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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for SEC24C

check button Gene summary
Gene informationGene symbol

SEC24C

Gene ID

9632

Gene nameSEC24 homolog C, COPII coat complex component
Synonyms-
Cytomap

10q22.2

Type of geneprotein-coding
Descriptionprotein transport protein Sec24CSEC24 family, member CSEC24 related gene family, member CSEC24-related protein C
Modification date20180522
UniProtAcc

P53992

ContextPubMed: SEC24C [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SEC24C

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


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Exon skipping events across known transcript of Ensembl for SEC24C from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for SEC24C

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for SEC24C

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_425031075504157:75504195:75506387:75506474:75506562:7550676275506387:75506474ENSG00000176986.10ENST00000339365.2
exon_skip_425061075504157:75504195:75506562:75506762:75510865:7551100175506562:75506762ENSG00000176986.10ENST00000465076.1,ENST00000345254.4
exon_skip_425071075504126:75504195:75506562:75506762:75519379:7551955275506562:75506762ENSG00000176986.10ENST00000411652.2
exon_skip_425201075506387:75506474:75506562:75506762:75510865:7551100175506562:75506762ENSG00000176986.10ENST00000339365.2
exon_skip_425221075506624:75506762:75510865:75511001:75511474:7551186075510865:75511001ENSG00000176986.10ENST00000477008.1
exon_skip_425231075506624:75506762:75510865:75511001:75519379:7551955275510865:75511001ENSG00000176986.10ENST00000465076.1,ENST00000339365.2,ENST00000345254.4
exon_skip_425251075506624:75506762:75519379:75519552:75519775:7552014475519379:75519552ENSG00000176986.10ENST00000411652.2
exon_skip_425261075510865:75511001:75519379:75519552:75519775:7551982375519379:75519552ENSG00000176986.10ENST00000465076.1,ENST00000339365.2,ENST00000345254.4
exon_skip_425271075520470:75520607:75521855:75521924:75523247:7552335975521855:75521924ENSG00000176986.10ENST00000411652.2
exon_skip_425301075525292:75525347:75525557:75525673:75525843:7552596875525557:75525673ENSG00000176986.10ENST00000411652.2,ENST00000465076.1,ENST00000339365.2,ENST00000345254.4
exon_skip_425341075525843:75525968:75526107:75526299:75526517:7552655575526107:75526299ENSG00000176986.10ENST00000411652.2,ENST00000465076.1,ENST00000339365.2,ENST00000345254.4
exon_skip_425361075526517:75526611:75526811:75526928:75527594:7552761675526811:75526928ENSG00000176986.10ENST00000411652.2,ENST00000465076.1,ENST00000339365.2,ENST00000345254.4
exon_skip_425381075526811:75526928:75527594:75527765:75528567:7552866475527594:75527765ENSG00000176986.10ENST00000411652.2,ENST00000465076.1,ENST00000339365.2,ENST00000345254.4
exon_skip_425411075528764:75528910:75529104:75529243:75529372:7552949175529104:75529243ENSG00000176986.10ENST00000411652.2,ENST00000465076.1,ENST00000339365.2,ENST00000535742.1,ENST00000345254.4,ENST00000540668.1
exon_skip_425451075529593:75529773:75530037:75530229:75530466:7553055675530037:75530229ENSG00000176986.10ENST00000411652.2,ENST00000339365.2,ENST00000535742.1,ENST00000345254.4,ENST00000540668.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for SEC24C

