|
||||||
|
 | |
| |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
| |
|
Gene summary for CD74 |
 Gene summary |
| Gene information | Gene symbol | CD74 | Gene ID | 972 |
| Gene name | CD74 molecule | |
| Synonyms | DHLAG|HLADG|II|Ia-GAMMA | |
| Cytomap | 5q33.1 | |
| Type of gene | protein-coding | |
| Description | HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated | |
| Modification date | 20180522 | |
| UniProtAcc | P04233 | |
| Context | PubMed: CD74 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CD74 | GO:0001516 | prostaglandin biosynthetic process | 12782713 |
| CD74 | GO:0001934 | positive regulation of protein phosphorylation | 24942581 |
| CD74 | GO:0002792 | negative regulation of peptide secretion | 19849849 |
| CD74 | GO:0007165 | signal transduction | 12782713 |
| CD74 | GO:0008283 | cell proliferation | 12782713 |
| CD74 | GO:0033674 | positive regulation of kinase activity | 24942581 |
| CD74 | GO:0043066 | negative regulation of apoptotic process | 12782713 |
| CD74 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24942581 |
| CD74 | GO:0043410 | positive regulation of MAPK cascade | 24942581 |
| CD74 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 17045821 |
| CD74 | GO:0045657 | positive regulation of monocyte differentiation | 24942581 |
| CD74 | GO:0045893 | positive regulation of transcription, DNA-templated | 24942581 |
| CD74 | GO:0046598 | positive regulation of viral entry into host cell | 24942581 |
| CD74 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 17045821 |
| CD74 | GO:0051290 | protein heterotetramerization | 24942581 |
| CD74 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17045821|24942581 |
Top |
Exon skipping events across known transcript of Ensembl for CD74 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Gene isoform structures and expression levels for CD74 |
| Expression levels of gene isoforms across TCGA. |
 |
| Expression levels of gene isoforms across GTEx. |
 |
Top |
Exon skipping events with PSIs in TCGA for CD74 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_445363 | 5 | 149781732:149781813:149782125:149782188:149782683:149782875 | 149782125:149782188 | ENSG00000019582.10 | ENST00000523208.1,ENST00000009530.7 |
| exon_skip_445366 | 5 | 149781732:149781813:149782125:149782188:149784242:149784330 | 149782125:149782188 | ENSG00000019582.10 | ENST00000353334.6 |
| exon_skip_445390 | 5 | 149782173:149782188:149782683:149782875:149784242:149784330 | 149782683:149782875 | ENSG00000019582.10 | ENST00000518797.1,ENST00000009530.7 |
| exon_skip_445393 | 5 | 149782172:149782188:149782683:149782875:149785821:149785884 | 149782683:149782875 | ENSG00000019582.10 | ENST00000523208.1 |
| exon_skip_445401 | 5 | 149782166:149782188:149784242:149784330:149784647:149784725 | 149784242:149784330 | ENSG00000019582.10 | ENST00000353334.6 |
| exon_skip_445410 | 5 | 149782125:149782188:149785821:149785884:149786443:149786523 | 149785821:149785884 | ENSG00000019582.10 | ENST00000377795.3 |
| exon_skip_445433 | 5 | 149782683:149782875:149784242:149784330:149784647:149784743 | 149784242:149784330 | ENSG00000019582.10 | ENST00000518797.1,ENST00000009530.7 |
| exon_skip_445441 | 5 | 149784242:149784330:149784647:149784743:149785821:149785884 | 149784647:149784743 | ENSG00000019582.10 | ENST00000353334.6,ENST00000518797.1,ENST00000522246.1,ENST00000517752.1,ENST00000009530.7 |
| exon_skip_445446 | 5 | 149784647:149784743:149785821:149785884:149786443:149786523 | 149785821:149785884 | ENSG00000019582.10 | ENST00000353334.6,ENST00000518797.1,ENST00000517752.1,ENST00000009530.7 |
| exon_skip_445449 | 5 | 149785821:149785884:149786443:149786523:149786714:149786742 | 149786443:149786523 | ENSG00000019582.10 | ENST00000353334.6,ENST00000518797.1,ENST00000524315.1,ENST00000523208.1,ENST00000523836.1,ENST00000377795.3,ENST00000517752.1,ENST00000009530.7 |
| exon_skip_445458 | 5 | 149785821:149785884:149786443:149786887:149792187:149792295 | 149786443:149786887 | ENSG00000019582.10 | ENST00000517791.1 |
| exon_skip_445463 | 5 | 149785821:149785884:149786714:149786887:149792187:149792295 | 149786714:149786887 | ENSG00000019582.10 | ENST00000522246.1 |
| exon_skip_445475 | 5 | 149786443:149786523:149786714:149786887:149792187:149792295 | 149786714:149786887 | ENSG00000019582.10 | ENST00000522153.1,ENST00000353334.6,ENST00000518797.1,ENST00000524315.1,ENST00000523208.1,ENST00000523836.1,ENST00000517752.1,ENST00000009530.7 |
| PSI values of skipped exons in TCGA. |
 |
Top |
Exon skipping events with PSIs in GTEx for CD74 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_445363 | 5 | 149781732:149781813:149782125:149782188:149782683:149782875 | 149782125:149782188 | ENSG00000019582.10 | ENST00000009530.7,ENST00000523208.1 |
| exon_skip_445366 | 5 | 149781732:149781813:149782125:149782188:149784242:149784330 | 149782125:149782188 | ENSG00000019582.10 | ENST00000353334.6 |
| exon_skip_445390 | 5 | 149782173:149782188:149782683:149782875:149784242:149784330 | 149782683:149782875 | ENSG00000019582.10 | ENST00000518797.1,ENST00000009530.7 |
| exon_skip_445393 | 5 | 149782172:149782188:149782683:149782875:149785821:149785884 | 149782683:149782875 | ENSG00000019582.10 | ENST00000523208.1 |
| exon_skip_445401 | 5 | 149782166:149782188:149784242:149784330:149784647:149784725 | 149784242:149784330 | ENSG00000019582.10 | ENST00000353334.6 |
| exon_skip_445410 | 5 | 149782125:149782188:149785821:149785884:149786443:149786523 | 149785821:149785884 | ENSG00000019582.10 | ENST00000377795.3 |
| exon_skip_445433 | 5 | 149782683:149782875:149784242:149784330:149784647:149784743 | 149784242:149784330 | ENSG00000019582.10 | ENST00000518797.1,ENST00000009530.7 |
| exon_skip_445441 | 5 | 149784242:149784330:149784647:149784743:149785821:149785884 | 149784647:149784743 | ENSG00000019582.10 | ENST00000353334.6,ENST00000518797.1,ENST00000009530.7,ENST00000517752.1,ENST00000522246.1 |
| exon_skip_445446 | 5 | 149784647:149784743:149785821:149785884:149786443:149786523 | 149785821:149785884 | ENSG00000019582.10 | ENST00000353334.6,ENST00000518797.1,ENST00000009530.7,ENST00000517752.1 |
| exon_skip_445449 | 5 | 149785821:149785884:149786443:149786523:149786714:149786742 | 149786443:149786523 | ENSG00000019582.10 | ENST00000377795.3,ENST00000353334.6,ENST00000518797.1,ENST00000524315.1,ENST00000009530.7,ENST00000523208.1,ENST00000517752.1,ENST00000523836.1 |
| exon_skip_445458 | 5 | 149785821:149785884:149786443:149786887:149792187:149792295 | 149786443:149786887 | ENSG00000019582.10 | ENST00000517791.1 |
| exon_skip_445463 | 5 | 149785821:149785884:149786714:149786887:149792187:149792295 | 149786714:149786887 | ENSG00000019582.10 | ENST00000522246.1 |
