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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for USP34

check button Gene summary
Gene informationGene symbol

USP34

Gene ID

9736

Gene nameubiquitin specific peptidase 34
Synonyms-
Cytomap

2p15

Type of geneprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase 34deubiquitinating enzyme 34ubiquitin specific protease 34ubiquitin thioesterase 34ubiquitin thiolesterase 34ubiquitin-specific-processing protease 34
Modification date20180523
UniProtAcc

Q70CQ2

ContextPubMed: USP34 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
USP34

GO:0016579

protein deubiquitination

14715245

USP34

GO:0071108

protein K48-linked deubiquitination

21383061

USP34

GO:0090263

positive regulation of canonical Wnt signaling pathway

21383061


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Exon skipping events across known transcript of Ensembl for USP34 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for USP34

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for USP34

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_339377261414684:61415844:61416044:61416204:61417405:6141754961416044:61416204ENSG00000115464.10ENST00000411912.1,ENST00000436269.1,ENST00000398571.2
exon_skip_339379261416044:61416204:61417405:61417549:61417652:6141779361417405:61417549ENSG00000115464.10ENST00000411912.1,ENST00000436269.1,ENST00000398571.2
exon_skip_339386261417405:61417549:61417652:61417793:61420035:6142011561417652:61417793ENSG00000115464.10ENST00000463046.1,ENST00000411912.1,ENST00000436269.1,ENST00000398571.2
exon_skip_339389261417761:61417793:61420035:61420115:61431631:6143173661420035:61420115ENSG00000115464.10ENST00000411912.1
exon_skip_339391261420035:61420115:61430274:61430341:61431390:6143146561430274:61430341ENSG00000115464.10ENST00000436269.1
exon_skip_339392261420035:61420115:61430274:61430398:61431390:6143146561430274:61430398ENSG00000115464.10ENST00000463046.1,ENST00000398571.2
exon_skip_339395261420035:61420115:61431631:61431736:61433151:6143325961431631:61431736ENSG00000115464.10ENST00000411912.1
exon_skip_339396261430274:61430398:61431390:61431515:61431631:6143173661431390:61431515ENSG00000115464.10ENST00000463046.1,ENST00000398571.2
exon_skip_339397261433151:61433259:61433894:61434021:61436033:6143611261433894:61434021ENSG00000115464.10ENST00000411912.1,ENST00000476716.1,ENST00000398571.2
exon_skip_339402261436033:61436112:61438906:61439064:61441194:6144135361438906:61439064ENSG00000115464.10ENST00000472689.1,ENST00000411912.1,ENST00000467128.1,ENST00000398571.2
exon_skip_339403261436033:61436112:61438906:61439064:61447444:6144750361438906:61439064ENSG00000115464.10ENST00000463046.1,ENST00000476716.1
exon_skip_339414261438906:61439064:61441194:61441413:61447444:6144750361441194:61441413ENSG00000115464.10ENST00000472689.1
exon_skip_339416261438906:61439064:61441194:61441829:61447444:6144750361441194:61441829ENSG00000115464.10ENST00000411912.1,ENST00000398571.2
