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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CLOCK |
 Gene summary |
| Gene information | Gene symbol | CLOCK | Gene ID | 9575 |
| Gene name | clock circadian regulator | |
| Synonyms | KAT13D|bHLHe8 | |
| Cytomap | 4q12 | |
| Type of gene | protein-coding | |
| Description | circadian locomoter output cycles protein kaputcircadian locomoter output cycles kaput proteinclass E basic helix-loop-helix protein 8clock homolog | |
| Modification date | 20180519 | |
| UniProtAcc | O15516 | |
| Context | PubMed: CLOCK [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CLOCK | GO:0006473 | protein acetylation | 28985504 |
| CLOCK | GO:0032922 | circadian regulation of gene expression | 24005054 |
| CLOCK | GO:0045893 | positive regulation of transcription, DNA-templated | 23785138 |
| CLOCK | GO:0051775 | response to redox state | 11441146 |
| CLOCK | GO:0071479 | cellular response to ionizing radiation | 21659603 |
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Exon skipping events across known transcript of Ensembl for CLOCK from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CLOCK |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CLOCK |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_429596 | 4 | 56304448:56304574:56308598:56308801:56309853:56309922 | 56308598:56308801 | ENSG00000134852.10 | ENST00000511124.1 |
| exon_skip_429597 | 4 | 56304448:56304704:56308598:56308801:56309853:56309922 | 56308598:56308801 | ENSG00000134852.10 | ENST00000309964.4,ENST00000381322.1,ENST00000513440.1 |
| exon_skip_429598 | 4 | 56310799:56310952:56314945:56315035:56315562:56315593 | 56314945:56315035 | ENSG00000134852.10 | ENST00000309964.4,ENST00000511124.1,ENST00000381322.1,ENST00000513440.1 |
| exon_skip_429599 | 4 | 56319220:56319296:56319843:56319991:56322063:56322170 | 56319843:56319991 | ENSG00000134852.10 | ENST00000309964.4,ENST00000381322.1,ENST00000513440.1 |
| exon_skip_429600 | 4 | 56325314:56325428:56329851:56329972:56336883:56336973 | 56329851:56329972 | ENSG00000134852.10 | ENST00000309964.4,ENST00000506747.1,ENST00000381322.1,ENST00000513440.1 |
| exon_skip_429602 | 4 | 56329864:56329972:56336883:56336973:56342129:56342221 | 56336883:56336973 | ENSG00000134852.10 | ENST00000309964.4,ENST00000506747.1,ENST00000435527.2,ENST00000381322.1,ENST00000513440.1 |
| exon_skip_429603 | 4 | 56336910:56336973:56342129:56342221:56344981:56345130 | 56342129:56342221 | ENSG00000134852.10 | ENST00000309964.4,ENST00000506747.1,ENST00000435527.2,ENST00000381322.1,ENST00000513440.1,ENST00000508049.1 |
| exon_skip_429604 | 4 | 56342129:56342221:56344981:56345130:56345806:56345866 | 56344981:56345130 | ENSG00000134852.10 | ENST00000309964.4,ENST00000506747.1,ENST00000435527.2,ENST00000381322.1,ENST00000513440.1 |
| exon_skip_429608 | 4 | 56348939:56348995:56352559:56352716:56355540:56355632 | 56352559:56352716 | ENSG00000134852.10 | ENST00000381322.1,ENST00000506923.1 |
| exon_skip_429609 | 4 | 56355540:56355632:56376078:56376232:56412648:56412713 | 56376078:56376232 | ENSG00000134852.10 | ENST00000513033.1,ENST00000509151.1 |
| exon_skip_429610 | 4 | 56355540:56355632:56376078:56376232:56412948:56413048 | 56376078:56376232 | ENSG00000134852.10 | ENST00000513440.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CLOCK |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_429596 | 4 | 56304448:56304574:56308598:56308801:56309853:56309922 | 56308598:56308801 | ENSG00000134852.10 | ENST00000511124.1 |
| exon_skip_429597 | 4 | 56304448:56304704:56308598:56308801:56309853:56309922 | 56308598:56308801 | ENSG00000134852.10 | ENST00000309964.4,ENST00000381322.1,ENST00000513440.1 |