| exon_skip_445475 | 5 | 149786443:149786523:149786714:149786887:149792187:149792295 | 149786714:149786887 | ENSG00000019582.10 | ENST00000353334.6,ENST00000518797.1,ENST00000524315.1,ENST00000009530.7,ENST00000523208.1,ENST00000517752.1,ENST00000523836.1,ENST00000522153.1 |
| PSI values of skipped exons in GTEx. |
 |
| * Skipped exon sequences. |
Top |
Open reading frame (ORF) annotation in the exon skipping event for CD74 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000009530 | 149784242 | 149784330 | Frame-shift |
| ENST00000009530 | 149786443 | 149786523 | Frame-shift |
| ENST00000009530 | 149786714 | 149786887 | Frame-shift |
| ENST00000009530 | 149782125 | 149782188 | In-frame |
| ENST00000009530 | 149782683 | 149782875 | In-frame |
| ENST00000009530 | 149784647 | 149784743 | In-frame |
| ENST00000009530 | 149785821 | 149785884 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000009530 | 149784242 | 149784330 | Frame-shift |
| ENST00000009530 | 149786443 | 149786523 | Frame-shift |
| ENST00000009530 | 149786714 | 149786887 | Frame-shift |
| ENST00000009530 | 149782125 | 149782188 | In-frame |
| ENST00000009530 | 149782683 | 149782875 | In-frame |
| ENST00000009530 | 149784647 | 149784743 | In-frame |
| ENST00000009530 | 149785821 | 149785884 | In-frame |
Top |
Infer the effects of exon skipping event on protein functional features for CD74 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
 |
| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000009530 | 998 | 296 | 149785821 | 149785884 | 381 | 443 | 126 | 147 |
| ENST00000009530 | 998 | 296 | 149784647 | 149784743 | 444 | 539 | 147 | 179 |
| ENST00000009530 | 998 | 296 | 149782683 | 149782875 | 628 | 819 | 208 | 272 |
| ENST00000009530 | 998 | 296 | 149782125 | 149782188 | 820 | 882 | 272 | 293 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000009530 | 998 | 296 | 149785821 | 149785884 | 381 | 443 | 126 | 147 |
| ENST00000009530 | 998 | 296 | 149784647 | 149784743 | 444 | 539 | 147 | 179 |
| ENST00000009530 | 998 | 296 | 149782683 | 149782875 | 628 | 819 | 208 | 272 |
| ENST00000009530 | 998 | 296 | 149782125 | 149782188 | 820 | 882 | 272 | 293 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
SNVs in the skipped exons for CD74 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
 |
| - Differential PSIs between mutated versus non-mutated samples. |
CD74_LIHC_exon_skip_445458_psi_boxplot.png |
CD74_SKCM_exon_skip_445458_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BLCA | TCGA-XF-AAME-01 | exon_skip_445401 exon_skip_445433 | 149784243 | 149784330 | 149784266 | 149784266 | Frame_Shift_Del | T | - | p.K201fs |
| THCA | TCGA-DJ-A4V2-01 | exon_skip_445401 exon_skip_445433 | 149784243 | 149784330 | 149784320 | 149784321 | Frame_Shift_Del | CT | - | p.S183fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_445449 | 149786444 | 149786523 | 149786455 | 149786455 | Frame_Shift_Del | G | - | p.L123fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_445458 | 149786444 | 149786887 | 149786455 | 149786455 | Frame_Shift_Del | G | - | p.L123fs |
| SKCM | TCGA-EE-A2A1-06 | exon_skip_445458 | 149786444 | 149786887 | 149786757 | 149786757 | Nonsense_Mutation | G | A | p.Q86* |
| SKCM | TCGA-EE-A2A1-06 | exon_skip_445475 exon_skip_445463 | 149786715 | 149786887 | 149786757 | 149786757 | Nonsense_Mutation | G | A | p.Q86* |
| BRCA | TCGA-BH-A0AY-01 | exon_skip_445441 | 149784648 | 149784743 | 149784647 | 149784647 | Splice_Site | C | - | e5+1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-EE-A2A1-06 |
| Cancer type: SKCM | |
| ESID: exon_skip_445458 | |
| Skipped exon start: 149786444 | |
| Skipped exon end: 149786887 | |
| Mutation start: 149786757 | |
| Mutation end: 149786757 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.Q86* | |
| Sample: TCGA-EE-A2A1-06 |
| Cancer type: SKCM | |
| ESID: exon_skip_445463 | |
| Skipped exon start: 149786715 | |
| Skipped exon end: 149786887 | |
| Mutation start: 149786757 | |
| Mutation end: 149786757 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.Q86* | |
exon_skip_138676_SKCM_TCGA-EE-A2A1-06.png | |
exon_skip_445458_SKCM_TCGA-EE-A2A1-06.png | |
exon_skip_49506_SKCM_TCGA-EE-A2A1-06.png | |
 | Sample: TCGA-DD-A39Y-01 |
| Cancer type: LIHC | |
| ESID: exon_skip_445458 | |
| Skipped exon start: 149786444 | |
| Skipped exon end: 149786887 | |
| Mutation start: 149786455 | |
| Mutation end: 149786455 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: G | |
| Mutation seq: - | |
| AAchange: p.L123fs | |
| Sample: TCGA-DD-A39Y-01 |
| Cancer type: LIHC | |
| ESID: exon_skip_445449 | |
| Skipped exon start: 149786444 | |
| Skipped exon end: 149786523 | |
| Mutation start: 149786455 | |
| Mutation end: 149786455 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: G | |
| Mutation seq: - | |
| AAchange: p.L123fs | |
exon_skip_105023_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_101824_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_106032_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_106378_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_106523_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_106524_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_109527_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_109529_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_110000_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_11029_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_111893_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_111894_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_112042_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_112647_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_114045_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_114046_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_114565_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_11916_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_1234_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_1237_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_124639_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_124693_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_124695_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_130535_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_13071_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_131505_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_133556_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_135211_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_135545_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_135553_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_135763_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_137564_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_138947_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_139