|
||||||
|
 | |
| |
| |
| |
| Open reading frame (ORF) annotation in the exon skipping event |
| |
| |
| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
| |
|
Gene summary for MORF4L2 |
 Gene summary |
| Gene information | Gene symbol | MORF4L2 | Gene ID | 9643 |
| Gene name | mortality factor 4 like 2 | |
| Synonyms | MORFL2|MRGX | |
| Cytomap | Xq22.2 | |
| Type of gene | protein-coding | |
| Description | mortality factor 4-like protein 2MORF-related gene X proteinMSL3-2 proteinprotein MSL3-2transcription factor-like protein MRGX | |
| Modification date | 20180523 | |
| UniProtAcc | Q15014 | |
| Context | PubMed: MORF4L2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
Top |
Exon skipping events across known transcript of Ensembl for MORF4L2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Gene isoform structures and expression levels for MORF4L2 |
| Expression levels of gene isoforms across TCGA. |
 |
| Expression levels of gene isoforms across GTEx. |
 |
Top |
Exon skipping events with PSIs in TCGA for MORF4L2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_516203 | X | 102931906:102931979:102933426:102933528:102939608:102939657 | 102933426:102933528 | ENSG00000123562.12 | ENST00000418819.1 |
| exon_skip_516204 | X | 102931906:102931979:102933426:102933528:102940098:102940188 | 102933426:102933528 | ENSG00000123562.12 | ENST00000474653.1,ENST00000498064.1,ENST00000360458.1 |
| exon_skip_516208 | X | 102931906:102931979:102933426:102933548:102939608:102939657 | 102933426:102933548 | ENSG00000123562.12 | ENST00000422355.1 |
| exon_skip_516214 | X | 102931906:102931979:102933426:102933577:102940098:102940817 | 102933426:102933577 | ENSG00000123562.12 | ENST00000423833.2 |
| exon_skip_516218 | X | 102931906:102931979:102933426:102933579:102939608:102939657 | 102933426:102933579 | ENSG00000123562.12 | ENST00000422154.2,ENST00000442614.1,ENST00000433176.2,ENST00000434230.1 |
| exon_skip_516219 | X | 102931906:102931979:102933426:102933579:102940098:102940188 | 102933426:102933579 | ENSG00000123562.12 | ENST00000467755.1,ENST00000441076.2 |
| exon_skip_516240 | X | 102933428:102933528:102939608:102939657:102940098:102940188 | 102939608:102939657 | ENSG00000123562.12 | ENST00000418819.1 |
| exon_skip_516249 | X | 102933428:102933528:102940098:102940188:102941558:102941596 | 102940098:102940188 | ENSG00000123562.12 | ENST00000498064.1 |
| exon_skip_516252 | X | 102933426:102933548:102939608:102939657:102940098:102940188 | 102939608:102939657 | ENSG00000123562.12 | ENST00000422355.1 |
| exon_skip_516264 | X | 102933426:102933579:102939608:102939657:102940098:102940188 | 102939608:102939657 | ENSG00000123562.12 | ENST00000422154.2,ENST00000442614.1,ENST00000433176.2,ENST00000434230.1 |
| PSI values of skipped exons in TCGA. |
 |
Top |
Exon skipping events with PSIs in GTEx for MORF4L2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_516203 | X | 102931906:102931979:102933426:102933528:102939608:102939657 | 102933426:102933528 | ENSG00000123562.12 | ENST00000418819.1 |
| exon_skip_516204 | X | 102931906:102931979:102933426:102933528:102940098:102940188 | 102933426:102933528 | ENSG00000123562.12 | ENST00000360458.1,ENST00000474653.1,ENST00000498064.1 |
| exon_skip_516208 | X | 102931906:102931979:102933426:102933548:102939608:102939657 | 102933426:102933548 | ENSG00000123562.12 | ENST00000422355.1 |
| exon_skip_516218 | X | 102931906:102931979:102933426:102933579:102939608:102939657 | 102933426:102933579 | ENSG00000123562.12 | ENST00000433176.2,ENST00000422154.2,ENST00000434230.1,ENST00000442614.1 |
| exon_skip_516219 | X | 102931906:102931979:102933426:102933579:102940098:102940188 | 102933426:102933579 | ENSG00000123562.12 | ENST00000441076.2,ENST00000467755.1 |
| exon_skip_516240 | X | 102933428:102933528:102939608:102939657:102940098:102940188 | 102939608:102939657 | ENSG00000123562.12 | ENST00000418819.1 |
| exon_skip_516249 | X | 102933428:102933528:102940098:102940188:102941558:102941596 | 102940098:102940188 | ENSG00000123562.12 | ENST00000498064.1 |
| exon_skip_516252 | X | 102933426:102933548:102939608:102939657:102940098:102940188 | 102939608:102939657 | ENSG00000123562.12 | ENST00000422355.1 |
| exon_skip_516264 | X | 102933426:102933579:102939608:102939657:102940098:102940188 | 102939608:102939657 | ENSG00000123562.12 | ENST00000433176.2,ENST00000422154.2,ENST00000434230.1,ENST00000442614.1 |
| PSI values of skipped exons in GTEx. |
 |
| * Skipped exon sequences. |
Top |
Open reading frame (ORF) annotation in the exon skipping event for MORF4L2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000360458 | 102933426 | 102933528 | 3UTR-3UTR |
| ENST00000422154 | 102933426 | 102933579 | 3UTR-3UTR |
| ENST00000433176 | 102933426 | 102933579 | 3UTR-3UTR |
| ENST00000441076 | 102933426 | 102933579 | 3UTR-3UTR |
| ENST00000422154 | 102939608 | 102939657 | 3UTR-3UTR |
| ENST00000433176 | 102939608 | 102939657 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000360458 | 102933426 | 102933528 | 3UTR-3UTR |
| ENST00000422154 | 102933426 | 102933579 | 3UTR-3UTR |
| ENST00000433176 | 102933426 | 102933579 | 3UTR-3UTR |
| ENST00000441076 | 102933426 | 102933579 | 3UTR-3UTR |
| ENST00000422154 | 102939608 | 102939657 | 3UTR-3UTR |
| ENST00000433176 | 102939608 | 102939657 | 3UTR-3UTR |
Top |
Infer the effects of exon skipping event on protein functional features for MORF4L2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
 |
| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
Top |
SNVs in the skipped exons for MORF4L2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
 |
| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
Top |
Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MORF4L2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MORF4L2 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MORF4L2 |
Top |
RelatedDrugs for MORF4L2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for MORF4L2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|