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_425031075504157:75504195:75506387:75506474:75506562:7550676275506387:75506474ENSG00000176986.10ENST00000339365.2
exon_skip_425061075504157:75504195:75506562:75506762:75510865:7551100175506562:75506762ENSG00000176986.10ENST00000465076.1,ENST00000345254.4
exon_skip_425071075504126:75504195:75506562:75506762:75519379:7551955275506562:75506762ENSG00000176986.10ENST00000411652.2
exon_skip_425201075506387:75506474:75506562:75506762:75510865:7551100175506562:75506762ENSG00000176986.10ENST00000339365.2
exon_skip_425221075506624:75506762:75510865:75511001:75511474:7551186075510865:75511001ENSG00000176986.10ENST00000477008.1
exon_skip_425231075506624:75506762:75510865:75511001:75519379:7551955275510865:75511001ENSG00000176986.10ENST00000465076.1,ENST00000345254.4,ENST00000339365.2
exon_skip_425251075506624:75506762:75519379:75519552:75519775:7552014475519379:75519552ENSG00000176986.10ENST00000411652.2
exon_skip_425261075510865:75511001:75519379:75519552:75519775:7551982375519379:75519552ENSG00000176986.10ENST00000465076.1,ENST00000345254.4,ENST00000339365.2
exon_skip_425271075520470:75520607:75521855:75521924:75523247:7552335975521855:75521924ENSG00000176986.10ENST00000411652.2
exon_skip_425301075525292:75525347:75525557:75525673:75525843:7552596875525557:75525673ENSG00000176986.10ENST00000465076.1,ENST00000345254.4,ENST00000339365.2,ENST00000411652.2
exon_skip_425341075525843:75525968:75526107:75526299:75526517:7552655575526107:75526299ENSG00000176986.10ENST00000465076.1,ENST00000345254.4,ENST00000339365.2,ENST00000411652.2
exon_skip_425361075526517:75526611:75526811:75526928:75527594:7552761675526811:75526928ENSG00000176986.10ENST00000465076.1,ENST00000345254.4,ENST00000339365.2,ENST00000411652.2
exon_skip_425381075526811:75526928:75527594:75527765:75528567:7552866475527594:75527765ENSG00000176986.10ENST00000465076.1,ENST00000345254.4,ENST00000339365.2,ENST00000411652.2
exon_skip_425411075528764:75528910:75529104:75529243:75529372:7552949175529104:75529243ENSG00000176986.10ENST00000535742.1,ENST00000465076.1,ENST00000345254.4,ENST00000540668.1,ENST00000339365.2,ENST00000411652.2
exon_skip_425451075529593:75529773:75530037:75530229:75530466:7553055675530037:75530229ENSG00000176986.10ENST00000535742.1,ENST00000345254.4,ENST00000540668.1,ENST00000339365.2,ENST00000411652.2

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for SEC24C

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000033936575506562755067625CDS-5UTR
ENST0000034525475506562755067625CDS-5UTR
ENST0000033936575506387755064745UTR-5UTR
ENST000003393657551086575511001Frame-shift
ENST000003452547551086575511001Frame-shift
ENST000003393657551937975519552Frame-shift
ENST000003452547551937975519552Frame-shift
ENST000003393657552555775525673Frame-shift
ENST000003452547552555775525673Frame-shift
ENST000003393657552910475529243Frame-shift
ENST000003452547552910475529243Frame-shift
ENST000003393657552610775526299In-frame
ENST000003452547552610775526299In-frame
ENST000003393657552681175526928In-frame
ENST000003452547552681175526928In-frame
ENST000003393657552759475527765In-frame
ENST000003452547552759475527765In-frame
ENST000003393657553003775530229In-frame
ENST000003452547553003775530229In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000033936575506562755067625CDS-5UTR
ENST0000034525475506562755067625CDS-5UTR
ENST0000033936575506387755064745UTR-5UTR
ENST000003393657551086575511001Frame-shift
ENST000003452547551086575511001Frame-shift
ENST000003393657551937975519552Frame-shift
ENST000003452547551937975519552Frame-shift
ENST000003393657552555775525673Frame-shift
ENST000003452547552555775525673Frame-shift
ENST000003393657552910475529243Frame-shift
ENST000003452547552910475529243Frame-shift
ENST000003393657552610775526299In-frame
ENST000003452547552610775526299In-frame
ENST000003393657552681175526928In-frame
ENST000003452547552681175526928In-frame
ENST000003393657552759475527765In-frame
ENST000003452547552759475527765In-frame
ENST000003393657553003775530229In-frame
ENST000003452547553003775530229In-frame

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Infer the effects of exon skipping event on protein functional features for SEC24C

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000033936545301094755261077552629917701961536599
ENST0000034525444501094755261077552629916901881536599
ENST0000033936545301094755268117552692820562172631670
ENST0000034525444501094755268117552692819762092631670
ENST0000033936545301094755275947552776521732343670727
ENST0000034525444501094755275947552776520932263670727
ENST00000339365453010947553003775530229302532169541018
ENST00000345254445010947553003775530229294531369541018