222_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_141370_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_141945_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_143515_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_143728_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_14772_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_148319_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_148332_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_14897_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_150985_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_151979_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_153387_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_153494_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_153786_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_155021_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_155962_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_155964_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_19897_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_19898_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_19902_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_20050_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_20053_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_21823_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_22411_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_22908_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_23470_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_24870_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_25336_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_26316_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_26461_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_26958_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_27038_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_27415_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_283977_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_284046_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_289275_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_291046_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_291218_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_291361_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_292293_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_292562_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_293040_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_293045_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_293052_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_293118_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_293546_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_293549_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_294064_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_294067_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_29565_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_29733_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_299242_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_299287_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_299304_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_299306_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_299307_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_30001_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_300924_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_301267_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_301272_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_302090_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_302094_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_302095_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_302097_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_3064_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_306549_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_30744_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_309425_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_310969_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_311352_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_313264_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_313342_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_313654_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_315571_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_315574_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_316800_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_316803_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_31730_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_317832_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_319816_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_320714_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_320715_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_320801LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_320805_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_321225_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_323910_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_32899_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_329221_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_331329_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_331444_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_332241_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_334248_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_335284_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_337247_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_34018_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_340419_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_34444_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_34446_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_346508_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_346721_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_346953_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_350661_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_352716_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_35400_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_354396_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_359435_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_360259_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_360261_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_360316_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_361235_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_364697_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_365330_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