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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TRIM41 |
 Gene summary |
| Gene information | Gene symbol | TRIM41 | Gene ID | 90933 |
| Gene name | tripartite motif containing 41 | |
| Synonyms | RINCK | |
| Cytomap | 5q35.3 | |
| Type of gene | protein-coding | |
| Description | E3 ubiquitin-protein ligase TRIM41RING finger-interacting protein with C kinaseRING-finger protein that interacts with C kinaseRING-type E3 ubiquitin transferase TRIM41 | |
| Modification date | 20180523 | |
| UniProtAcc | Q8WV44 | |
| Context | PubMed: TRIM41 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for TRIM41 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TRIM41 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TRIM41 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_440477 | 5 | 180659658:180659889:180660412:180660435:180660635:180660763 | 180660412:180660435 | ENSG00000146063.14 | ENST00000315073.5,ENST00000515499.1,ENST00000351937.5 |
| exon_skip_440489 | 5 | 180661173:180661349:180661931:180661995:180662353:180662397 | 180661931:180661995 | ENSG00000146063.14 | ENST00000503114.1,ENST00000351937.5 |
| exon_skip_440490 | 5 | 180661173:180661349:180661995:180662079:180662353:180662397 | 180661995:180662079 | ENSG00000146063.14 | ENST00000514219.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TRIM41 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_440477 | 5 | 180659658:180659889:180660412:180660435:180660635:180660763 | 180660412:180660435 | ENSG00000146063.14 | ENST00000515499.1,ENST00000351937.5,ENST00000315073.5 |
| exon_skip_440489 | 5 | 180661173:180661349:180661931:180661995:180662353:180662397 | 180661931:180661995 | ENSG00000146063.14 | ENST00000351937.5,ENST00000503114.1 |
| exon_skip_440490 | 5 | 180661173:180661349:180661995:180662079:180662353:180662397 | 180661995:180662079 | ENSG00000146063.14 | ENST00000514219.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TRIM41 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000315073 | 180660412 | 180660435 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000315073 | 180660412 | 180660435 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for TRIM41 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TRIM41 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BLCA | TCGA-XF-A9SK-01 | exon_skip_440489 | 180661932 | 180661995 | 180661962 | 180661962 | Nonsense_Mutation | C | T | p.Q500* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| A172_CENTRAL_NERVOUS_SYSTEM | 180660413 | 180660435 | 180660424 | 180660424 | Missense_Mutation | G | C | p.E384D |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRIM41 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIM41 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRIM41 |
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RelatedDrugs for TRIM41 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM41 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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