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000033936545301094755261077552629917701961536599
ENST0000034525444501094755261077552629916901881536599
ENST0000033936545301094755268117552692820562172631670
ENST0000034525444501094755268117552692819762092631670
ENST0000033936545301094755275947552776521732343670727
ENST0000034525444501094755275947552776520932263670727
ENST00000339365453010947553003775530229302532169541018
ENST00000345254445010947553003775530229294531369541018

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P539925365991752Alternative sequenceID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P539925365991752Alternative sequenceID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53992536599546560Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599546560Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599569573Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599569573Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599587589Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599587589Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P5399253659911094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P5399253659911094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P53992536599595609HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599595609HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599576578TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599576578TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599591594TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599591594TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539926316701752Alternative sequenceID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P539926316701752Alternative sequenceID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53992631670637643Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670637643Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670649651Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670649651Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P5399263167011094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P5399263167011094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P53992631670620632HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670620632HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670661663HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670661663HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670669672HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670669672HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539926707271752Alternative sequenceID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P539926707271752Alternative sequenceID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53992670727692698Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727692698Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727720722Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727720722Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P5399267072711094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P5399267072711094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P53992670727669672HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727669672HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727679689HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727679689HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727706709HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727706709HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727711715HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727711715HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539929541018980984Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539929541018980984Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539929541018986993Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539929541018986993Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992954101811094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P53992954101811094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P539929541018972974HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539929541018972974HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P5399295410189991006HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P5399295410189991006HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992954101810111013HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992954101810111013HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P5399295410189621034RepeatNote=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
P5399295410189621034RepeatNote=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P539925365991752Alternative sequenceID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P539925365991752Alternative sequenceID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53992536599546560Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599546560Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599569573Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599569573Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599587589Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599587589Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P5399253659911094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P5399253659911094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P53992536599595609HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599595609HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599576578TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599576578TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599591594TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992536599591594TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539926316701752Alternative sequenceID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P539926316701752Alternative sequenceID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53992631670637643Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670637643Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670649651Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670649651Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P5399263167011094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P5399263167011094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P53992631670620632HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670620632HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670661663HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670661663HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670669672HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992631670669672HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539926707271752Alternative sequenceID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P539926707271752Alternative sequenceID=VSP_056516;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039
P53992670727692698Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727692698Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727720722Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727720722Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P5399267072711094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P5399267072711094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P53992670727669672HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727669672HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727679689HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727679689HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727706709HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727706709HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727711715HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992670727711715HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539929541018980984Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539929541018980984Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539929541018986993Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539929541018986993Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992954101811094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P53992954101811094ChainID=PRO_0000205156;Note=Protein transport protein Sec24C
P539929541018972974HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P539929541018972974HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P5399295410189991006HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P5399295410189991006HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992954101810111013HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P53992954101810111013HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:3EH2
P5399295410189621034RepeatNote=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255
P5399295410189621034RepeatNote=Gelsolin-like;Ontology_term=ECO:0000255;evidence=ECO:0000255


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SNVs in the skipped exons for SEC24C

