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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ROCK2 |
 Gene summary |
| Gene information | Gene symbol | ROCK2 | Gene ID | 9475 |
| Gene name | Rho associated coiled-coil containing protein kinase 2 | |
| Synonyms | ROCK-II | |
| Cytomap | 2p25.1 | |
| Type of gene | protein-coding | |
| Description | rho-associated protein kinase 2p164 ROCK-2rho-associated, coiled-coil-containing protein kinase II | |
| Modification date | 20180527 | |
| UniProtAcc | O75116 | |
| Context | PubMed: ROCK2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ROCK2 | GO:0006468 | protein phosphorylation | 18559669 |
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Exon skipping events across known transcript of Ensembl for ROCK2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ROCK2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ROCK2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_337020 | 2 | 11332801:11332838:11333904:11333983:11334381:11334470 | 11333904:11333983 | ENSG00000134318.9 | ENST00000401753.1,ENST00000493096.1,ENST00000315872.6 |
| exon_skip_337023 | 2 | 11338616:11338711:11338806:11338900:11341082:11341269 | 11338806:11338900 | ENSG00000134318.9 | ENST00000401753.1,ENST00000315872.6 |
| exon_skip_337024 | 2 | 11348412:11348573:11351806:11351966:11354482:11354589 | 11351806:11351966 | ENSG00000134318.9 | ENST00000401753.1,ENST00000315872.6 |
| exon_skip_337026 | 2 | 11355485:11355538:11355635:11355771:11356283:11356332 | 11355635:11355771 | ENSG00000134318.9 | ENST00000401753.1,ENST00000261535.3,ENST00000315872.6 |
| exon_skip_337028 | 2 | 11361452:11361483:11362208:11362300:11364447:11364586 | 11362208:11362300 | ENSG00000134318.9 | ENST00000431087.1,ENST00000401753.1,ENST00000261535.3,ENST00000315872.6 |
| exon_skip_337030 | 2 | 11367379:11367524:11375827:11376088:11389786:11389924 | 11375827:11376088 | ENSG00000134318.9 | ENST00000261535.3,ENST00000315872.6 |
| exon_skip_337031 | 2 | 11376009:11376088:11389786:11389924:11426664:11426765 | 11389786:11389924 | ENSG00000134318.9 | ENST00000462366.1,ENST00000261535.3,ENST00000315872.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ROCK2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_337020 | 2 | 11332801:11332838:11333904:11333983:11334381:11334470 | 11333904:11333983 | ENSG00000134318.9 | ENST00000315872.6,ENST00000401753.1,ENST00000493096.1 |
| exon_skip_337023 | 2 | 11338616:11338711:11338806:11338900:11341082:11341269 | 11338806:11338900 | ENSG00000134318.9 | ENST00000315872.6,ENST00000401753.1 |
| exon_skip_337024 | 2 | 11348412:11348573:11351806:11351966:11354482:11354589 | 11351806:11351966 | ENSG00000134318.9 | ENST00000315872.6,ENST00000401753.1 |
| exon_skip_337026 | 2 | 11355485:11355538:11355635:11355771:11356283:11356332 | 11355635:11355771 | ENSG00000134318.9 | ENST00000315872.6,ENST00000401753.1,ENST00000261535.3 |
| exon_skip_337028 | 2 | 11361452:11361483:11362208:11362300:11364447:11364586 | 11362208:11362300 | ENSG00000134318.9 | ENST00000315872.6,ENST00000401753.1,ENST00000261535.3,ENST00000431087.1 |
| exon_skip_337030 | 2 | 11367379:11367524:11375827:11376088:11389786:11389924 | 11375827:11376088 | ENSG00000134318.9 | ENST00000315872.6,ENST00000261535.3 |
| exon_skip_337031 | 2 | 11376009:11376088:11389786:11389924:11426664:11426765 | 11389786:11389924 | ENSG00000134318.9 | ENST00000315872.6,ENST00000261535.3,ENST00000462366.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ROCK2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000315872 | 11333904 | 11333983 | Frame-shift |
| ENST00000315872 | 11338806 | 11338900 | Frame-shift |
