|
||||||
|
 | |
| |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
| |
|
Gene summary for CD79A |
 Gene summary |
| Gene information | Gene symbol | CD79A | Gene ID | 973 |
| Gene name | CD79a molecule | |
| Synonyms | IGA|MB-1 | |
| Cytomap | 19q13.2 | |
| Type of gene | protein-coding | |
| Description | B-cell antigen receptor complex-associated protein alpha chainCD79a antigen (immunoglobulin-associated alpha)CD79a molecule, immunoglobulin-associated alphaMB-1 membrane glycoproteinig-alphamembrane-bound immunoglobulin-associated proteinsurface IgM | |
| Modification date | 20180523 | |
| UniProtAcc | P11912 | |
| Context | PubMed: CD79A [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Exon skipping events across known transcript of Ensembl for CD79A from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Gene isoform structures and expression levels for CD79A |
| Expression levels of gene isoforms across TCGA. |
 |
| Expression levels of gene isoforms across GTEx. |
 |
Top |
Exon skipping events with PSIs in TCGA for CD79A |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_307616 | 19 | 42383059:42383359:42383604:42383723:42384736:42384769 | 42383604:42383723 | ENSG00000105369.5 | ENST00000221972.3 |
| PSI values of skipped exons in TCGA. |
 |
Top |
Exon skipping events with PSIs in GTEx for CD79A |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_307616 | 19 | 42383059:42383359:42383604:42383723:42384736:42384769 | 42383604:42383723 | ENSG00000105369.5 | ENST00000221972.3 |
| PSI values of skipped exons in GTEx. |
 |
| * Skipped exon sequences. |
Top |
Open reading frame (ORF) annotation in the exon skipping event for CD79A |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000221972 | 42383604 | 42383723 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000221972 | 42383604 | 42383723 | Frame-shift |
Top |
Infer the effects of exon skipping event on protein functional features for CD79A |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
 |
| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
SNVs in the skipped exons for CD79A |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-CM-4743-01 | exon_skip_307616 | 42383605 | 42383723 | 42383610 | 42383610 | Frame_Shift_Del | C | - | p.P90fs |
| ESCA | TCGA-L5-A4OI-01 | exon_skip_307616 | 42383605 | 42383723 | 42383610 | 42383610 | Frame_Shift_Del | C | - | p.P128fs |
| ESCA | TCGA-L5-A4OI-01 | exon_skip_307616 | 42383605 | 42383723 | 42383610 | 42383610 | Frame_Shift_Del | C | - | p.P130fs |
| ESCA | TCGA-L5-A4OI-01 | exon_skip_307616 | 42383605 | 42383723 | 42383610 | 42383610 | Frame_Shift_Del | C | - | p.R131fs |
| STAD | TCGA-CG-5723-01 | exon_skip_307616 | 42383605 | 42383723 | 42383610 | 42383610 | Frame_Shift_Del | C | - | p.P129fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC108_ENDOMETRIUM | 42383605 | 42383723 | 42383610 | 42383610 | Frame_Shift_Del | C | - | p.P130fs |
| KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 42383605 | 42383723 | 42383610 | 42383610 | Frame_Shift_Del | C | - | p.P130fs |
| SNUC2A_LARGE_INTESTINE | 42383605 | 42383723 | 42383610 | 42383610 | Frame_Shift_Del | C | - | p.P130fs |
| TOV21G_OVARY | 42383605 | 42383723 | 42383610 | 42383610 | Frame_Shift_Del | C | - | p.P130fs |
| 2313287_STOMACH | 42383605 | 42383723 | 42383610 | 42383610 | Frame_Shift_Del | C | - | p.P130fs |
| KM12_LARGE_INTESTINE | 42383605 | 42383723 | 42383610 | 42383610 | Frame_Shift_Del | C | - | p.P130fs |
| MEWO_SKIN | 42383605 | 42383723 | 42383628 | 42383628 | Missense_Mutation | G | A | p.D135N |
| SARC9371_BONE | 42383605 | 42383723 | 42383650 | 42383650 | Missense_Mutation | A | T | p.N142I |
| K029AX_SKIN | 42383605 | 42383723 | 42383653 | 42383653 | Missense_Mutation | G | A | p.R143Q |
| G361_SKIN | 42383605 | 42383723 | 42383668 | 42383668 | Missense_Mutation | A | G | p.E148G |
| LIM1215_LARGE_INTESTINE | 42383605 | 42383723 | 42383679 | 42383679 | Missense_Mutation | C | A | p.L152I |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CD79A |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CD79A |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CD79A |
Top |
RelatedDrugs for CD79A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CD79A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| CD79A | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|