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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DTD1 |
 Gene summary |
| Gene information | Gene symbol | DTD1 | Gene ID | 92675 |
| Gene name | D-tyrosyl-tRNA deacylase 1 | |
| Synonyms | C20orf88|DTD|DUE-B|DUEB|HARS2|pqn-68 | |
| Cytomap | 20p11.23 | |
| Type of gene | protein-coding | |
| Description | D-aminoacyl-tRNA deacylase 1D-tyrosyl-tRNA deacylase 1 homologD-tyrosyl-tRNA(Tyr) deacylase 1DNA-unwinding element-binding protein Bgly-tRNA(Ala) deacylasehistidyl-tRNA synthase-relatedhistidyl-tRNA synthetase 2 | |
| Modification date | 20180523 | |
| UniProtAcc | Q8TEA8 | |
| Context | PubMed: DTD1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for DTD1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DTD1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DTD1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_349448 | 20 | 18568607:18568759:18574374:18574465:18576649:18576885 | 18574374:18574465 | ENSG00000125821.7 | ENST00000494921.1 |
| exon_skip_349449 | 20 | 18576649:18576885:18608770:18608877:18724743:18724915 | 18608770:18608877 | ENSG00000125821.7 | ENST00000377452.3 |
| exon_skip_349454 | 20 | 18608770:18608877:18724743:18724915:18744003:18744561 | 18724743:18724915 | ENSG00000125821.7 | ENST00000377452.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DTD1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_349448 | 20 | 18568607:18568759:18574374:18574465:18576649:18576885 | 18574374:18574465 | ENSG00000125821.7 | ENST00000494921.1 |
| exon_skip_349449 | 20 | 18576649:18576885:18608770:18608877:18724743:18724915 | 18608770:18608877 | ENSG00000125821.7 | ENST00000377452.3 |
| exon_skip_349454 | 20 | 18608770:18608877:18724743:18724915:18744003:18744561 | 18724743:18724915 | ENSG00000125821.7 | ENST00000377452.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DTD1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000377452 | 18724743 | 18724915 | 3UTR-3CDS |
| ENST00000377452 | 18608770 | 18608877 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000377452 | 18724743 | 18724915 | 3UTR-3CDS |
| ENST00000377452 | 18608770 | 18608877 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for DTD1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for DTD1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HNSC | TCGA-CV-6961-01 | exon_skip_349454 | 18724744 | 18724915 | 18724748 | 18724748 | Nonsense_Mutation | C | G | p.S161* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| EFE184_ENDOMETRIUM | 18574375 | 18574465 | 18574410 | 18574410 | Missense_Mutation | A | C | p.I27L |
| MDST8_LARGE_INTESTINE | 18608771 | 18608877 | 18608864 | 18608864 | Missense_Mutation | C | T | p.S155F |
| VCAP_PROSTATE | 18608771 | 18608877 | 18608868 | 18608868 | Missense_Mutation | C | G | p.D156E |
| LS411N_LARGE_INTESTINE | 18608771 | 18608877 | 18608869 | 18608869 | Missense_Mutation | C | A | p.P157T |
| SNU1040_LARGE_INTESTINE | 18724744 | 18724915 | 18724747 | 18724747 | Missense_Mutation | T | C | p.S161P |
| MEWO_SKIN | 18724744 | 18724915 | 18724756 | 18724756 | Missense_Mutation | G | A | p.E164K |
| HEC59_ENDOMETRIUM | 18724744 | 18724915 | 18724850 | 18724850 | Missense_Mutation | C | T | p.A195V |
| EW1_BONE | 18724744 | 18724915 | 18724858 | 18724858 | Missense_Mutation | G | A | p.G198R |
| AU565_BREAST | 18724744 | 18724915 | 18724870 | 18724870 | Missense_Mutation | G | T | p.D202Y |
| LOVO_LARGE_INTESTINE | 18724744 | 18724915 | 18724885 | 18724885 | Missense_Mutation | C | T | p.R207W |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DTD1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DTD1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DTD1 |
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RelatedDrugs for DTD1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DTD1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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