ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for NCOR2

Gene summary

Gene information	Gene symbol	NCOR2
	Gene ID	9612
	Gene name	nuclear receptor corepressor 2
	Synonyms	CTG26\|N-CoR2\|SMAP270\|SMRT\|SMRTE\|SMRTE-tau\|TNRC14\|TRAC\|TRAC-1\|TRAC1
	Cytomap	12q24.31
	Type of gene	protein-coding
	Description	nuclear receptor corepressor 2CTG repeat protein 26T3 receptor-associating factorsilencing mediator for retinoid and thyroid hormone receptorsthyroid-, retinoic-acid-receptor-associated corepressor
	Modification date	20180527
	UniProtAcc	Q9Y618
	Context	PubMed: NCOR2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Exon skipping events across known transcript of Ensembl for NCOR2 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for NCOR2

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for NCOR2

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_98384	12	124810736:124810916:124811954:124812179:124815390:124815444	124811954:124812179	ENSG00000196498.9	ENST00000429285.2,ENST00000404121.2,ENST00000356219.3,ENST00000405201.1
exon_skip_98387	12	124810736:124810916:124812092:124812179:124815390:124815444	124812092:124812179	ENSG00000196498.9	ENST00000397355.1,ENST00000404621.1,ENST00000418829.1
exon_skip_98392	12	124810736:124810916:124815390:124815444:124816864:124816891	124815390:124815444	ENSG00000196498.9	ENST00000443451.2
exon_skip_98399	12	124812092:124812179:124815390:124815444:124816864:124816891	124815390:124815444	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1,ENST00000418829.1
exon_skip_98405	12	124813077:124813703:124815390:124815444:124816864:124816891	124815390:124815444	ENSG00000196498.9	ENST00000440337.2
exon_skip_98407	12	124816864:124817010:124817675:124817825:124818969:124819163	124817675:124817825	ENSG00000196498.9	ENST00000443451.2
exon_skip_98408	12	124816864:124817013:124817675:124817825:124818969:124819163	124817675:124817825	ENSG00000196498.9	ENST00000429285.2,ENST00000461081.1,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1
exon_skip_98414	12	124817675:124817825:124818969:124819163:124819680:124819727	124818969:124819163	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1
exon_skip_98416	12	124817675:124817825:124818969:124819826:124820028:124820178	124818969:124819826	ENSG00000196498.9	ENST00000461081.1
exon_skip_98420	12	124818969:124819163:124819680:124819826:124820028:124820178	124819680:124819826	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1
exon_skip_98425	12	124824839:124824989:124825147:124825240:124826368:124826409	124825147:124825240	ENSG00000196498.9	ENST00000453428.1
exon_skip_98426	12	124824839:124824989:124825147:124825297:124826368:124826409	124825147:124825297	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1
exon_skip_98429	12	124826368:124826620:124827550:124827772:124829142:124829420	124827550:124827772	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1
exon_skip_98431	12	124829142:124829497:124831109:124831396:124832370:124832457	124831109:124831396	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1
exon_skip_98433	12	124832719:124832860:124835132:124835283:124838638:124838742	124835132:124835283	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1,ENST00000458234.1
exon_skip_98435	12	124838638:124838742:124839023:124839128:124839382:124839485	124839023:124839128	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1,ENST00000458234.1
exon_skip_98441	12	124839023:124839128:124839382:124839485:124839977:124840117	124839382:124839485	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1,ENST00000458234.1
exon_skip_98447	12	124839382:124839485:124839977:124840117:124841187:124841231	124839977:124840117	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000536195.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1,ENST00000458234.1
exon_skip_98455	12	124839977:124840117:124841187:124841328:124846671:124846840	124841187:124841328	ENSG00000196498.9	ENST00000405201.1
exon_skip_98457	12	124839977:124840117:124841187:124841352:124846671:124846840	124841187:124841352	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000458234.1
exon_skip_98458	12	124846671:124846840:124848224:124848345:124856567:124857156	124848224:124848345	ENSG00000196498.9	ENST00000356219.3
exon_skip_98459	12	124846671:124846843:124848224:124848345:124856567:124857156	124848224:124848345	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000404621.1,ENST00000405201.1,ENST00000458234.1
exon_skip_98460	12	124848224:124848345:124856567:124857156:124862782:124862930	124856567:124857156	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000404621.1
exon_skip_98463	12	124857005:124857156:124858958:124859009:124862782:124862924	124858958:124859009	ENSG00000196498.9	ENST00000356219.3,ENST00000405201.1,ENST00000458234.1
exon_skip_98466	12	124857005:124857156:124862782:124862930:124870290:124870433	124862782:124862930	ENSG00000196498.9	ENST00000429285.2,ENST00000448614.1,ENST00000397355.1,ENST00000404121.2,ENST00000404621.1
exon_skip_98467	12	124862782:124862930:124870290:124870433:124882664:124882727	124870290:124870433	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1,ENST00000458234.1
exon_skip_98468	12	124870290:124870433:124882664:124882727:124885046:124885219	124882664:124882727	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1,ENST00000458234.1
exon_skip_98470	12	124911167:124911346:124914158:124914249:124915160:124915187	124914158:124914249	ENSG00000196498.9	ENST00000429285.2,ENST00000404621.1
exon_skip_98472	12	124911167:124911346:124914158:124914252:124915160:124915187	124914158:124914252	ENSG00000196498.9	ENST00000397355.1,ENST00000420698.1,ENST00000404121.2,ENST00000356219.3,ENST00000405201.1,ENST00000458234.1
exon_skip_98474	12	124915186:124915333:124922475:124922542:124934360:124934413	124922475:124922542	ENSG00000196498.9	ENST00000429285.2,ENST00000542927.1,ENST00000397355.1,ENST00000420698.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1,ENST00000458234.1,ENST00000448008.1
exon_skip_98479	12	124922475:124922542:124934360:124934413:124941651:124941708	124934360:124934413	ENSG00000196498.9	ENST00000429285.2,ENST00000542927.1,ENST00000397355.1,ENST00000420698.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1,ENST00000458234.1
exon_skip_98480	12	124922475:124922542:124934360:124934413:124950718:124950832	124934360:124934413	ENSG00000196498.9	ENST00000448008.1
exon_skip_98483	12	124934360:124934413:124941651:124941708:124950718:124950826	124941651:124941708	ENSG00000196498.9	ENST00000429285.2,ENST00000542927.1,ENST00000397355.1,ENST00000420698.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000405201.1,ENST00000458234.1
exon_skip_98487	12	124968141:124968319:124970986:124971114:124979692:124979798	124970986:124971114	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000420698.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000458234.1
exon_skip_98488	12	124970986:124971114:124979692:124979914:125020110:125020149	124979692:124979914	ENSG00000196498.9	ENST00000429285.2,ENST00000397355.1,ENST00000404121.2,ENST00000356219.3,ENST00000404621.1,ENST00000542565.1,ENST00000458234.1
exon_skip_98492	12	124979692:124979914:125020110:125020157:125051853:125052010	125020110:125020157	ENSG00000196498.9	ENST00000542565.1,ENST00000458234.1

