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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MAP3K13 |
 Gene summary |
| Gene information | Gene symbol | MAP3K13 | Gene ID | 9175 |
| Gene name | mitogen-activated protein kinase kinase kinase 13 | |
| Synonyms | LZK|MEKK13|MLK | |
| Cytomap | 3q27.2 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase 13leucine zipper-bearing kinasemixed lineage kinase | |
| Modification date | 20180523 | |
| UniProtAcc | O43283 | |
| Context | PubMed: MAP3K13 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAP3K13 | GO:0000186 | activation of MAPKK activity | 11726277 |
| MAP3K13 | GO:0006468 | protein phosphorylation | 9353328|11726277 |
| MAP3K13 | GO:0007254 | JNK cascade | 9353328|11726277 |
| MAP3K13 | GO:0046777 | protein autophosphorylation | 9353328 |
| MAP3K13 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 12492477 |
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Exon skipping events across known transcript of Ensembl for MAP3K13 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MAP3K13 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MAP3K13 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_379981 | 3 | 185003312:185003431:185009400:185009548:185046411:185047051 | 185009400:185009548 | ENSG00000073803.9 | ENST00000455188.1 |
| exon_skip_379987 | 3 | 185003312:185003431:185146284:185146844:185155234:185155418 | 185146284:185146844 | ENSG00000073803.9 | ENST00000424227.1 |
| exon_skip_379994 | 3 | 185046682:185046750:185146284:185146734:185155234:185155418 | 185146284:185146734 | ENSG00000073803.9 | ENST00000433092.1 |
| exon_skip_379998 | 3 | 185081029:185081156:185146284:185146844:185155234:185155418 | 185146284:185146844 | ENSG00000073803.9 | ENST00000265026.3 |
| exon_skip_379999 | 3 | 185146284:185146734:185155234:185155418:185161232:185161424 | 185155234:185155418 | ENSG00000073803.9 | ENST00000433092.1 |
| exon_skip_380000 | 3 | 185146284:185146844:185155234:185155418:185161232:185161424 | 185155234:185155418 | ENSG00000073803.9 | ENST00000424227.1,ENST00000265026.3 |
| exon_skip_380004 | 3 | 185155332:185155418:185161232:185161424:185165576:185165735 | 185161232:185161424 | ENSG00000073803.9 | ENST00000443863.1,ENST00000424227.1,ENST00000433092.1,ENST00000535426.1,ENST00000265026.3 |
| exon_skip_380006 | 3 | 185190762:185191549:185195113:185195184:185198019:185198317 | 185195113:185195184 | ENSG00000073803.9 | ENST00000443863.1,ENST00000438053.1,ENST00000424227.1,ENST00000446828.1,ENST00000535426.1,ENST00000265026.3 |
| exon_skip_380008 | 3 | 185195113:185195184:185198019:185198317:185200142:185200244 | 185198019:185198317 | ENSG00000073803.9 | ENST00000443863.1,ENST00000438053.1,ENST00000424227.1,ENST00000446828.1,ENST00000535426.1,ENST00000265026.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MAP3K13 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_379981 | 3 | 185003312:185003431:185009400:185009548:185046411:185047051 | 185009400:185009548 | ENSG00000073803.9 | ENST00000455188.1 |
| exon_skip_379987 | 3 | 185003312:185003431:185146284:185146844:185155234:185155418 | 185146284:185146844 | ENSG00000073803.9 | ENST00000424227.1 |
| exon_skip_379998 | 3 | 185081029:185081156:185146284:185146844:185155234:185155418 | 185146284:185146844 | ENSG00000073803.9 | ENST00000265026.3 |
| exon_skip_380000 | 3 | 185146284:185146844:185155234:185155418:185161232:185161424 | 185155234:185155418 | ENSG00000073803.9 | ENST00000424227.1,ENST00000265026.3 |
| exon_skip_380004 | 3 | 185155332:185155418:185161232:185161424:185165576:185165735 | 185161232:185161424 | ENSG00000073803.9 | ENST00000424227.1,ENST00000433092.1,ENST00000443863.1,ENST00000535426.1,ENST00000265026.3 |
| exon_skip_380006 | 3 | 185190762:185191549:185195113:185195184:185198019:185198317 | 185195113:185195184 | ENSG00000073803.9 | ENST00000446828.1,ENST00000424227.1,ENST00000443863.1,ENST00000535426.1,ENST00000265026.3,ENST00000438053.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MAP3K13 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265026 | 185146284 | 185146844 | 5CDS-5UTR |
| ENST00000424227 | 185146284 | 185146844 | 5CDS-5UTR |