_369483_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_369915_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_371550_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_371589_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_374387_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_374402_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_37475_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_37491_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_374945_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_375131_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_375133_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_375393_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_376191_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_378801_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_379758_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_379855_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_380880_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_3815_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_382091_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_382119_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_382121_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_382417_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_382738_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_383797_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_383994_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_385335_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_387812_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_387826_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_389735_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_39262_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_39479_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_39686_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_422548_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_423337_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_423570_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_424308_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_426528_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_426530_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_427280_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_430528_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_433655_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_434375_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_435237_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_435489_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_436454_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_436487_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_436488_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_436494_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_437675_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_437849_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_439418_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_440194_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_440267_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_441705_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_442657_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_443695_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_444190_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_445458_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_446492_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_446495_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_446671_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_450412_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_450419_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_453010_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_454760_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_456871_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_458039_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_458091_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_45824_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_458292_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_458727_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_459683_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_460515_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_463936_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_464994_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_465641_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_469364_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_470206_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_470208_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_470470_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_470485_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_471015_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_471018_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_471458_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_472524_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_472955_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_475132_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_47552_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_476535_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_477211_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_477637_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_478117_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_47838_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_478401_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_478926_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_483792_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_487634_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_489575_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_490603_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_491406_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_492075_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_492152_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_493904_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_493918_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_493920_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_494000_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_494030_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_494170_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_494284_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_499522_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_503301_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_503593_