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for NCOR2

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_98384	12	124810736:124810916:124811954:124812179:124815390:124815444	124811954:124812179	ENSG00000196498.9	ENST00000405201.1,ENST00000356219.3,ENST00000404121.2,ENST00000429285.2
exon_skip_98387	12	124810736:124810916:124812092:124812179:124815390:124815444	124812092:124812179	ENSG00000196498.9	ENST00000404621.1,ENST00000397355.1,ENST00000418829.1
exon_skip_98392	12	124810736:124810916:124815390:124815444:124816864:124816891	124815390:124815444	ENSG00000196498.9	ENST00000443451.2
exon_skip_98399	12	124812092:124812179:124815390:124815444:124816864:124816891	124815390:124815444	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000418829.1
exon_skip_98405	12	124813077:124813703:124815390:124815444:124816864:124816891	124815390:124815444	ENSG00000196498.9	ENST00000440337.2
exon_skip_98407	12	124816864:124817010:124817675:124817825:124818969:124819163	124817675:124817825	ENSG00000196498.9	ENST00000443451.2
exon_skip_98408	12	124816864:124817013:124817675:124817825:124818969:124819163	124817675:124817825	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000461081.1
exon_skip_98414	12	124817675:124817825:124818969:124819163:124819680:124819727	124818969:124819163	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2
exon_skip_98416	12	124817675:124817825:124818969:124819826:124820028:124820178	124818969:124819826	ENSG00000196498.9	ENST00000461081.1
exon_skip_98420	12	124818969:124819163:124819680:124819826:124820028:124820178	124819680:124819826	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2
exon_skip_98425	12	124824839:124824989:124825147:124825240:124826368:124826409	124825147:124825240	ENSG00000196498.9	ENST00000453428.1
exon_skip_98426	12	124824839:124824989:124825147:124825297:124826368:124826409	124825147:124825297	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2
exon_skip_98429	12	124826368:124826620:124827550:124827772:124829142:124829420	124827550:124827772	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2
exon_skip_98431	12	124829142:124829497:124831109:124831396:124832370:124832457	124831109:124831396	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2
exon_skip_98433	12	124832719:124832860:124835132:124835283:124838638:124838742	124835132:124835283	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000458234.1
exon_skip_98435	12	124838638:124838742:124839023:124839128:124839382:124839485	124839023:124839128	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000458234.1
exon_skip_98441	12	124839023:124839128:124839382:124839485:124839977:124840117	124839382:124839485	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000458234.1
exon_skip_98447	12	124839382:124839485:124839977:124840117:124841187:124841231	124839977:124840117	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000458234.1,ENST00000536195.1
exon_skip_98455	12	124839977:124840117:124841187:124841328:124846671:124846840	124841187:124841328	ENSG00000196498.9	ENST00000405201.1
exon_skip_98457	12	124839977:124840117:124841187:124841352:124846671:124846840	124841187:124841352	ENSG00000196498.9	ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000458234.1
exon_skip_98458	12	124846671:124846840:124848224:124848345:124856567:124857156	124848224:124848345	ENSG00000196498.9	ENST00000356219.3
exon_skip_98459	12	124846671:124846843:124848224:124848345:124856567:124857156	124848224:124848345	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000458234.1
exon_skip_98460	12	124848224:124848345:124856567:124857156:124862782:124862930	124856567:124857156	ENSG00000196498.9	ENST00000404621.1,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2
exon_skip_98463	12	124857005:124857156:124858958:124859009:124862782:124862924	124858958:124859009	ENSG00000196498.9	ENST00000405201.1,ENST00000356219.3,ENST00000458234.1
exon_skip_98466	12	124857005:124857156:124862782:124862930:124870290:124870433	124862782:124862930	ENSG00000196498.9	ENST00000404621.1,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000448614.1
exon_skip_98467	12	124862782:124862930:124870290:124870433:124882664:124882727	124870290:124870433	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000458234.1
exon_skip_98468	12	124870290:124870433:124882664:124882727:124885046:124885219	124882664:124882727	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000458234.1
exon_skip_98470	12	124911167:124911346:124914158:124914249:124915160:124915187	124914158:124914249	ENSG00000196498.9	ENST00000404621.1,ENST00000429285.2
exon_skip_98472	12	124911167:124911346:124914158:124914252:124915160:124915187	124914158:124914252	ENSG00000196498.9	ENST00000405201.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000458234.1,ENST00000420698.1
exon_skip_98474	12	124915186:124915333:124922475:124922542:124934360:124934413	124922475:124922542	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000458234.1,ENST00000420698.1,ENST00000542927.1,ENST00000448008.1
exon_skip_98479	12	124922475:124922542:124934360:124934413:124941651:124941708	124934360:124934413	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000458234.1,ENST00000420698.1,ENST00000542927.1
exon_skip_98480	12	124922475:124922542:124934360:124934413:124950718:124950832	124934360:124934413	ENSG00000196498.9	ENST00000448008.1
exon_skip_98483	12	124934360:124934413:124941651:124941708:124950718:124950826	124941651:124941708	ENSG00000196498.9	ENST00000405201.1,ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000458234.1,ENST00000420698.1,ENST00000542927.1
exon_skip_98487	12	124968141:124968319:124970986:124971114:124979692:124979798	124970986:124971114	ENSG00000196498.9	ENST00000404621.1,ENST00000356219.3,ENST00000397355.1,ENST00000404121.2,ENST00000429285.2,ENST00000458234.1,ENST00000420698.1
exon_skip_98492	12	124979692:124979914:125020110:125020157:125051853:125052010	125020110:125020157	ENSG00000196498.9	ENST00000458234.1,ENST00000542565.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for NCOR2