exon_skip_339419261441761:61441829:61447444:61447592:61448636:6144873661447444:61447592ENSG00000115464.10ENST00000411912.1,ENST00000490527.1,ENST00000472706.1,ENST00000398571.2
exon_skip_339421261448693:61448741:61449753:61449798:61450194:6145029961449753:61449798ENSG00000115464.10ENST00000463046.1,ENST00000411912.1,ENST00000487547.1,ENST00000398571.2
exon_skip_339425261449766:61449798:61450194:61450299:61450382:6145043161450194:61450299ENSG00000115464.10ENST00000463046.1,ENST00000411912.1,ENST00000487547.1,ENST00000398571.2
exon_skip_339428261450382:61450431:61454201:61454353:61455779:6145585461454201:61454353ENSG00000115464.10ENST00000463046.1,ENST00000411912.1,ENST00000398571.2
exon_skip_339430261459586:61459667:61462979:61463045:61463160:6146320861462979:61463045ENSG00000115464.10ENST00000463046.1,ENST00000453734.1,ENST00000411912.1,ENST00000398571.2
exon_skip_339432261463160:61463208:61463295:61463371:61463459:6146352461463295:61463371ENSG00000115464.10ENST00000453734.1,ENST00000411912.1,ENST00000398571.2
exon_skip_339433261484338:61484485:61486845:61486911:61492531:6149269261486845:61486911ENSG00000115464.10ENST00000453734.1,ENST00000398571.2
exon_skip_339435261486845:61486911:61492531:61492692:61493118:6149317461492531:61492692ENSG00000115464.10ENST00000453734.1,ENST00000398571.2
exon_skip_339438261505522:61505578:61507378:61507483:61508224:6150827461507378:61507483ENSG00000115464.10ENST00000484179.1,ENST00000494867.1,ENST00000398571.2
exon_skip_339440261510279:61510404:61510543:61510584:61512009:6151209261510543:61510584ENSG00000115464.10ENST00000398571.2
exon_skip_339443261510543:61510584:61512009:61512092:61515811:6151601261512009:61512092ENSG00000115464.10ENST00000398571.2
exon_skip_339445261520598:61520685:61522083:61522167:61522302:6152242561522083:61522167ENSG00000115464.10ENST00000398571.2
exon_skip_339447261523934:61524060:61528085:61528295:61528488:6152858961528085:61528295ENSG00000115464.10ENST00000398571.2
exon_skip_339449261528488:61528589:61538674:61538822:61538918:6153904561538674:61538822ENSG00000115464.10ENST00000398571.2
exon_skip_339451261541719:61541879:61542009:61542109:61544788:6154490261542009:61542109ENSG00000115464.10ENST00000398571.2
exon_skip_339455261542009:61542109:61544788:61544902:61546307:6154646261544788:61544902ENSG00000115464.10ENST00000398571.2
exon_skip_339457261546307:61546462:61552509:61552592:61558410:6155850661552509:61552592ENSG00000115464.10ENST00000398571.2
exon_skip_339458261570949:61571164:61573391:61573482:61575004:6157516361573391:61573482ENSG00000115464.10ENST00000460004.1
exon_skip_339459261577394:61577524:61577702:61577828:61597455:6159754861577702:61577828ENSG00000115464.10ENST00000453133.1,ENST00000398571.2
exon_skip_339461261607303:61607496:61610403:61610471:61621987:6162213761610403:61610471ENSG00000115464.10ENST00000453133.1,ENST00000398571.2
exon_skip_339463261622317:61622368:61632842:61633263:61647880:6164796861632842:61633263ENSG00000115464.10ENST00000398571.2