| ENST00000265026 | 185155234 | 185155418 | Frame-shift |
| ENST00000424227 | 185155234 | 185155418 | Frame-shift |
| ENST00000265026 | 185195113 | 185195184 | Frame-shift |
| ENST00000424227 | 185195113 | 185195184 | Frame-shift |
| ENST00000265026 | 185198019 | 185198317 | Frame-shift |
| ENST00000424227 | 185198019 | 185198317 | Frame-shift |
| ENST00000265026 | 185161232 | 185161424 | In-frame |
| ENST00000424227 | 185161232 | 185161424 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000265026 | 185146284 | 185146844 | 5CDS-5UTR |
| ENST00000424227 | 185146284 | 185146844 | 5CDS-5UTR |
| ENST00000265026 | 185155234 | 185155418 | Frame-shift |
| ENST00000424227 | 185155234 | 185155418 | Frame-shift |
| ENST00000265026 | 185195113 | 185195184 | Frame-shift |
| ENST00000424227 | 185195113 | 185195184 | Frame-shift |
| ENST00000265026 | 185161232 | 185161424 | In-frame |
| ENST00000424227 | 185161232 | 185161424 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAP3K13 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265026 | 9893 | 966 | 185161232 | 185161424 | 994 | 1185 | 220 | 283 |
| ENST00000424227 | 3173 | 966 | 185161232 | 185161424 | 915 | 1106 | 220 | 283 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000265026 | 9893 | 966 | 185161232 | 185161424 | 994 | 1185 | 220 | 283 |
| ENST00000424227 | 3173 | 966 | 185161232 | 185161424 | 915 | 1106 | 220 | 283 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for MAP3K13 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_379994 | 185146285 | 185146734 | 185146632 | 185146632 | Frame_Shift_Del | G | - | p.R88fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_379987 exon_skip_379998 | 185146285 | 185146844 | 185146632 | 185146632 | Frame_Shift_Del | G | - | p.R88fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_380004 | 185161233 | 185161424 | 185161393 | 185161393 | Frame_Shift_Del | A | - | p.K274fs |
| BRCA | TCGA-AO-A0JG-01 | exon_skip_380008 | 185198020 | 185198317 | 185198098 | 185198098 | Frame_Shift_Del | G | - | p.G861fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_380008 | 185198020 | 185198317 | 185198204 | 185198204 | Frame_Shift_Del | C | - | p.P896fs |
| LUAD | TCGA-55-8506-01 | exon_skip_379994 | 185146285 | 185146734 | 185146649 | 185146649 | Nonsense_Mutation | G | T | p.E94* |
| LUAD | TCGA-55-8506-01 | exon_skip_379987 exon_skip_379998 | 185146285 | 185146844 | 185146649 | 185146649 | Nonsense_Mutation | G | T | p.E94* |
| HNSC | TCGA-BA-6869-01 | exon_skip_380004 | 185161233 | 185161424 | 185161246 | 185161246 | Nonsense_Mutation | C | T | p.Q225* |
| LUAD | TCGA-55-A48Z-01 | exon_skip_380004 | 185161233 | 185161424 | 185161273 | 185161273 | Nonsense_Mutation | G | T | p.E234* |
| LUAD | TCGA-50-5946-01 | exon_skip_380008 | 185198020 | 185198317 | 185198315 | 185198315 | Nonsense_Mutation | G | T | p.E933* |
| SKCM | TCGA-FS-A4F5-06 | exon_skip_380004 | 185161233 | 185161424 | 185161232 | 185161232 | Splice_Site | G | C | . |
| KIRC | TCGA-B8-5549-01 | exon_skip_380006 | 185195114 | 185195184 | 185195185 | 185195185 | Splice_Site | G | A | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NEC8_TESTIS | 185146285 | 185146844 | 185146491 | 185146491 | Missense_Mutation | A | G | p.K41R |
| NEC8_TESTIS | 185146285 | 185146734 | 185146491 | 185146491 | Missense_Mutation | A | G | p.K41R |
| HEC108_ENDOMETRIUM | 185146285 | 185146844 | 185146515 | 185146515 | Missense_Mutation | A | T | p.K49M |
| HEC108_ENDOMETRIUM | 185146285 | 185146734 | 185146515 | 185146515 | Missense_Mutation | A | T | p.K49M |
| SNU349_KIDNEY | 185146285 | 185146844 | 185146515 | 185146515 | Missense_Mutation | A | G | p.K49R |
| SNU349_KIDNEY | 185146285 | 185146734 | 185146515 | 185146515 | Missense_Mutation | A | G | p.K49R |
| HCC1359_LUNG | 185146285 | 185146844 | 185146547 | 185146547 | Missense_Mutation | G | T | p.V60L |
| HCC1359_LUNG | 185146285 | 185146734 | 185146547 | 185146547 | Missense_Mutation | G | T | p.V60L |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 185146285 | 185146844 | 185146578 | 185146578 | Missense_Mutation | C | T | p.T70M |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 185146285 | 185146734 | 185146578 | 185146578 | Missense_Mutation | C | T | p.T70M |