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000405201	124818969	124819163	Frame-shift
ENST00000405201	124819680	124819826	Frame-shift
ENST00000405201	124831109	124831396	Frame-shift
ENST00000405201	124835132	124835283	Frame-shift
ENST00000405201	124839382	124839485	Frame-shift
ENST00000405201	124839977	124840117	Frame-shift
ENST00000405201	124848224	124848345	Frame-shift
ENST00000405201	124870290	124870433	Frame-shift
ENST00000405201	124914158	124914252	Frame-shift
ENST00000405201	124922475	124922542	Frame-shift
ENST00000405201	124934360	124934413	Frame-shift
ENST00000405201	124811954	124812179	In-frame
ENST00000405201	124815390	124815444	In-frame
ENST00000405201	124817675	124817825	In-frame
ENST00000405201	124825147	124825297	In-frame
ENST00000405201	124827550	124827772	In-frame
ENST00000405201	124839023	124839128	In-frame
ENST00000405201	124841187	124841328	In-frame
ENST00000405201	124858958	124859009	In-frame
ENST00000405201	124882664	124882727	In-frame
ENST00000405201	124941651	124941708	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000405201	124818969	124819163	Frame-shift
ENST00000405201	124819680	124819826	Frame-shift
ENST00000405201	124831109	124831396	Frame-shift
ENST00000405201	124835132	124835283	Frame-shift
ENST00000405201	124839382	124839485	Frame-shift
ENST00000405201	124839977	124840117	Frame-shift
ENST00000405201	124848224	124848345	Frame-shift
ENST00000405201	124870290	124870433	Frame-shift
ENST00000405201	124914158	124914252	Frame-shift
ENST00000405201	124922475	124922542	Frame-shift
ENST00000405201	124934360	124934413	Frame-shift
ENST00000405201	124811954	124812179	In-frame
ENST00000405201	124815390	124815444	In-frame
ENST00000405201	124817675	124817825	In-frame
ENST00000405201	124825147	124825297	In-frame
ENST00000405201	124827550	124827772	In-frame
ENST00000405201	124839023	124839128	In-frame
ENST00000405201	124841187	124841328	In-frame
ENST00000405201	124858958	124859009	In-frame
ENST00000405201	124882664	124882727	In-frame
ENST00000405201	124941651	124941708	In-frame

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Infer the effects of exon skipping event on protein functional features for NCOR2

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000405201	8550	2514	124941651	124941708	707	763	235	254
ENST00000405201	8550	2514	124882664	124882727	1815	1877	604	625
ENST00000405201	8550	2514	124858958	124859009	2169	2219	722	739
ENST00000405201	8550	2514	124841187	124841328	3102	3242	1033	1080
ENST00000405201	8550	2514	124839023	124839128	3486	3590	1161	1196
ENST00000405201	8550	2514	124827550	124827772	4716	4937	1571	1645
ENST00000405201	8550	2514	124825147	124825297	5190	5339	1729	1779
ENST00000405201	8550	2514	124817675	124817825	6607	6756	2202	2251
ENST00000405201	8550	2514	124815390	124815444	6906	6959	2301	2319
ENST00000405201	8550	2514	124811954	124812179	6960	7184	2319	2394

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000405201	8550	2514	124941651	124941708	707	763	235	254
ENST00000405201	8550	2514	124882664	124882727	1815	1877	604	625
ENST00000405201	8550	2514	124858958	124859009	2169	2219	722	739
ENST00000405201	8550	2514	124841187	124841328	3102	3242	1033	1080
ENST00000405201	8550	2514	124839023	124839128	3486	3590	1161	1196
ENST00000405201	8550	2514	124827550	124827772	4716	4937	1571	1645
ENST00000405201	8550	2514	124825147	124825297	5190	5339	1729	1779
ENST00000405201	8550	2514	124817675	124817825	6607	6756	2202	2251
ENST00000405201	8550	2514	124815390	124815444	6906	6959	2301	2319
ENST00000405201	8550	2514	124811954	124812179	6960	7184	2319	2394

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9Y618	235	254	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	235	254	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	235	254	242	245	Mutagenesis	Note=Abolishes interaction with TBL1X. HRIL->AEIA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21240272;Dbxref=PMID:21240272
Q9Y618	235	254	254	312	Region	Note=Interaction with SIN3A/B;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q9Y618	604	625	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	604	625	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	604	625	610	661	Domain	Note=SANT 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00624
Q9Y618	604	625	617	629	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2LTP
Q9Y618	604	625	612	613	Sequence conflict	Note=SS->EF;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9Y618	722	739	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	722	739	724	740	Alternative sequence	ID=VSP_036595;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10097068,ECO:0000303\|Ref.4;Dbxref=PMID:10097068
Q9Y618	722	739	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1033	1080	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1033	1080	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1161	1196	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1161	1196	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1161	1196	1168	1168	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y618	1161	1196	1173	1173	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1571	1645	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1571	1645	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1571	1645	1595	1595	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9WU42
Q9Y618	1571	1645	1619	1619	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1729	1779	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1729	1779	1775	1775	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1729	1779	1778	1778	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
Q9Y618	2202	2251	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	2202	2251	2203	2203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
Q9Y618	2202	2251	2223	2223	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID
Q9Y618	2301	2319	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	2319	2394	2350	2395	Alternative sequence	ID=VSP_003413;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8813722,ECO:0000303\|Ref.4;Dbxref=PMID:8813722
Q9Y618	2319	2394	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	2319	2394	2337	2347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5X8Q
Q9Y618	2319	2394	2339	2343	Motif	Note=CORNR box of ID2