| ENST00000315872 | 11351806 | 11351966 | Frame-shift |
| ENST00000315872 | 11355635 | 11355771 | Frame-shift |
| ENST00000315872 | 11362208 | 11362300 | Frame-shift |
| ENST00000315872 | 11375827 | 11376088 | In-frame |
| ENST00000315872 | 11389786 | 11389924 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000315872 | 11333904 | 11333983 | Frame-shift |
| ENST00000315872 | 11338806 | 11338900 | Frame-shift |
| ENST00000315872 | 11351806 | 11351966 | Frame-shift |
| ENST00000315872 | 11355635 | 11355771 | Frame-shift |
| ENST00000315872 | 11362208 | 11362300 | Frame-shift |
| ENST00000315872 | 11375827 | 11376088 | In-frame |
| ENST00000315872 | 11389786 | 11389924 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ROCK2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000315872 | 8309 | 1388 | 11389786 | 11389924 | 774 | 911 | 108 | 154 |
| ENST00000315872 | 8309 | 1388 | 11375827 | 11376088 | 912 | 1172 | 154 | 241 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000315872 | 8309 | 1388 | 11389786 | 11389924 | 774 | 911 | 108 | 154 |
| ENST00000315872 | 8309 | 1388 | 11375827 | 11376088 | 912 | 1172 | 154 | 241 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O75116 | 108 | 154 | 102 | 111 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 108 | 154 | 117 | 124 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 108 | 154 | 121 | 121 | Binding site | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O75116 | 108 | 154 | 1 | 1388 | Chain | ID=PRO_0000086625;Note=Rho-associated protein kinase 2 |
| O75116 | 108 | 154 | 92 | 354 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O75116 | 108 | 154 | 125 | 130 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 108 | 154 | 138 | 146 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 108 | 154 | 112 | 114 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 214 | 214 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 |
| O75116 | 154 | 241 | 155 | 160 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 162 | 169 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 220 | 222 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 228 | 230 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 241 | 246 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 1 | 1388 | Chain | ID=PRO_0000086625;Note=Rho-associated protein kinase 2 |
| O75116 | 154 | 241 | 92 | 354 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O75116 | 154 | 241 | 177 | 183 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 188 | 207 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 217 | 219 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O75116 | 108 | 154 | 102 | 111 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 108 | 154 | 117 | 124 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 108 | 154 | 121 | 121 | Binding site | Note=ATP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O75116 | 108 | 154 | 1 | 1388 | Chain | ID=PRO_0000086625;Note=Rho-associated protein kinase 2 |
| O75116 | 108 | 154 | 92 | 354 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O75116 | 108 | 154 | 125 | 130 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 108 | 154 | 138 | 146 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 108 | 154 | 112 | 114 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 214 | 214 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027 |
| O75116 | 154 | 241 | 155 | 160 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 162 | 169 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 220 | 222 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 228 | 230 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 241 | 246 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 1 | 1388 | Chain | ID=PRO_0000086625;Note=Rho-associated protein kinase 2 |