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.
SEC24C_DLBC_exon_skip_42534_psi_boxplot.png
boxplot
SEC24C_LUAD_exon_skip_42538_psi_boxplot.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
SKCMTCGA-EE-A2GL-06exon_skip_42520
exon_skip_42507
exon_skip_42506
75506563755067627550661275506612Frame_Shift_DelC-p.P9fs
SKCMTCGA-EE-A2GL-06exon_skip_42520
exon_skip_42507
exon_skip_42506
75506563755067627550661275506612Frame_Shift_DelC-p.V7fs
LIHCTCGA-DD-A3A0-01exon_skip_42523
exon_skip_42522
75510866755110017551089175510891Frame_Shift_DelG-p.S66fs
LIHCTCGA-G3-A3CJ-01exon_skip_42523
exon_skip_42522
75510866755110017551089175510891Frame_Shift_DelG-p.S66fs
LIHCTCGA-G3-A3CJ-01exon_skip_42525
exon_skip_42526
75519380755195527551940675519406Frame_Shift_DelC-p.S112fs
LIHCTCGA-DD-A1EG-01exon_skip_42530
75525558755256737552556075525560Frame_Shift_DelC-p.P458fs
LIHCTCGA-DD-A39Y-01exon_skip_42530
75525558755256737552556075525560Frame_Shift_DelC-p.P458fs
LIHCTCGA-DD-A39Y-01exon_skip_42530
75525558755256737552556075525560Frame_Shift_DelC-p.V456fs
LIHCTCGA-DD-A3A0-01exon_skip_42530
75525558755256737552556075525560Frame_Shift_DelC-p.P458fs
STADTCGA-F1-6177-01exon_skip_42530
75525558755256737552556075525560Frame_Shift_DelC-p.V456fs
STADTCGA-FP-A4BE-01exon_skip_42530
75525558755256737552556075525560Frame_Shift_DelC-p.V456fs
LIHCTCGA-DD-A1EG-01exon_skip_42530
75525558755256737552559675525596Frame_Shift_DelA-p.K469fs
LIHCTCGA-DD-A1EG-01exon_skip_42530
75525558755256737552563075525630Frame_Shift_DelC-p.S480fs
LUADTCGA-50-5946-01exon_skip_42538
75527595755277657552768175527681Frame_Shift_DelC-p.F699fs
LIHCTCGA-DD-A1EG-01exon_skip_42545
75530038755302297553018975530189Frame_Shift_DelT-p.L1005fs
LUADTCGA-50-7109-01exon_skip_42520
exon_skip_42507
exon_skip_42506
75506563755067627550661375506614Frame_Shift_Ins-Ap.P8fs
LIHCTCGA-BC-A112-01exon_skip_42525
exon_skip_42526
75519380755195527551939575519396Frame_Shift_Ins-Cp.I109fs
COADTCGA-G4-6586-01exon_skip_42530
75525558755256737552555975525560Frame_Shift_Ins-Cp.V456fs
LUADTCGA-44-2656-01exon_skip_42530
75525558755256737552555975525560Frame_Shift_Ins-Cp.V456fs
LUADTCGA-64-1678-01exon_skip_42530
75525558755256737552555975525560Frame_Shift_Ins-Cp.V456fs
STADTCGA-HU-A4G8-01exon_skip_42530
75525558755256737552555975525560Frame_Shift_Ins-Cp.V456fs
STADTCGA-HU-A4G9-01exon_skip_42530
75525558755256737552555975525560Frame_Shift_Ins-Cp.V456fs
UCECTCGA-B5-A0K2-01exon_skip_42530
75525558755256737552555975525560Frame_Shift_Ins-Cp.V456fs
UCECTCGA-BG-A0M3-01exon_skip_42530
75525558755256737552555975525560Frame_Shift_Ins-Cp.V456fs
UCECTCGA-BG-A0M9-01exon_skip_42530
75525558755256737552555975525560Frame_Shift_Ins-Cp.V456fs
STADTCGA-HU-A4G8-01exon_skip_42530
75525558755256737552556075525561Frame_Shift_Ins-Cp.V456fs
STADTCGA-HU-A4G9-01exon_skip_42530
75525558755256737552556075525561Frame_Shift_Ins-Cp.V456fs
SKCMTCGA-BF-AAP4-01exon_skip_42530
75525558755256737552557575525575Nonsense_MutationCTp.Q462*
HNSCTCGA-CR-6472-01exon_skip_42530
75525558755256737552564475525644Nonsense_MutationGTp.E485*
ESCATCGA-V5-AASW-01exon_skip_42536
75526812755269287552686675526866Nonsense_MutationGTp.E650*
BLCATCGA-K4-A6MB-01exon_skip_42538
75527595755277657552762575527625Nonsense_MutationCTp.Q681*
BLCATCGA-K4-A6MB-01exon_skip_42538
75527595755277657552776375527763Nonsense_MutationCTp.Q727*
BRCATCGA-AR-A1AK-01exon_skip_42545
75530038755302297553008075530080Nonsense_MutationCTp.R969*
DLBCTCGA-FF-A7CX-01exon_skip_42534
75526108755262997552610775526107Splice_SiteGA.

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description
SEC24C_75526811_75526928_75527594_75527765_75528567_75528664_TCGA-50-5946-01Sample: TCGA-50-5946-01
Cancer type: LUAD
ESID: exon_skip_42538
Skipped exon start: 75527595
Skipped exon end: 75527765
Mutation start: 75527681
Mutation end: 75527681
Mutation type: Frame_Shift_Del
Reference seq: C
Mutation seq: -
AAchange: p.F699fs
exon_skip_42538_LUAD_TCGA-50-5946-01.png
boxplot
SEC24C_75525843_75525968_75526107_75526299_75526517_75526555_TCGA-FF-A7CX-01Sample: TCGA-FF-A7CX-01
Cancer type: DLBC
ESID: exon_skip_42534
Skipped exon start: 75526108
Skipped exon end: 75526299
Mutation start: 75526107
Mutation end: 75526107
Mutation type: Splice_Site
Reference seq: G
Mutation seq: A
AAchange: .
exon_skip_331556_DLBC_TCGA-FF-A7CX-01.png
boxplot
exon_skip_42534_DLBC_TCGA-FF-A7CX-01.png
boxplot