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9Y618	235	254	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	235	254	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	235	254	242	245	Mutagenesis	Note=Abolishes interaction with TBL1X. HRIL->AEIA;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:21240272;Dbxref=PMID:21240272
Q9Y618	235	254	254	312	Region	Note=Interaction with SIN3A/B;Ontology_term=ECO:0000250;evidence=ECO:0000250
Q9Y618	604	625	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	604	625	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	604	625	610	661	Domain	Note=SANT 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00624
Q9Y618	604	625	617	629	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:2LTP
Q9Y618	604	625	612	613	Sequence conflict	Note=SS->EF;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9Y618	722	739	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	722	739	724	740	Alternative sequence	ID=VSP_036595;Note=In isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:10097068,ECO:0000303\|Ref.4;Dbxref=PMID:10097068
Q9Y618	722	739	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1033	1080	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1033	1080	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1161	1196	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1161	1196	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1161	1196	1168	1168	Cross-link	Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:28112733;Dbxref=PMID:28112733
Q9Y618	1161	1196	1173	1173	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1571	1645	1	1702	Alternative sequence	ID=VSP_003412;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:8813722;Dbxref=PMID:8813722
Q9Y618	1571	1645	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1571	1645	1595	1595	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250\|UniProtKB:Q9WU42
Q9Y618	1571	1645	1619	1619	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1729	1779	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	1729	1779	1775	1775	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:23186163;Dbxref=PMID:23186163
Q9Y618	1729	1779	1778	1778	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:21406692,ECO:0000244\|PubMed:23186163;Dbxref=PMID:21406692,PMID:23186163
Q9Y618	2202	2251	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	2202	2251	2203	2203	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244\|PubMed:20068231;Dbxref=PMID:20068231
Q9Y618	2202	2251	2223	2223	Modified residue	Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244\|PubMed:18669648,ECO:0000244\|PubMed:19690332,ECO:0000244\|PubMed:20068231,ECO:0000244\|PubMed:23186163;Dbxref=PMID:18669648,PMID:19690332,PMID:20068231,PMID
Q9Y618	2301	2319	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	2319	2394	2350	2395	Alternative sequence	ID=VSP_003413;Note=In isoform 2 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303\|PubMed:8813722,ECO:0000303\|Ref.4;Dbxref=PMID:8813722
Q9Y618	2319	2394	1	2514	Chain	ID=PRO_0000055622;Note=Nuclear receptor corepressor 2
Q9Y618	2319	2394	2337	2347	Helix	Ontology_term=ECO:0000244;evidence=ECO:0000244\|PDB:5X8Q
Q9Y618	2319	2394	2339	2343	Motif	Note=CORNR box of ID2

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SNVs in the skipped exons for NCOR2

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

NCOR2_HNSC_exon_skip_98416_psi_boxplot.png
boxplot

NCOR2_KIRC_exon_skip_98460_psi_boxplot.png
boxplot

NCOR2_LIHC_exon_skip_98384_psi_boxplot.png
boxplot

NCOR2_STAD_exon_skip_98460_psi_boxplot.png
boxplot

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-BC-A3KG-01	exon_skip_98384	124811955	124812179	124812065	124812065	Frame_Shift_Del	G	-	p.P2366fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_98414	124818970	124819163	124818976	124818976	Frame_Shift_Del	C	-	p.G2207fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_98416	124818970	124819826	124818976	124818976	Frame_Shift_Del	C	-	p.G2207fs
LIHC	TCGA-DD-A1EG-01	exon_skip_98426	124825148	124825297	124825249	124825249	Frame_Shift_Del	G	-	p.P1753fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_98429	124827551	124827772	124827673	124827673	Frame_Shift_Del	G	-	p.P1612fs
COAD	TCGA-A6-5665-01	exon_skip_98431	124831110	124831396	124831256	124831256	Frame_Shift_Del	G	-	p.L1405fs
LIHC	TCGA-DD-A3A0-01	exon_skip_98433	124835133	124835283	124835183	124835183	Frame_Shift_Del	T	-	p.K1272fs
STAD	TCGA-CG-5726-01	exon_skip_98441	124839383	124839485	124839388	124839388	Frame_Shift_Del	T	-	p.K1160fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_98441	124839383	124839485	124839393	124839393	Frame_Shift_Del	G	-	p.P1165fs
LIHC	TCGA-DD-A1EG-01	exon_skip_98441	124839383	124839485	124839407	124839407	Frame_Shift_Del	G	-	p.L1161fs
LIHC	TCGA-DD-A3A1-01	exon_skip_98447	124839978	124840117	124840111	124840111	Frame_Shift_Del	G	-	p.P1090fs
COAD	TCGA-CM-6674-01	exon_skip_98455	124841188	124841328	124841251	124841251	Frame_Shift_Del	G	-	p.R1050fs
COAD	TCGA-CM-6674-01	exon_skip_98457	124841188	124841352	124841251	124841251	Frame_Shift_Del	G	-	p.R1050fs
COAD	TCGA-G4-6588-01	exon_skip_98455	124841188	124841328	124841289	124841289	Frame_Shift_Del	G	-	p.P1047fs
COAD	TCGA-G4-6588-01	exon_skip_98457	124841188	124841352	124841289	124841289	Frame_Shift_Del	G	-	p.P1047fs
STAD	TCGA-CD-A4MG-01	exon_skip_98455	124841188	124841328	124841289	124841289	Frame_Shift_Del	G	-	p.P1055fs
STAD	TCGA-CD-A4MG-01	exon_skip_98457	124841188	124841352	124841289	124841289	Frame_Shift_Del	G	-	p.P1055fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_98457	124841188	124841352	124841331	124841331	Frame_Shift_Del	G	-	p.P1040fs
COAD	TCGA-AD-6889-01	exon_skip_98459 exon_skip_98458	124848225	124848345	124848228	124848228	Frame_Shift_Del	G	-	p.I976fs
COAD	TCGA-AU-6004-01	exon_skip_98459 exon_skip_98458	124848225	124848345	124848228	124848228	Frame_Shift_Del	G	-	p.I976fs
COAD	TCGA-G4-6309-01	exon_skip_98459 exon_skip_98458	124848225	124848345	124848228	124848228	Frame_Shift_Del	G	-	p.I976fs
STAD	TCGA-VQ-A8P2-01	exon_skip_98459 exon_skip_98458	124848225	124848345	124848228	124848228	Frame_Shift_Del	G	-	p.P975fs
UCEC	TCGA-D1-A174-01	exon_skip_98459 exon_skip_98458	124848225	124848345	124848228	124848228	Frame_Shift_Del	G	-	p.P975fs
UCEC	TCGA-D1-A177-01	exon_skip_98459 exon_skip_98458	124848225	124848345	124848228	124848228	Frame_Shift_Del	G	-	p.P975fs
UCEC	TCGA-D1-A17U-01	exon_skip_98459 exon_skip_98458	124848225	124848345	124848228	124848228	Frame_Shift_Del	G	-	p.P975fs
UCS	TCGA-N7-A4Y0-01	exon_skip_98459 exon_skip_98458	124848225	124848345	124848228	124848228	Frame_Shift_Del	G	-	p.P975fs
THYM	TCGA-XU-A92X-01	exon_skip_98460	124856568	124857156	124856668	124856668	Frame_Shift_Del	C	-	p.A903fs
STAD	TCGA-HU-A4H8-01	exon_skip_98460	124856568	124857156	124856837	124856837	Frame_Shift_Del	G	-	p.A847fs
STAD	TCGA-HU-A4H8-01	exon_skip_98460	124856568	124857156	124856837	124856837	Frame_Shift_Del	G	-	p.P846fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_98468	124882665	124882727	124882677	124882677	Frame_Shift_Del	T	-	p.T622fs
LIHC	TCGA-CC-A7IE-01	exon_skip_98470	124914159	124914249	124914165	124914166	Frame_Shift_Del	CT	-	p.381_382del
LIHC	TCGA-CC-A7IE-01	exon_skip_98472	124914159	124914252	124914165	124914166	Frame_Shift_Del	CT	-	p.381_382del
COAD	TCGA-G4-6628-01	exon_skip_98483	124941652	124941708	124941663	124941663	Frame_Shift_Del	G	-	p.Q251fs
LIHC	TCGA-DD-A39Y-01	exon_skip_98488	124979693	124979914	124979758	124979758	Frame_Shift_Del	C	-	p.A14fs
LGG	TCGA-HT-7854-01	exon_skip_98407 exon_skip_98408	124817676	124817825	124817682	124817683	Frame_Shift_Ins	-	C	p.A2257fs
LGG	TCGA-HT-7854-01	exon_skip_98407 exon_skip_98408	124817676	124817825	124817682	124817683	Frame_Shift_Ins	-	C	p.E2240fs
KIRC	TCGA-B0-5117-01	exon_skip_98460	124856568	124857156	124856836	124856837	Frame_Shift_Ins	-	G	p.G847fs
BRCA	TCGA-A8-A091-01	exon_skip_98468	124882665	124882727	124882708	124882709	Frame_Shift_Ins	-	T	p.S612fs
HNSC	TCGA-D6-6516-01	exon_skip_98416	124818970	124819826	124819764	124819764	Nonsense_Mutation	G	A	p.Q2117*
HNSC	TCGA-D6-6516-01	exon_skip_98416	124818970	124819826	124819764	124819764	Nonsense_Mutation	G	A	p.Q2120*
HNSC	TCGA-D6-6516-01	exon_skip_98420	124819681	124819826	124819764	124819764	Nonsense_Mutation	G	A	p.Q2117*
HNSC	TCGA-D6-6516-01	exon_skip_98420	124819681	124819826	124819764	124819764	Nonsense_Mutation	G	A	p.Q2120*
LUAD	TCGA-50-5930-01	exon_skip_98460	124856568	124857156	124856713	124856713	Nonsense_Mutation	C	A	p.E888*
HNSC	TCGA-CR-7379-01	exon_skip_98466	124862783	124862930	124862849	124862849	Nonsense_Mutation	C	A	p.E701*