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for USP34

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_339377261414684:61415844:61416044:61416204:61417405:6141754961416044:61416204ENSG00000115464.10ENST00000411912.1,ENST00000398571.2,ENST00000436269.1
exon_skip_339379261416044:61416204:61417405:61417549:61417652:6141779361417405:61417549ENSG00000115464.10ENST00000411912.1,ENST00000398571.2,ENST00000436269.1
exon_skip_339386261417405:61417549:61417652:61417793:61420035:6142011561417652:61417793ENSG00000115464.10ENST00000411912.1,ENST00000398571.2,ENST00000436269.1,ENST00000463046.1
exon_skip_339389261417761:61417793:61420035:61420115:61431631:6143173661420035:61420115ENSG00000115464.10ENST00000411912.1
exon_skip_339391261420035:61420115:61430274:61430341:61431390:6143146561430274:61430341ENSG00000115464.10ENST00000436269.1
exon_skip_339392261420035:61420115:61430274:61430398:61431390:6143146561430274:61430398ENSG00000115464.10ENST00000398571.2,ENST00000463046.1
exon_skip_339395261420035:61420115:61431631:61431736:61433151:6143325961431631:61431736ENSG00000115464.10ENST00000411912.1
exon_skip_339396261430274:61430398:61431390:61431515:61431631:6143173661431390:61431515ENSG00000115464.10ENST00000398571.2,ENST00000463046.1
exon_skip_339397261433151:61433259:61433894:61434021:61436033:6143611261433894:61434021ENSG00000115464.10ENST00000411912.1,ENST00000398571.2,ENST00000476716.1
exon_skip_339402261436033:61436112:61438906:61439064:61441194:6144135361438906:61439064ENSG00000115464.10ENST00000411912.1,ENST00000398571.2,ENST00000467128.1,ENST00000472689.1
exon_skip_339403261436033:61436112:61438906:61439064:61447444:6144750361438906:61439064ENSG00000115464.10ENST00000463046.1,ENST00000476716.1
exon_skip_339414261438906:61439064:61441194:61441413:61447444:6144750361441194:61441413ENSG00000115464.10ENST00000472689.1
exon_skip_339416261438906:61439064:61441194:61441829:61447444:6144750361441194:61441829ENSG00000115464.10ENST00000411912.1,ENST00000398571.2
exon_skip_339419261441761:61441829:61447444:61447592:61448636:6144873661447444:61447592ENSG00000115464.10ENST00000411912.1,ENST00000398571.2,ENST00000472706.1,ENST00000490527.1
exon_skip_339421261448693:61448741:61449753:61449798:61450194:6145029961449753:61449798ENSG00000115464.10ENST00000411912.1,ENST00000398571.2,ENST00000463046.1,ENST00000487547.1
exon_skip_339425261449766:61449798:61450194:61450299:61450382:6145043161450194:61450299ENSG00000115464.10ENST00000411912.1,ENST00000398571.2,ENST00000463046.1,ENST00000487547.1
exon_skip_339428261450382:61450431:61454201:61454353:61455779:6145585461454201:61454353ENSG00000115464.10ENST00000411912.1,ENST00000398571.2,ENST00000463046.1
exon_skip_339430261459586:61459667:61462979:61463045:61463160:6146320861462979:61463045ENSG00000115464.10ENST00000411912.1,ENST00000398571.2,ENST00000463046.1,ENST00000453734.1
exon_skip_339432261463160:61463208:61463295:61463371:61463459:6146352461463295:61463371ENSG00000115464.10ENST00000411912.1,ENST00000398571.2,ENST00000453734.1
exon_skip_339433261484338:61484485:61486845:61486911:61492531:6149269261486845:61486911ENSG00000115464.10ENST00000398571.2,ENST00000453734.1
exon_skip_339435261486845:61486911:61492531:61492692:61493118:6149317461492531:61492692ENSG00000115464.10ENST00000398571.2,ENST00000453734.1
exon_skip_339438261505522:61505578:61507378:61507483:61508224:6150827461507378:61507483ENSG00000115464.10ENST00000398571.2,ENST00000484179.1,ENST00000494867.1
exon_skip_339440261510279:61510404:61510543:61510584:61512009:6151209261510543:61510584ENSG00000115464.10ENST00000398571.2
exon_skip_339443261510543:61510584:61512009:61512092:61515811:6151601261512009:61512092ENSG00000115464.10ENST00000398571.2
exon_skip_339445261520598:61520685:61522083:61522167:61522302:6152242561522083:61522167ENSG00000115464.10ENST00000398571.2
exon_skip_339447261523934:61524060:61528085:61528295:61528488:6152858961528085:61528295ENSG00000115464.10ENST00000398571.2
exon_skip_339449261528488:61528589:61538674:61538822:61538918:6153904561538674:61538822ENSG00000115464.10ENST00000398571.2
exon_skip_339451261541719:61541879:61542009:61542109:61544788:6154490261542009:61542109ENSG00000115464.10ENST00000398571.2
exon_skip_339455261542009:61542109:61544788:61544902:61546307:6154646261544788:61544902ENSG00000115464.10ENST00000398571.2
exon_skip_339457261546307:61546462:61552509:61552592:61558410:6155850661552509:61552592ENSG00000115464.10ENST00000398571.2
exon_skip_339458261570949:61571164:61573391:61573482:61575004:6157516361573391:61573482ENSG00000115464.10ENST00000460004.1
exon_skip_339459261577394:61577524:61577702:61577828:61597455:6159754861577702:61577828ENSG00000115464.10ENST00000398571.2,ENST00000453133.1
exon_skip_339461261607303:61607496:61610403:61610471:61621987:6162213761610403:61610471ENSG00000115464.10ENST00000398571.2,ENST00000453133.1
exon_skip_339463261622317:61622368:61632842:61633263:61647880:6164796861632842:61633263ENSG00000115464.10ENST00000398571.2