| exon_skip_429598 | 4 | 56310799:56310952:56314945:56315035:56315562:56315593 | 56314945:56315035 | ENSG00000134852.10 | ENST00000309964.4,ENST00000511124.1,ENST00000381322.1,ENST00000513440.1 |
| exon_skip_429599 | 4 | 56319220:56319296:56319843:56319991:56322063:56322170 | 56319843:56319991 | ENSG00000134852.10 | ENST00000309964.4,ENST00000381322.1,ENST00000513440.1 |
| exon_skip_429600 | 4 | 56325314:56325428:56329851:56329972:56336883:56336973 | 56329851:56329972 | ENSG00000134852.10 | ENST00000309964.4,ENST00000381322.1,ENST00000513440.1,ENST00000506747.1 |
| exon_skip_429603 | 4 | 56336910:56336973:56342129:56342221:56344981:56345130 | 56342129:56342221 | ENSG00000134852.10 | ENST00000309964.4,ENST00000381322.1,ENST00000513440.1,ENST00000506747.1,ENST00000435527.2,ENST00000508049.1 |
| exon_skip_429604 | 4 | 56342129:56342221:56344981:56345130:56345806:56345866 | 56344981:56345130 | ENSG00000134852.10 | ENST00000309964.4,ENST00000381322.1,ENST00000513440.1,ENST00000506747.1,ENST00000435527.2 |
| exon_skip_429608 | 4 | 56348939:56348995:56352559:56352716:56355540:56355632 | 56352559:56352716 | ENSG00000134852.10 | ENST00000381322.1,ENST00000506923.1 |
| exon_skip_429609 | 4 | 56355540:56355632:56376078:56376232:56412648:56412713 | 56376078:56376232 | ENSG00000134852.10 | ENST00000509151.1,ENST00000513033.1 |
| exon_skip_429610 | 4 | 56355540:56355632:56376078:56376232:56412948:56413048 | 56376078:56376232 | ENSG00000134852.10 | ENST00000513440.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CLOCK |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000381322 | 56352559 | 56352716 | 3UTR-3UTR |
| ENST00000513440 | 56376078 | 56376232 | 3UTR-3UTR |
| ENST00000309964 | 56308598 | 56308801 | Frame-shift |
| ENST00000381322 | 56308598 | 56308801 | Frame-shift |
| ENST00000513440 | 56308598 | 56308801 | Frame-shift |
| ENST00000309964 | 56319843 | 56319991 | Frame-shift |
| ENST00000381322 | 56319843 | 56319991 | Frame-shift |
| ENST00000513440 | 56319843 | 56319991 | Frame-shift |
| ENST00000309964 | 56329851 | 56329972 | Frame-shift |
| ENST00000381322 | 56329851 | 56329972 | Frame-shift |
| ENST00000513440 | 56329851 | 56329972 | Frame-shift |
| ENST00000309964 | 56342129 | 56342221 | Frame-shift |
| ENST00000381322 | 56342129 | 56342221 | Frame-shift |
| ENST00000513440 | 56342129 | 56342221 | Frame-shift |
| ENST00000309964 | 56344981 | 56345130 | Frame-shift |
| ENST00000381322 | 56344981 | 56345130 | Frame-shift |
| ENST00000513440 | 56344981 | 56345130 | Frame-shift |
| ENST00000309964 | 56314945 | 56315035 | In-frame |
| ENST00000381322 | 56314945 | 56315035 | In-frame |
| ENST00000513440 | 56314945 | 56315035 | In-frame |
| ENST00000309964 | 56336883 | 56336973 | In-frame |
| ENST00000381322 | 56336883 | 56336973 | In-frame |
| ENST00000513440 | 56336883 | 56336973 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000381322 | 56352559 | 56352716 | 3UTR-3UTR |
| ENST00000513440 | 56376078 | 56376232 | 3UTR-3UTR |
| ENST00000309964 | 56308598 | 56308801 | Frame-shift |
| ENST00000381322 | 56308598 | 56308801 | Frame-shift |
| ENST00000513440 | 56308598 | 56308801 | Frame-shift |
| ENST00000309964 | 56319843 | 56319991 | Frame-shift |
| ENST00000381322 | 56319843 | 56319991 | Frame-shift |
| ENST00000513440 | 56319843 | 56319991 | Frame-shift |
| ENST00000309964 | 56329851 | 56329972 | Frame-shift |
| ENST00000381322 | 56329851 | 56329972 | Frame-shift |
| ENST00000513440 | 56329851 | 56329972 | Frame-shift |
| ENST00000309964 | 56342129 | 56342221 | Frame-shift |
| ENST00000381322 | 56342129 | 56342221 | Frame-shift |
| ENST00000513440 | 56342129 | 56342221 | Frame-shift |