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons	Mutation description
	Sample: TCGA-B0-5117-01
	Cancer type: KIRC
	ESID: exon_skip_98460
	Skipped exon start: 124856568
	Skipped exon end: 124857156
	Mutation start: 124856836
	Mutation end: 124856837
	Mutation type: Frame_Shift_Ins
	Reference seq: -
	Mutation seq: G
	AAchange: p.G847fs
exon_skip_98460_KIRC_TCGA-B0-5117-01.png
	Sample: TCGA-HU-A4H8-01
	Cancer type: STAD
	ESID: exon_skip_98460
	Skipped exon start: 124856568
	Skipped exon end: 124857156
	Mutation start: 124856837
	Mutation end: 124856837
	Mutation type: Frame_Shift_Del
	Reference seq: G
	Mutation seq: -
	AAchange: p.A847fs
	Sample: TCGA-HU-A4H8-01
	Cancer type: STAD
	ESID: exon_skip_98460
	Skipped exon start: 124856568
	Skipped exon end: 124857156
	Mutation start: 124856837
	Mutation end: 124856837
	Mutation type: Frame_Shift_Del
	Reference seq: G
	Mutation seq: -
	AAchange: p.P846fs
exon_skip_300502_STAD_TCGA-HU-A4H8-01.png
exon_skip_343108_STAD_TCGA-HU-A4H8-01.png
exon_skip_450280_STAD_TCGA-HU-A4H8-01.png
exon_skip_452918_STAD_TCGA-HU-A4H8-01.png
exon_skip_472769_STAD_TCGA-HU-A4H8-01.png
exon_skip_472770_STAD_TCGA-HU-A4H8-01.png
exon_skip_496317_STAD_TCGA-HU-A4H8-01.png
exon_skip_66251_STAD_TCGA-HU-A4H8-01.png
exon_skip_66260_STAD_TCGA-HU-A4H8-01.png
exon_skip_66262_STAD_TCGA-HU-A4H8-01.png
exon_skip_98460_STAD_TCGA-HU-A4H8-01.png
	Sample: TCGA-D6-6516-01
	Cancer type: HNSC
	ESID: exon_skip_98416
	Skipped exon start: 124818970
	Skipped exon end: 124819826
	Mutation start: 124819764
	Mutation end: 124819764
	Mutation type: Nonsense_Mutation
	Reference seq: G
	Mutation seq: A
	AAchange: p.Q2117*
	Sample: TCGA-D6-6516-01
	Cancer type: HNSC
	ESID: exon_skip_98420
	Skipped exon start: 124819681
	Skipped exon end: 124819826
	Mutation start: 124819764
	Mutation end: 124819764
	Mutation type: Nonsense_Mutation
	Reference seq: G
	Mutation seq: A
	AAchange: p.Q2117*
	Sample: TCGA-D6-6516-01
	Cancer type: HNSC
	ESID: exon_skip_98416
	Skipped exon start: 124818970
	Skipped exon end: 124819826
	Mutation start: 124819764
	Mutation end: 124819764
	Mutation type: Nonsense_Mutation
	Reference seq: G
	Mutation seq: A
	AAchange: p.Q2120*
	Sample: TCGA-D6-6516-01
	Cancer type: HNSC
	ESID: exon_skip_98420
	Skipped exon start: 124819681
	Skipped exon end: 124819826
	Mutation start: 124819764
	Mutation end: 124819764
	Mutation type: Nonsense_Mutation
	Reference seq: G
	Mutation seq: A
	AAchange: p.Q2120*
exon_skip_98416_HNSC_TCGA-D6-6516-01.png
	Sample: TCGA-BC-A3KG-01
	Cancer type: LIHC
	ESID: exon_skip_98384
	Skipped exon start: 124811955
	Skipped exon end: 124812179
	Mutation start: 124812065
	Mutation end: 124812065
	Mutation type: Frame_Shift_Del
	Reference seq: G
	Mutation seq: -
	AAchange: p.P2366fs
exon_skip_107008_LIHC_TCGA-BC-A3KG-01.png
exon_skip_107009_LIHC_TCGA-BC-A3KG-01.png
exon_skip_107010_LIHC_TCGA-BC-A3KG-01.png
exon_skip_10760_LIHC_TCGA-BC-A3KG-01.png
exon_skip_11532_LIHC_TCGA-BC-A3KG-01.png
exon_skip_123519_LIHC_TCGA-BC-A3KG-01.png
exon_skip_17069_LIHC_TCGA-BC-A3KG-01.png
exon_skip_300924_LIHC_TCGA-BC-A3KG-01.png
exon_skip_346623_LIHC_TCGA-BC-A3KG-01.png
exon_skip_374970_LIHC_TCGA-BC-A3KG-01.png
exon_skip_387350_LIHC_TCGA-BC-A3KG-01.png
exon_skip_423555_LIHC_TCGA-BC-A3KG-01.png
exon_skip_441299_LIHC_TCGA-BC-A3KG-01.png
exon_skip_441300_LIHC_TCGA-BC-A3KG-01.png
exon_skip_444819_LIHC_TCGA-BC-A3KG-01.png
exon_skip_450818_LIHC_TCGA-BC-A3KG-01.png
exon_skip_456987_LIHC_TCGA-BC-A3KG-01.png
exon_skip_459274_LIHC_TCGA-BC-A3KG-01.png
exon_skip_494352_LIHC_TCGA-BC-A3KG-01.png
exon_skip_64409_LIHC_TCGA-BC-A3KG-01.png
exon_skip_64412_LIHC_TCGA-BC-A3KG-01.png
exon_skip_69788_LIHC_TCGA-BC-A3KG-01.png
exon_skip_98384_LIHC_TCGA-BC-A3KG-01.png

