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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for VGLL4 |
 Gene summary |
| Gene information | Gene symbol | VGLL4 | Gene ID | 9686 |
| Gene name | vestigial like family member 4 | |
| Synonyms | VGL-4 | |
| Cytomap | 3p25.3-p25.2 | |
| Type of gene | protein-coding | |
| Description | transcription cofactor vestigial-like protein 4Vestigial-like 4vestigial like 4 | |
| Modification date | 20180519 | |
| UniProtAcc | Q14135 | |
| Context | PubMed: VGLL4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for VGLL4 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for VGLL4 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for VGLL4 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_381281 | 3 | 11600231:11600301:11600805:11600929:11606270:11606493 | 11600805:11600929 | ENSG00000144560.9 | ENST00000273038.3,ENST00000445411.1,ENST00000404339.1,ENST00000451674.2,ENST00000424529.2,ENST00000426568.1,ENST00000413604.1,ENST00000430365.2 |
| exon_skip_381286 | 3 | 11606388:11606493:11643306:11643496:11684910:11685398 | 11643306:11643496 | ENSG00000144560.9 | ENST00000430365.2 |
| exon_skip_381287 | 3 | 11606388:11606493:11643306:11643496:11744444:11744521 | 11643306:11643496 | ENSG00000144560.9 | ENST00000273038.3,ENST00000417206.2,ENST00000445411.1,ENST00000419541.1,ENST00000418000.1 |
| exon_skip_381290 | 3 | 11643465:11643496:11712735:11712868:11734518:11734637 | 11712735:11712868 | ENSG00000144560.9 | ENST00000417466.1 |
| exon_skip_381292 | 3 | 11643465:11643496:11712735:11712868:11744444:11744521 | 11712735:11712868 | ENSG00000144560.9 | ENST00000404339.1,ENST00000426568.1 |
| exon_skip_381297 | 3 | 11643465:11643496:11744444:11744521:11760890:11761068 | 11744444:11744521 | ENSG00000144560.9 | ENST00000418000.1 |
| exon_skip_381299 | 3 | 11712747:11712868:11734518:11734637:11744444:11744521 | 11734518:11734637 | ENSG00000144560.9 | ENST00000417466.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for VGLL4 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_381281 | 3 | 11600231:11600301:11600805:11600929:11606270:11606493 | 11600805:11600929 | ENSG00000144560.9 | ENST00000273038.3,ENST00000413604.1,ENST00000451674.2,ENST00000424529.2,ENST00000430365.2,ENST00000426568.1,ENST00000404339.1,ENST00000445411.1 |
| exon_skip_381286 | 3 | 11606388:11606493:11643306:11643496:11684910:11685398 | 11643306:11643496 | ENSG00000144560.9 | ENST00000430365.2 |
| exon_skip_381287 | 3 | 11606388:11606493:11643306:11643496:11744444:11744521 | 11643306:11643496 | ENSG00000144560.9 | ENST00000273038.3,ENST00000445411.1,ENST00000418000.1,ENST00000417206.2,ENST00000419541.1 |
| exon_skip_381290 | 3 | 11643465:11643496:11712735:11712868:11734518:11734637 | 11712735:11712868 | ENSG00000144560.9 | ENST00000417466.1 |
| exon_skip_381292 | 3 | 11643465:11643496:11712735:11712868:11744444:11744521 | 11712735:11712868 | ENSG00000144560.9 | ENST00000426568.1,ENST00000404339.1 |
| exon_skip_381299 | 3 | 11712747:11712868:11734518:11734637:11744444:11744521 | 11734518:11734637 | ENSG00000144560.9 | ENST00000417466.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for VGLL4 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for VGLL4 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for VGLL4 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_381281 | 11600806 | 11600929 | 11600921 | 11600921 | Frame_Shift_Del | G | - | p.P162fs |
| OV | TCGA-23-1030-01 | exon_skip_381287 exon_skip_381286 | 11643307 | 11643496 | 11643368 | 11643368 | Nonsense_Mutation | C | A | p.E71* |
| BLCA | TCGA-BT-A20R-01 | exon_skip_381297 | 11744445 | 11744521 | 11744444 | 11744444 | Splice_Site | C | - | p.R22_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| D425_CENTRAL_NERVOUS_SYSTEM | 11643307 | 11643496 | 11643484 | 11643484 | Missense_Mutation | A | C | p.L32R |
| D458_CENTRAL_NERVOUS_SYSTEM | 11643307 | 11643496 | 11643484 | 11643484 | Missense_Mutation | A | C | p.L32R |
| CROAP3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 11744445 | 11744521 | 11744459 | 11744459 | Missense_Mutation | G | C | p.A17G |
| NCIH661_LUNG | 11744445 | 11744521 | 11744451 | 11744451 | Nonsense_Mutation | C | A | p.E20* |
| TOV21G_OVARY | 11744445 | 11744521 | 11744445 | 11744445 | Splice_Site | G | A | p.R22C |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for VGLL4 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for VGLL4 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for VGLL4 |
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RelatedDrugs for VGLL4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for VGLL4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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