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for USP34

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003985716141604461416204Frame-shift
ENST000003985716143027461430398Frame-shift
ENST000003985716143139061431515Frame-shift
ENST000003985716143389461434021Frame-shift
ENST000003985716143890661439064Frame-shift
ENST000003985716144119461441829Frame-shift
ENST000003985716144744461447592Frame-shift
ENST000003985716145420161454353Frame-shift
ENST000003985716146329561463371Frame-shift
ENST000003985716149253161492692Frame-shift
ENST000003985716151054361510584Frame-shift
ENST000003985716151200961512092Frame-shift
ENST000003985716153867461538822Frame-shift
ENST000003985716154200961542109Frame-shift
ENST000003985716155250961552592Frame-shift
ENST000003985716161040361610471Frame-shift
ENST000003985716163284261633263Frame-shift
ENST000003985716141740561417549In-frame
ENST000003985716141765261417793In-frame
ENST000003985716144975361449798In-frame
ENST000003985716145019461450299In-frame
ENST000003985716146297961463045In-frame
ENST000003985716148684561486911In-frame
ENST000003985716150737861507483In-frame
ENST000003985716152208361522167In-frame
ENST000003985716152808561528295In-frame
ENST000003985716154478861544902In-frame
ENST000003985716157770261577828In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST000003985716141604461416204Frame-shift
ENST000003985716143027461430398Frame-shift
ENST000003985716143139061431515Frame-shift
ENST000003985716143389461434021Frame-shift
ENST000003985716143890661439064Frame-shift
ENST000003985716144119461441829Frame-shift
ENST000003985716144744461447592Frame-shift
ENST000003985716145420161454353Frame-shift
ENST000003985716146329561463371Frame-shift
ENST000003985716149253161492692Frame-shift
ENST000003985716151054361510584Frame-shift
ENST000003985716151200961512092Frame-shift
ENST000003985716153867461538822Frame-shift
ENST000003985716154200961542109Frame-shift
ENST000003985716155250961552592Frame-shift
ENST000003985716161040361610471Frame-shift
ENST000003985716163284261633263Frame-shift
ENST000003985716141740561417549In-frame
ENST000003985716141765261417793In-frame
ENST000003985716144975361449798In-frame
ENST000003985716145019461450299In-frame
ENST000003985716146297961463045In-frame
ENST000003985716148684561486911In-frame
ENST000003985716150737861507483In-frame
ENST000003985716152208361522167In-frame
ENST000003985716152808561528295In-frame
ENST000003985716154478861544902In-frame
ENST000003985716157770261577828In-frame

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Infer the effects of exon skipping event on protein functional features for USP34

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000398571113743546615777026157782813291454417459
ENST0000039857111374354661544788615449023246335910561094
ENST0000039857111374354661528085615282953996420513061376
ENST0000039857111374354661522083615221674455453814591487
ENST0000039857111374354661507378615074835229533317171752
ENST0000039857111374354661486845614869115856592119261948
ENST0000039857111374354661462979614630457044710923222344
ENST0000039857111374354661450194614502997722782625482583
ENST0000039857111374354661449753614497987827787125832598
ENST0000039857111374354661417652614177939666980631963243
ENST0000039857111374354661417405614175499807995032433291

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST00000398571113743546615777026157782813291454417459
ENST0000039857111374354661544788615449023246335910561094
ENST0000039857111374354661528085615282953996420513061376
ENST0000039857111374354661522083615221674455453814591487
ENST0000039857111374354661507378615074835229533317171752
ENST0000039857111374354661486845614869115856592119261948
ENST0000039857111374354661462979614630457044710923222344
ENST0000039857111374354661450194614502997722782625482583
ENST0000039857111374354661449753614497987827787125832598
ENST0000039857111374354661417652614177939666980631963243
ENST0000039857111374354661417405614175499807995032433291

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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SNVs in the skipped exons for USP34

