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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RAB11B |
 Gene summary |
| Gene information | Gene symbol | RAB11B | Gene ID | 9230 |
| Gene name | RAB11B, member RAS oncogene family | |
| Synonyms | H-YPT3|NDAGSCW | |
| Cytomap | 19p13.2 | |
| Type of gene | protein-coding | |
| Description | ras-related protein Rab-11BGTP-binding protein YPT3RAB11B, member of RAS oncogene family | |
| Modification date | 20180523 | |
| UniProtAcc | Q15907 | |
| Context | PubMed: RAB11B [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| RAB11B | GO:0071468 | cellular response to acidic pH | 20717956 |
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Exon skipping events across known transcript of Ensembl for RAB11B from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RAB11B |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RAB11B |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_301783 | 19 | 8455272:8455340:8464746:8464942:8466969:8467041 | 8464746:8464942 | ENSG00000185236.7 | ENST00000328024.6,ENST00000594216.1 |
| exon_skip_301787 | 19 | 8466969:8467163:8467368:8467449:8468296:8469318 | 8467368:8467449 | ENSG00000185236.7 | ENST00000328024.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RAB11B |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_301783 | 19 | 8455272:8455340:8464746:8464942:8466969:8467041 | 8464746:8464942 | ENSG00000185236.7 | ENST00000328024.6,ENST00000594216.1 |
| exon_skip_301787 | 19 | 8466969:8467163:8467368:8467449:8468296:8469318 | 8467368:8467449 | ENSG00000185236.7 | ENST00000328024.6 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RAB11B |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000328024 | 8464746 | 8464942 | Frame-shift |
| ENST00000328024 | 8467368 | 8467449 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000328024 | 8464746 | 8464942 | Frame-shift |
| ENST00000328024 | 8467368 | 8467449 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RAB11B |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000328024 | 1768 | 218 | 8467368 | 8467449 | 649 | 729 | 143 | 170 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000328024 | 1768 | 218 | 8467368 | 8467449 | 649 | 729 | 143 | 170 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for RAB11B |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_301783 | 8464747 | 8464942 | 8464758 | 8464758 | Frame_Shift_Del | G | - | p.G18fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH716_LARGE_INTESTINE | 8464747 | 8464942 | 8464804 | 8464804 | Missense_Mutation | G | A | p.R33H |
| KYSE140_OESOPHAGUS | 8464747 | 8464942 | 8464882 | 8464882 | Missense_Mutation | C | T | p.T59I |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 8464747 | 8464942 | 8464908 | 8464908 | Missense_Mutation | G | A | p.A68T |
| LS180_LARGE_INTESTINE | 8464747 | 8464942 | 8464942 | 8464942 | Splice_Site | C | T | p.A79V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RAB11B |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAB11B |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RAB11B |
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RelatedDrugs for RAB11B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RAB11B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| RAB11B | C0019693 | HIV Infections | 1 | CTD_human |
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