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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SLC25A21 |
 Gene summary |
| Gene information | Gene symbol | SLC25A21 | Gene ID | 89874 |
| Gene name | solute carrier family 25 member 21 | |
| Synonyms | ODC|ODC1 | |
| Cytomap | 14q13.3 | |
| Type of gene | protein-coding | |
| Description | mitochondrial 2-oxodicarboxylate carrieroxodicarboxylate carriersolute carrier family 25 (mitochondrial oxoadipate carrier), member 21solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9BQT8 | |
| Context | PubMed: SLC25A21 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SLC25A21 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SLC25A21 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SLC25A21 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_112838 | 14 | 37153032:37153085:37153948:37154130:37180522:37180687 | 37153948:37154130 | ENSG00000183032.6 | ENST00000331299.5,ENST00000555449.1 |
| exon_skip_112840 | 14 | 37194774:37194882:37198711:37198771:37203711:37203778 | 37198711:37198771 | ENSG00000183032.6 | ENST00000331299.5,ENST00000546428.2,ENST00000555449.1 |
| exon_skip_112841 | 14 | 37203711:37203778:37283122:37283206:37344160:37344209 | 37283122:37283206 | ENSG00000183032.6 | ENST00000331299.5,ENST00000555449.1 |
| exon_skip_112843 | 14 | 37283122:37283206:37344160:37344209:37641485:37641551 | 37344160:37344209 | ENSG00000183032.6 | ENST00000331299.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SLC25A21 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_112838 | 14 | 37153032:37153085:37153948:37154130:37180522:37180687 | 37153948:37154130 | ENSG00000183032.6 | ENST00000555449.1,ENST00000331299.5 |
| exon_skip_112840 | 14 | 37194774:37194882:37198711:37198771:37203711:37203778 | 37198711:37198771 | ENSG00000183032.6 | ENST00000555449.1,ENST00000331299.5,ENST00000546428.2 |
| exon_skip_112841 | 14 | 37203711:37203778:37283122:37283206:37344160:37344209 | 37283122:37283206 | ENSG00000183032.6 | ENST00000555449.1,ENST00000331299.5 |
| exon_skip_112843 | 14 | 37283122:37283206:37344160:37344209:37641485:37641551 | 37344160:37344209 | ENSG00000183032.6 | ENST00000331299.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SLC25A21 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000331299 | 37153948 | 37154130 | Frame-shift |
| ENST00000331299 | 37344160 | 37344209 | Frame-shift |
| ENST00000331299 | 37198711 | 37198771 | In-frame |
| ENST00000331299 | 37283122 | 37283206 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000331299 | 37153948 | 37154130 | Frame-shift |
| ENST00000331299 | 37344160 | 37344209 | Frame-shift |
| ENST00000331299 | 37198711 | 37198771 | In-frame |
| ENST00000331299 | 37283122 | 37283206 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SLC25A21 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000331299 | 2802 | 299 | 37283122 | 37283206 | 636 | 719 | 40 | 67 |
| ENST00000331299 | 2802 | 299 | 37198711 | 37198771 | 787 | 846 | 90 | 110 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000331299 | 2802 | 299 | 37283122 | 37283206 | 636 | 719 | 40 | 67 |
| ENST00000331299 | 2802 | 299 | 37198711 | 37198771 | 787 | 846 | 90 | 110 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BQT8 | 40 | 67 | 1 | 299 | Chain | ID=PRO_0000090644;Note=Mitochondrial 2-oxodicarboxylate carrier |
| Q9BQT8 | 40 | 67 | 11 | 100 | Repeat | Note=Solcar 1 |
| Q9BQT8 | 90 | 110 | 1 | 299 | Chain | ID=PRO_0000090644;Note=Mitochondrial 2-oxodicarboxylate carrier |
| Q9BQT8 | 90 | 110 | 11 | 100 | Repeat | Note=Solcar 1 |
| Q9BQT8 | 90 | 110 | 107 | 196 | Repeat | Note=Solcar 2 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9BQT8 | 40 | 67 | 1 | 299 | Chain | ID=PRO_0000090644;Note=Mitochondrial 2-oxodicarboxylate carrier |
| Q9BQT8 | 40 | 67 | 11 | 100 | Repeat | Note=Solcar 1 |
| Q9BQT8 | 90 | 110 | 1 | 299 | Chain | ID=PRO_0000090644;Note=Mitochondrial 2-oxodicarboxylate carrier |
| Q9BQT8 | 90 | 110 | 11 | 100 | Repeat | Note=Solcar 1 |
| Q9BQT8 | 90 | 110 | 107 | 196 | Repeat | Note=Solcar 2 |
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SNVs in the skipped exons for SLC25A21 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_112838 | 37153949 | 37154130 | 37153977 | 37153977 | Frame_Shift_Del | T | - | p.T253fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_112838 | 37153949 | 37154130 | 37153981 | 37153981 | Frame_Shift_Del | A | - | p.F251fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_112838 | 37153949 | 37154130 | 37153981 | 37153981 | Frame_Shift_Del | A | - | p.F251fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_112840 | 37198712 | 37198771 | 37198767 | 37198767 | Frame_Shift_Del | A | - | p.F92fs |
| HNSC | TCGA-QK-A8Z9-01 | exon_skip_112838 | 37153949 | 37154130 | 37153953 | 37153953 | Nonsense_Mutation | C | A | p.E261* |
| SKCM | TCGA-BF-A5ES-01 | exon_skip_112838 | 37153949 | 37154130 | 37153959 | 37153959 | Nonsense_Mutation | G | A | p.Q259* |
| SKCM | TCGA-GN-A266-06 | exon_skip_112838 | 37153949 | 37154130 | 37153959 | 37153959 | Nonsense_Mutation | G | A | p.Q259* |
| SKCM | TCGA-GN-A266-06 | exon_skip_112838 | 37153949 | 37154130 | 37153959 | 37153959 | Nonsense_Mutation | G | A | p.Q259X |
| LUAD | TCGA-86-A4JF-01 | exon_skip_112840 | 37198712 | 37198771 | 37198738 | 37198738 | Nonsense_Mutation | C | A | p.G102* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SNU81_LARGE_INTESTINE | 37153949 | 37154130 | 37154079 | 37154079 | Missense_Mutation | T | C | p.T219A |
| KHYG_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 37198712 | 37198771 | 37198732 | 37198732 | Missense_Mutation | C | A | p.V104L |
| WM1799_SKIN | 37283123 | 37283206 | 37283140 | 37283140 | Missense_Mutation | C | T | p.M62I |
| HKA1_SKIN | 37344161 | 37344209 | 37344201 | 37344201 | Nonsense_Mutation | C | A | p.E27* |
| NCIH1435_LUNG | 37283123 | 37283206 | 37283123 | 37283123 | Splice_Site | C | A | p.G68V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLC25A21 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC25A21 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC25A21 |
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RelatedDrugs for SLC25A21 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC25A21 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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