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
DOV13_OVARY	124818970	124819826	124819097	124819097	Frame_Shift_Del	G	-	p.L2160fs
DOV13_OVARY	124818970	124819163	124819097	124819097	Frame_Shift_Del	G	-	p.L2160fs
WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124827551	124827772	124827599	124827599	Frame_Shift_Del	G	-	p.L1630fs
HEC59_ENDOMETRIUM	124841188	124841352	124841251	124841251	Frame_Shift_Del	G	-	p.R1060fs
HEC59_ENDOMETRIUM	124841188	124841328	124841251	124841251	Frame_Shift_Del	G	-	p.R1060fs
DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124841188	124841352	124841251	124841251	Frame_Shift_Del	G	-	p.R1060fs
DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124841188	124841328	124841251	124841251	Frame_Shift_Del	G	-	p.R1060fs
WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124841188	124841352	124841251	124841251	Frame_Shift_Del	G	-	p.R1060fs
WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124841188	124841328	124841251	124841251	Frame_Shift_Del	G	-	p.R1060fs
MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124841188	124841352	124841274	124841274	Frame_Shift_Del	C	-	p.G1052fs
MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124841188	124841328	124841274	124841274	Frame_Shift_Del	C	-	p.G1052fs
SNUC2A_LARGE_INTESTINE	124841188	124841352	124841289	124841289	Frame_Shift_Del	G	-	p.P1047fs
SNUC2A_LARGE_INTESTINE	124841188	124841328	124841289	124841289	Frame_Shift_Del	G	-	p.P1047fs
DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124848225	124848345	124848228	124848228	Frame_Shift_Del	G	-	p.P975fs
HEC151_ENDOMETRIUM	124848225	124848345	124848228	124848228	Frame_Shift_Del	G	-	p.P975fs
2313287_STOMACH	124848225	124848345	124848228	124848228	Frame_Shift_Del	G	-	p.P975fs
CL34_LARGE_INTESTINE	124848225	124848345	124848228	124848228	Frame_Shift_Del	G	-	p.P975fs
MFE319_ENDOMETRIUM	124848225	124848345	124848228	124848228	Frame_Shift_Del	G	-	p.P975fs
HEC265_ENDOMETRIUM	124856568	124857156	124856638	124856638	Frame_Shift_Del	G	-	p.Q913fs
ISHIKAWAHERAKLIO02ER_ENDOMETRIUM	124856568	124857156	124856837	124856837	Frame_Shift_Del	G	-	p.P846fs
KM12_LARGE_INTESTINE	124856568	124857156	124856982	124856982	Frame_Shift_Del	G	-	p.P798fs
RKO_LARGE_INTESTINE	124856568	124857156	124857035	124857036	Frame_Shift_Ins	-	G	p.P780fs
HEC151_ENDOMETRIUM	124811955	124812179	124811960	124811960	Missense_Mutation	G	A	p.S2393L
RAJI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124811955	124812179	124811966	124811966	Missense_Mutation	A	T	p.L2391H
OSRC2_KIDNEY	124811955	124812179	124811967	124811967	Missense_Mutation	G	T	p.L2391I
LS411N_LARGE_INTESTINE	124811955	124812179	124811984	124811984	Missense_Mutation	C	T	p.G2385E
ZR7530_BREAST	124811955	124812179	124811990	124811990	Missense_Mutation	G	A	p.A2383V
HCT15_LARGE_INTESTINE	124811955	124812179	124812156	124812156	Missense_Mutation	C	T	p.A2328T
HCT15_LARGE_INTESTINE	124812093	124812179	124812156	124812156	Missense_Mutation	C	T	p.A2328T
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124811955	124812179	124812177	124812177	Missense_Mutation	G	A	p.L2321F
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124812093	124812179	124812177	124812177	Missense_Mutation	G	A	p.L2321F
SNUC5_LARGE_INTESTINE	124817676	124817825	124817704	124817704	Missense_Mutation	A	G	p.Y2243H
HEC265_ENDOMETRIUM	124817676	124817825	124817803	124817803	Missense_Mutation	A	G	p.S2210P
MFE319_ENDOMETRIUM	124817676	124817825	124817811	124817811	Missense_Mutation	T	A	p.N2207I
NCIH650_LUNG	124818970	124819826	124819042	124819042	Missense_Mutation	C	A	p.S2178I
NCIH650_LUNG	124818970	124819163	124819042	124819042	Missense_Mutation	C	A	p.S2178I
RERFLCAD1_LUNG	124818970	124819826	124819103	124819103	Missense_Mutation	C	A	p.A2158S
RERFLCAD1_LUNG	124818970	124819163	124819103	124819103	Missense_Mutation	C	A	p.A2158S
HEC265_ENDOMETRIUM	124818970	124819826	124819689	124819689	Missense_Mutation	G	A	p.H2135Y
HEC265_ENDOMETRIUM	124819681	124819826	124819689	124819689	Missense_Mutation	G	A	p.H2135Y
SNU324_PANCREAS	124818970	124819826	124819701	124819701	Missense_Mutation	T	C	p.T2131A
SNU324_PANCREAS	124819681	124819826	124819701	124819701	Missense_Mutation	T	C	p.T2131A
PACADD137_PANCREAS	124818970	124819826	124819710	124819710	Missense_Mutation	G	A	p.R2128W
PACADD137_PANCREAS	124819681	124819826	124819710	124819710	Missense_Mutation	G	A	p.R2128W
PEDS015T_SOFT_TISSUE	124818970	124819826	124819746	124819746	Missense_Mutation	G	T	p.L2116M
PEDS015T_SOFT_TISSUE	124819681	124819826	124819746	124819746	Missense_Mutation	G	T	p.L2116M
HCC2450_LUNG	124818970	124819826	124819806	124819806	Missense_Mutation	C	G	p.E2096Q
HCC2450_LUNG	124819681	124819826	124819806	124819806	Missense_Mutation	C	G	p.E2096Q
NCIH2347_LUNG	124825148	124825240	124825162	124825162	Missense_Mutation	G	T	p.S1775Y
NCIH2347_LUNG	124825148	124825297	124825162	124825162	Missense_Mutation	G	T	p.S1775Y