| ENST00000309964 | 56344981 | 56345130 | Frame-shift |
| ENST00000381322 | 56344981 | 56345130 | Frame-shift |
| ENST00000513440 | 56344981 | 56345130 | Frame-shift |
| ENST00000309964 | 56314945 | 56315035 | In-frame |
| ENST00000381322 | 56314945 | 56315035 | In-frame |
| ENST00000513440 | 56314945 | 56315035 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CLOCK |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000309964 | 10321 | 846 | 56336883 | 56336973 | 600 | 689 | 116 | 146 |
| ENST00000381322 | 4076 | 846 | 56336883 | 56336973 | 1275 | 1364 | 116 | 146 |
| ENST00000513440 | 3597 | 846 | 56336883 | 56336973 | 995 | 1084 | 116 | 146 |
| ENST00000309964 | 10321 | 846 | 56314945 | 56315035 | 1701 | 1790 | 483 | 513 |
| ENST00000381322 | 4076 | 846 | 56314945 | 56315035 | 2376 | 2465 | 483 | 513 |
| ENST00000513440 | 3597 | 846 | 56314945 | 56315035 | 2096 | 2185 | 483 | 513 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000309964 | 10321 | 846 | 56314945 | 56315035 | 1701 | 1790 | 483 | 513 |
| ENST00000381322 | 4076 | 846 | 56314945 | 56315035 | 2376 | 2465 | 483 | 513 |
| ENST00000513440 | 3597 | 846 | 56314945 | 56315035 | 2096 | 2185 | 483 | 513 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15516 | 116 | 146 | 1 | 846 | Chain | ID=PRO_0000127163;Note=Circadian locomoter output cycles protein kaput |
| O15516 | 116 | 146 | 1 | 846 | Chain | ID=PRO_0000127163;Note=Circadian locomoter output cycles protein kaput |
| O15516 | 116 | 146 | 1 | 846 | Chain | ID=PRO_0000127163;Note=Circadian locomoter output cycles protein kaput |
| O15516 | 116 | 146 | 107 | 177 | Domain | Note=PAS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140 |
| O15516 | 116 | 146 | 107 | 177 | Domain | Note=PAS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140 |
| O15516 | 116 | 146 | 107 | 177 | Domain | Note=PAS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00140 |
| O15516 | 116 | 146 | 116 | 116 | Mutagenesis | Note=3-fold increase in PER1 reporter activity by CLOCK-ARNTL/BMAL1. Some reduction of CRY1 inhibition of CLOCK-ARNTL/BMAL1 transcriptional activity%3B when associated with K-367 and L-601. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:164744 |
| O15516 | 116 | 146 | 116 | 116 | Mutagenesis | Note=3-fold increase in PER1 reporter activity by CLOCK-ARNTL/BMAL1. Some reduction of CRY1 inhibition of CLOCK-ARNTL/BMAL1 transcriptional activity%3B when associated with K-367 and L-601. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:164744 |
| O15516 | 116 | 146 | 116 | 116 | Mutagenesis | Note=3-fold increase in PER1 reporter activity by CLOCK-ARNTL/BMAL1. Some reduction of CRY1 inhibition of CLOCK-ARNTL/BMAL1 transcriptional activity%3B when associated with K-367 and L-601. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:164744 |
| O15516 | 483 | 513 | 1 | 846 | Chain | ID=PRO_0000127163;Note=Circadian locomoter output cycles protein kaput |
| O15516 | 483 | 513 | 1 | 846 | Chain | ID=PRO_0000127163;Note=Circadian locomoter output cycles protein kaput |
| O15516 | 483 | 513 | 1 | 846 | Chain | ID=PRO_0000127163;Note=Circadian locomoter output cycles protein kaput |
| O15516 | 483 | 513 | 371 | 845 | Region | Note=Interaction with NR3C1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785 |
| O15516 | 483 | 513 | 371 | 845 | Region | Note=Interaction with NR3C1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785 |
| O15516 | 483 | 513 | 371 | 845 | Region | Note=Interaction with NR3C1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785 |
| O15516 | 483 | 513 | 450 | 570 | Region | Note=Interaction with SIRT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785 |