| O75116 | 154 | 241 | 92 | 354 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| O75116 | 154 | 241 | 177 | 183 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 188 | 207 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
| O75116 | 154 | 241 | 217 | 219 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4L6Q |
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SNVs in the skipped exons for ROCK2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_337023 | 11338807 | 11338900 | 11338820 | 11338820 | Frame_Shift_Del | T | - | p.K997fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_337024 | 11351807 | 11351966 | 11351854 | 11351854 | Frame_Shift_Del | T | - | p.N719fs |
| COAD | TCGA-G4-6588-01 | exon_skip_337024 | 11351807 | 11351966 | 11351960 | 11351960 | Frame_Shift_Del | T | - | p.S684fs |
| READ | TCGA-EI-6510-01 | exon_skip_337026 | 11355636 | 11355771 | 11355647 | 11355647 | Frame_Shift_Del | A | - | p.L529fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_337026 | 11355636 | 11355771 | 11355698 | 11355698 | Frame_Shift_Del | T | - | p.N512fs |
| STAD | TCGA-RD-A8MW-01 | exon_skip_337028 | 11362209 | 11362300 | 11362172 | 11362219 | Frame_Shift_Del | TGTGATGGAATGAAAATATTTAGGTTTATTGACTTACTTTCTCTTATG | - | p.364_367del |
| STAD | TCGA-F1-A448-01 | exon_skip_337030 | 11375828 | 11376088 | 11375864 | 11375864 | Frame_Shift_Del | T | - | p.L230X |
| KIRC | TCGA-CZ-5468-01 | exon_skip_337031 | 11389787 | 11389924 | 11389808 | 11389814 | Frame_Shift_Del | GGCAAAG | - | p.146_148del |
| HNSC | TCGA-CV-7095-01 | exon_skip_337031 | 11389787 | 11389924 | 11389837 | 11389837 | Frame_Shift_Del | A | - | p.W138fs |
| STAD | TCGA-BR-4184-01 | exon_skip_337031 | 11389787 | 11389924 | 11389837 | 11389837 | Frame_Shift_Del | A | - | p.W138fs |
| STAD | TCGA-BR-8363-01 | exon_skip_337031 | 11389787 | 11389924 | 11389837 | 11389837 | Frame_Shift_Del | A | - | p.W138fs |
| STAD | TCGA-CG-5723-01 | exon_skip_337031 | 11389787 | 11389924 | 11389837 | 11389837 | Frame_Shift_Del | A | - | p.W138fs |
| UCEC | TCGA-BS-A0U8-01 | exon_skip_337031 | 11389787 | 11389924 | 11389837 | 11389837 | Frame_Shift_Del | A | - | p.W138fs |
| PRAD | TCGA-KK-A59V-01 | exon_skip_337031 | 11389787 | 11389924 | 11389836 | 11389837 | Frame_Shift_Ins | - | A | p.G138fs |
| SKCM | TCGA-EE-A3J7-06 | exon_skip_337031 | 11389787 | 11389924 | 11389836 | 11389837 | Frame_Shift_Ins | - | A | p.G138fs |
| SKCM | TCGA-EE-A3J7-06 | exon_skip_337031 | 11389787 | 11389924 | 11389836 | 11389837 | Frame_Shift_Ins | - | A | p.W138fs |
| STAD | TCGA-BR-6452-01 | exon_skip_337031 | 11389787 | 11389924 | 11389836 | 11389837 | Frame_Shift_Ins | - | A | p.W138fs |
| STAD | TCGA-BR-8360-01 | exon_skip_337031 | 11389787 | 11389924 | 11389836 | 11389837 | Frame_Shift_Ins | - | A | p.W138fs |
| UCEC | TCGA-BG-A0M0-01 | exon_skip_337031 | 11389787 | 11389924 | 11389836 | 11389837 | Frame_Shift_Ins | - | A | p.W138fs |
| UCEC | TCGA-BG-A0M9-01 | exon_skip_337031 | 11389787 | 11389924 | 11389836 | 11389837 | Frame_Shift_Ins | - | A | p.W138fs |
| STAD | TCGA-BR-8360-01 | exon_skip_337031 | 11389787 | 11389924 | 11389837 | 11389838 | Frame_Shift_Ins | - | A | p.W138fs |
| PCPG | TCGA-QR-A70J-01 | exon_skip_337020 | 11333905 | 11333983 | 11333967 | 11333967 | Nonsense_Mutation | G | A | p.R1209* |
| SKCM | TCGA-3N-A9WC-06 | exon_skip_337024 | 11351807 | 11351966 | 11351870 | 11351870 | Nonsense_Mutation | G | A | p.R714* |
| SKCM | TCGA-EE-A3JD-06 | exon_skip_337030 | 11375828 | 11376088 | 11376073 | 11376073 | Nonsense_Mutation | G | A | p.Q160* |