CCLFPEDS0018T_SOFT_TISSUE	124825148	124825240	124825175	124825175	Missense_Mutation	G	A	p.R1771C
CCLFPEDS0018T_SOFT_TISSUE	124825148	124825297	124825175	124825175	Missense_Mutation	G	A	p.R1771C
NCIH2073_LUNG	124825148	124825240	124825216	124825216	Missense_Mutation	C	A	p.R1757L
NCIH2073_LUNG	124825148	124825297	124825216	124825216	Missense_Mutation	C	A	p.R1757L
NCIH1993_LUNG	124825148	124825240	124825216	124825216	Missense_Mutation	C	A	p.R1757L
NCIH1993_LUNG	124825148	124825297	124825216	124825216	Missense_Mutation	C	A	p.R1757L
SUDHL10_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124825148	124825240	124825217	124825217	Missense_Mutation	G	A	p.R1757C
SUDHL10_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124825148	124825297	124825217	124825217	Missense_Mutation	G	A	p.R1757C
EN_ENDOMETRIUM	124825148	124825240	124825225	124825225	Missense_Mutation	G	A	p.A1754V
EN_ENDOMETRIUM	124825148	124825297	124825225	124825225	Missense_Mutation	G	A	p.A1754V
HCC1438_LUNG	124825148	124825240	124825243	124825243	Missense_Mutation	G	A	p.P1748L
HCC1438_LUNG	124825148	124825297	124825243	124825243	Missense_Mutation	G	A	p.P1748L
RCCER_KIDNEY	124827551	124827772	124827569	124827569	Missense_Mutation	C	T	p.G1640S
PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124827551	124827772	124827613	124827613	Missense_Mutation	C	T	p.R1625H
CW2_LARGE_INTESTINE	124827551	124827772	124827620	124827620	Missense_Mutation	G	T	p.L1623M
SW684_SOFT_TISSUE	124827551	124827772	124827641	124827641	Missense_Mutation	G	A	p.R1616W
LS411N_LARGE_INTESTINE	124827551	124827772	124827667	124827667	Missense_Mutation	G	T	p.P1607H
SW48_LARGE_INTESTINE	124827551	124827772	124827689	124827689	Missense_Mutation	C	T	p.V1600M
OC316_OVARY	124831110	124831396	124831162	124831162	Missense_Mutation	G	A	p.T1436M
OC314_OVARY	124831110	124831396	124831162	124831162	Missense_Mutation	G	A	p.T1436M
NCIH2172_LUNG	124831110	124831396	124831217	124831217	Missense_Mutation	C	A	p.V1418L
SNU407_LARGE_INTESTINE	124831110	124831396	124831354	124831354	Missense_Mutation	C	T	p.R1372H
FTC238_THYROID	124831110	124831396	124831354	124831354	Missense_Mutation	C	T	p.R1372H
NCIH1688_LUNG	124835133	124835283	124835154	124835154	Missense_Mutation	C	A	p.G1275C
SNU1040_LARGE_INTESTINE	124835133	124835283	124835166	124835166	Missense_Mutation	C	T	p.E1271K
IGROV1_OVARY	124835133	124835283	124835175	124835175	Missense_Mutation	C	T	p.V1268I
HEC6_ENDOMETRIUM	124835133	124835283	124835189	124835189	Missense_Mutation	A	G	p.L1263P
CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124835133	124835283	124835207	124835207	Missense_Mutation	C	T	p.R1257H
SNU81_LARGE_INTESTINE	124835133	124835283	124835232	124835232	Missense_Mutation	C	T	p.E1249K
HEC108_ENDOMETRIUM	124835133	124835283	124835253	124835253	Missense_Mutation	T	C	p.T1242A
MCC26_SKIN	124839024	124839128	124839042	124839042	Missense_Mutation	C	T	p.E1191K
SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124839024	124839128	124839057	124839057	Missense_Mutation	C	T	p.V1186M
MDST8_LARGE_INTESTINE	124839024	124839128	124839089	124839089	Missense_Mutation	C	T	p.R1175Q
NCIH510_LUNG	124839024	124839128	124839114	124839114	Missense_Mutation	C	T	p.V1167M
NCIH1573_LUNG	124839383	124839485	124839416	124839416	Missense_Mutation	C	G	p.G1151R
NCIH716_LARGE_INTESTINE	124839383	124839485	124839417	124839417	Missense_Mutation	C	T	p.M1150I
KYAE1_OESOPHAGUS	124839383	124839485	124839421	124839421	Missense_Mutation	G	A	p.T1149I
NCIH1385_LUNG	124839383	124839485	124839427	124839427	Missense_Mutation	G	C	p.P1147R
HT115_LARGE_INTESTINE	124839383	124839485	124839433	124839433	Missense_Mutation	A	G	p.V1145A
LS411N_LARGE_INTESTINE	124839383	124839485	124839449	124839449	Missense_Mutation	G	A	p.H1140Y
CORL88_LUNG	124839978	124840117	124840045	124840045	Missense_Mutation	G	A	p.P1105L
DV90_LUNG	124839978	124840117	124840076	124840076	Missense_Mutation	C	T	p.V1095I
DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124839978	124840117	124840085	124840085	Missense_Mutation	C	T	p.A1092T
SNUC2A_LARGE_INTESTINE	124841188	124841352	124841220	124841220	Missense_Mutation	G	T	p.P1070Q
SNUC2A_LARGE_INTESTINE	124841188	124841328	124841220	124841220	Missense_Mutation	G	T	p.P1070Q
MCF7_BREAST	124841188	124841352	124841248	124841248	Missense_Mutation	C	T	p.E1061K
MCF7_BREAST	124841188	124841328	124841248	124841248	Missense_Mutation	C	T	p.E1061K
JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124841188	124841352	124841260	124841260	Missense_Mutation	C	T	p.V1057M
JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124841188	124841328	124841260	124841260	Missense_Mutation	C	T	p.V1057M
HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124848225	124848345	124848247	124848247	Missense_Mutation	C	T	p.R969Q
SW1271_LUNG	124856568	124857156	124856635	124856635	Missense_Mutation	C	A	p.D914Y
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124856568	124857156	124856668	124856668	Missense_Mutation	C	T	p.A903T