| O15516 | 483 | 513 | 450 | 570 | Region | Note=Interaction with SIRT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785 |
| O15516 | 483 | 513 | 450 | 570 | Region | Note=Interaction with SIRT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O15516 | 483 | 513 | 1 | 846 | Chain | ID=PRO_0000127163;Note=Circadian locomoter output cycles protein kaput |
| O15516 | 483 | 513 | 1 | 846 | Chain | ID=PRO_0000127163;Note=Circadian locomoter output cycles protein kaput |
| O15516 | 483 | 513 | 1 | 846 | Chain | ID=PRO_0000127163;Note=Circadian locomoter output cycles protein kaput |
| O15516 | 483 | 513 | 371 | 845 | Region | Note=Interaction with NR3C1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785 |
| O15516 | 483 | 513 | 371 | 845 | Region | Note=Interaction with NR3C1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785 |
| O15516 | 483 | 513 | 371 | 845 | Region | Note=Interaction with NR3C1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785 |
| O15516 | 483 | 513 | 450 | 570 | Region | Note=Interaction with SIRT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785 |
| O15516 | 483 | 513 | 450 | 570 | Region | Note=Interaction with SIRT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785 |
| O15516 | 483 | 513 | 450 | 570 | Region | Note=Interaction with SIRT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O08785 |
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SNVs in the skipped exons for CLOCK |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_429596 exon_skip_429597 | 56308599 | 56308801 | 56308642 | 56308642 | Frame_Shift_Del | G | - | p.Q688fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_429599 | 56319844 | 56319991 | 56319870 | 56319870 | Frame_Shift_Del | A | - | p.F368fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_429600 | 56329852 | 56329972 | 56329866 | 56329866 | Frame_Shift_Del | G | - | p.P182fs |
| ACC | TCGA-OR-A5J5-01 | exon_skip_429602 | 56336884 | 56336973 | 56336954 | 56336954 | Frame_Shift_Del | A | - | p.L123fs |
| GBM | TCGA-32-4213-01 | exon_skip_429602 | 56336884 | 56336973 | 56336954 | 56336954 | Frame_Shift_Del | A | - | p.L123fs |
| GBM | TCGA-76-6286-01 | exon_skip_429602 | 56336884 | 56336973 | 56336954 | 56336954 | Frame_Shift_Del | A | - | p.L123fs |
| HNSC | TCGA-CN-A640-01 | exon_skip_429602 | 56336884 | 56336973 | 56336954 | 56336954 | Frame_Shift_Del | A | - | p.L123fs |
| LUAD | TCGA-49-4487-01 | exon_skip_429602 | 56336884 | 56336973 | 56336954 | 56336954 | Frame_Shift_Del | A | - | p.L123fs |
| PAAD | TCGA-M8-A5N4-01 | exon_skip_429602 | 56336884 | 56336973 | 56336954 | 56336954 | Frame_Shift_Del | A | - | p.L123fs |
| SKCM | TCGA-D3-A3CF-06 | exon_skip_429602 | 56336884 | 56336973 | 56336954 | 56336954 | Frame_Shift_Del | A | - | p.L123fs |
| STAD | TCGA-CD-A4MG-01 | exon_skip_429602 | 56336884 | 56336973 | 56336954 | 56336955 | Frame_Shift_Del | AA | - | p.123_123del |
| THYM | TCGA-ZB-A966-01 | exon_skip_429602 | 56336884 | 56336973 | 56336954 | 56336954 | Frame_Shift_Del | A | - | p.L123fs |
| LIHC | TCGA-BC-A112-01 | exon_skip_429596 exon_skip_429597 | 56308599 | 56308801 | 56308790 | 56308791 | Frame_Shift_Ins | - | T | p.S638fs |
| ACC | TCGA-PK-A5HB-01 | exon_skip_429602 | 56336884 | 56336973 | 56336953 | 56336954 | Frame_Shift_Ins | - | A | p.C123fs |
| ACC | TCGA-PK-A5HB-01 | exon_skip_429602 | 56336884 | 56336973 | 56336953 | 56336954 | Frame_Shift_Ins | - | A | p.L123fs |
| COAD | TCGA-A6-5661-01 | exon_skip_429602 | 56336884 | 56336973 | 56336953 | 56336954 | Frame_Shift_Ins | - | A | p.L123fs |
| UCS | TCGA-NG-A4VW-01 | exon_skip_429602 | 56336884 | 56336973 | 56336953 | 56336954 | Frame_Shift_Ins | - | A | p.C123fs |