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE75510866755110017551089175510891Frame_Shift_DelG-p.S66fs
NCIH2122_LUNG75510866755110017551094675510947Frame_Shift_Ins-Ap.Q85fs
HCC2157_BREAST75510866755110017551090775510907Missense_MutationTCp.S72P
HCC2157_MATCHED_NORMAL_TISSUE75510866755110017551090775510907Missense_MutationTCp.S72P
IMR5_AUTONOMIC_GANGLIA75510866755110017551091975510919Missense_MutationGCp.A76P
IMR32_AUTONOMIC_GANGLIA75510866755110017551091975510919Missense_MutationGCp.A76P
SC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE75510866755110017551099875510998Missense_MutationATp.Q102L
SCI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE75510866755110017551099875510998Missense_MutationATp.Q102L
TGBC11TKB_STOMACH75519380755195527551947575519475Missense_MutationAGp.Q135R
SKM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE75519380755195527551951175519511Missense_MutationGAp.G147D
LNCAPCLONEFGC_PROSTATE75525558755256737552556775525567Missense_MutationACp.Q459P
LK2_LUNG75525558755256737552561475525614Missense_MutationGAp.D475N
LIM1215_LARGE_INTESTINE75525558755256737552561775525617Missense_MutationCTp.R476C
EW7_BONE75525558755256737552566075525660Missense_MutationTCp.V490A
SNU1040_LARGE_INTESTINE75526108755262997552628475526284Missense_MutationGAp.R595Q
HCC2998_LARGE_INTESTINE75526108755262997552629275526292Missense_MutationACp.I598L
DIPG007_CENTRAL_NERVOUS_SYSTEM75526812755269287552691175526911Missense_MutationACp.N665H
BICR18_UPPER_AERODIGESTIVE_TRACT75527595755277657552761975527619Missense_MutationGAp.A679T
MDST8_LARGE_INTESTINE75527595755277657552768275527682Missense_MutationCTp.P700S
KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE75529105755292437552914775529147Missense_MutationCTp.R823C
HAL01_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE75529105755292437552914775529147Missense_MutationCTp.R823C
MDAMB453_BREAST75530038755302297553005375530053Missense_MutationGCp.E960Q
JHU028_LUNG75530038755302297553010775530107Missense_MutationGTp.G978W
BCPAP_THYROID75530038755302297553012175530121Missense_MutationACp.L982F
HEC108_ENDOMETRIUM75530038755302297553019575530195Missense_MutationGAp.S1007N
COLO792_SKIN75519380755195527551944475519444Nonsense_MutationCTp.Q125*
NCIH661_LUNG75529105755292437552920675529206Nonsense_MutationTAp.C842*
ISHIKAWAHERAKLIO02ER_ENDOMETRIUM75525558755256737552555975525559Splice_SiteTCp.V456V
EN_ENDOMETRIUM75525558755256737552555975525560Splice_Site-CCp.P457fs

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SEC24C

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_425201075506387:75506474:75506562:75506762:75510865:7551100175506562:75506762ENST00000339365.2THCArs2306325chr10:75506674T/C1.46e-03
exon_skip_425381075526811:75526928:75527594:75527765:75528567:7552866475527594:75527765ENST00000411652.2,ENST00000465076.1,ENST00000339365.2,ENST00000345254.4THCArs4746147chr10:75527708A/G1.05e-03
exon_skip_425071075504126:75504195:75506562:75506762:75519379:7551955275506562:75506762ENST00000411652.2THCArs2306325chr10:75506674T/C1.46e-03
exon_skip_425061075504157:75504195:75506562:75506762:75510865:7551100175506562:75506762ENST00000465076.1,ENST00000345254.4THCArs2306325chr10:75506674T/C1.46e-03

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SEC24C


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SEC24C


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RelatedDrugs for SEC24C

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC24C

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource
SEC24CC0005586Bipolar Disorder1PSYGENET
SEC24CC0041696Unipolar Depression1PSYGENET
SEC24CC1269683Major Depressive Disorder1PSYGENET