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
USP34_LIHC_exon_skip_339392_psi_boxplot.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A3A0-01exon_skip_339377
61416045614162046141605161416051Frame_Shift_DelT-p.T3343fs
LIHCTCGA-G3-A3CJ-01exon_skip_339377
61416045614162046141605161416051Frame_Shift_DelT-p.T3343fs
COADTCGA-A6-6781-01exon_skip_339386
61417653614177936141769961417699Frame_Shift_DelA-p.L3228fs
LIHCTCGA-DD-A1EG-01exon_skip_339386
61417653614177936141769961417699Frame_Shift_DelA-p.L3228fs
LIHCTCGA-G3-A3CJ-01exon_skip_339386
61417653614177936141777761417777Frame_Shift_DelT-p.N3202fs
LIHCTCGA-DD-A1EG-01exon_skip_339396
61431391614315156143145961431459Frame_Shift_DelT-p.S3106fs
LIHCTCGA-DD-A39Y-01exon_skip_339416
61441195614418296144148361441483Frame_Shift_DelT-p.K2798fs
LIHCTCGA-DD-A1EG-01exon_skip_339416
61441195614418296144152961441529Frame_Shift_DelA-p.F2783fs
LIHCTCGA-G3-A3CJ-01exon_skip_339416
61441195614418296144171961441719Frame_Shift_DelT-p.T2721fs
LIHCTCGA-G3-A3CJ-01exon_skip_339428
61454202614543536145430561454305Frame_Shift_DelC-p.E2499fs
LIHCTCGA-DD-A39Y-01exon_skip_339432
61463296614633716146332061463320Frame_Shift_DelT-p.K2298fs
LIHCTCGA-DD-A1EG-01exon_skip_339438
61507379615074836150742961507429Frame_Shift_DelA-p.W1736fs
LIHCTCGA-DD-A3A0-01exon_skip_339438
61507379615074836150742961507429Frame_Shift_DelA-p.W1736fs
LIHCTCGA-G3-A3CJ-01exon_skip_339438
61507379615074836150742961507429Frame_Shift_DelA-p.W1736fs
LIHCTCGA-DD-A39Y-01exon_skip_339440
61510544615105846151057561510575Frame_Shift_DelT-p.K1614fs
LIHCTCGA-DD-A3A0-01exon_skip_339440
61510544615105846151057561510575Frame_Shift_DelT-p.K1614fs
LIHCTCGA-DD-A1EG-01exon_skip_339445
61522084615221676152214961522149Frame_Shift_DelA-p.Y1466fs
LIHCTCGA-DD-A3A0-01exon_skip_339457
61552510615525926155253761552537Frame_Shift_DelA-p.S996fs
LIHCTCGA-DD-A1EG-01exon_skip_339457
61552510615525926155255961552559Frame_Shift_DelA-p.L988fs
LUADTCGA-95-7562-01exon_skip_339463
61632843616332636163297361632974Frame_Shift_DelTT-p.K141fs
COADTCGA-A6-6780-01exon_skip_339463
61632843616332636163302061633020Frame_Shift_DelT-p.S126fs
STADTCGA-BR-4201-01exon_skip_339463
61632843616332636163302061633020Frame_Shift_DelT-p.S126fs
LUADTCGA-44-3398-01exon_skip_339463
61632843616332636163306561633068Frame_Shift_DelCTCT-p.RE109fs
LIHCTCGA-DD-A1EG-01exon_skip_339463
61632843616332636163321861633218Frame_Shift_DelA-p.F59fs
COADTCGA-AD-6889-01exon_skip_339445
61522084615221676152209961522100Frame_Shift_Ins-Tp.N1482fs
LGGTCGA-DU-6392-01exon_skip_339463
61632843616332636163301961633020Frame_Shift_Ins-Tp.NK125fs
UCECTCGA-BG-A0M0-01exon_skip_339463
61632843616332636163301961633020Frame_Shift_Ins-Tp.K125fs
LIHCTCGA-BC-A112-01exon_skip_339463
61632843616332636163321761633218Frame_Shift_Ins-Ap.LS59fs
HNSCTCGA-P3-A5QE-01exon_skip_339391
61430275614303416143032361430323Nonsense_MutationGAp.R3154*
HNSCTCGA-P3-A5QE-01exon_skip_339392
61430275614303986143032361430323Nonsense_MutationGAp.R3154*
STADTCGA-HU-A4GN-01exon_skip_339402
exon_skip_339403
61438907614390646143903761439037Nonsense_MutationGAp.Q2904*
UCECTCGA-AP-A0LE-01exon_skip_339419
61447445614475926144750861447508Nonsense_MutationGAp.Q2662*
PRADTCGA-XK-AAIW-01exon_skip_339432
61463296614633716146336261463362Nonsense_MutationCTp.W2284*
BRCATCGA-A8-A09A-01exon_skip_339435
61492532614926926149266561492665Nonsense_MutationCTp.W1882*
BLCATCGA-KQ-A41P-01exon_skip_339447
61528086615282956152824161528241Nonsense_MutationGAp.Q1325*
LIHCTCGA-ED-A66Y-01exon_skip_339392
61430275614303986143040061430400Splice_SiteTG.
STADTCGA-BR-8487-01exon_skip_339445
61522084615221676152216861522168Splice_SiteCA.
STADTCGA-BR-8487-01exon_skip_339445
61522084615221676152216861522168Splice_SiteCAp.G1460_splice
READTCGA-EI-6510-01exon_skip_339459
61577703615778286157770261577702Splice_SiteCT.