| UCS | TCGA-NG-A4VW-01 | exon_skip_429602 | 56336884 | 56336973 | 56336953 | 56336954 | Frame_Shift_Ins | - | A | p.L123fs |
| BLCA | TCGA-UY-A9PF-01 | exon_skip_429599 | 56319844 | 56319991 | 56319883 | 56319883 | Nonsense_Mutation | G | C | p.S364* |
| BLCA | TCGA-FD-A6TA-01 | exon_skip_429600 | 56329852 | 56329972 | 56329885 | 56329885 | Nonsense_Mutation | C | A | p.E176* |
| SKCM | TCGA-EE-A3J5-06 | exon_skip_429603 | 56342130 | 56342221 | 56342132 | 56342132 | Nonsense_Mutation | C | A | p.E116* |
| SKCM | TCGA-EE-A3J5-06 | exon_skip_429603 | 56342130 | 56342221 | 56342132 | 56342132 | Nonsense_Mutation | C | A | p.E116X |
| KIRC | TCGA-B0-5097-01 | exon_skip_429598 | 56314946 | 56315035 | 56314944 | 56314944 | Splice_Site | A | G | . |
| KIRC | TCGA-B0-5097-01 | exon_skip_429598 | 56314946 | 56315035 | 56314945 | 56314945 | Splice_Site | C | A | . |
| STAD | TCGA-BR-8363-01 | exon_skip_429602 | 56336884 | 56336973 | 56336882 | 56336882 | Splice_Site | A | G | . |
| STAD | TCGA-BR-8363-01 | exon_skip_429602 | 56336884 | 56336973 | 56336882 | 56336882 | Splice_Site | A | G | p.P146_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SKNDZ_AUTONOMIC_GANGLIA | 56308599 | 56308801 | 56308719 | 56308719 | Missense_Mutation | T | C | p.Y662C |
| SJSA1_BONE | 56314946 | 56315035 | 56315029 | 56315029 | Missense_Mutation | T | G | p.N486H |
| SNUC2A_LARGE_INTESTINE | 56319844 | 56319991 | 56319895 | 56319895 | Missense_Mutation | T | C | p.H360R |
| SNUC2B_LARGE_INTESTINE | 56319844 | 56319991 | 56319895 | 56319895 | Missense_Mutation | T | C | p.H360R |
| DMS454_LUNG | 56319844 | 56319991 | 56319961 | 56319961 | Missense_Mutation | T | C | p.Y338C |
| HCC1806_BREAST | 56329852 | 56329972 | 56329917 | 56329917 | Missense_Mutation | T | G | p.E165A |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 56336884 | 56336973 | 56336927 | 56336927 | Missense_Mutation | A | G | p.I132T |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 56336884 | 56336973 | 56336927 | 56336927 | Missense_Mutation | A | G | p.I132T |
| KGN_OVARY | 56336884 | 56336973 | 56336957 | 56336957 | Missense_Mutation | A | G | p.F122S |
| KYSE50_OESOPHAGUS | 56336884 | 56336973 | 56336957 | 56336957 | Missense_Mutation | A | G | p.F122S |
| PANC0403_PANCREAS | 56344982 | 56345130 | 56345091 | 56345091 | Missense_Mutation | T | G | p.Q49H |
| HEC1B_ENDOMETRIUM | 56344982 | 56345130 | 56345101 | 56345101 | Missense_Mutation | C | T | p.R46H |
| 2313287_STOMACH | 56342130 | 56342221 | 56342130 | 56342130 | Splice_Site | C | A | p.E116D |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CLOCK |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CLOCK |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CLOCK |
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RelatedDrugs for CLOCK |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLOCK |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| CLOCK | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| CLOCK | C0011570 | Mental Depression | 5 | PSYGENET |
| CLOCK | C0011581 | Depressive disorder | 5 | PSYGENET |
| CLOCK | C0041696 | Unipolar Depression | 5 | PSYGENET |
| CLOCK | C0525045 | Mood Disorders | 5 | PSYGENET |
| CLOCK | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
| CLOCK | C0085159 | Seasonal Affective Disorder | 3 | PSYGENET |
| CLOCK | C3496069 | cocaine use | 2 | PSYGENET |
| CLOCK | C0001957 | Alcohol Withdrawal Delirium | 1 | PSYGENET |
| CLOCK | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| CLOCK | C0036341 | Schizophrenia | 1 | PSYGENET |
| CLOCK | C0600427 | Cocaine Dependence | 1 | PSYGENET |
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