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_503665_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_504513_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_507316_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_507513_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_50803_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_50804_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_510119_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_512208_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_513207_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_513240_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_5141_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_52393_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_54542_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_55185_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_56398_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_56399_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_56834_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_58444_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_58452_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_5861_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_60290_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_60294_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_60561_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_61147_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_6331_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_6399_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_64652_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_64657_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_65996_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_66666_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_67549_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_68080_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_6817_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_69250_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_70509_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_71759_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_71774_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_73487_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_73796_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_74728_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_75089_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_75391_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_77962_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_78386_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_82069_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_82070_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_83493_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_83494_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_83512_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_83602_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_84090_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_84528_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_87720_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_87721_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_89597_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_93891_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_94842_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_94844_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_96282_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_96298_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_96557_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_96886_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_97738_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_97739_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_9807_LIHC_TCGA-DD-A39Y-01.png | |
exon_skip_98550_LIHC_TCGA-DD-A39Y-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SISO_CERVIX | 149782684 | 149782875 | 149782722 | 149782722 | Missense_Mutation | A | G | p.V260A |
| HEC59_ENDOMETRIUM | 149782684 | 149782875 | 149782722 | 149782722 | Missense_Mutation | A | G | p.V260A |
| KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 149782684 | 149782875 | 149782722 | 149782722 | Missense_Mutation | A | G | p.V260A |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 149782684 | 149782875 | 149782722 | 149782722 | Missense_Mutation | A | G | p.V260A |
| CW2_LARGE_INTESTINE | 149782684 | 149782875 | 149782782 | 149782782 | Missense_Mutation | G | A | p.P240L |
| SW1710_URINARY_TRACT | 149782684 | 149782875 | 149782827 | 149782827 | Missense_Mutation | G | A | p.P225L |
| SNU213_PANCREAS | 149782684 | 149782875 | 149782873 | 149782873 | Missense_Mutation | G | T | p.L210M |
| SC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 149784648 | 149784743 | 149784736 | 149784736 | Missense_Mutation | T | G | p.D150A |
| NCIH2228_LUNG | 149785822 | 149785884 | 149785881 | 149785881 | Missense_Mutation | T | C | p.M128V |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 149786444 | 149786887 | 149786724 | 149786724 | Missense_Mutation | G | T | p.L97I |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 149786715 | 149786887 | 149786724 | 149786724 | Missense_Mutation | G | T | p.L97I |
| JHU029_UPPER_AERODIGESTIVE_TRACT | 149786444 | 149786887 | 149786740 | 149786740 | Missense_Mutation | C | A | p.E91D |
| JHU029_UPPER_AERODIGESTIVE_TRACT | 149786715 | 149786887 | 149786740 | 149786740 | Missense_Mutation | C | A | p.E91D |
| TOLEDO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 149786444 | 149786887 | 149786835 | 149786835 | Missense_Mutation | G | A | p.L60F |
| TOLEDO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 149786715 | 149786887 | 149786835 | 149786835 | Missense_Mutation | G | A | p.L60F |
| HSC4_UPPER_AERODIGESTIVE_TRACT | 149784243 | 149784330 | 149784273 | 149784273 | Nonsense_Mutation | C | A | p.E199* |
| SNU1040_LARGE_INTESTINE | 149786444 | 149786887 | 149786715 | 149786715 | Splice_Site | G | A | p.P100S |
| SNU1040_LARGE_INTESTINE | 149786715 | 149786887 | 149786715 | 149786715 | Splice_Site | G | A | p.P100S |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CD74 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CD74 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CD74 |
Top |
RelatedDrugs for CD74 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CD74 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| CD74 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| CD74 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| CD74 | C0162557 | Liver Failure, Acute | 1 | CTD_human |
| CD74 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|