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
USP34_61420035_61420115_61430274_61430398_61431390_61431465_TCGA-ED-A66Y-01Sample: TCGA-ED-A66Y-01
Cancer type: LIHC
ESID: exon_skip_339392
Skipped exon start: 61430275
Skipped exon end: 61430398
Mutation start: 61430400
Mutation end: 61430400
Mutation type: Splice_Site
Reference seq: T
Mutation seq: G
AAchange: .
exon_skip_339392_LIHC_TCGA-ED-A66Y-01.png
boxplot
exon_skip_488549_LIHC_TCGA-ED-A66Y-01.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
MEL202_EYE61433895614340216143401161434015Frame_Shift_DelGTGTT-p.NT2976fs
JHUEM2_ENDOMETRIUM61632843616332636163290561632905Frame_Shift_DelT-p.I164fs
22RV1_PROSTATE61632843616332636163302061633020Frame_Shift_DelT-p.K125fs
OC316_OVARY61632843616332636163302061633020Frame_Shift_DelT-p.K125fs
DV90_LUNG61632843616332636163302061633020Frame_Shift_DelT-p.K125fs
CW2_LARGE_INTESTINE61632843616332636163302061633020Frame_Shift_DelT-p.K125fs
OC314_OVARY61632843616332636163302061633020Frame_Shift_DelT-p.K125fs
C33A_CERVIX61542010615421096154208361542084Frame_Shift_Ins-Cp.G1103fs
NCIH1155_LUNG61632843616332636163301961633020Frame_Shift_Ins-Tp.S126fs
OSC20_UPPER_AERODIGESTIVE_TRACT61416045614162046141607061416070Missense_MutationTGp.Q3336H
SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61416045614162046141607561416075Missense_MutationCTp.E3335K
L33_PANCREAS61416045614162046141613561416135Missense_MutationTCp.T3315A
AU565_BREAST61416045614162046141614461416144Missense_MutationGCp.L3312V
SKBR3_BREAST61416045614162046141614461416144Missense_MutationGCp.L3312V
BICR18_UPPER_AERODIGESTIVE_TRACT61417406614175496141741761417417Missense_MutationACp.S3288A
LOVO_LARGE_INTESTINE61417406614175496141744661417446Missense_MutationTCp.N3278S
CW2_LARGE_INTESTINE61417406614175496141746461417464Missense_MutationAGp.L3272P
HCC1569_BREAST61417406614175496141750161417501Missense_MutationTCp.T3260A
CHLA06ATRT_SOFT_TISSUE61417653614177936141768261417682Missense_MutationAGp.Y3234H
SNU1040_LARGE_INTESTINE61417653614177936141770261417702Missense_MutationAGp.F3227S
LB1047EBV_MATCHED_NORMAL_TISSUE61420036614201156142004361420043Missense_MutationTCp.Q3194R
LB1047RCC_KIDNEY61420036614201156142004361420043Missense_MutationTCp.Q3194R
UMUC1_URINARY_TRACT61430275614303986143037461430374Missense_MutationTAp.M3137L
HCC2998_LARGE_INTESTINE61430275614303986143037861430378Missense_MutationACp.D3135E
LN18_CENTRAL_NERVOUS_SYSTEM61431391614315156143140561431405Missense_MutationCAp.V3124L
NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61431391614315156143141161431411Missense_MutationTCp.T3122A
HEC59_ENDOMETRIUM61431391614315156143144161431441Missense_MutationGAp.R3112C
JHUEM7_ENDOMETRIUM61431391614315156143148561431485Missense_MutationTGp.E3097A
HEC1A_ENDOMETRIUM61431391614315156143150661431506Missense_MutationCAp.G3090V
HEC1_ENDOMETRIUM61431391614315156143150661431506Missense_MutationCAp.G3090V
HEC1B_ENDOMETRIUM61431391614315156143150661431506Missense_MutationCAp.G3090V
JHUEM7_ENDOMETRIUM61431632614317366143166061431660Missense_MutationACp.H3077Q
TGBC24TKB_BILIARY_TRACT61431632614317366143168661431686Missense_MutationGCp.L3069V
HEC108_ENDOMETRIUM61431632614317366143170361431703Missense_MutationTCp.H3063R
PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61433895614340216143394361433943Missense_MutationTCp.I3000V
FTC238_THYROID61433895614340216143398861433988Missense_MutationCTp.A2985T
HCT15_LARGE_INTESTINE61438907614390646143904561439045Missense_MutationTCp.N2901S
KIJK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61441195614418296144120861441208Missense_MutationCAp.S2890I
KIJK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61441195614414136144120861441208Missense_MutationCAp.S2890I
SW48_LARGE_INTESTINE61441195614418296144139361441393Missense_MutationGTp.N2828K
