
| ENST00000375098 | 100854190 | 100854283 | In-frame |
| ENST00000341469 | 100862212 | 100862446 | In-frame |
| ENST00000342043 | 100862212 | 100862446 | In-frame |
| ENST00000375098 | 100862212 | 100862446 | In-frame |
| ENST00000341469 | 100872170 | 100872266 | In-frame |
| ENST00000342043 | 100872170 | 100872266 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRIM14 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000341469 | 4471 | 442 | 100872170 | 100872266 | 218 | 313 | 69 | 101 |
| ENST00000342043 | 1496 | 442 | 100872170 | 100872266 | 218 | 313 | 69 | 101 |
| ENST00000341469 | 4471 | 442 | 100862212 | 100862446 | 314 | 547 | 101 | 179 |
| ENST00000342043 | 1496 | 442 | 100862212 | 100862446 | 314 | 547 | 101 | 179 |
| ENST00000375098 | 1809 | 442 | 100862212 | 100862446 | 326 | 559 | 101 | 179 |
| ENST00000341469 | 4471 | 442 | 100854190 | 100854283 | 711 | 803 | 233 | 264 |
| ENST00000342043 | 1496 | 442 | 100854190 | 100854283 | 711 | 803 | 233 | 264 |
| ENST00000375098 | 1809 | 442 | 100854190 | 100854283 | 723 | 815 | 233 | 264 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000341469 | 4471 | 442 | 100872170 | 100872266 | 218 | 313 | 69 | 101 |
| ENST00000342043 | 1496 | 442 | 100872170 | 100872266 | 218 | 313 | 69 | 101 |
| ENST00000341469 | 4471 | 442 | 100862212 | 100862446 | 314 | 547 | 101 | 179 |
| ENST00000342043 | 1496 | 442 | 100862212 | 100862446 | 314 | 547 | 101 | 179 |
| ENST00000375098 | 1809 | 442 | 100862212 | 100862446 | 326 | 559 | 101 | 179 |
| ENST00000341469 | 4471 | 442 | 100854190 | 100854283 | 711 | 803 | 233 | 264 |
| ENST00000342043 | 1496 | 442 | 100854190 | 100854283 | 711 | 803 | 233 | 264 |
| ENST00000375098 | 1809 | 442 | 100854190 | 100854283 | 723 | 815 | 233 | 264 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TRIM14 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_505318 | 100862213 | 100862446 | 100862329 | 100862329 | Frame_Shift_Del | G | - | p.L141fs |
| KIRP | TCGA-A4-8515-01 | exon_skip_505318 | 100862213 | 100862446 | 100862406 | 100862406 | Frame_Shift_Del | A | - | p.F115fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_505320 | 100872171 | 100872266 | 100872244 | 100872244 | Frame_Shift_Del | T | - | p.K77fs |
| BLCA | TCGA-GC-A3RC-01 | exon_skip_505318 | 100862213 | 100862446 | 100862212 | 100862212 | Splice_Site | C | T | p.Q179_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| DMS273_LUNG | 100862213 | 100862446 | 100862410 | 100862411 | Frame_Shift_Ins | - | C | p.K114fs |
| C8166_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 100857149 | 100857311 | 100857241 | 100857241 | Missense_Mutation | A | T | p.L203H |
| SNU1040_LARGE_INTESTINE | 100857149 | 100857311 | 100857248 | 100857248 | Missense_Mutation | C | T | p.V201M |
| SARC9371_BONE | 100857149 | 100857311 | 100857296 | 100857296 | Missense_Mutation | C | T | p.E185K |
| NCIH2286_LUNG | 100862213 | 100862446 | 100862233 | 100862233 | Missense_Mutation | C | A | p.D173Y |
| HEL9217_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 100862213 | 100862446 | 100862412 | 100862412 | Missense_Mutation | C | T | p.G113E |
| CMK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 100862213 | 100862446 | 100862412 | 100862412 | Missense_Mutation | C | T | p.G113E |
| HEL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 100862213 | 100862446 | 100862412 | 100862412 | Missense_Mutation | C | T | p.G113E |
| DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 100862213 | 100862446 | 100862214 | 100862214 | Splice_Site | T | C | p.Q179R |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIM14 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIM14 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIM14 |
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RelatedDrugs for TRIM14 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM14 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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