| SKCM | TCGA-EE-A3JD-06 | exon_skip_337030 | 11375828 | 11376088 | 11376073 | 11376073 | Nonsense_Mutation | G | A | p.Q160X |
| STAD | TCGA-BR-8591-01 | exon_skip_337024 | 11351807 | 11351966 | 11351805 | 11351805 | Splice_Site | A | G | . |
| STAD | TCGA-BR-8591-01 | exon_skip_337024 | 11351807 | 11351966 | 11351805 | 11351805 | Splice_Site | A | G | p.E735_splice |
| LUAD | TCGA-55-7914-01 | exon_skip_337026 | 11355636 | 11355771 | 11355773 | 11355773 | Splice_Site | T | G | p.I488_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| OC316_OVARY | 11389787 | 11389924 | 11389837 | 11389837 | Frame_Shift_Del | A | - | p.W138fs |
| SNUC4_LARGE_INTESTINE | 11389787 | 11389924 | 11389837 | 11389837 | Frame_Shift_Del | A | - | p.W138fs |
| SNU407_LARGE_INTESTINE | 11389787 | 11389924 | 11389837 | 11389837 | Frame_Shift_Del | A | - | p.W138fs |
| LIM1215_LARGE_INTESTINE | 11389787 | 11389924 | 11389837 | 11389837 | Frame_Shift_Del | A | - | p.W138fs |
| NCIH630_LARGE_INTESTINE | 11389787 | 11389924 | 11389837 | 11389837 | Frame_Shift_Del | A | - | p.W138fs |
| OC314_OVARY | 11389787 | 11389924 | 11389837 | 11389837 | Frame_Shift_Del | A | - | p.W138fs |
| CHP126_AUTONOMIC_GANGLIA | 11355636 | 11355771 | 11355654 | 11355655 | Frame_Shift_Ins | - | T | p.R527fs |
| LOVO_LARGE_INTESTINE | 11389787 | 11389924 | 11389836 | 11389837 | Frame_Shift_Ins | - | A | p.W138fs |
| GIMEN_AUTONOMIC_GANGLIA | 11338807 | 11338900 | 11338811 | 11338811 | Missense_Mutation | T | A | p.Q1000H |
| SNU1040_LARGE_INTESTINE | 11351807 | 11351966 | 11351836 | 11351836 | Missense_Mutation | A | G | p.I725T |
| IPC298_SKIN | 11351807 | 11351966 | 11351881 | 11351881 | Missense_Mutation | G | A | p.A710V |
| NUGC3_STOMACH | 11355636 | 11355771 | 11355693 | 11355693 | Missense_Mutation | C | T | p.E514K |
| SHP77_LUNG | 11355636 | 11355771 | 11355761 | 11355761 | Missense_Mutation | C | A | p.R491L |
| DU145_PROSTATE | 11375828 | 11376088 | 11375908 | 11375908 | Missense_Mutation | C | A | p.V215L |
| MDAMB453_BREAST | 11375828 | 11376088 | 11375962 | 11375962 | Missense_Mutation | C | T | p.E197K |
| GMEL_SKIN | 11375828 | 11376088 | 11375964 | 11375964 | Missense_Mutation | G | A | p.A196V |
| 639V_URINARY_TRACT | 11375828 | 11376088 | 11375970 | 11375970 | Missense_Mutation | T | C | p.Y194C |
| BT20_BREAST | 11375828 | 11376088 | 11376055 | 11376055 | Missense_Mutation | A | C | p.Y166D |
| TTC442_SOFT_TISSUE | 11389787 | 11389924 | 11389806 | 11389806 | Missense_Mutation | T | C | p.N148S |
| LB1047RCC_KIDNEY | 11389787 | 11389924 | 11389816 | 11389816 | Missense_Mutation | C | T | p.A145T |
| SNU81_LARGE_INTESTINE | 11389787 | 11389924 | 11389825 | 11389825 | Missense_Mutation | C | A | p.D142Y |
| SNU1079_BILIARY_TRACT | 11389787 | 11389924 | 11389904 | 11389904 | Missense_Mutation | C | G | p.Q115H |
| HEC59_ENDOMETRIUM | 11389787 | 11389924 | 11389924 | 11389924 | Splice_Site | C | T | p.V109I |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ROCK2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ROCK2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ROCK2 |
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RelatedDrugs for ROCK2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| O75116 | DB13931 | Netarsudil | Rho-associated protein kinase 2 | small molecule | approved | |
| O75116 | DB12010 | Fostamatinib | Rho-associated protein kinase 2 | small molecule | approved|investigational |
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RelatedDiseases for ROCK2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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