| COLO824_BREAST | 185146285 | 185146844 | 185146593 | 185146593 | Missense_Mutation | A | T | p.D75V |
| COLO824_BREAST | 185146285 | 185146734 | 185146593 | 185146593 | Missense_Mutation | A | T | p.D75V |
| NCIH1793_LUNG | 185146285 | 185146844 | 185146729 | 185146729 | Missense_Mutation | C | G | p.F120L |
| NCIH1793_LUNG | 185146285 | 185146734 | 185146729 | 185146729 | Missense_Mutation | C | G | p.F120L |
| LS411N_LARGE_INTESTINE | 185146285 | 185146844 | 185146748 | 185146748 | Missense_Mutation | A | G | p.S127G |
| NCIH2004RT_SOFT_TISSUE | 185146285 | 185146844 | 185146803 | 185146803 | Missense_Mutation | T | C | p.I145T |
| MDAMB361_BREAST | 185146285 | 185146844 | 185146823 | 185146823 | Missense_Mutation | G | A | p.D152N |
| BT20_BREAST | 185155235 | 185155418 | 185155292 | 185155292 | Missense_Mutation | C | G | p.A178G |
| C33A_CERVIX | 185155235 | 185155418 | 185155303 | 185155303 | Missense_Mutation | G | A | p.V182I |
| SNU1040_LARGE_INTESTINE | 185155235 | 185155418 | 185155321 | 185155321 | Missense_Mutation | C | T | p.R188W |
| SNU886_LIVER | 185155235 | 185155418 | 185155327 | 185155327 | Missense_Mutation | G | A | p.E190K |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 185155235 | 185155418 | 185155367 | 185155367 | Missense_Mutation | C | T | p.T203M |
| HEC108_ENDOMETRIUM | 185155235 | 185155418 | 185155411 | 185155411 | Missense_Mutation | G | A | p.A218T |
| SNU1040_LARGE_INTESTINE | 185155235 | 185155418 | 185155411 | 185155411 | Missense_Mutation | G | A | p.A218T |
| NB1_AUTONOMIC_GANGLIA | 185161233 | 185161424 | 185161372 | 185161372 | Missense_Mutation | A | C | p.M267L |
| DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 185161233 | 185161424 | 185161374 | 185161374 | Missense_Mutation | G | C | p.M267I |
| C33A_CERVIX | 185198020 | 185198317 | 185198027 | 185198027 | Missense_Mutation | C | T | p.R837C |
| DU145_PROSTATE | 185198020 | 185198317 | 185198037 | 185198037 | Missense_Mutation | G | A | p.S840N |
| LCLC97TM1_LUNG | 185198020 | 185198317 | 185198175 | 185198175 | Missense_Mutation | A | G | p.D886G |
| HEC251_ENDOMETRIUM | 185198020 | 185198317 | 185198313 | 185198313 | Missense_Mutation | A | G | p.Y932C |
| CL40_LARGE_INTESTINE | 185146285 | 185146844 | 185146416 | 185146416 | Nonsense_Mutation | T | A | p.L16* |
| CL40_LARGE_INTESTINE | 185146285 | 185146734 | 185146416 | 185146416 | Nonsense_Mutation | T | A | p.L16* |
| SW48_LARGE_INTESTINE | 185146285 | 185146844 | 185146526 | 185146526 | Nonsense_Mutation | C | T | p.R53* |
| SW48_LARGE_INTESTINE | 185146285 | 185146734 | 185146526 | 185146526 | Nonsense_Mutation | C | T | p.R53* |
| HCT15_LARGE_INTESTINE | 185146285 | 185146844 | 185146604 | 185146604 | Nonsense_Mutation | C | T | p.Q79* |
| HCT15_LARGE_INTESTINE | 185146285 | 185146734 | 185146604 | 185146604 | Nonsense_Mutation | C | T | p.Q79* |
| HRT18_LARGE_INTESTINE | 185146285 | 185146844 | 185146604 | 185146604 | Nonsense_Mutation | C | T | p.Q79* |
| HRT18_LARGE_INTESTINE | 185146285 | 185146734 | 185146604 | 185146604 | Nonsense_Mutation | C | T | p.Q79* |
| JEG3_PLACENTA | 185146285 | 185146844 | 185146647 | 185146647 | Nonsense_Mutation | C | A | p.S93* |
| JEG3_PLACENTA | 185146285 | 185146734 | 185146647 | 185146647 | Nonsense_Mutation | C | A | p.S93* |
| TGBC11TKB_STOMACH | 185155235 | 185155418 | 185155297 | 185155297 | Nonsense_Mutation | G | T | p.G180* |
| MFE319_ENDOMETRIUM | 185146285 | 185146844 | 185146844 | 185146844 | Splice_Site | G | T | p.D159Y |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP3K13 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP3K13 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP3K13 |
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RelatedDrugs for MAP3K13 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| O43283 | DB12010 | Fostamatinib | Mitogen-activated protein kinase kinase kinase 13 | small molecule | approved|investigational |
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RelatedDiseases for MAP3K13 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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