SNU175_LARGE_INTESTINE	124856568	124857156	124856706	124856706	Missense_Mutation	G	A	p.A890V
OCUBM_BREAST	124856568	124857156	124856725	124856725	Missense_Mutation	C	T	p.E884K
SNU1040_LARGE_INTESTINE	124856568	124857156	124856736	124856736	Missense_Mutation	G	A	p.A880V
NCIH510_LUNG	124856568	124857156	124856775	124856775	Missense_Mutation	G	A	p.T867M
BT483_BREAST	124856568	124857156	124856808	124856808	Missense_Mutation	C	G	p.G856A
TOV21G_OVARY	124856568	124857156	124856836	124856836	Missense_Mutation	C	T	p.A847T
NCIH1573_LUNG	124856568	124857156	124856846	124856846	Missense_Mutation	C	G	p.Q843H
HEC108_ENDOMETRIUM	124856568	124857156	124856852	124856852	Missense_Mutation	C	A	p.E841D
HCC1569_BREAST	124856568	124857156	124856935	124856935	Missense_Mutation	A	G	p.S814P
NCIH2731_PLEURA	124856568	124857156	124856965	124856965	Missense_Mutation	C	T	p.G804R
NCIH358_LUNG	124856568	124857156	124856982	124856982	Missense_Mutation	G	A	p.P798L
WIL2NS_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124856568	124857156	124857003	124857003	Missense_Mutation	G	A	p.P791L
IPC298_SKIN	124856568	124857156	124857022	124857022	Missense_Mutation	G	T	p.P785T
IPC298_SKIN	124856568	124857156	124857022	124857023	Missense_Mutation	GG	TA	p.P785T
IGROV1_OVARY	124856568	124857156	124857130	124857130	Missense_Mutation	C	T	p.E749K
PEDS015T_SOFT_TISSUE	124858959	124859009	124858974	124858974	Missense_Mutation	C	G	p.E735Q
PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124862783	124862930	124862822	124862822	Missense_Mutation	C	T	p.V710M
SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124862783	124862930	124862822	124862822	Missense_Mutation	C	T	p.V710M
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124862783	124862930	124862830	124862830	Missense_Mutation	G	A	p.A707V
647V_URINARY_TRACT	124862783	124862930	124862846	124862846	Missense_Mutation	C	T	p.D702N
NCIH1092_LUNG	124862783	124862930	124862852	124862852	Missense_Mutation	C	A	p.V700L
HEC1_ENDOMETRIUM	124862783	124862930	124862855	124862855	Missense_Mutation	C	T	p.V699M
SNUC5_LARGE_INTESTINE	124862783	124862930	124862863	124862863	Missense_Mutation	A	T	p.F696Y
2313287_STOMACH	124862783	124862930	124862911	124862911	Missense_Mutation	C	T	p.R680Q
MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124862783	124862930	124862914	124862914	Missense_Mutation	G	A	p.A679V
SW626_OVARY	124870291	124870433	124870305	124870305	Missense_Mutation	G	T	p.H669N
PANC0213_PANCREAS	124870291	124870433	124870370	124870370	Missense_Mutation	G	A	p.S647L
SNU1040_LARGE_INTESTINE	124870291	124870433	124870398	124870398	Missense_Mutation	C	T	p.A638T
HEC1A_ENDOMETRIUM	124870291	124870433	124870415	124870415	Missense_Mutation	C	T	p.R632H
HEC1_ENDOMETRIUM	124870291	124870433	124870415	124870415	Missense_Mutation	C	T	p.R632H
HEC1B_ENDOMETRIUM	124870291	124870433	124870415	124870415	Missense_Mutation	C	T	p.R632H
PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124914159	124914249	124914172	124914172	Missense_Mutation	A	G	p.L379P
PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124914159	124914252	124914172	124914172	Missense_Mutation	A	G	p.L379P
EW24_BONE	124914159	124914249	124914209	124914209	Missense_Mutation	G	A	p.R367C
EW24_BONE	124914159	124914252	124914209	124914209	Missense_Mutation	G	A	p.R367C
NCIH2066_LUNG	124914159	124914249	124914221	124914221	Missense_Mutation	T	A	p.M363L
NCIH2066_LUNG	124914159	124914252	124914221	124914221	Missense_Mutation	T	A	p.M363L
HEC59_ENDOMETRIUM	124914159	124914249	124914229	124914229	Missense_Mutation	C	T	p.G360E
HEC59_ENDOMETRIUM	124914159	124914252	124914229	124914229	Missense_Mutation	C	T	p.G360E
MFE319_ENDOMETRIUM	124941652	124941708	124941692	124941692	Missense_Mutation	G	T	p.A241E
CA922_UPPER_AERODIGESTIVE_TRACT	124970987	124971114	124971047	124971047	Missense_Mutation	A	T	p.I58N
RERFLCFM_LUNG	124979693	124979914	124979697	124979697	Missense_Mutation	T	A	p.H34L
KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	124817676	124817825	124817676	124817676	Splice_Site	C	A	p.S2252I
MDAMB435S_SKIN	124835133	124835283	124835133	124835133	Splice_Site	C	A	p.G1282C

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NCOR2

sQTL information located at the skipped exons.

Exon skip ID

Chromosome

Three exons

Skippped exon

ENST

Cancer type

SNP id

Location

DNA change (ref/var)

P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NCOR2

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NCOR2

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RelatedDrugs for NCOR2

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for NCOR2

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
NCOR2	C0005586	Bipolar Disorder	1	PSYGENET
NCOR2	C0023893	Liver Cirrhosis, Experimental	1	CTD_human

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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