SW48_LARGE_INTESTINE61441195614414136144139361441393Missense_MutationGTp.N2828K
NCIH2342_LUNG61441195614418296144142761441427Missense_MutationCTp.R2817H
CP66MEL_SKIN61441195614418296144158361441583Missense_MutationGAp.S2765F
BICR18_UPPER_AERODIGESTIVE_TRACT61441195614418296144160961441609Missense_MutationACp.F2756L
DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61441195614418296144160961441609Missense_MutationACp.F2756L
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61441195614418296144160961441609Missense_MutationACp.F2756L
OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61441195614418296144160961441609Missense_MutationACp.F2756L
BICR18_UPPER_AERODIGESTIVE_TRACT61441195614418296144161161441611Missense_MutationAGp.F2756L
DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61441195614418296144161161441611Missense_MutationAGp.F2756L
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61441195614418296144161161441611Missense_MutationAGp.F2756L
OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61441195614418296144161161441611Missense_MutationAGp.F2756L
NCIH1793_LUNG61441195614418296144168961441689Missense_MutationCTp.V2730M
LS180_LARGE_INTESTINE61441195614418296144170061441700Missense_MutationTAp.Q2726L
RERFGC1B_STOMACH61441195614418296144173961441739Missense_MutationTCp.D2713G
KM12_LARGE_INTESTINE61441195614418296144174361441743Missense_MutationGAp.R2712C
OVK18_OVARY61441195614418296144180261441802Missense_MutationAGp.I2692T
HEC151_ENDOMETRIUM61441195614418296144180661441806Missense_MutationGAp.L2691F
CALU1_LUNG61447445614475926144745361447453Missense_MutationACp.V2680G
HCC2998_LARGE_INTESTINE61447445614475926144752261447522Missense_MutationTCp.H2657R
SHP77_LUNG61449754614497986144975961449759Missense_MutationGAp.P2597S
BT474_BREAST61450195614502996145026961450269Missense_MutationCTp.D2559N
GB1_CENTRAL_NERVOUS_SYSTEM61450195614502996145029461450294Missense_MutationATp.F2550L
CHP134_AUTONOMIC_GANGLIA61454202614543536145430661454306Missense_MutationCAp.E2497D
HCT116_LARGE_INTESTINE61462980614630456146299261462992Missense_MutationCAp.Q2340H
SKMEL28_SKIN61463296614633716146333961463339Missense_MutationCTp.S2292N
MDAMB361_BREAST61486846614869116148688161486881Missense_MutationGCp.L1937V
JHU029_UPPER_AERODIGESTIVE_TRACT61486846614869116148689461486894Missense_MutationCAp.K1932N
JHUEM2_ENDOMETRIUM61492532614926926149258861492588Missense_MutationTCp.T1908A
EKVX_LUNG61492532614926926149266861492668Missense_MutationTCp.Y1881C
NCIH810_LUNG61507379615074836150742361507423Missense_MutationACp.L1738V
HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61512010615120926151203761512037Missense_MutationGAp.A1602V
2313287_STOMACH61512010615120926151206561512065Missense_MutationTCp.S1593G
LCLC103H_LUNG61512010615120926151207761512077Missense_MutationCAp.V1589F
HEC251_ENDOMETRIUM61512010615120926151208661512086Missense_MutationGTp.L1586I
NCIH1836_LUNG61522084615221676152212261522122Missense_MutationCGp.D1475H
CAKI1_KIDNEY61528086615282956152812361528123Missense_MutationTCp.K1364R
NCIH2122_LUNG61528086615282956152822561528225Missense_MutationCAp.C1330F
22RV1_PROSTATE61528086615282956152823961528239Missense_MutationCGp.Q1325H
ES2_OVARY61528086615282956152825361528253Missense_MutationCGp.G1321R
RKO_LARGE_INTESTINE61528086615282956152825861528258Missense_MutationCTp.R1319Q
TE8_OESOPHAGUS61538675615388226153877761538777Missense_MutationCTp.A1239T
CAL54_KIDNEY61538675615388226153880661538806Missense_MutationTAp.Y1229F
22RV1_PROSTATE61538675615388226153880761538807Missense_MutationAGp.Y1229H
BC3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61538675615388226153881161538811Missense_MutationTAp.E1227D
BC3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61538675615388226153881361538813Missense_MutationCTp.E1227K
RERFLCAD2_LUNG61542010615421096154202161542021Missense_MutationTCp.Y1124C
MDAMB361_BREAST61542010615421096154206161542061Missense_MutationCTp.G1111S
BICR18_UPPER_AERODIGESTIVE_TRACT61544789615449026154480361544803Missense_MutationACp.C1090G
JHUEM7_ENDOMETRIUM61544789615449026154482961544829Missense_MutationCTp.R1081Q
CAL120_BREAST61544789615449026154487461544874Missense_MutationCGp.S1066T
TE12_OESOPHAGUS61552510615525926155256161552561Missense_MutationGAp.L988F
COGN305_AUTONOMIC_GANGLIA61577703615778286157771061577710Missense_MutationGTp.T457N
BFTC905_URINARY_TRACT61577703615778286157773161577731Missense_MutationGCp.A450G
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61577703615778286157780761577807Missense_MutationTCp.I425V
HEC108_ENDOMETRIUM61632843616332636163285661632856Missense_MutationTCp.H180R
KALS1_CENTRAL_NERVOUS_SYSTEM61632843616332636163292161632921Missense_MutationTAp.L158F
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61632843616332636163294661632946Missense_MutationCTp.S150N
BICR18_UPPER_AERODIGESTIVE_TRACT61632843616332636163294661632946Missense_MutationCTp.S150N
VMRCRCW_KIDNEY61632843616332636163297061632970Missense_MutationCAp.S142I
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61632843616332636163300361633003Missense_MutationAGp.I131T
OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61632843616332636163300361633003Missense_MutationAGp.I131T
BICR18_UPPER_AERODIGESTIVE_TRACT61632843616332636163300361633003Missense_MutationAGp.I131T
RMUGS_OVARY61632843616332636163300661633006Missense_MutationCAp.R130I
BT12_SOFT_TISSUE61632843616332636163302861633028Missense_MutationCTp.E123K
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61632843616332636163305161633051Missense_MutationCTp.S115N
MDAMB415_BREAST61632843616332636163307361633073Missense_MutationCGp.D108H
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61632843616332636163307861633078Missense_MutationTCp.N106S
BICR18_UPPER_AERODIGESTIVE_TRACT61632843616332636163307861633078Missense_MutationTCp.N106S
MKN7_STOMACH61632843616332636163312461633124Missense_MutationCAp.D91Y
CW2_LARGE_INTESTINE61632843616332636163313561633135Missense_MutationGAp.T87I
DMS273_LUNG61632843616332636163319661633196Missense_MutationTGp.I67L
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61632843616332636163322361633223Missense_MutationTAp.I58F
AU565_BREAST61416045614162046141608361416083Nonsense_MutationGCp.S3332*
SKBR3_BREAST61416045614162046141608361416083Nonsense_MutationGCp.S3332*
SW48_LARGE_INTESTINE61416045614162046141609661416096Nonsense_MutationGAp.Q3328*
TGBC11TKB_STOMACH61417653614177936141769961417699Nonsense_MutationATp.L3228*
OCIM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61441195614418296144146261441462Nonsense_MutationCTp.W2805*
NCIH1568_LUNG61492532614926926149258261492582Nonsense_MutationGAp.Q1910*
KGN_OVARY61542010615421096154208661542086Nonsense_MutationCTp.W1102*
BT12_SOFT_TISSUE61632843616332636163303361633033Nonsense_MutationGTp.S121*
SNU1040_LARGE_INTESTINE61417653614177936141779261417792Splice_SiteGTp.S3197Y
C2BBE1_LARGE_INTESTINE61492532614926926149269161492691Splice_SiteGCp.S1873S
HEC151_ENDOMETRIUM61512010615120926151209161512091Splice_SiteAGp.V1584A
SJSA1_BONE61538675615388226153867561538675Splice_SiteCAp.G1273*
HCT15_LARGE_INTESTINE61610404616104716161040461610404Splice_SiteCAp.R274M

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for USP34

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for USP34


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for USP34


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RelatedDrugs for USP34

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for USP34

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource